Advanced search
Publication Cover
Pharmaceutical Biology Volume 55, 2017 - Issue 1
Submit an article Journal homepage
1,633
Views
37
CrossRef citations to date
0
Altmetric
Research Article

Antihyperlipidaemic effect of triterpenic acid-enriched fraction from Cyclocarya paliurus leaves in hyperlipidaemic rats

Zhengfeng WuDepartment of Natural Medicinal Chemistry & State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P.R. China; ;Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, P.R. China; View further author information
,
Tianhong GaoDepartment of Natural Medicinal Chemistry & State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P.R. China; View further author information
,
Rongling ZhongLaboratory Animal Research Center, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu Province, P.R. China; View further author information
,
Zi LinDepartment of Natural Medicinal Chemistry & State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P.R. China; ;Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, P.R. China; View further author information
,
Cuihua JiangDepartment of Natural Medicinal Chemistry & State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P.R. China; ;Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, P.R. China; View further author information
,
Sheng OuyangDepartment of Pharmacy, JiangXi University of Traditional Chinese Medicine, Nanchang, P.R. China; ;Department of Medicinal Chemistry and Pharmacognosy, and WHO Collaborating Center for Tradition Medicine, University of Illinois at Chicago, Chicago, IL, USAView further author information
,
Ming ZhaoDepartment of Medicinal Chemistry and Pharmacognosy, and WHO Collaborating Center for Tradition Medicine, University of Illinois at Chicago, Chicago, IL, USAView further author information
,
Chuntao CheDepartment of Medicinal Chemistry and Pharmacognosy, and WHO Collaborating Center for Tradition Medicine, University of Illinois at Chicago, Chicago, IL, USAView further author information
,
Jian ZhangLaboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, P.R. China; Correspondence[email protected]
View further author information
&
Zhiqi YinDepartment of Natural Medicinal Chemistry & State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P.R. China; ;Department of Medicinal Chemistry and Pharmacognosy, and WHO Collaborating Center for Tradition Medicine, University of Illinois at Chicago, Chicago, IL, USACorrespondence[email protected]
View further author information
 show all
Pages 712-721 | Received 26 Apr 2016, Accepted 28 Nov 2016, Published online: 31 Jan 2017

References

  • Borthwick F, Mangat R, Warnakula S, Jacome-Sosa M, Vine DF, Proctor SD. 2014. Simvastatin treatment upregulates intestinal lipid secretion pathways in a rodent model of the metabolic syndrome. Atherosclerosis. 232:141–148.
  • Chen MQ, Liang JY, Jiao ZH, Guo YH, Meng GZ, Shen XQ, Li F, Zhang RS, Chen LX GB. 2002. Clinical observation on regulation action of Green Qian Willow tea on blood lipid level. Chin J Pr Chin Mod Med. 2:863–865.
  • Chen SH, Habib G, Yang CY, Gu ZW, Lee BR, Weng SA, Silberman SR, Cai SJ, Deslypere JP, Rosseneu M, et al. 1987. Apolipoprotein B-48 is the product of a messenger RNA with an organ-specific in-frame stop codon. Science. 238:363–366.
  • Chen X, Xun K, Chen L, Wang Y. 2009. TNF-alpha, a potent lipid metabolism regulator. Cell Biochem Funct. 27:407–416.
  • Cohn JS, Johnson EJ, Millar JS, Cohn SD, Milne RW, Marcel Y, Russell R, Schaefer E. 1993. Contribution of apoB-48 and apoB-100 triglyceride-rich lipoproteins (TRL) to postprandial increases in the plasma concentration of TRL triglycerides and retinyl esters. J Lipid Res. 34:2033–2040.
  • Cui B, Li S. 2012. Chemical constituents from leaves of Cyclocarya paliurus. Chin Tradit Herb Drugs. 43:2132–2136.
  • Delgado Roche L, Acosta Medina E, Fraga Perez A, Becquer Viart MA, Soto Lopez Y, Falcon Cama V, Vazquez Lopez AM, Martinez-Sanchez G, Fernandez-Sanchez E. 2012. Lipofundin-induced hyperlipidemia promotes oxidative stress and atherosclerotic lesions in New Zealand white rabbits. Int J Vas Med. 2012:898769.
  • Dong CJ, Xie MY, Nie SP, Xie JH, Jia SH, Huang P. 2007. Study on antioxidant activity of Cyclocarya paliurus (Bata1.) Iljinskaya extracts in vitro. Food Sci. 28:31–34.
