3,216
Views
55
CrossRef citations to date
0
Altmetric
Research Article

Silibinin sensitizes chemo-resistant breast cancer cells to chemotherapy

, , , , , , & show all
Pages 729-739 | Received 14 Jul 2016, Accepted 03 Dec 2016, Published online: 27 Dec 2016

References

  • Al Zaid Siddiquee K, Turkson J. 2008. STAT3 as a target for inducing apoptosis in solid and hematological tumors. Cell Res. 18:254–267.
  • Baguley BC. 2010. Multiple drug resistance mechanisms in cancer. Mol Biotechnol. 46:308–316.
  • Bosch-Barrera J, Menendez JA. 2015. Silibinin and STAT3: a natural way of targeting transcription factors for cancer therapy. Cancer Treat Rev. 41:540–546.
  • Cheung CW, Gibbons N, Johnson DW, Nicol DL. 2010. Silibinin-a promising new treatment for cancer. Anticancer Agents Med Chem. 10:186–195.
  • Chou TC. 2010. Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res. 70:440–446.
  • Comelli MC, Mengs U, Schneider C, Prosdocimi M. 2007. Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy. Integr Cancer Ther. 6:120–129.
  • Dhillon AS, Hagan S, Rath O, Kolch W. 2007. MAP kinase signalling pathways in cancer. Oncogene. 26:3279–3290.
  • Donepudi MS, Kondapalli K, Amos SJ, Venkanteshan P. 2014. Breast cancer statistics and markers. J Cancer Res Ther. 10:506–511.
  • Eom YW, Kim MA, Park SS, Goo MJ, Kwon HJ, Sohn S, Kim WH, Yoon G, Choi KS. 2005. Two distinct modes of cell death induced by doxorubicin: apoptosis and cell death through mitotic catastrophe accompanied by senescence-like phenotype. Oncogene. 24:4765–4777.
  • Falamarzian A, Aliabadi HM, Molavi O, Seubert JM, Lai R, Uludag H, Lavasanifar A. 2014. Effective down-regulation of signal transducer and activator of transcription 3 (STAT3) by polyplexes of siRNA and lipid-substituted polyethyleneimine for sensitization of breast tumor cells to conventional chemotherapy. J Biomed Mater Res A. 102:3216–3228.
  • Ferenci P, Dragosics B, Dittrich H, Frank H, Benda L, Lochs H, Meryn S, Base W, Schneider B. 1989. Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. J Hepatol. 9:105–113.
  • Flaig TW, Glode M, Gustafson D, van Bokhoven A, Tao Y, Wilson S, Su LJ, Li Y, Harrison G, Agarwal R, et al. 2010. A study of high-dose oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer. Prostate. 70:848–855.
  • Flaig TW, Gustafson DL, Su LJ, Zirrolli JA, Crighton F, Harrison GS, Pierson AS, Agarwal R, Glode LM. 2007. A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients. Invest New Drugs. 25:139–146.
  • Hoh C, Boocock D, Marczylo T, Singh R, Berry DP, Dennison AR, Hemingway D, Miller A, West K, Euden S, et al. 2006. Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences. Clin Cancer Res. 12:2944–2950.
  • Jang GB, Hong IS, Kim RJ, Lee SY, Park SJ, Lee ES, Park JH, Yun CH, Chung JU, Lee KJ, et al. 2015 . Wnt/β-catenin small-molecule inhibitor CWP232228 preferentially inhibits the growth of breast cancer stem-like cells. Cancer Res. 75:1691–1702.
  • Kauntz H, Bousserouel S, Gosse F, Marescaux J, Raul F. 2012. Silibinin, a natural flavonoid, modulates the early expression of chemoprevention biomarkers in a preclinical model of colon carcinogenesis. Int J Oncol. 41:849–854.
  • Kil WH, Kim SM, Lee JE, Park KS, Nam SJ. 2014. Anticancer effect of silibinin on the xenograft model using MDA-MB-468 breast cancer cells. Ann Surg Treat Res. 87:167–173.
  • Kondo T. 2007. Stem cell-like cancer cells in cancer cell lines. Cancer Biomark. 3:245–250.
  • Ladas EJ, Kroll DJ, Oberlies NH, Cheng B, Ndao DH, Rheingold SR, Kelly KM. 2010. A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL). Cancer. 116:506–513.
  • Molavi O, Samadi N, Wu C, Lavasanifar A, Lai R. 2016. Silibinin suppresses NPM-ALK, potently induces apoptosis and enhances chemosensitivity in ALK-positive anaplastic large cell lymphoma. Leuk Lymphoma. 57:1154–1162.
  • Molavi O, Wang P, Zak Z, Gelebart P, Belch A, Lai R. 2013. Gene methylation and silencing of SOCS3 in mantle cell lymphoma. Br J Haematol. 161:348–356.
  • Mulrow C, Lawrence V, Jacobs B, Dennehy C, Sapp J, Ramirez G, Aguilar C, Montgomery K, Morbidoni L, Arterburn JM, et al. 2000. Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects. Evid Rep Technol Assess (Summ). 4:1–3.
