Inhibition of key enzymes linked to type 2 diabetes by compounds isolated from Aframomum melegueta fruit

References

• Abo KA, Fred-Jaiyesimi AA, Jaiyesimi AEA. 2008. Ethnobotanical studies of medicinal plants used in the management of diabetes mellitus in South Western Nigeria. J Ethnopharmacol. 115:67–71.
   PubMed Web of Science ®Google Scholar
• Adefegha SA, Oboh G. 2012. Inhibition of key enzymes linked to type 2 diabetes and sodium nitroprusside-induced lipid peroxidation in rat pancreas by water extractable phytochemicals from some tropical species. Pharm Biol. 50:857–865.
   PubMed Web of Science ®Google Scholar
• Adefegha SA, Oboh G. 2011. Water extractable phytochemicals from some Nigerian spices inhibit Fe2+- induced lipid peroxidation in rat’s brain-in vitro. J Food Process Technol. 2:1–6.
   Google Scholar
• Adesokan AA, Akanji MA, Adewara GS. 2010. Evaluation of hypoglycaemic efficacy of aqueous seed extract of Aframomum melegueta in alloxan-induced diabetic rats. Sierra Leone J Biomed Res. 2:91–94.
   Google Scholar
• Ali MS, Jahangir M, Hussan SS, Choudhary MI. 2002. Inhibition of alpha-glucosidase by oleanolic acid and its synthetic derivatives. Phytochemistry. 60:295–299.
   PubMed Web of Science ®Google Scholar
• American Diabetes Association (ADA). 2015. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 38:S8–S16.
   Web of Science ®Google Scholar
• Chakraborty D, Mukherjee A, Sikdar S, Paul A, Ghosh S, Khuda-Bukhsh AR. 2012. [6]-Gingerol isolated from ginger attenuates sodium arsenite induced oxidative stress and plays a corrective role in improving insulin signaling in mice. Toxicol Lett. 210:34–43.
   PubMed Web of Science ®Google Scholar
• Cragg GM, Newman DJ. 2013. Natural products: a continuing source of novel drug leads. Biochim Biophys Acta. 1830:3670–3695.
   PubMed Web of Science ®Google Scholar
• de Melo CL, Queiroz MGR, Fonseca SGC. 2010. Oleanolic acid, a natural triterpenoid improves blood glucose tolerance in normal mice and ameliorates visceral obesity in mice fed a high-fat diet. Chem Biol Interact. 185:59–65.
   PubMed Web of Science ®Google Scholar
• Dugasani S, Pichika MR, Nadarajah VD, Balijepalli MK, Tandra S, Korlakunta JN. 2010. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. J Ethnopharmacol. 127:515–520.
   PubMed Web of Science ®Google Scholar
• El-Halawany AM, El Dine RS, El Sayed NS, Hattori M. 2014. Protective effect of Aframomum melegueta phenolics against CCl4-induced rat hepatocytes damage; role of apoptosis and pro-inflammatory cytokines inhibition. Sci Rep. 4:1–9.
   Web of Science ®Google Scholar
• Etoundi CB, Kuaté D, Ngondi JL, Oben J. 2010. Anti-amylase, anti-lipase and antioxidant effects of aqueous extracts of some Cameroonian spices. J Nat Prod. 3:165–171.
   Google Scholar
• Fujisawa T, Ikegami H, Inoue K, Kawabata Y, Ogihara T. 2005. Effect of two α-glucosidase inhibitors, voglibose and acarbose, on postprandial hyperglycemia correlates with subjective abdominal symptoms. Metabolism. 54:387–390.
   PubMed Web of Science ®Google Scholar
• Gastaldelli A. 2011. Role of beta-cell dysfunction, ectopic fat accumulation and insulin resistance in the pathogenesis of type 2 diabetes mellitus. Diabetes Res Clin Pract. 93:S63–S66.