  • Glass CK, Witztum JL. 2001. Atherosclerosis. the road ahead. Cell. 104:503–516.
  • Gutiérrez RMP, Solis RV, Baez EG, Navarro YG. 2009. Hypoglycemic activity of constituents from Astianthus viminalis in normal and streptozotocin-induced diabetic mice. J Nat Med. 63:393–401.
  • Han L, Lai P, Du JR. 2014. Deciphering molecular mechanism underlying hypolipidemic activity of echinocystic acid. Exid-Based Compl Alt. 2014:823154.
  • Hirunpanich V, Utaipat A, Morales NP, Bunyapraphatsara N, Sato H, Herunsale A, Suthisisang C. 2006. Hypocholesterolemic and antioxidant effects of aqueous extracts from the dried calyx of Hibiscus sabdariffa L. in hypercholesterolemic rats. J Ethnopharmacol. 103:252–260.
  • Huang MQ, Shang GXC, Xu MS, Wang WJ, Shen YG, Jiang Y, Chen Q, Chen TT. 2011. Studies on hypolipemic effect of Cyclocarya paliurus (Batal) Iljinskaja polysaccharide. Acta Agr U Jiangxi. 33:157–161.
  • Hussain MM, Shi J, Dreizen P. 2003. Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly. J Lipid Res. 44:22–32.
  • Jiang C, Yao N, Wang Q, Zhang J, Sun Y, Xiao N, Liu K, Huang F, Fang S, Shang X, et al. 2014. Cyclocarya paliurus extract modulates adipokine expression and improves insulin sensitivity by inhibition of inflammation in mice. J Ethnopharmacol. 153:344–351.
  • Khaliq F, Parveen A, Singh S, Hussain ME, Fahim M. 2013. Terminalia arjuna improves cardiovascular autonomic neuropathy in streptozotocin-induced diabetic rats. Cardiovas Toxicol. 13:68–76.
  • Kim DH, Han KM, Chung IS, Kim DK, Kim SH, Kwon BM, Jeong TS, Park MH, Ahn EM, Baek NI. 2005. Triterpenoids from the flower of Campsis grandiflora K. Schum. as human Acyl-CoA: cholesterol acyltransferase inhibitors. Arch Pharm Res. 28:550–556.
  • Kurihara H, Asami S, Shibata H, Fukami H, Tanaka T. 2003. Hypolipemic effect of Cyclocarya paliurus (Batal) Iljinskaja in lipid-loaded mice. Biol Pharm Bull. 26:383–385.
  • Ma Y, Jiang C, Yao N, Li Y, Wang Q, Fang S, Shang X, Zhao M, Che C, Ni Y, et al. 2015. Antihyperlipidemic effect of Cyclocarya paliurus (Batal.) Iljinskaja extract and inhibition of apolipoprotein B48 overproduction in hyperlipidemic mice. J Ethnopharmacol. 166:286–296.
  • Masuda D, Sakai N, Sugimoto T, Kitazume-Taneike R, Yamashita T, Kawase R, Nakaoka H, Inagaki M, Nakatani K, Yuasa-Kawase M. 2011. Fasting serum apolipoprotein B-48 can be a marker of postprandial hyperlipidemia. J Atheroscler Thromb. 18:1062–1070.
  • Mori K, Ishida T, Yasuda T, Monguchi T, Sasaki M, Kondo K, Hasokawa M, Nakajima H, Haraguchi Y, Sun L, et al. 2013. Fasting serum concentration of apolipoprotein B48 represents residual risks in patients with new-onset and chronic coronary artery disease. Clin Chim Acta. 421:51–56.
  • Naser A, Jafar S, Kumar GV, Hadi HS, Saeed D, Mohamadreza S, Hossein MA. 2008. Cardiac risk factor changes through an intensive multifactorial life style modification program in CHD patients: results from a two year follow up. J Biol Sci. 8:248–257.
  • Natarajan P, Ray KK, Cannon CP. 2010. High-density lipoprotein and coronary heart disease: current and future therapies. J Am Coll Cardiol. 55:1283–1299.
  • Pal S, Ho SS, Takechi R. 2005. Red wine polyphenolics suppress the secretion of ApoB48 from human intestinal CaCo-2 cells. J Agr Food Chem. 53:2767–2772.
  • Pang X, Yao M, Lu Y, Gong Q. 2002. Effect of soy isoflavones on malondialdehyde and superoxide dismutase of blood and liver in hypercholesterolemia rats. Chin J New Drugs Clin Remedies. 21:257–260.
