2,309
Views
16
CrossRef citations to date
0
Altmetric
Original Article

Beetroot (Beta vulgaris) rescues mice from γ-ray irradiation by accelerating hematopoiesis and curtailing immunosuppression

, , , , , & show all
Pages 306-316 | Received 27 Aug 2015, Accepted 09 Sep 2016, Published online: 07 Dec 2016

References

  • Adhikari M, Arora R. 2016. The flavonolignan-silymarin protects enzymatic, hematological, and immune system against ?-radiation-induced toxicity. Environ Toxicol. 31:641–654.
  • Allegraa M, Furtmullerb PG, Jantschkob W, Zederbauerb M, Tesorierea L, Livreaa MA, Obingerb C. 2005. Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid. Biochem Biophys Res Commun. 332:837–844.
  • Arora R, Gupta D, Chawla R, Sagar R, Sharma A, Kumar R, Prasad J, Singh S, Samanta N, Sharma RK. 2005. Radioprotection by plant products: present status and future prospects. Phytother Res. 19:1–22.
  • Atta AH, Alokfahi A. 1998. Anti-nociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts. J Ethnopharmacol. 60:117–124.
  • Benkovic V, Knezevic AH, Orsolic N, Basic I, Ramic S, Viculin T, Knezevic F, Kopjar N. 2009. Evaluation of radioprotective effects of propolis and its flavonoid constituents: in vitro study on human white blood cells. Phytother Res. 23:1159–1168.
  • Bing SJ, Kim MJ, Ahn G, Im J, Kim DS, Ha D, Cho J, Kim A, Jee Y. 2014. Acidic polysaccharide of Panax ginseng regulates the mitochondria/caspase-dependent apoptotic pathway in radiation-induced damage to the jejunum in mice. Acta Histochem. 116:514–521.
  • Budke H, Orazi A, Neiman RS, Cattoretti G, John K, Barberis M. 1994. Assessment of cell proliferation in paraffin sections of normal bone marrow by the monoclonal antibodies Ki-67 and PCNA. Mod Pathol. 7:860–866.
  • Bump EA, Malaker K. 1997. Radioprotectors: chemical, biological, and clinical perspectives. London, UK: CRC press.
  • Citrin D, Cotrime AP, Hyodo F, Baum BJ, Krishna MC, Mitchell J. 2010. Radioprotectors and mitigators of radiation-induced normal tissue injury. Oncologist. 15:360–371.
  • Copp RR, Peebles DD, Soref CM, Fahl WE. 2013. Radioprotective efficacy and toxicity of a new family of aminothiol analogs. Int J Radiat Biol. 89:485–492.
  • Cramers P, Verhoeven EE, Filon AR, Rockx DA, Santos SJ, van der Leer AA, Kleinjans JC, van Zeelanda AA, Mullendersa LH. 2011. Impaired repair of ionizing radiation-induced DNA damage in cockayne syndrome cells. Radiat Res. 175:432–443.
  • Escribano J, Pedreno MA, Garcia-Carmona F, Munoz R. 1998. Characterization of the antiradical activity of betalains from Beta vulgaris L. roots. Phytochem Anal. 9:124–127.
  • Ewing D, Jones SR. 1987. Superoxide removal and radiation protection in bacteria. Arch Biochem Biophys. 254:53–62.
  • Gale RP, Butturini A. 1990. Use of hematopoietic growth factors in radiation accidents. Int J Radiat Oncol Biol Phys. 19:1291–1295.
  • Harrington NP, Chambers KA, Ross WM, Filion LG. 1997. Radiation damage and immune suppression in splenic mononuclear cell populations. Clin Exp Immunol. 107:417–424.
  • Heylmann D, Rodel F, Kindler T, Kaina B. 2014. Radiation sensitivity of human and murine peripheral blood lymphocytes, stem and progenitor cells. Biochim Biophys Acta. 1846:121–129.
  • Imai Y, Nakao I. 1987. In vivo radiosensitivity and recovery pattern of the hematopoietic precursor cells and stem cells in mouse bone marrow. Exp Hematol. 15:890–895.