   PubMed Web of Science ®Google Scholar
• Gbolade A. 2009. Inventory of antidiabetic plants in selected districts of Lagos State, Nigeria. J Ethnopharmacol. 121:135–139.
   PubMed Web of Science ®Google Scholar
• Hsu JH, Wu YC, Liu IM, Cheng JT. 2006. Release of acetylcholine to raise insulin secretion in Wistar rats by oleanolic acid, one of the active principles contained in Cornus officinalis. Neurosci Lett. 404:112–116.
   PubMed Web of Science ®Google Scholar
• Ibrahim MA, Islam MS. 2014. Butanol fraction of Khaya senegalensis root modulates β-cell function and ameliorates diabetes-related biochemical parameters in a type 2 diabetes rat model. J Ethnopharmacol. 154:832–838.
   PubMed Web of Science ®Google Scholar
• Ilic NM, Dey M, Poulev AA, Logendra S, Kuhn PE, Raskin I. 2014. Anti-inflammatory activity of grains of paradise (Aframomum melegueta Schum) extract. J Agric Food Chem. 62:10452–10457.
   PubMed Web of Science ®Google Scholar
• Imam SK. 2015. Diabetes: a new horizon and approach to management. In: Watson RR, Dokken BB, editors. Glucose Intake and Utilization in Pre-diabetes and Diabetes Implications for Cardiovascular Disease. UK: Elsevier Academic Press. p. 30–44.
   Google Scholar
• Irons BK, Minze MG. 2014. Drug treatment of type 2 diabetes mellitus in patients for whom metformin is contraindicated. Diabetes Metab Syndr Obes. 7:15–24.
   PubMedGoogle Scholar
• Isa Y, Miyakawa Y, Yanagisawa M, Goto T, Kang MS, Kawada T, Morimitsu Y, Kubota K, Tsuda T. 2008. 6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 373:429–434.
   PubMed Web of Science ®Google Scholar
• Iwu MM. 2014. Handbook of African Medicinal Plants. 2nd ed. Taylor and Francis Group (NY): CRC Press.
   Google Scholar
• Kazeem MI, Akanji MA, Hafizur Rahman M, Choudhary MI. 2012. Antiglycation, antioxidant and toxicological potential of polyphenol extracts of alligator pepper, ginger and nutmeg from Nigeria. Asian Pac J Trop Biomed. 2:727–732.
   PubMedGoogle Scholar
• Kim YM, Jeong YK, Wang MH, Lee WY, Rhee HI. 2005. Inhibitory effect of pine extract on alpha-glucosidase activity and postprandial hyperglycemia. Nutrition. 21:756–761.
   PubMed Web of Science ®Google Scholar
• Komaki E, Yamaguchi S, Maru I. 2003. Identification of anti-amylase components from olive leaf extracts. Food Sci Technol Res. 9:35–39.
   Web of Science ®Google Scholar
• Lee C, Park GH, Kim CY, Jang JH. 2011. [6]-Gingerol attenuates β-amyloid-induced oxidative cell death via fortifying cellular antioxidant defense system. Food Chem Toxicol. 49:1261–1269.
   PubMed Web of Science ®Google Scholar
• Lee JO, Kim N, Lee HJ, Moon JW, Lee SK, Kim SJ, Park SH, Kim HS. 2015. [6]‐Gingerol affects glucose metabolism by dual regulation via the AMPKα2‐mediated AS160-Rab5 pathway and AMPK‐mediated insulin sensitizing effects. J Cell Biochem. 116:1401–1410.
   PubMed Web of Science ®Google Scholar
• Ma J, Jin X, Yang L, Liu ZL. 2004. Diarylheptanoids from the rhizomes of Zingiber officinale. Phytochemistry. 65:1137–1143.
   PubMed Web of Science ®Google Scholar
• Mahato SB, Kundu AP. 1994. 13C NMR spectra of pentacyclic triterpenoids-A compilation and some salient features. Phytochemistry. 37:1517–1575.
