Evaluation of genotoxic effects of 3-methyl-5-(4-carboxycyclohexylmethyl)-tetrahydro-2H-1,3,5-thiadiazine-2-thione on human peripheral lymphocytes

References

• Araldi RP, Melo TCD, Mendes TB, Sa′Ju′nior PL, Nozima BH, Ito ET, Carvalho RFD, Souza EBD, Stocco RDC. 2015. Using the comet and micronucleus assays genotoxicity studies: a review. Biomed Pharmacother. 72:74–82.
   PubMed Web of Science ®Google Scholar
• Ashfaq M, Aslam A, Mustafa G, Danish M, Faizan Nazar M, Nadeem Asghar M. 2015. Derivatization/chromophore introduction of anexamic acid and its HPLC determination in pharmaceutical formulations. J Assoc Arab Univ Basic Appl Sci. 17:51–56.
   Google Scholar
• Blasczyk A, Osiecka R, Skolimowski J. 2003. Induction of chromosome aberrations in cultured human lymphocytes treated with ethoxyquin. Mutat Res. 542:117–128.
   PubMed Web of Science ®Google Scholar
• Bonassi S, El-Zein R, Bolognesi C, Fenech M. 2010. Micronuclei frequency in peripheral blood lymphocytes and cancer risk: evidence from human studies. Mutagenesis. 26:93–100.
   Web of Science ®Google Scholar
• Bozkurt G, Abay E, Ates I, Karabogaz G, Ture M, Savran FO, Palanduz S, Temocin K, Algunes C. 2004. Clastogenicity of selective serotonin-reuptake inhibitors. Mutat Res. 558:137–144.
   PubMed Web of Science ®Google Scholar
• Brambilla G, Martelli A. 2006. Genotoxicity and carcinogenicity studies of antihypertensive agents. Mutat Res. 612:115–149.
   PubMed Web of Science ®Google Scholar
• Brambilla G, Martelli A. 2009. Update on genotoxicity and carcinogenicity testing of 472 marketed pharmaceuticals. Mutat Res. 681:209–229.
   PubMed Web of Science ®Google Scholar
• Brambilla G, Mattioli F, Martelli A. 2009. Genotoxic and carcinogenic effects of antipsychotics and antidepressants. Toxicology. 261:77–88.
   PubMed Web of Science ®Google Scholar
• Brambilla G, Mattioli F, Robbiano L, Martelli A. 2012. Update of carcinogenicity studies in animals and humans of 535 marketed pharmaceuticals. Mutat Res. 750:1–51.
   PubMed Web of Science ®Google Scholar
• Chandirasekar R, Kumar BL, Sasikala K, Jayakumar R, Suresh K, Venkatesan R, Jacob R, Krishnapriya EK, Kavitha H, Ganesh GK. 2014. Assessment of genotoxic and molecular mechanisms of cancer risk in smoking and smokeless tobacco users. Mutat Res Genet Toxicol Environ Mutagen. 767:21–27.
   PubMed Web of Science ®Google Scholar
• Doak SH, Liu Y, Chen C. 2012. Genotoxicity and cancer In: Fadeel B, Pietroiusti A, Shvedova AA, editors. Adverse effects of engineered nanomaterials. Cambridge (MA): Academic Press, p. 243–261.
   Google Scholar
• Dunn CJ, Goa KL. 1999. Tranexamic acid: a review of its use in surgery and other indications. Drugs. 57:1005–1032.
   PubMed Web of Science ®Google Scholar
• Eastmond DA. 2014. Sister chromatid exchanges. In: Wexler P, editor. Encyclopedia of toxicology. 3rd ed. Cambridge (MA): Academic Press; p. 276–277.
   Google Scholar
• Eroğlu Y, Eroğlu HE, Ilbas AI. 2007. Gamma ray reduces mitotik index in embriyonic roots of Hordeum vulgare L. Adv Biol Res. 1:26–28.
   Google Scholar
• European Medicines Agency (EMEA). 2012. Europan Medicines Agency recommends lifting suspension of aprotinin. EMA/CHMP/119704/2012.
   Google Scholar
• Evans HJ. 1984. Human peripheral blood lymphocytes for the analysis of chromosome aberrations in mutagentests in mutagen tests In: Kilbey BJ, Legator M, Nichols W, Ramel C, editors. Handbook of mutagenicity test procedures. Amsterdam: Elsevier Science Publishers; p. 405–427.