  • Jain S, Garg VK, Sharma PK. 2011. Anti-inflammatory activity of aqueous extract of Beta vulgaris L. J Basic Clin Pharm. 2:83–86.
  • Kujawska M, Ignatowicz E, Murias M, Ewertowska M, Mikolajczyk K, Jodynis-Liebert J. 2009. Protective effect of red beetroot against carbon tetrachloride- and N-nitrosodiethylamine-induced oxidative stress in rats. J Agric Food Chem. 57:2570–2575.
  • Lu X, Wang Y, Zhang Z. 2009. Radioprotective activity of betalains from red beets in mice exposed to gamma irradiation. Eur J Pharmacol. 615:223–227.
  • Mukherjee B, Tomimatsu N, Amancherla K, Camacho CV, Pichamoorthy N, Burma S. 2012. The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage responses. Neoplasia. 14:34–43.
  • Nair CK, Parida DK, Nomura T. 2001. Radioprotectors in radiotherapy. J Radiat Res. 42:21–37.
  • Ninfali P, Angelino D. 2013. Nutritional and functional potential of Beta vulgaris cicla and rubra. Fitoterapia. 89:188–199.
  • Pal S, Saha C, Dey SK. 2013. Studies on black tea (Camellia sinensis) extract as a potential antioxidant and a probable radioprotector. Radiat Environ Biophys. 52:269–278.
  • Park E, Hwang I, Song J, Jee Y. 2011. Acidic polysaccharide of Panax ginseng as a defense against small intestinal damage by whole-body gamma irradiation of mice. Acta Histochem. 113:19–23.
  • Park E, Lee NH, Baik JS, Jee Y. 2008. Elaeocarpus sylvestris modulates gamma-ray-induced immunosuppression in mice: implications in radioprotection. Phytother Res. 22:1046–1051.
  • Peng R, Wang D, Xiong C, Li Y, Gao Y, Wang B, Cui Y, Yang H, Hu W. 1998. The changes and significance of c-kit expression in the irradiated bone marrow of mice. J Environ Pathol Toxicol Oncol. 17:129–133.
  • Reddy MK, Alexander-lindo RL, Nair MG. 2005. Relative inhibition of lipid peroxidation, cyclooxygenase enzymes, and human tumor cell proliferation by natural food colors. J Agric Food Chem. 53:9268–9273.
  • Regenbrecht CRA, Jung M, Lehrach H, Adjave J. 2008. The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines. BMC Med Genomics. 1:49. doi: 10.1186/1755-8794-1-49.
  • Riccardi C, Nicoletti I. 2006. Analysis of apoptosis by propidium iodide staining and flow cytometry. Nat Protoc. 1:1458–1461.
  • Shi Y, Liu CH, Roberts AI, Das J, Xu G, Ren G, Zhang Y, Zhang L, Yuan ZR, Tan HS, et al. 2006. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know. Cell Res. 16:126–133.
  • Tesoriere L, Butera D, Allegra M, Fazzari M, Livrea MA. 2005. Distribution of betalain pigments in red blood cells after consumption of cactus pear fruits and increased resistance of the cells to ex vivo induced oxidative hemolysis in humans. J Agric Food Chem. 53:1266–1270.
  • Vulic JJ, Cebovic TN, Canadanovic VM, Cetkovic GS, Djilas SM, Canadanovic-Brunet JM, Velicanski AS, Cyetkovic DD, Tumbas VT. 2013. Antiradical, antimicrobial and cytotoxic activities of commercial beetroot pomace. Food Funct. 4:713–721.
  • Waselenko JK, MacVittie TJ, Blakely WF, Pesik N, Wiley AL, Dickerson WE, Tsu H, Confer DL, Coleman CN, Seed T, et al. 2004. Medical management of the acute radiation syndrome: recommendations of the strategic national stockpile radiation working group. Ann Intern Med. 140:1037–1051.
  • Zou Q, Hong W, Zhou Y, Ding Q, Wang J, Jin W, Gao J, Hua G, Xu X. 2016. Bone marrow stem cell dysfunction in radiation-induced abscopal bone loss. J Orthop Surg Res. 11:3. doi: 10.1186/s13018-015-0339-9.