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Research Article

Metformin attenuates hepatic insulin resistance in type-2 diabetic rats through PI3K/Akt/GLUT-4 signalling independent to bicuculline-sensitive GABAA receptor stimulation

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Pages 722-728 | Received 01 Sep 2015, Accepted 30 Nov 2016, Published online: 31 Jan 2017

References

  • Ackermann TF, Hörtnagl H, Wolfer DP, Colacicco G, Sohr R, Lang F, Hellweg R, Lang UE. 2008. Phosphatidylinositide dependent kinase deficiency increases anxiety and decreases GABA and serotonin abundance in the amygdala. Cell Physiol Biochem. 22:735–744.
  • Alessi DR, Caudwell FB, Andjelkovic M, Hemmings BA, Cohen P. 1996. Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase. FEBS Lett. 399:333–338.
  • Barnett AH, Brice R, Hanif W, James J, Langerman H. 2013. Increasing awareness of hypoglycaemia in patients with type 2 diabetes treated with oral agents. Curr Med Res Opin. 29:1503–1513.
  • Bertrand L, Horman S, Beaulove C, Vanoverschelde JL. 2008. Insulin signalling in the heart. Cardiovasc Res. 79:238–248.
  • Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:248–254.
  • Coffer PJ, Jin J, Woodgett JR. 1998. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J. 335:1–13.
  • Donath MY, Shoelson SE. 2011. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 11:98–107.
  • Duseja A, Thumburu KK, Das A, Dhiman RK, Chawla YK, Bhadada S, Bhansali A. 2007. Insulin tolerance test is comparable to homeostasis model assessment for insulin resistance in patients with nonalcoholic fatty liver disease. Ind J Gastroenterol. 26:170–173.
  • Gao Y, Zhang M, Wu T, Xu M, Cai H, Zhang Z. 2015. Effects of D-pinitol on insulin resistance through the PI3K/Akt signalling pathway in type 2 diabetes mellitus rats. J Agric Food Chem. 63:6019–6026.
  • Garabadu D, Krishnamurthy S. 2013. Temporal effect of repeated stress on type-2 experimental diabetes. In: George A, Augustine R, Sebastian M, editors. Diabetes mellitus and human health care: a holistic approach to diagnosis and treatment. Waretown (NJ): Apple Academic Press Inc; p. 357–392.
  • Garabadu D, Krishnamurthy S. 2014. Diazepam potentiates the antidiabetic, antistress and anxiolytic activities of metformin in type-2 diabetes mellitus with cooccurring stress in experimental animals. Biomed Res Int. 2014:693074.
  • Grynkiewicz G, Poenie M, Tsien RY. 1985. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem. 260:3440–3450.
  • Holman GD, Kasuga M. 1997. From receptor to transporter: insulin signalling to glucose transport. Diabetologia. 40:991–1003.
  • Kanai T, Nemoto T, Yanagita T, Maruta T, Satoh S, Yoshikawa N, Wada A. 2009. Nav1.7 sodium channel-induced Ca2+ influx decreases tau phosphorylation via glycogen synthase kinase-3beta in adrenal chromaffin cells. Neurochem Int. 54:497–505.
  • Koning EJ, Bonner-Weir S, Rabelink TJ. 2008. Preservation of beta-cell function by targeting beta-cell mass. Trends Pharmacol Sci. 29:218–227.
  • Lazar MA. 2005. How obesity causes diabetes: not a tall tale. Science. 307:373–375.
  • LeRoith D, Gavrilova O. 2006. Mouse models created to study the pathophysiology of Type 2 diabetes. Int J Biochem Cell Biol. 38:904–912.
  • Manning BD, Cantley LC. 2007. Akt/PKB signalling: navigating downstream. Cell. 129:1261–1274.
  • Masiello P, Broca C, Gross R, Roye M, Manteghetti M, Hillaire-Buys D, Novelli M, Ribes G. 1998. Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide. Diabetes. 47:224–229.
  • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. 1985. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 28:412–419.
  • Minuk GY, Bear CE, Sarjeant EJ. 1987. Sodium-independent, bicuculline-sensitive [3H]GABA binding to isolated rat hepatocytes. Am J Physiol. 252:G642–G647.
  • Muniyappa R, Lee S, Chen H, Quon MJ. 2008. Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metabol. 294:E15–E26.
  • National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals (NIH). 2011. Guide for the care and use of laboratory animals, 8th edn. Washington (DC): National Academies Press.
  • Nishiumi S, Ashida H. 2007. Rapid preparation of a plasma membrane fraction from adipocytes and muscle cells: application to detection of translocated glucose transporter 4 on the plasma membrane. Biosci Biotechnol Biochem. 71:2343–2346.
  • Ren C, Zhang Y, Cui W, Lu G, Wang Y, Gao H, Huang L, Mu Z. 2015. A polysaccharide extract of mulberry leaf ameliorates hepatic glucose metabolism and insulin signalling in rats with type 2 diabetes induced by high fat-diet and streptozotocin. Int J Biol Macromol. 72:951–959.
  • Rijkelijkhuizen JM, Doesburg T, Girman CJ, Mari A, Rhodes T, Gastaldelli A, Nijpels G, Dekker JM. 2009. Hepatic fat is not associated with beta-cell function or postprandial free fatty acid response. Metab Clin Exp. 58:196–203.
  • Sale EM, Sale GJ. 2008. Protein kinase B: signalling roles and therapeutic targeting. Cell Mol Life Sci. 65:113–127.
  • Sollozo-Dupont I, Estrada-Camarena E, Carro-Juárez M, López-Rubalcava C. 2015. GABAA/benzodiazepine receptor complex mediates the anxiolytic-like effect of Montanoa tomentosa. J Ethnopharmacol. 162:278–286.
  • Soltani N, Qiu H, Aleksic M, Glinka Y, Zhao F, Liu R, Li Y, Zhang N, Chakrabarti R, Ng T, et al. 2011. GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes. Proc Natl Acad Sci USA. 108:11692–11697.
  • Tahara A, Matsuyama-Yokono A, Nakano R, Someya Y, Shibasaki M. 2008. Hypoglycaemic effects of antidiabetic drugs in streptozotocin-nicotinamide-induced mildly diabetic and streptozotocin-induced severely diabetic rats. Basic Clin Pharmacol Toxicol. 103:560–568.
  • Tersey SA, Bolanis E, Holman TR, Maloney DJ, Nadler JL, Mirmira RG. 2015. Minireview: 12-lipoxygenase and islet β-cell dysfunction in diabetes. Mol Endocrinol. 29:791–800.
  • Tian J, Dang HN, Yong J, Chui WS, Dizon MP, Yaw CK, Kaufman DL. 2011. Oral treatment with γ-aminobutyric acid improves glucose tolerance and insulin sensitivity by inhibiting inflammation in high fat diet-fed mice. PLoS One. 6:e25338.
  • Tian J, Lu Y, Zhang H, Chau CH, Dang HN, Kaufman DL. 2004. Gamma-aminobutyric acid inhibits T cell autoimmunity and the development of inflammatory responses in a mouse type 1 diabetes model. J Immunol. 173:5298–5304.
  • Wang Q, Jiang C, Fang S, Wang J, Ji Y, Shang X, Ni Y, Yin Z, Zhang J. 2013. Antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of Cyclocarya paliurus leaves in type 2 diabetic rats. J Ethnopharmacol. 150:1119–1127.
  • Wen XR, Fu YY, Liu HZ, Wu J, Shao XP, Zhang XB, Tang M, Shi Y, Ma K, Zhang F, et al. 2015. Neuroprotection of sevoflurane against ischemia/reperfusion-induced brain injury through inhibiting JNK3/Caspase-3 by enhancing Akt signalling pathway. Mol Neurobiol. 53:1661–1671.
  • Whiting DR, Guariguata L, Weil C, Shaw J. 2011. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract. 94:311–321.