Triflavin, an α_IIβ₃ disintegrin, inhibits cell adhesion and protein kinase C-α translocation in vascular smooth muscle cells

References

• Baron JH, Moiseeva EP, de Bono DP, Abrams KR, Gershlick AH (2000): Inhibition of vascular smooth muscle cell adhesion and migration by c7E3 Fab (abciximab): A possible mechanism for influencing restenosis. Cardiovasc Res 48: 464–472.
   PubMed Web of Science ®Google Scholar
• Batchelor WB, Robinson R, Strauss BH (1998): The extracellular matrix in balloon arterial injury: A novel target for restenosis prevention. Prog Cardiovasc Dis 41: 35–49.
   PubMedGoogle Scholar
• Choi ET, Engel L, Callow AD, Sun S, Trachtenberg J, Santoro S, Ryan US (1994): Inhibition of neointimal hyperplasia by blocking alpha V beta 3 integrin with a small peptide antagonist GpenGRGDSPCA. J Vasc Surg 19: 125–134.
   PubMed Web of Science ®Google Scholar
• Clark EA, Brugge JS (1995): Integrins and signal transduction pathways: the road taken. Science 268: 233–239.
   PubMed Web of Science ®Google Scholar
• Gould RJ, Polokoff MA, Friedman PA, Huang TF, Holt JC, Cood JJ (1990): Disintegrins: a family of integrin inhibitory proteins from viper venoms. Proc Soc Exp Biol Med 195: 168–171.
   PubMed Web of Science ®Google Scholar
• Haller H, Lindschau C, Maasch C, Olthoff H, Kurscheid D, Luft FC (1998): Integrin-induced protein kinase C alpha and C epsilon translocation to focal adhesions mediates vascular smooth muscle cell spreading. Circ Res 82: 157–165.
   PubMedGoogle Scholar
• Huang TF, Sheu JR, Teng CM (1991a): A potent antiplatelet peptide, triflavin, from Trimeresurus flavoviridis snake venom. Biochem J 277: 351–357.
   PubMed Web of Science ®Google Scholar
• Huang TF, Sheu JR, Teng CM, Chen SW, Liu CS (1991b): Triflavin, an antiplatelet Arg-Gly-Asp-containing peptide, is a specific antagonist of platelet membrane glycoprotein IIb/IIIa complex. J Biochem 109: 328–334.
   PubMed Web of Science ®Google Scholar
• Hynes RO (1992): Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69: 11–25.
   PubMed Web of Science ®Google Scholar
• Kintscher U, Kappert K, Schmidt G, Doerr G, Grill M, Wollert-Wulf B, Graefe M, Fleck E, Graf K (2000): Effects of abciximab and tirofiban on vitronectin receptors in human endothelial and smooth muscle cells. Eur J Pharmacol 390: 75–87.
   PubMedGoogle Scholar
• Krook A, Rapoport MJ, Anderson S, Pross H, Zhou YC, Denhardt DT, Delovitch TL, Haliotis T (1993): p21ras and protein kinase C function in distinct and interdependent signaling pathways in C3H 10T1/2 fibroblasts. Mol Cell Biol 13: 1471–1479.
   PubMedGoogle Scholar
• Libby P, Sukhova G, Lee RT, Liao JK (1997): Molecular biology of atherosclerosis. Int J Cardiol. 62(Suppl 2): S23–S29.
   PubMedGoogle Scholar
• Lusis AJ (2000): Atherosclerosis. Nature 407: 233–241.
   PubMed Web of Science ®Google Scholar
• McNamee HP, Ingber DE, Schwartz MA (1993): Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown. J Cell Biol 121: 673–678.
   PubMed Web of Science ®Google Scholar
• Moiseeva EP (2001): Adhesion receptors of vascular smooth muscle cells and their functions. Cardiovasc Res 52: 372–386.
   PubMed Web of Science ®Google Scholar
• Okazaki J, Mawatari K, Liu B, Kent KC (2000): The effect of protein kinase C and its alpha subtype on human vascular smooth muscle cell proliferation, migration and fibronectin production. Surgery 128: 192–197.
   PubMed Web of Science ®Google Scholar
• Pauly RR, Bilato C, Cheng L, Monticone R, Crow MT (1997): Vascular smooth muscle cell cultures. Meth Cell Biol 52: 133–154.
