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Research Article

Effects of astaxanthin on blood coagulation, fibrinolysis and platelet aggregation in hyperlipidemic rats

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Pages 663-672 | Received 05 Jan 2015, Accepted 14 Nov 2016, Published online: 12 Dec 2016

References

  • Aleksunes LM, Manautou JE. 2007. Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease. Toxicol Pathol. 35:459–473.
  • Arunkumar E, Bhuvaneswari S, Anuradha CV. 2012. An intervention study in obese mice with astaxanthin, a marine carotenoid-effects on insulin signaling and pro-inflammatory cytokines. Food Funct. 3:120–126.
  • Bai H, Liu BW, Deng ZY, Shen T, Fang DZ, Zhao YH, Liu Y. 2006. Plasma very-low-density lipoprotein, low-density lipoprotein, and high-density lipoprotein oxidative modification induces procoagulant profiles in endogenous hypertriglyceridemia. Free Radic. Biol. Med. 40:1796–1803.
  • Chan KC, Pen PJ, Yin MC. 2012. Anticoagulatory and antiinflammatory effects of astaxanthin in diabetic rats. J Food Sci. 77:H76–H80.
  • Choi HD, Kim JH, Chang MJ. 2011. Effects of astaxanthin on oxidative stress in overweight and obese adults. Phytother Res. 25:1813–1818.
  • Förstermann U. 2010. Nitric oxide and oxidative stress in vascular disease. Pflugers Archiv: Eur J Physiol. 459:923–939.
  • Ikeuchi M, Koyama T, Takahashi J, Yazawa K. 2007. Effects of astaxanthin in obese mice fed a high-fat diet. Biosci Biotechnol Biochem. 71:893–899.
  • Jin BH, Qian LB, Chen S, Li J, Wang HP, Bruce IC, Lin J, Xia Q. 2009. Apigenin protects endothelium-dependent relaxation of rat aorta against oxidative stress. Eur J Pharmacol. 616:200–205.
  • Kaspar JW, Niture SK, Jaiswal AK. 2009. Nrf2:INrf2 (Keap1) signaling in oxidative stress. Free Radic Biol Med. 47:1304–1309.
  • Kjalke M, Silveira A, Hamsten A, Hedner U, Ezban M. 2000. Plasma lipoproteins enhance tissue factor-independent factor VII activation. Arterioscler Thromb Vasc Biol. 20:1835–1841.
  • Hayakawa T, Kulkarni A, Terada Y. 2008. Reaction of astaxanthin with peroxynitrite. Biosci Biotechnol Biochem. 27:2716–2722.
  • Huang HC, Nguyen T, Pickett CB. 2002. Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription. J Biol Chem. 277:42769–42774.
  • Lauver DA, Driscoll EM, Lucchesi BR. 2008. Disodium disuccinate astaxanthin prevents carotid artery rethrombosis and ex vivo platelet activation. Pharmacology. 82:67–73.
  • Lee SJ, Bai SK, Lee KS, Namkoong S, Na HJ, Ha KS, Han JA, Yim SV, Chang K, Kwon YG, et al. 2003. Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappaB activation. Mol Cells. 16:97–105.
  • Levin GY, Egorihina MN. 2013. The role of oxidized albumin in blood cell aggregation disturbance in burn disease. Int J Burns Trauma. 3:115–121.
  • Li J, Ichikawa T, Janicki JS, Cui T. 2009. Targeting the Nrf2 pathway against cardiovascular disease. Expert Opin Ther Targets. 13:785–794.
  • Liu L, Liu Y, Cui J, Liu H, Liu YB, Qiao WL, Sun H, Yan CD. 2013. Oxidative stress induces gastric submucosal arteriolar dysfuction in the elderly. World J Gastroenterol. 19:9439–9446.
  • Mahfouz MM, Kummerow FA. 2000. Oxidized low-density lipoprotein (LDL) enhances thromboxane A(2) synthesis by platelets, but lysolecithin as a product of LDL oxidation has an inhibitory effect. Prostaglandins Other Lipid Mediat. 62:183–200.