  • Mundi PS, Sachdev J, McCourt C, Kalinsky K. 2016. AKT in cancer: new molecular insights and advances in drug development. Br J Clin Pharmacol. 82:943–956.
  • Navolanic PM, Steelman LS, McCubrey JA. 2003. EGFR family signaling and its association with breast cancer development and resistance to chemotherapy (Review). Int J Oncol. 22:237–252.
  • Orlandi L, Bearzatto A, Abolafio G, De Marco C, Daidone MG, Zaffaroni N. 1999. Involvement of bcl-2 and p21waf1 proteins in response of human breast cancer cell clones to Tomudex. Br J Cancer. 81:252–260.
  • Pirouzpanah MB, Sabzichi M, Pirouzpanah S, Chavoshi H, Samadi N. 2015. Silibilin-induces apoptosis in breast cancer cells by modulating p53, p21, Bak and Bcl-XL pathways. Asian Pac J Cancer Prev. 16:2087–2092.
  • Raina K, Agarwal R. 2007. Combinatorial strategies for cancer eradication by silibinin and cytotoxic agents: efficacy and mechanisms. Acta Pharmacol Sin. 28:1466–1475.
  • Real PJ, Sierra A, De Juan A, Segovia JC, Lopez-Vega JM, Fernandez-Luna JL. 2002. Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells. Oncogene. 21:7611–7618.
  • Scully OJ, Bay BH, Yip G, Yu Y. 2012. Breast cancer metastasis. Cancer Genomics Proteomics. 9:311–320.
  • Sharifi S, Barar J, Hejazi MS, Samadi N. 2014. Roles of the Bcl-2/Bax ratio, caspase-8 and 9 in resistance of breast cancer cells to paclitaxel. Asian Pac J Cancer Prev. 15:8617–8622.
  • Singh RP, Raina K, Sharma G, Agarwal R. 2008. Silibinin inhibits established prostate tumor growth, progression, invasion, and metastasis and suppresses tumor angiogenesis and epithelial-mesenchymal transition in transgenic adenocarcinoma of the mouse prostate model mice. Clin Cancer Res. 14:7773–7780.
  • Steelman LS, Navolanic P, Chappell WH, Abrams SL, Wong EW, Martelli AM, Cocco L, Stivala F, Libra M, Nicoletti F, et al. 2011. Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells. Cell Cycle. 10:3003–3015.
  • Syed SB, Coumar MS. 2016 . P-Glycoprotein mediated multidrug resistance reversal by phytochemicals: a review of SAR future perspective for drug design. Curr Top Med Chem. 16:2484–2508.
  • Tan FH, Putoczki TL, Stylli SS, Luwor RB. 2014. The role of STAT3 signaling in mediating tumor resistance to cancer therapy. Curr Drug Targets. 15:1341–1353.
  • Ting H, Deep G, Agarwal R. 2013. Molecular mechanisms of silibinin-mediated cancer chemoprevention with major emphasis on prostate cancer. AAPS J. 15:707–716.
  • Turkson J, Kim JS, Zhang S, Yuan J, Huang M, Glenn M, Haura E, Sebti S, Hamilton AD, Jove R. 2004. Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity. Mol Cancer Ther. 3:261–269.
  • Tyagi AK, Agarwal C, Chan DC, Agarwal R. 2004. Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells. Oncol Rep. 11:493–499.
  • Wang X, Crowe PJ, Goldstein D, Yang JL. 2012. STAT3 inhibition, a novel approach to enhancing targeted therapy in human cancers (review). Int J Oncol. 41:1181–1191.
  • Wu C, Molavi O, Zhang H, Gupta N, Alshareef A, Bone KM, Gopal K, Wu F, Lewis JT, Douglas DN, et al. 2015. STAT1 is phosphorylated and downregulated by the oncogenic tyrosine kinase NPM-ALK in ALK-positive anaplastic large-cell lymphoma. Blood. 126:336–345.
  • Wu F, Zhang J, Wang P, Ye X, Jung K, Bone KM, Pearson JD, Ingham RJ, McMullen TP, Ma Y, et al. 2012. Identification of two novel phenotypically distinct breast cancer cell subsets based on Sox2 transcription activity. Cell Signal. 24:1989–1998.
  • Wu K, Ning Z, Zeng J, Fan J, Zhou J, Zhang T, Zhang L, Chen Y, Gao Y, Wang B, et al. 2013 . Silibinin inhibits β-catenin/ZEB1 signaling and suppresses bladder cancer metastasis via dual-blocking epithelial-mesenchymal transition and stemness. Cell Signal. 25:2625–2633.
  • Zhang Y, Ge Y, Chen Y, Li Q, Chen J, Dong Y, Shi W. 2012. Cellular and molecular mechanisms of silibinin induces cell-cycle arrest and apoptosis on HeLa cells. Cell Biochem Funct. 30:243–248.
  • Zhou L, Liu P, Chen B, Wang Y, Wang X, Chiriva Internati M, Wachtel MS, Frezza EE. 2008. Silibinin restores paclitaxel sensitivity to paclitaxel-resistant human ovarian carcinoma cells. Anticancer Res. 28:1119–1127.