Antimalarial, antiplasmodial and analgesic activities of root extract of Alchornea laxiflora

References

• Adams RP. 2001. Identification of essential oils by gas chromatography quadrupole mass spectrometry. Carol Stream (IL): Allured Publishing Corporation.
   Google Scholar
• Adeloye AO, Aderogba MA, Idowu TO, Obuotor EM, Ogundaini AO. 2005. Investigation of the antioxidant activity of Alchornea laxiflora (Benth) and its constituents. J Food Technol. 3:365–369.
   Google Scholar
• Adzu B, Amos S, Kapu SD, Gamaniel KS. 2003. Anti-inflammatory and anti-nociceptive effects of Sphaeranthus senegalensis. J Ethnopharmacol. 84:169–173.
   PubMed Web of Science ®Google Scholar
• Akinpelu DA, Abioye EO, Aiyegoro OA, Akinpelu OF, Okoh AI. 2015. Evaluation of antibacterial and antifungal properties of Alchornea laxiflora (Benth.) Pax. & Hoffman. Evid Based Complement Alternat Med. doi: 10.1155/2015/684839.
   PubMed Web of Science ®Google Scholar
• Amico-Roxas M, Caruso A, Trombadore S, Scifo R, Scapagnime U. 1984. Gangliosides antinociceptive effects in rodents. Arch Int Pharmacodyn Ther. 272:103–117.
   PubMedGoogle Scholar
• Attioua B, Lagnikab L, Yeoc D, Antheaumed C, Kaisere M, Wenigerf B, Lobsteinf A, Vonthron-Sénécheauf C. 2011. In vitro antiplasmodial and antileishmanial activities of flavonoids from Anogeissus leiocarpus (Combretaceae). Int J Pharmaceut Rev Res. 11:1–6.
   Google Scholar
• Attioua B, Weniger B, Chabert P. 2007. Antiplasmodial activity of constituents isolated from Croton lobatus. Pharm Biol. 45:263–266.
   Web of Science ®Google Scholar
• Bentley GA, Newton SH, Starr J. 1983. Studies on the antinociceptive action of alpha-agonist drugs and their interactions with opioid mechanisms. Br J Pharmacol. 79:125–134.
   PubMed Web of Science ®Google Scholar
• Berken T, Ostunes L, Lermioglu F, Ozer A. 1991. Antiinflammatory, analgesic, and antipyretic effects of an aqueous extract of Erythraea centaurium. Planta Med. 57:34–37.
   PubMed Web of Science ®Google Scholar
• Burkill HM. 1994. The useful plants of West Tropical Africa. Volume 2: Families E-I. 2nd ed. kew, Richmond, UK: Royal Botanical Gardens.
   Google Scholar
• Carlo Di G, Mascolo N, Izzo AA, Capasso F. 1999. Flavonoids: old and new aspects of a class of natural therapeutic drugs. Life Sci. 65:337–353.
   PubMed Web of Science ®Google Scholar
• Chakrabarti R, Srivastava PK, Kundu K, Khare RS, Shanta B. 2012. Evaluation of immunostimulatory and growth promoting effect of seed fractions of Achyranthes aspera in common carp Cyprinus carpio and identification of active constituents. Fish Shellfish Immunol. 32:839–843.
   PubMed Web of Science ®Google Scholar
• Christensen SB, Kharazmi A. 2001. Antimalarial natural products. Isolation, characterization and biological properties. In: Tringali C, editor. Bioactive compounds from natural sources: isolation, characterization and biological properties. London: Taylor & Francis; p. 379–432.
   Google Scholar
• Cimanga RK, Tona GL, Kambu OK, Mesia GK, Muyembe JJ, Apers S. 2009. Antimalarial, antiamoebic and cytotoxic activities of some extracts and isolated constituents from the leaves of Morinda morindoides (Baker) Milne-Redh. (Rubiaceae). Rec Progr Med Plants. 25:225–242.
   Google Scholar
• Correa CR, Kyle DJ, Chakravarty S, Calixto JB. 1996. Antinociceptive profile or the pseudopeptide β2 bradykinin receptors antagonist NPC 18688 in mice. Br J Pharmacol. 117:552–556.