   Google Scholar
• Food and Drug Administration (FDA). 2013. Highlights of prescribing information. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/022430s004lbl.pdf
   Google Scholar
• Fei C, Zhang J, Lin Y, Wang X, Zhang K, Zhang L, Zheng W, Wang M, Li T, Xiao S, et al. 2015. Safety evaluation of a triazine compound nitromezuril by assessing bacterial reverse mutation, sperm abnormalities, micronucleus and chromosomal aberration. Regul Toxicol Pharm. 71:585–589.
   PubMed Web of Science ®Google Scholar
• Fenech M. 2000. The in vitro micronucleus technique. Mutat Res. 455:81–95.
   PubMed Web of Science ®Google Scholar
• Garcia-Sagredo JM. 2008. Fifty years of cytogenetics: a parallel view of the evolution of cytogenetics and genotoxicology. Biochim Biophys Acta. 1779:363–375.
   PubMed Web of Science ®Google Scholar
• Genualdo V, Perucatti A, Pauciullo A, Iannuzzi A, Incarnato D, Spagnuolo MS, Solinas N, Bullitta S, Iannuzzi L. 2015. Analysis of chromosome damage by sister chromatid exchange (SCE) and redox homeostasis characterization on sheep flocks from Sardinia pasturelands. Sci Total Environ. 527:393–400.
   PubMed Web of Science ®Google Scholar
• Hagmar L, Bonassi S, Stromberg U, Brogger A, Knudsen LE, Norppa H, Reuterwall C. 1998. Chromosomal aberrations in lymphocytes predict human cancer: a report from the European Study Group on Cytogenetic Biomarkers and Health (ESCH). Cancer Res. 58:4117–4121.
   PubMed Web of Science ®Google Scholar
• Ionescu ME, Ciocirlan M, Becheanu G, Nicolaie T, Ditescu C, Teiusanu AG, Gologan SI, Arbanas T, Diculescu MM. 2011. Nuclear division index may predict neoplastic colorectal lesions. Maedica J Clin Med. 6:173–178.
   Google Scholar
• Johnson MD, Schilz J, Djordjevic MV, Rice JR, Shields PG. 2009. Evaluation of in vitro assays for assessing the toxicity of cigarette smoke and smokeless tobacco. Cancer Epidemiol Biomarkers Prev. 18:3263–3304.
   PubMed Web of Science ®Google Scholar
• Jyoti S, Siddique YH, Khan S, Naz F, Ali RF. 2015. Effect on micronucleus frequency and DNA damage in buccal epithelial cells of various factors among pan masala and gutkha chewers. Oral Science Int. 12:9–14.
   Web of Science ®Google Scholar
• Kirkland D. 2010. Evaluation of different cytotoxic and cytostatic measures for the in vitro micronucleus test (MNVit): summary of results in the collaborative trial. Mutat Res. 702:139–147.
   PubMed Web of Science ®Google Scholar
• Kirsch-Volders M, Plas G, Elhajouji A, Lukamowicz M, Gonzalez L, Loock KV, Decordier I. 2011. The in vitro MN assay in 2011: origin and fate, biological significance, protocols, high throughput methodologies and toxicological relevance. Arch Toxicol. 85:873–899.
   PubMed Web of Science ®Google Scholar
• Lewis CM, Tarrant GM. 1971. Intduction of mutation by 5-fluorouracil and amino acid analogues in Ustilago maydis. Mutat Res. 12:349–356.
   Web of Science ®Google Scholar
• Liou SH, Chen YH, Loh CH, Yang T, Wu TN, Chen CJ, Hsieh LL. 2002. The association between frequencies of mitomycin C-induced sister chromatid exchange and cancer risk in arseniasis. Toxicol Lett. 129:237–243.
   PubMed Web of Science ®Google Scholar
• Norppa H, Bonassi S, Hansteen L, et al. 2006. Chromosomal aberrations and SCEs as biomarkers of cancer risk. Mutat Res. 600:37–45.
   PubMed Web of Science ®Google Scholar
• Özçelik AB, Ersan S, Ural AU, Özkan S, Ertan M. 2007. Synthesis of 3-substituted-5-(4-carboxycyclohexylmethyl)-tetrahydro-2H-1,3,5-thiadiazine-2-thione derivates as antifibrinolytic and antimicrobial agents. Arzneimittel-Forschung (Drug Res). 57:554–559.
   PubMed Web of Science ®Google Scholar
• Palus J, Rydzynski K, Dziubaltowska E, Wyszynska K, Natarajan AT, Nilsson R. 2003. Genotoxic effects of occupational exposure to lead and cadmium. Mutat Res. 540:19–28.