  • Paraschos S, Magiatis P, Mitakou S, Petraki K, Kalliaropoulos A, Maragkoudakis P, Mentis A, Sgouras D, Skaltsounis AL. 2007. In vitro and in vivo activities of Chios mastic gum extracts and constituents against Helicobacter pylori. Antimicrob Agents Chemother. 51:551–559.
  • Qin B, Dawson H, Anderson RA. 2010. Elevation of tumor necrosis factor-alpha induces the overproduction of postprandial intestinal apolipoprotein B48-containing very low-density lipoprotein particles: evidence for related gene expression of inflammatory, insulin and lipoprotein signaling in enterocytes. Exp Biol Med (Maywood). 235:199–205.
  • Qin B, Polansky MM, Sato Y, Adeli K, Anderson RA. 2009. Cinnamon extract inhibits the postprandial overproduction of apolipoprotein B48-containing lipoproteins in fructose-fed animals. J Nutr Biochem. 20:901–908.
  • Qin B, Qiu W, Avramoglu RK, Adeli K. 2007. Tumor necrosis factor-alpha induces intestinal insulin resistance and stimulates the overproduction of intestinal apolipoprotein B48-containing lipoproteins. Diabetes. 56:450–461.
  • Ren L. 1994. Fundamental research and clinical observations of Cyclocarya paliurus. Jiangxi U Tradit Chin Med. 25:64–65.
  • Ros E. 2000. Intestinal absorption of triglyceride and cholesterol. Dietary and pharmacological inhibition to reduce cardiovascular risk. Atherosclerosis. 151:357–379.
  • Shu RG, Xu CR, Li LN, Yu ZL. 1995. Cyclocariosides II and III: Two secodammarane triterpenoid saponins from Cyclocarya paliurus. Planta Med. 61:551–553.
  • Somova L, Nadar A, Rammanan P, Shode F. 2003. Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension. Phytomedicine. 10:115–121.
  • Tran TT, Poirier H, Clement L, Nassir F, Pelsers MM, Petit V, Degrace P, Monnot MC, Glatz JFC, Abumrad NA. 2011. Luminal lipid regulates CD36 levels and downstream signaling to stimulate chylomicron synthesis. J Biol Chem. 286:25201–25210.
  • Wang Q, Jiang C, Fang S, Wang J, Ji Y, Shang X, Ni Y, Yin Z, Zhang J. 2013a. Antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of Cyclocarya paliurus leaves in type 2 diabetic rats. J Ethnopharmacol. 150:1119–1127.
  • Wang X, Liu R, Zhang W, Zhang X, Liao N, Wang Z, Li W, Qin X, Hai C. 2013b. Oleanolic acid improves hepatic insulin resistance via antioxidant, hypolipidemic and anti-inflammatory effects. Mol Cell Endocrinol. 376:70–80.
  • Welty FK, Lichtenstein AH, Barrett PHR, Dolnikowski GG, Schaefer EJ. 1999. Human apolipoprotein (Apo) B-48 and ApoB-100 kinetics with stable isotopes. Arterioscl Throm Vas. 19:2966–2974.
  • Xia W, Sun C, Zhao Y, Wu L. 2011. Hypolipidemic and antioxidant activities of Sanchi (Radix Notoginseng) in rats fed with a high fat diet. Phytomedicine. 18:516–520.
  • Xie MY, Li L. 2001. Review in studies on chemical constituents and bioactivities of Cyclocarya paliurus. Chin Tradit Herb Drugs. 32:365–366.
  • Xie MY, Xie JH. 2008. Review about the research on Cyclocarya paliurus (Batal.) Iljinskaja. J Food Sci Biotechnol. 27:113–121.
  • Yi X, Xie MY, Wen HL, Deng ZY. 2001. Hypoglycemic effects of Cyclocarya Paliurus (Batal.) Iljinsk. on alloxan diabetic mice. Nat Prod Res Dev. 13:52–57.
  • Yun MR, Im DS, Lee SJ, Park HM, Bae SS, Lee WS, Kim CD. 2009. 4-Hydroxynonenal enhances CD36 expression on murine macrophages via p38 MAPK-mediated activation of 5-lipoxygenase. Free Radic Biol Med. 46:692–698.
  • Zilversmit DB. 1995. Atherogenic nature of triglycerides, postprandial lipidemia, and triglyceride-rich remnant lipoproteins. Clin Chem. 41:153–158.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.