Effects and mechanisms of pirfenidone, prednisone and acetylcysteine on pulmonary fibrosis in rat idiopathic pulmonary fibrosis models

References

• Antoniades H, Bravo M, Avila R, Galanopoulos T, Neville-Golden J, Maxwell M, Selman M. 1990. Platelet-derived growth factor in idiopathic pulmonary fibrosis. J Clin Invest. 86:1055.
   PubMed Web of Science ®Google Scholar
• Fakhrzadeh L, Laskin JD, Laskin DL. 2008. Regulation of caveolin-1 expression, nitric oxide production and tissue injury by tumor necrosis factor-α following ozone inhalation. Toxicol Appl Pharm. 227:380–389.
   PubMed Web of Science ®Google Scholar
• Galdo FD, Sotgia F, de Almeida CJ, Jasmin JF, Musick M, Lisanti MP, Jiménez SA. 2008. Decreased expression of caveolin 1 in patients with systemic sclerosis: crucial role in the pathogenesis of tissue fibrosis. Arthritis Rheum. 58:2854–2865.
   PubMedGoogle Scholar
• Gurujeyalakshmi G, Hollinger M, Giri S. 1999. Pirfenidone inhibits PDGF isoforms in bleomycin hamster model of lung fibrosis at the translational level. Am J Physiol. 276:L311–L318.
   PubMed Web of Science ®Google Scholar
• Iyer S, Gurujeyalakshmi G, Giri S. 1999. Effects of pirfenidone on transforming growth factor-beta gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis. J Pharmacol Exp Ther. 291:367–373.
   PubMed Web of Science ®Google Scholar
• Lasky JA, Brody AR. 2000. Interstitial fibrosis and growth factors. Environ Health Persp. 108:751–762.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2− ΔΔCT method. Methods. 25:402–408.
   PubMed Web of Science ®Google Scholar
• Moises S, Girod CE, Shifren A, Estrada A, Fitzgerald JE, Safrin S, Bradford WZ. 2003. A double-blind, multicenter study comparing pirfenidone and prednisone for moderate-to-severe pulmonary fibrosis. Chest. 124:116S-b–116S.
   Web of Science ®Google Scholar
• Nakazato H, Oku H, Yamane S, Tsuruta Y, Suzuki R. 2002. A novel anti-fibrotic agent pirfenidone suppresses tumor necrosis factor-alpha at the translational level. Eur J Pharmacol. 446:177–185.
   PubMed Web of Science ®Google Scholar
• Okamoto T, Schlegel A, Scherer PE, Lisanti MP. 1998. Caveolins, a family of scaffolding proteins for organizing “preassembled signaling complexes” at the plasma membrane. J Biol Chem. 273:5419–5422.
   PubMed Web of Science ®Google Scholar
• Oku H, Shimizu T, Kawabata T, Nagira M, Hikita I, Ueyama A, Matsushima S, Torii M, Arimura A. 2008. Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis. Eur J Pharmacol. 590:400–408.
   PubMed Web of Science ®Google Scholar
• Pantelidis P, Fanning GC, Wells AU, Welsh KI, Du Bois RM. 2001. Analysis of tumor necrosis factor-alpha, lymphotoxin-alpha, tumor necrosis factor receptor II, and interleukin-6 polymorphisms in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 163:1432–1436.
   PubMed Web of Science ®Google Scholar
• Peterson TE, Guicciardi ME, Gulati R, Kleppe LS, Mueske CS, Mookadam M, Sowa G, Gores GJ, Sessa WC, Simari RD. 2003. Caveolin-1 can regulate vascular smooth muscle cell fate by switching platelet-derived growth factor signaling from a proliferative to an apoptotic pathway. Arterioscler Thromb Vasc Biol. 23:1521–1527.
   PubMed Web of Science ®Google Scholar
• Prasse A. 2015. [Idiopathic Pulmonary Fibrosis]. Pneumologie. 69:608–614.