   PubMed Web of Science ®Google Scholar
• Pytela R, Pierschbacher MD, Ginsberg MH, Plow EF, Ruoslahti E (1986): Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp specific adhesion receptors. Science 231: 1559–1562.
   PubMed Web of Science ®Google Scholar
• Richardson A, Parsons T (1996): A mechanism for regulation of the adhesion associated protein tyrosine kinase pp125FAK. Nature 380: 538–540.
   PubMed Web of Science ®Google Scholar
• Salamanca DA, Khalil RA (2005): Protein kinase C isoforms as specific targets for modulation of vascular smooth muscle function in hypertension. Biochem Pharmacol 70: 1537–1547.
   PubMed Web of Science ®Google Scholar
• Schwartz SM (1997): Perspectives series: Cell adhesion in vascular biology. Smooth muscle migration in atherosclerosis and restenosis. J Clin Invest 99: 2814–2816.
   PubMed Web of Science ®Google Scholar
• Sheu JR, Chao SH, Yen MH, Huang TF (1994): In vivo antithrombotic effect of triflavin, an Arg-Gly-Asp-containing peptide on platelet plug formation in mesenteric microvessels of mice. Thromb Haemost 72: 617–621.
   PubMedGoogle Scholar
• Sheu JR, Huang TF (1996): Triflavin, an Arg-Gly-Asp-containing peptide, inhibits B16-F10 mouse melanoma cell adhesion to matrix proteins via direct binding to tumor cells. J Biomed Sci 3: 359–364.
   PubMedGoogle Scholar
• Sheu JR, Hung WC, Wu CH, Ma MC, Kan YC, Lin CH, Lin MS, Luk HN, Yen MH (1999): Reduction in lipopolysaccharide-induced thrombocytopenia by triflavin in a rat model of septicemia. Circulation 99: 3056–3062.
   PubMed Web of Science ®Google Scholar
• Sheu JR, Teng CM, Huang TF (1992): Triflavin, an RGD-containing antiplatelet peptide, binds to GpIIIa of ADP-stimulated platelets. Biochem Biophys Res Commun 189: 1236–1242.
   PubMed Web of Science ®Google Scholar
• Sheu JR, Wu CH, Chen YC, Hsiao G, Lin CH (2001): Mechanisms in the inhibition of neointimal hyperplasia with triflavin in a rat model of balloon angioplasty. J Lab Clin Med 137: 270–278.
   PubMedGoogle Scholar
• Sheu JR, Yen MH, Kan YC, Hung WC, Chang PT, Luk HN (1997a): Inhibition of angiogenesis in vitro and in vivo: comparison of the relative activities of triflavin, an Arg-Gly-Asp-containing peptide and anti-αVβ3 integrin monoclonal antibody. Biochim Biophys Acta 1336: 445–454.
   PubMed Web of Science ®Google Scholar
• Sheu JR, Yen MH, Hung WC, Lee YM, Su CH, Huang TF (1997b): Triflavin inhibits platelet-induced vasocontraction in deendothelialized aorta. Arterioscle Thromb Vacs Biol 17: 3461–3468.
   PubMedGoogle Scholar
• Smith JW, Ruggeri ZM, Kunicki TJ, Cheresh DA (1990): Interactions of integrins αVβ3 and glycoprotein IIb/IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites. J Biol Chem 265: 12267–12271.
   PubMedGoogle Scholar
• Tricoci P, Peterson ED, Chen AY, Newby LK, Harrington RA, Greenbaum AB, Cannon CP, Gibson CM, Hoekstra JW, Pollack CV Jr, Ohman EM, Gibler WB, Roe MT (2007): Timing of glycoprotein IIb/IIIa inhibitor use and outcomes among patients with non-ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention (results from CRUSADE). Am J Cardiol 99: 1389–1393.
   PubMedGoogle Scholar
• Vuori K, Ruoslahti E (1993): Activation of protein kinase C precedes alpha 5 beta 1 integrin-mediated cell spreading on fibronectin. J Biol Chem 268: 21459–21462.
   PubMed Web of Science ®Google Scholar
• Willis AI, Pierre-Paul D, Sumpio BE, Gahtan V (2004): Vascular smooth muscle cell migration: current research and clinical implications. Vasc Endovasc Surg 38: 11–23.
   PubMedGoogle Scholar