  • Maruyama I. 1998. Coagulation/fibrinolytic system and platelet in acute coronary syndrome. Nihon rinsho. Jpn J Clin Med. 56:2488–2492.
  • Moncada S, Palmer RM, Higgs EA. 1991. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev. 43:109–142.
  • Motohashi H, Yamamoto M. 2004. Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med. 10:549–557.
  • Ohkawa H, Ohishi N, Yagi K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 95:351–358.
  • Olivieri O, Martinelli N, Baroni M, Branchini A, Girelli D, Friso S, Pizzolo F, Bernardi F. 2013. Factor II activity is similarly increased in patients with elevated apolipoprotein CIII and in carriers of the factor II 20210A allele. J Am Heart Assoc. 2:e000440. doi: 10.1161/JAHA.113.000440.
  • Ren S, Man RY, Angel A, et al. 1997. Oxidative modification enhances lipoprotein(a)-induced overproduction of plasminogen activator inhibitor-1 in cultured vascular endothelial cells. Atherosclerosis. 128:1–10.
  • Riccioni G, Speranza L, Pesce M, Cusenza S, D’Orazio N, Glade MJ. 2012. Novel phytonutrient contributors to antioxidant protection against cardiovascular disease. Nutrition. 28:605–610.
  • Ryu SK, King TJ, Fujioka K, Pattison J, Pashkow FJ, Tsimikas S. 2012. Effect of an oral astaxanthin prodrug (CDX-085) on lipoprotein levels and progression of atherosclerosis in LDLR(−/−) and ApoE(−/−) mice. Atherosclerosis. 222:99–105.
  • Santos SD, Cahu TB, Firmino GO, de Castro CC, Carvalho LB Jr, Bezerra RS, Filho JL. 2012. Shrimp waste extract and astaxanthin: rat alveolar macrophage, oxidative stress and inflammation. J Food Sci. 77:H141–H146.
  • Sasaki Y, Kobara N, Higashino S, Giddings JC, Yamamoto J. 2011. Astaxanthin inhibits thrombosis in cerebral vessels of stroke-prone spontaneously hypertensive rats. Nutr Res. 31:784–789.
  • Sener A, Ozsavci D, Oba R, Demirel GY, Uras F, Yardimci KT. 2005. Do platelet apoptosis, activation, aggregation, lipid peroxidation and platelet-leukocyte aggregate formation occur simultaneously in hyperlipidemia? Clin Biochem. 38:1081–1087.
  • Serebruany V, Malinin A, Goodin T, Pashkow F. 2010. The in vitro effects of Xancor, a synthetic astaxanthine derivative, on hemostatic biomarkers in aspirin-naïve and aspirin-treated subjects with multiple risk factors for vascular disease. Am J Ther. 17:125–132.
  • Stahl W, Sies H. 2012. Photoprotection by dietary carotenoids: concept, mechanisms, evidence and future development. Mol Nutr Food Res. 56:287–295.
  • Tripathi DN, Jena GB. 2010. Astaxanthin intervention ameliorates cyclophosphamide- induced oxidative stress, DNA damage and early hepatocarcinogenesis in rat: role of Nrf2, p53, p38 and phase-II enzymes. Mutat Res. 696:69–80.
  • Wang HQ, Sun XB, Xu YX, Zhao H, Zhu QY, Zhu CQ. 2010. Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells. Brain Res. 1360:159–167.
  • Yang Y, Seo JM, Nguyen A, Pham TX, Park HJ, Park Y, Kim B, Bruno RS, Lee J. 2011. Astaxanthin-rich extract from the green alga Haematococcus pluvialis lowers plasma lipid concentrations and enhances antioxidant defense in apolipoprotein E knockout mice. J Nutr. 141:1611–1617. 1
  • Yuan JP, Peng J, Yin K, Wang JH. 2011. Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae. Mol Nutr Food Res. 55:150–165.
  • Zhu J, Wang CG, Xu YG. 2011. Lycopene attenuates endothelial dysfunction in streptozotocin-induced diabetic rats by reducing oxidative stress. Pharm Biol. 49:1144–1149.