   PubMed Web of Science ®Google Scholar
• Patlolla AK, Hackett D, Tchounwou PB. 2015. Genotoxicity study of silver nanoparticles in bone marrow cells of Sprague-Dawley rats. Food Chem Toxicol. 85:52–60.
   PubMed Web of Science ®Google Scholar
• Perry PE, Thompson EJ. 1984. The methodology of sister chromatid exchanges. In: Kilbey BJ, Legator M, Nichols W, Ramel C, editors. Handbook of mutagenicity test procedures. Amsterdam: Elsevier Science Publishers; p. 495–529.
   Google Scholar
• Santovito A, Cervella P, Delpero M. 2014. Increased frequency of chromosomal aberrationsand sister chromatid exchanges in peripheral lymphocytes of radiology technicians chronically exposed to low levels of ionizing radiations. Environ Toxicol Phar. 37:396–403.
   PubMed Web of Science ®Google Scholar
• Schneider EL, Nakanishi Y, Lewis J, Sternberg H. 1981. Simultaneous examination of sister chromatid exchanges and cell replication kinetics in tumor and normal cells in vivo. Cancer Res. 41:4973–4975.
   PubMed Web of Science ®Google Scholar
• Sebastià N, Hervás D, Almonacid M, et al. 2014. Sister chromatid exchange, (SCE), High-Frequency Cells (HFCs) and SCE distribution patterns in peripheral blood lymphocytes of Spanish adult smokers compared to non-smokers. Food Chem Toxicol. 66:107–112.
   PubMed Web of Science ®Google Scholar
• Singh NP, McCoy MT, Tice RR, Schneider EL. 1988. A simple technique for quantification of low levels of DNA damage in individual cells. Exp Cell Res. 175:184–191.
   PubMed Web of Science ®Google Scholar
• Snyder RD, Green JW. 2001. A review of the genotoxicity of marketed pharmaceuticals. Mutat Res. 488:151–169.
   PubMed Web of Science ®Google Scholar
• Speit G, Henderson L. 2005. Review of the in vivo genotoxicity tests performed with styrene. Mutat Res. 589:67–79.
   PubMed Web of Science ®Google Scholar
• Speit G, Houpter S. 1985. On the mechanism of differential Giemsa staining of bromodeoxyuridine substitute chromosomes. II. Differences between the demonstrations of sister chromatid differentiation and replication patterns. Hum Genet. 70:126–129.
   PubMed Web of Science ®Google Scholar
• Stich HF, Stich W, Parida BB. 1982. Elevated frequency of micronucleated cells in the buccal mucosa of individuals at high risk for oral cancer: betel quid chewers. Cancer Lett. 17:125–134.
   PubMed Web of Science ®Google Scholar
• Surrales J, Xamena N, Creus A, Catalan J, Norppa H, Marcos R. 1995. Induction of micronuclei by five pyrethroid insecticides in whole-blood and isolated human lymphocyte cultures. Mutat Res. 341:169–184.
   PubMed Web of Science ®Google Scholar
• U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER). 1997a. Guidance for industry. S2B. Genotoxicity: a standard battery for genotoxicity testing of pharmaceuticals.
   Google Scholar
• U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER). 1997b. Guidance for industry. S1B. Testing for carcinogenicity of pharmaceuticals.
   Google Scholar
• Wang CG, Sun ZH, Liu J, Cao JG, Li ZJ. 2015. Safety and efficacy of intra-articular tranexamic acid injection without drainage on blood loss in total knee arthroplasty: a randomized clinical trial. Int J Surg. 20:1–7.
   PubMed Web of Science ®Google Scholar
• Wilson IIIDM, Thompson LH. 2007. Molecular mechanisms of sister-chromatid exchange. Mutat Res. 616:11–23.
   PubMed Web of Science ®Google Scholar
• Yılmaz S, Ünal F, Yüzbaşıoğlu D, Çelik M. 2014. DNA damage in human lymphocytes exposed to four food additives in vitro. Toxicol Ind Health. 30:926–37.
   PubMed Web of Science ®Google Scholar
• Yüzbaşıoğlu D, Çelik M, Yılmaz S, Ünal F, Aksoy H. 2006. Clastogenicity of the fungicide afugan in cultured human lymphocytes. Mutat Res. 604:53–59.
   PubMed Web of Science ®Google Scholar
• Zengin N, Yüzbaşıoğlu D, Ünal F, Yılmaz S, Aksoy H. 2011. The evaluation of the genotoxicity of two food preservatives: sodium benzoate and potassium benzoate. Food Chem Toxicol. 49:763–769.
   PubMed Web of Science ®Google Scholar