   PubMed Web of Science ®Google Scholar
• Deraedt R, Jougney S, Falhout M. 1980. Release of prostaglandin E and F in an algogenic reaction and its inhibition. Eur J Pharm. 51:17–24.
   Web of Science ®Google Scholar
• Esosa US, Omage K, Erifeta O, Georgina JS, Spencer NC. 2013. Possible reversal of sodium arsenate-induced liver toxicity by hexane leaf extract of Alchornea laxiflora. Asian J Med Sci. 5:3–8.
   Google Scholar
• Ezenyi IC, Salawu OA, Kulkarni R, Emeje M. 2014. Antiplasmodial activity-aided isolation and identification of quercetin-4′-methyl ether in Chromolaena odorata leaf fraction with high activity against chloroquine-resistant Plasmodium falciparum. Parasitol Res. 113:4415–4422.
   PubMed Web of Science ®Google Scholar
• Farombi EO, Ogundipe OO, Uhunwagho ES, Adeyanju MA, Moody JO. 2003. Antioxidant properties of extracts from Alchornea laxiflora (Benth) Pax and Hoffman. Phytother Res. 17:713–716.
   PubMed Web of Science ®Google Scholar
• Ferreira JF, Luthria DL, Sasaki T, Heyerick A. 2010. Flavonoids from Artemisia annua L. as antioxidants and their potential synergism with artemisinin against malaria and cancer. Molecules. 15:3135–3170.
   PubMed Web of Science ®Google Scholar
• Franzotti EM, Santos CVF, Rodrigues HMSL, Mourao RHV, Andrade MR, Antoniolli AR. 2002. Anti-inflammatory, analgesic activity and acute toxicity of Sida cordifolia L. J Ethnopharmacol. 72:273–278.
   Web of Science ®Google Scholar
• Ganesh D, Fuehrer H, Starzengrüber P, Swoboda P, Khan WA, Reismann JA, Mueller MS, Chiba P, Noedl H. 2012. Antiplasmodial activity of flavonol quercetin and its analogues in Plasmodium falciparum: evidence from clinical isolates in Bangladesh and standardized parasite clones. Parasitol Res. 110:2289–2295.
   PubMed Web of Science ®Google Scholar
• Gorski F, Correa CR, Filhe VC, Yunes RA, Calixto JB. 1993. Potent antinociceptive activity of a hydroalcoholic extract of Phyllanthus corcovadensis. J Pharm Pharmacol. 45:1046–1049.
   PubMed Web of Science ®Google Scholar
• Heapy CG, Jamieson A, Russell NJW. 1987. Afferent C-fiber and A-delta activity in models of inflammation. Br J Pharmacol. 90:164.
   Google Scholar
• Homburger F. 1989. In vivo testing in the study of toxicity and safety evaluation. In: Marquis JK, editor. A guide to general toxicology. 2nd ed. New York: Karger.
   Google Scholar
• Hunskaar S, Hole K. 1987. The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain. 30:103–114.
   PubMed Web of Science ®Google Scholar
• Jolayemi AT, Ojewole JA. 2014. Analgesic effects of Capsicum frutescens Linn. (Solanaceae) fruit aqueous extract in mice. Global Adv Res J Med Med Sci. 3:325–330.
   Google Scholar
• Kirby GC, O’Neill MJ, Phillipson JD, Warhurst DC. 1989. In vitro studies on the mode of action of quassinoids with activity against chloroquine-resistant Plasmodium falciparum. Biochem Pharmacol. 38:4367–4374.
   PubMed Web of Science ®Google Scholar
• Kirmizibekmez H, Calis I, Perozzo R, Brun R, Donmez AA, Linden A, Ruedi P, Tasdemir D. 2004. Inhibiting activities of the secondary metabolites of Phlomis brunneogaleata against parasitic protozoa and plasmodial enoyl-ACP reductase, a crucial enzyme in fatty acid biosynthesis. Planta Med. 70:711.
   PubMed Web of Science ®Google Scholar
• Knight DJ, Peters W. 1980. The antimalarial activity of N-benzyloxydihydrotriazines. I. The activity of clociguanil (BRL 50216) against rodent malaria, and studies on its mode of action. Ann Trop Med Parasitol. 74:393–404.
