11,273
Views
36
CrossRef citations to date
0
Altmetric
Review Article

Clinacanthus nutans: a review on ethnomedicinal uses, chemical constituents and pharmacological properties

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 1093-1113 | Received 27 May 2016, Accepted 25 Jan 2017, Published online: 15 Feb 2017

References

  • Abdul Rahim MH, Zakaria ZA, Mohd Sani MH, Omar MH, Yakob Y, Cheema MS, Ching SM, Ahmad Z, Abdul Kadir A. 2016. Methanolic Extract of Clinacanthus nutans Exerts Antinociceptive Activity via the Opioid/Nitric Oxide-Mediated, but cGMP-Independent, Pathways. Evidence-Based Complement Altern Med. 2016:1–11.
  • Anti-cancer and Anti-inflammation Herbs Sabah Snake Grass. 2009. [cited 2015 Jun 17]. Available from: http://sennyong.blogspot.com/2009/11/anti-cancer-herbs-and-anti-inflammation.html
  • Arullappan S, Rajamanickam P, Thevar N, Kodimani C. 2014. In vitro screening of cytotoxic, antimicrobial and antioxidant activities of Clinacanthus nutans (Acanthaceae) leaf extracts. Trop J Pharm Res. 13:1455–1461.
  • Aslam MS, Ahmad MS, Mamat ASOH. 2015. A review on the phytochemical constituents and pharmacological activities of Clinacanthus nutans. Int J Pharm Pharm Sci. 7:2–5.
  • Barle E, Looser R, Erne M, Bechter R. 2012. The value of acute toxicity testing of pharmaceuticals for estimation of human response. Regul Toxicol Pharmacol. 62:412–418.
  • Buajeeb W, Kraivaphan P. 1994. Clinical evaluation of Clinacanthus nutans Lindau in orabase in the treatment of recurrent aphthous stomatitis. Mahidol Dent J. 14:10–16.
  • Cancer cure. 2015. [cited 2015 Jun 17]. Available from: http://yourhealth.asiaone.com/content/can-sabah-snake-grass-cure-cancer.
  • Charuwichitratana S, Wongrattanapasson N, Timpatanapong P, Bunjob M. 1996. Herpes zoster: treatment with Clinacanthus nutans cream. Int J Dermatol. 35:665–666.
  • Chavalittumrong P, Attawish A, Rugsamon P, Chuntapet P. 1995. Toxicological study of Clinacanthus nutans (Burm.f.) Lindau. Bull Dep Med Sci. 37:323–338.
  • Cheeptham N, Towers GHN. 2002. Light-mediated activities of some Thai medicinal plant teas. Fitoterapia. 73:651–662.
  • Chelyn JL, Omar MH, Mohd Yousof NSA, Ranggasamy R, Wasiman MI, Ismail Z. 2014. Analysis of flavone C-glycosides in the leaves of Clinacanthus nutans (Burm. f.) Lindau by HPTLC and HPLC-UV/DAD. Sci World J. 2014:1–6.
  • Ching SM, Zakaria ZA, Paimin F, Jalalian M. 2013. Complementary alternative medicine use among patients with type 2 diabetes mellitus in the primary care setting: a cross-sectional study in Malaysia. BMC Complement Altern Med. 13:148.
  • Chomnawang MT, Surassmo S, Nukoolkarn VS, Gritsanapan W. 2005. Antimicrobial effects of Thai medicinal plants against acne-inducing bacteria. J Ethnopharmacol. 101:330–333.
  • Chomnawang MT, Surassmo S, Wongsariya K, Bunyapraphatsara N. 2009. Antibacterial activity of Thai medicinal plants against methicillin-resistant Staphylococcus aureus. Fitoterapia. 80:102–104.
  • Chompuki L, Sriwanthana B, Chavalittumrong P, Chompuk L. 1996. Effect of Clinacanthus nutans on Human Cell-mediated In Vitro Immune Response. Thail J Pharm Sci. 20:261–267.
  • Chotchoungchatchai S, Saralamp P, Jenjittikul T, Pornsiripongse S, Prathanturarug S. 2012. Medicinal plants used with Thai Traditional Medicine in modern healthcare services: A case study in Kabchoeng Hospital, Surin Province, Thailand. J Ethnopharmacol. 141:193–205.