   Web of Science ®Google Scholar
• McCue P, Shetty K. 2004. Inhibitory effects of rosmarinic acid extracts on porcine pancreatic amylase in vitro. Asian Pac J Clin Nutr. 13:101–106.
   PubMed Web of Science ®Google Scholar
• Mohammed A, Koorbanally NA, Islam MS. 2016. Antioxidative activity, phytochemistry, and inhibition of key enzymes linked to type 2 diabetes by various parts of Aframomum melegueta in vitro. Acta Pol Pharm Drug Res. 73:403–417.
   PubMed Web of Science ®Google Scholar
• Mohammed A, Koorbanally NA, Islam MS. 2015. Ethyl acetate fraction of Aframomum melegueta fruit ameliorates pancreatic β-cell dysfunction and major diabetes-related parameters in a type 2 diabetes model of rats. J Ethnopharmacol. 175:518–527.
   PubMed Web of Science ®Google Scholar
• Mojekwu TO, Yama OE, Ojokuku SA, Oyebadejo SA. 2011. Hypoglyceamic effects of aqueous extract of Aframomum melegueta leaf on alloxan-induced diabetic male albino rats. Pac J Med Sci. 8:28–36.
   Google Scholar
• Ngwoke KG, Chevallier O, Wirkom VK, Stevenson P, Elliott CT, Situ C. 2014. In vitro bactericidal activity of diterpenoids isolated from Aframomum melegueta K. Schum against strains of Esceherichia coli, Listeria monocytogenes and Staphylococcus aureus. J Ethnopharmacol. 153:1147–1154.
   Web of Science ®Google Scholar
• Nwozo SO, Oyinloye BE. 2011. Hepatoprotective effect of aqueous extract of Aframomum melegueta on ethanol-induced toxicity in rats. Acta Biochim Pol. 58:355–358.
   PubMed Web of Science ®Google Scholar
• Onoja SO, Omeh YN, Ezeja MI, Chukwu MN. 2014. Evaluation of the in vitro and in vivo antioxidant potentials of Aframomum melegueta Methanolic Seed Extract. J Trop Med. 2014: http://dx.doi.org/10.1155/2014/159343.
   PubMedGoogle Scholar
• Pollier J, Goossens A. 2012. Oleanolic acid. Phytochemistry. 77:10–15.
   PubMed Web of Science ®Google Scholar
• Rahati S, Shahraki M, Arjomand G, Shahraki T. 2014. Food pattern, lifestyle and diabetes mellitus. Int J High Risk Behav Addict. 3:e8725
   PubMedGoogle Scholar
• Shao Y, Yu Y, Li C, Yu J, Zong R, Pei C. 2016. Synergistic effect of quercetin and 6-gingerol treatment in streptozotocin induced type 2 diabetic rats and poloxamer P-407 induced hyperlipidemia. RSC Adv. 6:12235–12242.
   Web of Science ®Google Scholar
• Singh AB, Singh N, Maurya R, Srivastava AK. 2009. Anti-hyperglycaemic, lipid lowering and antioxidant properties of [6]-gingerol in db/db mice. Int J Med Sci. 1:536–544.
   Google Scholar
• Tane P, Tatsimo SD, Ayimele GA, Connolly JD. 2005. Bioactive metabolites from Aframomum species. 11th NAPRECA Symposium Book of Proceedings; Antananarivo, Madagascar. p. 214–223.
   Google Scholar
• Taveira M, Silva LR, Vale-Silva LA, Pinto E, Valentão P, Ferreres F, Guedes P, Andrade PB. 2010. Lycopersicon esculentum seeds: an industrial byproduct as an antimicrobial agent. J Agric Food Chem. 58:9529–9536.
   PubMed Web of Science ®Google Scholar
• Teodoro T, Zhang L, Alexander T, Yue J, Vranic M, Volchuk A. 2008. Oleanolic acid enhances insulin secretion in pancreatic beta-cells. FEBS Lett. 582:1375–1380.
   PubMed Web of Science ®Google Scholar