   PubMed Web of Science ®Google Scholar
• Kohno Y, Egawa Y, Itoh S, Nagaoka S, Takahashi M, Mukai K. 1995. Kinetic study of quenching reaction of singlet oxygen and scavenging reaction of free radical by squalene in n-butanol. Biochim Biophys Acta. 1256:52–56.
   PubMed Web of Science ®Google Scholar
• Kolodziej H, Kayser O, Kiderlen AF, Ito H, Hatano T, Yoshida T, Foo LY. 2001. Antileishmanial activity of hydrolyzable tannins and their modulatory effects on nitric oxide and tumour necrosis factor-alpha release in macrophages in vitro. Planta Med. 67:825–832.
   PubMed Web of Science ®Google Scholar
• Krogh R, Kroth R, Berti C, Madereira AO, Souza MM, Cechinel-Filho V, Delle-Monache F, Yunes RA. 1999. Isolation and identification of compounds with antinociceptive action from Ipomoea pes-caprae (L.) R. Br. Pharmazie. 54:464–466.
   PubMed Web of Science ®Google Scholar
• Krugliak M, Deharo E, Shalmiev G, Sauvain M, Moretti C, Ginsburg H. 1995. Antimalarial effects of C18 fatty acids on Plasmodium falciparum in culture and on Plasmodium vinckei petteri and Plasmodium yoelii nigeriensis in vivo. Expl Parasitol. 81:97–105.
   PubMed Web of Science ®Google Scholar
• Kumaradevan G, Damodaran R, Mani P, Dineshkumar G, Jayaseelan T. 2015. Phytochemical screening and GC–MS analysis of bioactive components of ethanol leaves extract of Clerodendrum phlomidis (L.). Am J Biol Pharm Res. 2:142–148.
   Google Scholar
• Kumaratilake LM, Robinson BS, Ferrante A, Poulos A. 1992. Antimalarial properties of n-3 and n-6 polyunsaturated fatty acids: in vitro effects on Plasmodium falciparum and in vivo effects on P. berghei. J Clin Investig. 89:961–967.
   PubMed Web of Science ®Google Scholar
• Lembeck F, Holzer P. 1979. Substance P as neurogenic mediator of antidromic, vasodilatation and neurogenic plasma extravasation. Naunyn-Schmiedeberg’s Arch Pharm. 310:175–183.
   Google Scholar
• Liang YC, Huang YT, Tsau SH, Lin-Shiau SY, Chen CF, Lin JK. 1999. Suppression of inducible cyclo-oxygenase and inducible nitric acid synthase by apigenia and related flavonoid in mouse macrophages. Carcinogenesis. 20:1945–1952.
   PubMed Web of Science ®Google Scholar
• Liu J. 1995. Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol. 49:57–68.
   PubMed Web of Science ®Google Scholar
• Lorke D. 1983. A new approach to practical acute toxicity testing. Arch Toxicol. 54:275–286.
   PubMed Web of Science ®Google Scholar
• Lui KC, Yang SC, Roberts MF. 1992. Antimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures. Plants Cell. II:637–640.
   Google Scholar
• Maia JL, Lima-Junior RC, David JP, David JM, Santos FA, Rao VS. 2006. Oleanolic acid, a pentacyclic triterpene attenuates the mustard oil-induced colonic nociception in mice. Biol Pharm Bull. 29:82–85.
   PubMed Web of Science ®Google Scholar
• Melariri P, Campbell W, Etusim P, Smith P. 2011. Antiplasmodial properties and bioassay-guided fractionation of ethyl acetate extracts from Carica papaya leaves. J Parasitol Res. doi: 10.1155/2011/10495.
   PubMedGoogle Scholar
• Melariri P, Campbell W, Etusim P, Smith P. 2012. In vitro and in vivo antimalarial activity of linolenic and linoleic acids and their methyl esters. Adv Stud Biol. 4:333–349.
   Google Scholar
• Middleton E Jr, Kandaswami C, Theoharides TC. 2000. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev. 52:673–751.
   PubMed Web of Science ®Google Scholar
• Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 65:55–63.