  • Dampawan P, Huntrakul C, Reutrakul V. 1977. Constituents of Clinacanthus nutans and the crystal structure of LUP-20 (29)-ene-3-one. J Sci Soc Thail. 3:14–26.
  • Deng Y, Hu J, Daniel TF, Wood JRI, Wood JRI, Burman NL. 2002. Flora of China. In: Zhengyi W, Raven PH, Deyuan H, editors. Beijing: Science Press; St. Louis: Missouri Botanical Garden.
  • Direkbusarakom S, Ruangpan L, Ezura Y, Yoshimizu M. 1998. Protective efficacy of Clinacanthus nutans on yellow-head disease in black tiger shrimp (Penaeus monodon). Fish Pathol. 33:401–404.
  • Dunn GP, Koebel CM, Schreiber RD. 2006. Interferons, immunity and cancer immunoediting. Nat Rev Immunol. 6:836–848.
  • FAMIC. 2014. How are MRLs established? [Internet]. [cited 2016 May 28]. Available from: http://www.acis.famic.go.jp/eng/chishiki/04.htm.
  • Farsi E, Esmailli K, Shafaei A, Moradi Khaniabadi P, Al Hindi B, Khadeer Ahamed MB, Sandai D, Abdul Sattar M, Ismail Z, Abdul Majid AMS, et al. 2016. Mutagenicity and preclinical safety assessment of the aqueous extract of Clinacanthus nutans leaves. Drug Chem Toxicol. 545:1–13.
  • Fong SY, Piva T, Urban S, Huynh T. 2014. Genetic homogeneity of vegetatively propagated Clinacanthus nutans (Acanthaceae). J Med Plant Res. 8:903–914.
  • Ghasemzadeh A, Nasiri A, Jaafar HZE, Baghdadi A, Ahmad I. 2014. Changes in phytochemical synthesis, chalcone synthase activity and pharmaceutical qualities of Sabah Snake Grass (Clinacanthus nutans L.) in relation to plant age. Molecules. 19:17632–17648.
  • Globinmed. 2015. [cited 2015 Jun 22]. Available from: http://www.globinmed.com/index.php?option=com_content&view=article&id=79320:clinacanthus-nutans-burmf-lindau.
  • Hanelt P. editor. 2001. Research I of PG and CP. Mansfeld’s Encyclopedia of Agricultural and Horticultural Crops (Except Ornamentals). Berlin, Heidelberg: Springer-Verlag; p. 1912–1918.
  • Hariana AH. 2013. Ki Tajam/Dandang Gendis. In: 262 Tumbuh Obat dan Khasiatnya. Jakarta: Penebar Swadaya Grup; p. 183?185.
  • Huang D, Guo W, Gao J, Chen J, Olatunji J. 2015. Clinacanthus nutans (Burm. f.) Lindau ethanol extract inhibits hepatoma in mice through upregulation of the immune response. Molecules. 20:17405–17428.
  • Huang D, Li Y, Cui F, Chen J, Sun J. 2016. Purification and characterization of a novel polysaccharide-peptide complex from Clinacanthus nutans Lindau leaves. Carbohydr Polym. 137:701–708.
  • Janwitayanuchit W, Suwanborirux K, Patarapanich C, Pummangura S, Lipipun V, Vilaivan T. 2003. Synthesis and anti-Herpes simplex viral activity of monoglycosyl diglycerides. Phytochemistry. 64:1253–1264.
  • Jayavasu C, Dechatiwongse T, Balachandra K. 1992. Virucidal activity of Clinacanthus nutans Lindau extracts against herpes simplex virus type 2?: In vitro study. Bull Dep Med Serv. 34.
  • Jayavasu C, Dechatiwongse T, Balachandra K, Chavalittumrong P, Jongtrakulsiri S. 2013. The virucidal activity of Clinacanthus nutans lindau extracts against Herpes simplex virus type-2: an in vitro study. Bull Dep Med Sci. 4:153–158.
  • Khoo LW, Mediani A, Zolkeflee NKZ, Leong SW, Ismail IS, Khatib A, Shaari K, Abas F. 2015. Phytochemical diversity of Clinacanthus nutans extracts and their bioactivity correlations elucidated by NMR based metabolomics. Phytochem Lett. 14:123–133.
