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Research Article

Cytoprotective activity of amifostine on HeLa cell cultures treated with daunorubicin and evaluation of gene expression by RT-PCR

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Pages 527-532 | Received 08 Oct 2008, Accepted 15 Nov 2008, Published online: 01 Jun 2009

References

  • Bruckheimer EM, Cho S, Brisbay S, Johnson DJ, Gingrich JR, Greenberg N, McDonnell TJ (2000): The impact of bcl-2 expression and bax deficiency on prostate homeostasis in vivo. Oncogene 19: 2404–2412.
  • Dai D, Holmes AM, Nguyen T, Davies S, Theele DP, Verschraegen C, Leslie KK (2005): A potential synergistic anticancer effect of paclitaxel and amifostine on endometrial cancer. Cancer Res 65: 9517–9524.
  • Das A, Belagodu A, Relter RJ, Ray SK, Banik NL (2008): Cytoprotective effects melatonin on C6 astroglial cells exposed to glutamate excitotoxicity and oxidative stress. J Pineal Res 45: 117–124.
  • Das B, Yeger H, Baruchel H, Freedman MH, Koren G, Baruchel S (2003): In vitro cytoprotective activity of squalene on a bone marrow versus neuroblastoma model of cisplatin-induced toxicity: Implications in cancer chemotherapy. Eur J Cancer 39: 2556–2565.
  • Gewirtz DA (1999): A critical evaluation of the mechanism of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem Pharmacol 57: 727–741.
  • Grazide S, Terrisse A-D, Leronge S, Laurent G, Jaffrézou J-P (2004): Cytoprotective effect of glucosylceramide synthase inhibition against daunorubicin-induced apoptosis in human leukemic cell lines. J Biol Chem 30: 18258–18261.
  • Grochova D, Ŝmardova J (2007): The antimutagenic and cytoprotective effects of amifostine: the role of p53. J Appl Biomed 5: 171–178.
  • Hanada M, Aime-Sempe C, Sato T, Reed JC (1995): Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax. J Biol Chem 270: 11962–11969.
  • Hueber A, Weller M, Welsandt G, Kociok N, Kirchhof B, Eser P (2003): Characterization of dounorubicin-induced apoptosis in retinal pigment epithelial cells: modulation by CD95L. Investigative Ophtalmology & Visual Science 44: 2851–2857.
  • Jäckel MC, Dorudian MA, Marx D, Brinck U, Schaurer A, Steiner W (1999): Spontaneous apoptosis in laryngeal squamous cell carcinoma is independent of bcl-2 and bax protein expression. American Cancer Society 85: 591–599.
  • Jaffrezou JP, Levade T, Bettaieb A, Andrieu N, Bezombes C, Maestre N, Vermeersch S, Rousse A, Laurent G (1996): Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis. EMBO J 15: 2417–2424.
  • Keprtova J, Vyhnakova M, Minarova E, Kleinwachter V (1993): Effects of daunomycin and its macromolecular analog daunophilin on the proliferation of mammalian cells. Neoplasma 40: 161–165.
  • Ling YH, Priebe W, Perez-Solar R (1993): Apoptosis induced by anthracycline antibiotics in P388 parent and multidrug resistant cells. Cancer Res 53: 1845–1852.
  • Lucianot F, Zhai D, Zhu X, Bailly-Maitre B, Ricci J-E, Satterthwait AC, Reed JC (2006): Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2/Bax family protein BimEl. J Biol Chem 280: 15825–15836.
  • Meriwether WD, Bachur NR (1972): Inhibition of DNA and RNA metobolism by daunorubicin and adrimycin in L1210 mouse leukemia. Cancer Res 32: 1137–1142.
  • Mirjolet J-F, Barberi-Heyob M, Didelot C, Peyrat J-P, Abecassis J, Millon R, Merlin J-L (2000): Bcl-2/Bax protein ratio predicts 5-fluorouracil sensitivity independently of p53 status. Br J Cancer 83: 1380–1388.
  • Nitsu N, Kasukabe T, Yokoyama A, Okabe-Kado J, Yamamoto-Yamaguchi Y, Umeda M, Honma Y (2000): Anticancer derivative of butyric acid (pivalyloxymethyl butyrate) specifically potentiates the cytotoxicity of doxorubicin and daunorubicin through the suppression of microsomal glycosidic activity. Mol Pharmacol 58: 27–36.
  • Oliver CL, Miranda MB, Shangary S, Land S, Wang S, Johnson DE (2005): (-)-Gossypol acts directly on the mitochondria to overcome Bcl-2 and Bcl-XL-mediated apoptosis resistance. Mol Cancer Therapeut 4: 23–31.
  • Özcan Arıcan G (2005): Cytoprotective effects of amifostine and cysteamine on cultured normal and tumor cells treated with paclitaxel in terms of mitotic index and 3H-tymidine labeling index. Cancer Chemo Pharmacol 56: 221–229.
  • Özcan Arıcan G, Özalpan A (2007): Evaluation of the effect of PAC, EPI and TAM by cell kinetics parameters in estrogen-receptor-positive Ehrlich Ascites Tumor (EAT) cells growing in vitro. Acta Biologia Hungarica 58: 49–59.
  • Özcan Arıcan G, Soy NN (2005): Effects of epirubicin and daunorubicin on cell proliferation and cell death in HeLa cells. J Cell Mol Biol 4: 47–52.
  • Periman H, Zhang X, Chen MW, Walsh K, Buttyan R (1999): An elevated bax/bcl-2 ratio corresponds with the onset of prostate epithelial cell apoptosis. Cell Death Different 6: 48–54.
  • Plosker GL, Faulds D (1993): A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in cancer chemotherapy. Drugs 45: 788–856.
  • Roˇźalski M, Mirowski M, Balcerczak E, Krajewska U, Mlynarski W, Wierzbicki R (2005): Induction of caspase 3 activity, bcl-2 bax and p65 gene expression modulation in human acute promyeloctic leukemia HL-60 cells by doxorubicin with amifostine. Pharmacol Rep 57: 360–366.
  • Skladanowski A, Konopa J (1993): Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumor cells. Biochem Pharmacol 46: 375–382.
  • Takara K, Obata Y, Yoshikawa E, Kitada N, Sakaeda T, Ohnishi N, Yokoyama T (2006): Molecular changes to HeLa cells on continuous exposure to cisplatin or paclitaxel. Cancer Chemo Pharmacol 58: 785–793.
  • Viera HLA, Boya P, Cohen I, El Hamel C, Haouzi D, Druillenec S, Belzacq A-S, Brenner C, Roques B, Kroemer G (2002): Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and Bcl-XL. Oncogene 21: 1963–1977.
  • Werner AB, de Viries E, Stephen WG, Tait SWG, Bontjer I, Borst J (2002): Bcl-2 family member Bfl-1/A1 sequesters truncated bid to inhibit its collaboration with pro-apoptotic Bak or Bax. J Biol Chem 277: 22781–22788.
  • Zeng S, Chen YZ, Fu L, Johnson KR, Fan W (2000): In vitro evaluation of schedule-dependent interactions between docataxel and doxorubicin against human breast and ovarian cancer cells. Clin Cancer Res 6: 3766–3773.

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