   PubMed Web of Science ®Google Scholar
• Nwafor PA, Jacks TW, Ekanem AU. 2007. Analgesic and anti-inflammatory effects of methanol extract of Pausinystalia mecroceras stem bark in rodents. J Pharmacol. 3:86–90.
   Google Scholar
• Nwafor PA, Nwajiobi N, Uko IE, Obot JS. 2010. Analgesic and anti-inflammatory activities of an ethanol extract of Smilax krausiana leaf in mice. Afr J Biomed Res. 13:141–148.
   Google Scholar
• Odetola A, Basir O. 1980. Evaluation of antimalarial properties of some Nigerian Medicinal Plants. In: Sofowora A, editor. Proceeding of African Bioscience Network, Federal Ministry of Science and Technology, Nigerian Society of Pharmacology and Drug Research and Production Unit. Ife: University of Ife organized Workshop; p. 275–283.
   Google Scholar
• Ogundipe OO, Moody JO, Houghton PJ, Odelola HA. 2001. Bioactive chemical constituents from Alchornea laxiflora (Benth) pax and Hoffman. J Ethnopharmacol. 74:275–280.
   PubMed Web of Science ®Google Scholar
• Okokon JE, Nwafor PA. 2010. Antiinflammatory, analgesic and antipyretic activities of ethanolic root extract of Croton zambesicus. Pak J Pharmaceut Sci. 23:383–390.
   Google Scholar
• Oladiji AT, Olatunde A, Oloyede HO. 2014. Evaluation of anti-anaemic potential of aqueous extract of Alchornea laxiflora (Benth) leaf in iron deficient rats. Acad Arena. 6:2–29.
   Google Scholar
• Oladunmoye MK, Kehinde FY. 2011. Ethnobotanical survey of medicinal plants used in treating viral infections among Yoruba tribe of South Western Nigeria. Afr J Microbiol Res. 5:2991–3004.
   Google Scholar
• Oloyede GK, Onocha PA, Adaramoye OA, Thonda SE. 2011. Hepatoprotective activity and flavonoids of Alchornea laxiflora leaf extract. Res J Phytochem. 5:190.
   Google Scholar
• Oloyede GK, Onocha PA, Soyinka J, Oguntokun O, Thonda E. 2010. Phytochemical screening, antimicrobial and antioxidant activities of four Nigerian medicinal plants. Ann Biol Res. 1:114–120.
   Google Scholar
• Otuki MF, Ferreira J, Lima FV, Meyre-Silva C, Malheiros Â, Muller LA, Cani GS, Santos ARS, Yunes RA, Calixto JB. 2005. Antinociceptive properties of mixture of α-amyrin and β-amyrin triterpenes: evidence for participation of protein kinase C and protein kinase A pathways. J Pharmacol Exp Ther. 313:310–318.
   PubMed Web of Science ®Google Scholar
• Peters W. 1965. Drug resistance in Plasmodium berghei Vincke and Lips, 1948. I. Chloroquine resistance. Exp Parasitol. 17:80–89.
   PubMed Web of Science ®Google Scholar
• Philipson JD, Wright CW. 1991. Antiprotozoal compounds from plants sources. Planta Med. 57:553–559.
   Web of Science ®Google Scholar
• Rajendran NN, Thirugnanasambandam P, Viswanathan S, Parvathavarthini S, Ramaswamy S. 2000. Antinociceptive pattern of flavone and its mechanism as tested by formalin assay. Indian J Exp Biol. 38:182–185.
   PubMedGoogle Scholar
• Ringbom T, Segura L, Noreen Y, Perera P, Bohlin L. 1998. Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalysed prostaglandin biosynthesis. J Nat Prod. 61:1212–1215.
   PubMed Web of Science ®Google Scholar
• Robak J, Shridi F, Wolbis M, Krolikowska M. 1998. Screening of the influence of flavonoids on lipoxygenase and cyclooxygenase activity, as well as on nonenzymic lipid oxidation. Polish J Pharmacol Pharm. 40:451–458.
   Google Scholar
• Ryley JF, Peters W. 1970. The antimalarial activity of some quinolone esters. Ann Trop Med Parasitol. 84:209–222.