  • Kongkaew C, Chaiyakunapruk N. 2011. Efficacy of Clinacanthus nutans extracts in patients with Herpes infection: systematic review and meta-analysis of randomised clinical trials. Complement Ther Med. 19:47–53. [Internet]. [cited 2014 Nov 25]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/21296267.
  • Kumar S, Pandey AK. 2013. Chemistry and biological activities of flavonoids: an overview. Sci World J. 2013. doi: 10.1155/2013/162750
  • Kunsorn P, Ruangrungsi N, Lipipun V, Khanboon A, Rungsihirunrat K. 2013. The identities and anti-Herpes simplex virus activity of Clinacanthus nutans and Clinacanthus siamensis. Asian Pac J Trop Biomed. 3:284–290.
  • Lau K, Lee S, Chin J. 2014. Effect of the methanol leaves extract of Clinacanthus nutans on the activity of acetylcholinesterase in male mice. J Acute Dis. 3:22–25.
  • Liew S-Y, Stanbridge EJ, Yusoff K, Shafee N. 2012. Hypoxia affects cellular responses to plant extracts. J Ethnopharmacol. 144:453–456.
  • Lim YC, Rajabalaya R, Lee S, Tennakoon K, Le Q-V, Idris A, Zulkipli I, Keasberry N, David S. 2016. Parasitic mistletoes of the genera Scurrula and Viscum: from bench to bedside. Molecules. 21:1048.
  • Lipipun V, Kurokawa M, Suttisri R, Taweechotipatr P, Pramyothin P, Hattori M, Shiraki K. 2003. Efficacy of Thai medicinal plant extracts against herpes simplex virus type 1 infection in vitro and in vivo. Antiviral Res. 60:175–180.
  • Lipipun V, Sasivimolphan P, Yoshida Y, Daikoku T, Sritularak B, Ritthidej G, Likhitwitayawuid K, Pramyothin P, Hattori M, Shiraki K. 2011. Topical cream-based oxyresveratrol in the treatment of cutaneous HSV-1 infection in mice. Antiviral Res. 91:154–160.
  • Mai CW, Yap KSI, Kho MT, Ismail NH, Yusoff K, Shaari K, Chin SY, Lim ESH. 2016. Mechanisms Underlying the Anti-Inflammatory Effects of Clinacanthus nutans Lindau Extracts: Inhibition of Cytokine Production and Toll-Like Receptor-4 Activation. Front Pharmacol. 7:1–11.
  • Mat Ali R, Abu Samah Z, Mustapha NM, Hussein NN, Ali RM, Samah ZA, Mustapha NM, Hussein NN. 2010. ASEAN Herbal and Medicinal Plants. [Internet]. Jakarta: ASEAN; [cited 2015 Aug 25]. Available from: http://www.asean.org/archive/publications/aseanherbal2010.pdf.
  • Mohlenbrock RH. 2008. Acanthaceae to Myricaceae: water willows to wax myrtles. 1st ed. Carbondale, Illinois, US: Southern Illinois University Press.
  • Mustapa AN, Martin A, Gallego JR, Mato RB, Cocero MJ. 2015. Microwave-assisted extraction of polyphenols from Clinacanthus nutans Lindau medicinal plant: energy perspective and kinetics modeling. Chem Eng Process Process Intensif. 97:66–74.
  • Mustapa AN, Martin A, Mato RB, Cocero MJ. 2015. Extraction of phytocompounds from the medicinal plant Clinacanthus nutans Lindau by microwave-assisted extraction and supercritical carbon dioxide extraction. Ind Crops Prod. 74:83–94.
  • P’ng XW, Akowuah GA, Chin JH. 2013. Evaluation of the sub–acute oral toxic effect of methanol extract of Clinacanthus nutans leaves in rats. J Acute Dis. 2:29–32.
  • Pannangpetch P, Laupattarakasem P, Kukongviriyapan V, Kukongviriyapan U, Kongyingyoes B, Aromdee C. 2007. Antioxidant activity and protective effect against oxidative hemolysis of Clinacanthus nutans (Burm. f) Lindau. Songklanakarin J Sci Technol. 29:1–9.
  • Pongmuangmul S, Phumiamorn S, Sanguansermsri P, Wongkattiya N, Fraser IH, Sanguansermsri D. 2016. Monogalactosyl diglyceride and digalactosyl diglyceride from Clinacanthus nutans, a traditional Thai herbal medicine, exhibits anti-Herpes simplex virus activities. Asian Pac J Trop Biomed 6:192–197.
