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Research Article

Effect of Purified Saponin Mixture from Astragalus corniculatus on Toxicity Models in Isolated Rat Hepatocytes

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Pages 866-870 | Accepted 21 May 2008, Published online: 20 Jan 2009

References

  • JHA Bae, and JY Lee. (2003). The effect of chondroitin sulfate against CCl4-induced hepatotoxicity. Biol Pharm Bull 26:622–626.
  • D Fau, A Berson, D Eugene, B Fromenty, C Fisch, and D Pessayre. (1992). Mechanism for the hepatotoxicity of the antiandrogen, nilutamide. Evidence suggesting that redox cycling of this nitroaromatic drug leads to oxidative stress in isolated hepatocytes. J Pharm Exp Ther 263:69–77.
  • M Ferreira, O Nunes, L Leal, O Pessoa, T Lemos, and G Viana. (2003). Antioxidant effects in the quinine fraction from Auxemma oncocalyx Taub. Biol Pharm Bull 26:595–599.
  • C Hong, YC Lo, FC Tan, YH Wei, and CF Chen. (1994). Astragalus membranaceus and Polygonum multiflorum protect rat heart mitochondria against lipid peroxidation. Am J Chin Med 22:63–70.
  • I Krasteva, S Nikolov, and M Kaloga. (2007). A new saponin lactone from Astragalus corniculatus. Nat Prod Res 21:941–945.
  • I Krasteva, S Nikolov, M Kaloga, and G Mayer. (2006). Triterpenoid saponins from Astragalus corniculatus. Z Naturforsch 61b:1166–1169.
  • I Krasteva, R Toshkova, and S Nikolov. (2004). Protective effect of Astragalus corniculatus saponins against myeloid Graffi tumor in hamsters. Phytoter Res 18:255–257.
  • G Kroemer, B Dallaporta, and M Resche-Rigon. (1998). The mitochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol 60:619–642.
  • M Mitcheva, M Kondeva, V Vitcheva, P Nedialkov, and G Kitanov. (2006). Effect of benzophenones from Hypericum annulatum on carbon tetrachloride-induced toxicity in freshly isolated rat hepatocytes. Redox Report 11:3–8.
  • V O'Donnell, and MJ Burkit. (1994). Mitochondrial metabolism of a hydroperoxide to free radicals in human endothelial cells: An electron spin resonance spin–trapping investigation. Biochem J 304:707–713.
  • K Ollinger, and UT Brunk. (1995). Cellular injury induced by oxidative stress is mediated through lysosome damage. Free Radic Biol Med 19:565–574.
  • R Rate, A Bensoussan, and Y Fan. (1998). Preliminary report of randomized, double-blind, placebo-controlled trail of a Chinese herbal medicine preparation CH-100 in the treatment of chronic hepatitis C. J Gastro Hep 13:244–247.
  • LJ Rios, and PG Waterman. (1997). A review of the pharmacology and toxicology of Astragalus.. Phytoter Res 11:411–418.
  • RA Toshkova, N Krasteva, W Wesselinova, I Ivanov, and SD Nikolov. (2007). Influence of purified saponin mixture from Astragalus corniculatus Bieb. on phagocytic cells in Graffi tumor bearing hamsters. J Ethnopharmacol 109:394–399.
  • L Verotta, and N El-Sebakhy. (2001). Cycloartane and oleanane saponins from Astragalus sp. In: Studies in Natural Products Chemistry (Bioactive Natural Products, Part F), Elsevier Science, Karachi, pp. 179–234.
  • LW Weber, M Boll, and A Stampfl. (2003). Hepatotoxicity and mechanism of action of haloalkanes: Carbon tetrachloride as a toxicological model. Crit Rev Toxicol 33:105–36.
  • Y Zhang, Z Gong, J Zheng, X Liu, and B Shen. (1992a). Effect of Astragalus membranaceus, injection component XGA on lipid peroxides level in mice. Acad Med Shanghai 19:378–380.
  • YJ Zhang, J Shen, S Zhu, D Huang, Y Ding, and X Zhang. (1992b). Effects of Astragalus (ASI, SK) on experimental liver injury. Acta Pharm Sinica 27:401–406.

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