   Google Scholar
• Santos AR, Cechinel Filho V, Niero R, Viana AM, Moreno FN, Campos MM, Yunes RA, Calixto JB. 1994. Analgesic effects of callus culture from selected species of Phyllanthus. J Pharm Pharmacol. 46:755–759.
   PubMed Web of Science ®Google Scholar
• Setzer WN, Stokes SL, Penton AF, Takaku S, Haber WA, Hansell E, Caffrey CR, McKerrow JH. 2007. Cruzain Inhibitory activity of leaf essential oils of neotropical lauraceae and essential oil components. Nat Prod Commun. 2:1203–1210.
   Web of Science ®Google Scholar
• Smilkstein M, Sriwilaijaroen N, Kelly JX, Wilairat P, Riscoe M. 2004. Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening. Antimicrob Agents Chemother. 48:1803–1806.
   PubMed Web of Science ®Google Scholar
• Smith H, Brooks JR. 2014. Capsaicin-based therapies for pain control. Prog Drug Res. 68:129–146.
   PubMedGoogle Scholar
• Sofowora A. 1993. Medicinal plants and traditional medicine in Africa. 2nd ed. Ibadan, Nigeria: Spectrum Books Limited.
   Google Scholar
• Suh HW, Song DK, Son KH, Wie MB, Lee KH, Jung KY, Do JC, Kim YH. 1996. Antinociceptive mechanisms of dipsacus saponin C administered intracerebroventricularly in the mouse. Gen Pharmacol. 27:1167–1172.
   PubMedGoogle Scholar
• Suksamrarn A, Buaprom M, Udtip S, Nuntawong N, Haritakun R, Kanokmedhakul S. 2005. Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum. Chem Pharm Bull. 53:1327–1329.
   PubMed Web of Science ®Google Scholar
• Tapondjou LA, Lontsi D, Sondengam BL, Choi J, Lee KT, Jung HJ, Park HJ. 2003. In vivo anti-nociceptive and anti-inflammatory effect of the two triterpenes, ursolic acid and 23-hydroxyursolic acid, from Cussonia bancoensis. Arch Pharm Res. 26:143–146.
   PubMed Web of Science ®Google Scholar
• Teffo LS, Aderogba MA, Eloff JN. 2010. Antibacterial and antioxidant activities of four kaempferol methyl ethers isolated from Dodonaea viscosa Jacq. Var. angustifolia leaf extracts. South Afr J Bot. 76:25–29.
   Web of Science ®Google Scholar
• Trager W, Jensen JB. 1976. Human malaria parasites in continuous culture. Science. 193:673–675.
   PubMed Web of Science ®Google Scholar
• Trease GE, Evans WC. 1989. Pharmacognosy. 13th ed. London: Bailliere Tindall; p. 683–684.
   Google Scholar
• Turner RA. 1995. Screening methods in pharmacology. Vol. 1. New York: Academic Press; p. 85–106.
   Google Scholar
• Vaz ZR, Cechinel V, Yunes RA, Calixto JB. 1996. Antinociceptive action of 2-(4-bromobenzoyl)-3-methyl-4-6-dimethoxy bezofuran, a novel xanthoxyline derivative of chemical and thermal models of nociception in mice. J Pharm Exp Ther. 278:304–312.
   PubMed Web of Science ®Google Scholar
• Vaz ZR, Risley EA, Calixto JB. 1997. Analgesic effect of the herbal medicine catuama in thermal and chemical models of nociception in mice. Phytother Res. 11:101–106.
   Web of Science ®Google Scholar
• Wibool R, Sae WC, Reanmongkol W, Wongnawaa M. 2008. Antinociceptive activity of the methanolic extract of Kaempferia galanga Linn. in experimental animals. J Ethnopharmacol. 118:225–230.
   PubMed Web of Science ®Google Scholar
• Yi YL, Zong HA, Lu ZM, Xu HY, Zhang XM, Dou WF, Xu ZH. 2008. Analgesic and anti-inflammatory effects of the dry matter of culture broth of Termitomyces albuminosus and its extracts. J Ethnopharmacol. 120:432–436.
   PubMed Web of Science ®Google Scholar