  • Quattrocchi U. 2012. Clinacanthus Nees Acanthaceae. In: CRC World Dict Med Poisonous Plants Common Names, Sci Names, Eponyms, Synonyms, Etymology. CRC Press; p. 1020.
  • Ramesh S, Rajan R, Santhanam R. 2014. Freshwater phytopharmaceutical compounds. Boca Raton, Florida: CRC Press; Taylor & Francis.
  • Rathnasamy S, Mohamed K Bin, Sulaiman SF, Akinboro A. 2013. Evaluation of cytotoxic, mutagenic and antimutagenic potential of leaf extracts of three medicinal plants using Allium cepa chromosome assay. Int Curr Pharm J. 2:131–140.
  • Raya KB, Ahmad SH, Farhana SF, Mohammad M, Tajidin NE, Parvez A. 2015. Changes in phytochemical contents in different parts of Clinacanthus nutans (Burm. f.) Lindau due to storage duration. Bragantia. 74:445–452.
  • Roeslan MO, Ayudhya TDN, Kootongkaew S. 2012. Characteristics of Clinacanthus nutans extraction from Thailand and Indonesia (preliminary study). Sci-Health. 2.
  • Roleira FMF, Tavares-da-Silva EJ, Varela CL, Costa SC, Silva T, Garrido J, Borges F. 2015. Plant derived and dietary phenolic antioxidants: anticancer properties. Food Chem. 183:235–258.
  • Roosita K, Kusharto CM, Sekiyama M, Fachrurozi Y, Ohtsuka R. 2008. Medicinal plants used by the villagers of a Sundanese community in West Java, Indonesia. J Ethnopharmacol. 115:72–81.
  • Sakdarat S, Shuyprom A, Na ATD, Waterman PG, Karagianis G. 2006. Chemical composition investigation of the Clinacanthus nutans Lindau leaves. Thai J Phytopharm. 13:13–24.
  • Sakdarat S, Shuyprom A, Pientong C, Ekalaksananan T, Thongchai S. 2009. Bioactive constituents from the leaves of Clinacanthus nutans Lindau. Bioorganic Med Chem. 17:1857–1860.
  • Sangkitporn S, Chaiwat S, Balachandra K, Na-Ayudhaya TD, Bunjob M, Jayavasu C. 1995. Treatment of Herpes zoster with Clinacanthus nutans (bi phaya yaw) extract. J Med Assoc Thai. 78:624–627.
  • Sangkitporn S, Polchan K, Thawatsupa P, Bunchob M, Chawalitthumrong P. 1993. Treatment of recurrent genital Herpes simplex virus infection with Clinacanthus nutans extract. Bull Dep Med Serv. 18:226–231.
  • Sarega N, Imam MU, Ooi D, Chan KW, Md Esa N, Zawawi N, Ismail M. 2016a. Phenolic Rich Extract from Clinacanthus nutans Attenuates Hyperlipidemia-Associated Oxidative Stress in Rats. Oxid Med Cell Longev. 2016:1–16.
  • Sarega N, Imam MU, Md Esa N, Zawawi N, Ismail M. 2016b. Effects of phenolic-rich extracts of Clinacanthus nutans on high fat and high cholesterol diet-induced insulin resistance. BMC Complement Altern Med. 16 (1):1–11.
  • Shim SY, Aziana I, Khoo BY. 2013. Perspective and insight on Clinacanthus nutans Lindau in traditional medicine. Int J Integr Biol. 14:7–9.
  • Siew YY, Zareisedehizadeh S, Seetoh WG, Neo SY, Tan CH, Koh HL. 2014. Ethnobotanical survey of usage of fresh medicinal plants in Singapore. J Ethnopharmacol. 155:1450–1466.
  • Singapore Sabah Snake Grass. 2011. [cited 2015 Jun 17]. Available from: http://sabahsnakegrasssingapore.blogspot.com/.
  • Sittiso S, Ekalaksananan T, Pientong C, Sakdarat S, Charoensri N, Kongyingyoes B. 2010. Effects of compounds from Clinacanthus nutans on dengue virus type 2 infection. Srinagarind Med J. 25:272–275.