   PubMed Web of Science ®Google Scholar
• Raghu G, Anstrom KJ, King TE, Jr., Lasky JA, Martinez FJ, Idiopathic Pulmonary Fibrosis Clinical Research Network. 2012. Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis. N Engl J Med. 366:1968–1977.
   PubMed Web of Science ®Google Scholar
• Razani B, Zhang XL, Bitzer M, von Gersdorff G, Böttinger EP, Lisanti MP. 2001. Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor. J Biol Chem. 276:6727–6738.
   PubMed Web of Science ®Google Scholar
• Rothberg KG, Heuser JE, Donzell WC, Ying Y-S, Glenney JR, Anderson RG. 1992. Caveolin, a protein component of caveolae membrane coats. Cell. 68:673–682.
   PubMed Web of Science ®Google Scholar
• Shivshankar P, Brampton C, Miyasato S, Kasper M, Thannickal VJ, Le Saux CJ. 2012. Caveolin-1 deficiency protects from pulmonary fibrosis by modulating epithelial cell senescence in mice. Am J Respir Cell Mol Biol. 47:28–36.
   PubMed Web of Science ®Google Scholar
• Sun R. 2003. Translocation of caveolin-1 induced by shearing stress in endothelial cells. Awarded Papers of the 7th Beijing youth science and technology paper award competition.
   Google Scholar
• Szapiel SV, Elson NA, Fulmer JD, Hunninghake GW, Crystal RG. 1979. Bleomycin-induced interstitial pulmonary disease in the nude, athymic mouse 1, 2. Am Rev Respir Dis. 120:893–899.
   PubMed Web of Science ®Google Scholar
• Taniguchi H, Ebina M, Kondoh Y, Ogura T, Azuma A, Suga M, Taguchi Y, Takahashi H, Nakata K, Sato A. 2010. Pirfenidone in idiopathic pulmonary fibrosis. Eur Respir J. 35:821–829.
   PubMed Web of Science ®Google Scholar
• Thannickal VJ, Toews GB, White ES, Lynch Iii JP, Martinez FJ. 2004. Mechanisms of pulmonary fibrosis. Annu Rev Med. 55:395–417.
   PubMed Web of Science ®Google Scholar
• Tourkina E, Richard M, Oates J, Hofbauer A, Bonner M, Gööz P, Visconti R, Zhang J, Znoyko S, Hatfield CM. 2010. Caveolin-1 regulates leucocyte behaviour in fibrotic lung disease. Ann Rheum Dis. 69:1220–1226.
   PubMed Web of Science ®Google Scholar
• Wang L, Lim E-J, Toborek M, Hennig B. 2008. The role of fatty acids and caveolin-1 in tumor necrosis factor alpha-induced endothelial cell activation. Metab Clin Exp. 57:1328–1339.
   PubMed Web of Science ®Google Scholar
• Wang XM, Zhang Y, Kim HP, Zhou Z, Feghali-Bostwick CA, Liu F, Ifedigbo E, Xu X, Oury TD, Kaminski N. 2006. Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. J Exp Med. 203:2895–2906.
   PubMed Web of Science ®Google Scholar
• Willis BC, Liebler JM, Luby-Phelps K, Nicholson AG, Crandall ED, du Bois RM, Borok Z. 2005. Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis. Am J Pathol. 166:1321–1332.
   PubMed Web of Science ®Google Scholar
• Xia H, Khalil W, Kahm J, Jessurun J, Kleidon J, Henke CA. 2010. Pathologic caveolin-1 regulation of PTEN in idiopathic pulmonary fibrosis. Am J Pathol. 176:2626–2637.
   PubMed Web of Science ®Google Scholar
• Yamamoto M, Toya Y, Jensen RA, Ishikawa Y. 1999. Caveolin is an inhibitor of platelet-derived growth factor receptor signaling. Exp Cell Res. 247:380–388.
   PubMed Web of Science ®Google Scholar