Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice

References

• Anghel SI, Wahli W. 2007. Fat poetry: a kingdom for PPAR gamma. Cell Res. 17:486–511.
   PubMed Web of Science ®Google Scholar
• Basu M, Prasad R, Jayamurthy P, Pal K, Arumughan C, Sawhney RC. 2007. Anti-atherogenic effects of seabuckthorn (Hippophaea rhamnoides) seed oil. Phytomedicine. 14:770–777.
   PubMed Web of Science ®Google Scholar
• Cheng J, Kondo K, Suzuki Y, Ikeda Y, Meng X, Umemura K. 2003. Inhibitory effects of total flavones of Hippophae rhamnoides L. on thrombosis in mouse femoral artery and in vitro platelet aggregation. Life Sci. 72:2263–2271.
   PubMed Web of Science ®Google Scholar
• Chinese Pharmacopoeia Commission. 2010. Chinese material medica and prepared slices of Chinese crude drugs. In: Chinese Pharmacopoeia Commission, editor. The Chinese Pharmacopoeia 2010 Edition. Beijing, China: China Medical Science Press, vol. I: 171–2.
   Google Scholar
• Christodoulides C, Lagathu C, Sethi JK, Vidal-Puig A. 2009. Adipogenesis and WNT signalling. Trends Endocrinol Metab. 20:16–24.
   PubMed Web of Science ®Google Scholar
• Day CP, Saksena S. 2002. Non-alcoholic steatohepatitis: definitions and pathogenesis. J Gastroenterol Hepatol. 17(Suppl 3):S377–S384.
   PubMedGoogle Scholar
• Fruchart JC. 2009. Peroxisome proliferator-activated receptor-alpha (PPARalpha): at the crossroads of obesity, diabetes and cardiovascular disease. Atherosclerosis. 205:1–8.
   PubMed Web of Science ®Google Scholar
• Fruhbeck G, Gomez-Ambrosi J, Muruzabal FJ, Burrell MA. 2001. The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. Am J Physiol Endocrinol Metab. 280:E827–E847.
   PubMed Web of Science ®Google Scholar
• Geetha S, Sai Ram M, Singh V, Ilavazhagan G, Sawhney RC. 2002. Anti-oxidant and immunomodulatory properties of seabuckthorn (Hippophae rhamnoides)–an in vitro study. J Ethnopharmacol. 79:373–378.
   PubMed Web of Science ®Google Scholar
• Gesta S, Tseng YH, Kahn CR. 2007. Developmental origin of fat: tracking obesity to its source. Cell. 131:242–256.
   PubMed Web of Science ®Google Scholar
• Hemmeryckx B, Hoylaerts MF, Gallacher DJ, Rong Lu H, Himmelreich U, D'Hooge J, Swinnen M, Lijnen HR. 2013. Does rosiglitazone affect adiposity and cardiac function in genetic diabetic mice? Eur J Pharmacol. 700:23–31.
   PubMed Web of Science ®Google Scholar
• Jeong S, Yoon M. 2009. Fenofibrate inhibits adipocyte hypertrophy and insulin resistance by activating adipose PPARalpha in high fat diet-induced obese mice. Exp Mol Med. 41:397–405.
   PubMed Web of Science ®Google Scholar
• Koeck ES, Iordanskaia T, Sevilla S, Ferrante SC, Hubal MJ, Freishtat RJ, Nadler EP. 2014. Adipocyte exosomes induce transforming growth factor beta pathway dysregulation in hepatocytes: a novel paradigm for obesity-related liver disease. J Surg Res. 192:268–275.
   PubMed Web of Science ®Google Scholar
• MacDougald OA, Mandrup S. 2002. Adipogenesis: forces that tip the scales. Trends Endocrinol Metab. 13:5–11.
   PubMed Web of Science ®Google Scholar
• Maheshwari DT, Yogendra Kumar MS, Verma SK, Singh VK, Singh SN. 2011. Antioxidant and hepatoprotective activities of phenolic rich fraction of Seabuckthorn (Hippophae rhamnoides L.) leaves. Food Chem Toxicol. 49:2422–2428.
   PubMed Web of Science ®Google Scholar
• Mayerson AB, Hundal RS, Dufour S, Lebon V, Befroy D, Cline GW, Enocksson S, Inzucchi SE, Shulman GI, Petersen KF. 2002. The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. Diabetes. 51:797–802.
   PubMed Web of Science ®Google Scholar
• Okabe T, Toda T, Nukitrangsan N, Inafuku M, Iwasaki H, Oku H. 2011. Peucedanum japonicum Thunb inhibits high-fat diet induced obesity in mice. Phytother Res. 25:870–877.
   PubMed Web of Science ®Google Scholar
• Pang X, Zhao J, Zhang W, Zhuang X, Wang J, Xu R, Xu Z, Qu W. 2008. Antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L. in sucrose-fed rats. J Ethnopharmacol. 117:325–331.
   PubMed Web of Science ®Google Scholar
• Spiegelman BM, Flier JS. 2001. Obesity and the regulation of energy balance. Cell. 104:531–543.
   PubMed Web of Science ®Google Scholar
• Suleyman H, Demirezer LO, Buyukokuroglu ME, Akcay MF, Gepdiremen A, Banoglu ZN, Gocer F. 2001. Antiulcerogenic effect of Hippophae rhamnoides L. Phytother Res. 15:625–627.
   PubMed Web of Science ®Google Scholar
• Sundaresan A, Radhiga T, Pugalendi KV. 2014. Effect of ursolic acid and Rosiglitazone combination on hepatic lipid accumulation in high fat diet-fed C57BL/6J mice. Eur J Pharmacol. 741:297–303.
   PubMed Web of Science ®Google Scholar
• van de Woestijne AP, Monajemi H, Kalkhoven E, Visseren FL. 2011. Adipose tissue dysfunction and hypertriglyceridemia: mechanisms and management. Obes Rev. 12:829–840.
   PubMed Web of Science ®Google Scholar
• Wang J, Zhang W, Zhu D, Zhu X, Pang X, Qu W. 2011. Hypolipidaemic and hypoglycaemic effects of total flavonoids from seed residues of Hippophae rhamnoides L. in mice fed a high-fat diet. J Sci Food Agric. 91:1446–1451.
   PubMed Web of Science ®Google Scholar
• Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW. 2003. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 112:1796–1808.
   PubMed Web of Science ®Google Scholar
• Yoon M. 2009. The role of PPARalpha in lipid metabolism and obesity: focusing on the effects of estrogen on PPARalpha actions. Pharmacol Res. 60:151–159.
   PubMed Web of Science ®Google Scholar
• Yu J, Shen J, Sun TT, Zhang X, Wong N. 2013. Obesity, insulin resistance, NASH and hepatocellular carcinoma. Semin Cancer Biol. 23:483–491.
   PubMed Web of Science ®Google Scholar