  • Sriwanthana B, Chavalittumrong P, Chompuk L. 1996. Effect of Clinacanthus nutans on kuman cell-mediated in vitro immune response. Thail J Pharm Sci. 20:261–267.
  • Sabah Snake Grass. 2009. [cited 2015 Jun 17]. Available from: http://sennyong.blogspot.com/2009/11/anti-cancer-herbs-and-anti-inflammation.html.
  • Teshima K-I, Kaneko T, Ohtani K, Kasai R, Lhieochaiphant S, Picheansoonthon C, Yamasaki K. 1998. Sulfur-containing glucosides from Clinacanthus nutans. Phytochemistry. 48:831–835.
  • The Plant List A. 2013. [cited 2016 Jan 14]. Available from: http://www.theplantlist.org/tpl1.1/record/tro-100366425.
  • The Plant List B. 2013. [cited 2016 Jan 14]. Available from: http://www.theplantlist.org/tpl1.1/record/kew-2727902.
  • Thormar H, Isaacs CE, Kim KS, Brown HR. 1994. Inactivation of visna virus and other enveloped viruses by free fatty acids and monoglycerides. Ann N Y Acad Sci. 24:465–471.
  • Tsai H-D, Wu J-S, Kao M-H, Chen J-J, Sun GY, Ong W-Y, Lin T-N. 2016. Clinacanthus nutans Protects Cortical Neurons Against Hypoxia-Induced Toxicity by Downregulating HDAC1/6. NeuroMolecular Med. 18:274–282.
  • Tu S-F, Liu R, Cheng Y-B, Hsu Y-M, Du Y-C, El-Shazly M, Wu Y-C, Chang F-R. 2014. Chemical constituents and bioactivities of Clinacanthus nutans aerial parts. Molecules. 19:20382–20390.
  • Uawonggul N, Chaveerach A, Thammasirirak S, Arkaravichien T, Chuachan C, Daduang S. 2006. Screening of plants acting against Heterometrus laoticus scorpion venom activity on fibroblast cell lysis. J Ethnopharmacol. 103:201–207.
  • Wanikiat P, Panthong A, Sujayanon P, Yoosook C, Rossi AG, Reutrakul V. 2008. The anti-inflammatory effects and the inhibition of neutrophil responsiveness by Barleria lupulina and Clinacanthus nutans extracts. J Ethnopharmacol. 116:234–244.
  • Watson RR, Preedy VR. 2008. Clinacanthus nutans. In: Bot Med Clin Pract. CABI; p. 819.
  • World Health Organization. 2004. IPCS Harmonization Project-IPCS Risk assessment terminology. Geneva: World Health Organization.
  • Yang HS, Peng TW, Madhacan P, Abdul Shukkoor MS, Akowuah GA. 2013. Phytochemical analysis and antibacterial activity of methanolic extract of Clinacanthus nutans leaf. Int J Drug Dev Res. 5:349–355.
  • Ying NL. 2013. Establishment of Axenic Explants and Callus Culture of Clinacanthus nutans (Rumput Belalai Gajah). [PhD Thesis]: University Malaysia Sarawak.
  • Yong YK, Tan JJ, Teh SS, Mah SH, Ee GCL, Chiong HS, Ahmad Z. 2013. Clinacanthus nutans extracts are antioxidant with antiproliferative effect on cultured human cancer cell lines. Evid Based Complement Alternat Med. 2013:462751.
  • Yoosook C, Bunyapraphatsara N, Boonyakiat Y, Kantasuk C. 2000. Anti-herpes simplex virus activities of crude water extracts of Thai medicinal plants. Phytomedicine. 6:411–419.
  • Yoosook C, Panpisutchai Y, Chaichana S, Santisuk T, Reutrakul V. 1999. Evaluation of anti-HSV-2 activities of Barleria lupulina and Clinacanthus nutans. J Ethnopharmacol. 67:179–187.
  • Yuann J-MP, Wang J-S, Jian H-L, Lin C-C, Liang J-Y. 2012. Effects of Clinacanthus nutans (Burm. f) Lindau leaf extracts on protection of plasmid DNA from riboflavin photoreaction. MC-Transaction Biotechnol. 4:45–58.
  • Zulkipli I, Rajabalaya R, David S, Idris A. 2015. Medicinal plants: a potential source of compounds for targeting cell division. Drug Target Insights 9:919.