Geraniol, a natural monoterpene, ameliorates hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats

References

• Baltrusch S, Schmitt H, Brix A, Langer S, Lenzen S. 2012. Additive activation of glucokinase by the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and the chemical activator LY2121260. Biochem Pharmacol. 83:1300–1306.
   PubMed Web of Science ®Google Scholar
• Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. 2001. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med. 7:947–953.
   PubMed Web of Science ®Google Scholar
• Bisse E, Abraham EC. 1985. New less temperature-sensitive microchromatographic method for the separation and quantitation of glycosylated hemoglobins using a non-cyanide buffer system. J Chromatogr. 344:81–91.
   PubMed Web of Science ®Google Scholar
• Brandstrup N, Kirk JE, Bruni C. 1957. The hexokinase and phosphoglucoisomerase activities of aortic and pulmonary artery tissue in individuals of various ages. J Gerontol. 12:166–171.
   PubMedGoogle Scholar
• Bunn HF, Gabbay KH, Gallop PM. 1978. The glycosylation of hemoglobin: relevance to diabetes mellitus. Science. 200:21–27.
   PubMed Web of Science ®Google Scholar
• Ceriello AI. 2005. Postprandial hyperglycemia and diabetes complications: is it time to treat? Diabet. 54:1–7.
   PubMed Web of Science ®Google Scholar
• Cernea S, Dobreanu M. 2013. Diabetes and beta cell function: from mechanisms to evaluation and clinical implications. Biochem Med (Zagreb). 23:266–280.
   PubMed Web of Science ®Google Scholar
• Chen W, Viljoen AM. 2010. Geraniol-A review of a commercially important fragrance material. S Afr J Bot. 76:643–651.
   Web of Science ®Google Scholar
• Choi HS, Song HS, Ukeda H, Sawamura M. 2000. Radical-scavenging activities of citrus essential oils and their components: detection using 1,1-diphenyl-2-picrylhydrazyl. J Agric Food Chem. 48:4156–4161.
   PubMed Web of Science ®Google Scholar
• Colosia AD, Palencia R, Khan S. 2013. Prevalence of hypertension and obesity in patients with type 2 diabetes mellitus in observational studies: a systematic literature review. Diabet Metab Syndr Obes. 6:327–338.
   PubMedGoogle Scholar
• Deepa B, Anuradha CV. 2011. Linalool, a plant derived monoterpene alcohol, rescues kidney from diabetic-induced, nephropathic changes via blood glucose reduction. Diabetol Croat. 3:40–44.
   Google Scholar
• Duncan RE, Lau D, Sohemy A, Archer MC. 2004. Geraniol and beta-ionone inhibit proliferation, cell cycle progression, and cyclin-dependent kinase 2 activity in MCF-7 breast cancer cells independent of effects on HMG-CoA reductase activity. Biochem Pharmacol. 68:1739–1747.
   PubMed Web of Science ®Google Scholar
• Ellis HA, Kirkman HN. 1961. A colorimetric method for assay of erythrocytic glucose 6-phosphate dehydrogenase. Proc Soc Exp Biol Med. 106:607–609.
   PubMed Web of Science ®Google Scholar
• Fatima SS, Rajasekhar MD, Kumar KV, Kumar MT, Babu KR, Rao CA. 2010. Antidiabetic and antihyperlipidemic activity of ethyl acetate:isopropanol (1:1) fraction of Vernonia anthelmintica seeds in streptozotocin induced diabetic rats. Food Chem Toxicol. 48:495–501.
   PubMed Web of Science ®Google Scholar
• Gancedo JM, Gancedo C. 1971. Fructose-1,6-diphosphatase, phospho-fructokinase and glucose-6-phosphate dehydrogenase from fermenting and none fermenting yeasts. Arch Micro. 76:132–138.
   Google Scholar
• Gandhi GR, Sasikumar P. 2012. Antidiabetic effect of Merremia emarginata Burm. F. in streptozotocin induced diabetic rats. Asian Pac J Trop Biomed. 2:281–286.
   PubMedGoogle Scholar
• Grover JK, Yadav S, Vats V. 2002. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol. 81:81–100.
   PubMed Web of Science ®Google Scholar
• Jainandunsing S, Ozcan B, Rietveld T, van Miert JN, Isaacs AJ, Langendonk JG, de Rooij FW, Sijbrands EJ. 2015. Failing beta-cell adaptation in South Asian families with a high risk of type 2 diabetes. Acta Diabetol. 52:11–19.
   PubMed Web of Science ®Google Scholar
• Ji P, Si M, Podnos Y, Imagawa DK. 2002. Monoterpene geraniol prevents acute allograft rejection. Transplant Proc. 34:1418–1419.
   PubMed Web of Science ®Google Scholar
• Kaveeshwar SA, Cornwall J. 2014. The current state of diabetes mellitus in India. Australas Med J. 7:45–48.
   PubMedGoogle Scholar
• Koide H, Oda T. 1959. Pathological occurrence of glucose-6-phosphatase in serum in liver diseases. Clin Chim Acta. 4:554–561.
   PubMed Web of Science ®Google Scholar
• Kondeti VK, Badri KR, Maddirala DR, Thur SK, Fatima SS, Kasetti RB, Rao CA. 2010. Effect of Pterocarpus santalinus bark, on blood glucose, serum lipids, plasma insulin and hepatic carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats. Food Chem Toxicol. 48:1281–1287.
   PubMed Web of Science ®Google Scholar
• Lakshmi BS, Sujatha S, Anand S, Sangeetha KN, Narayanan RB, Katiyar C, Kanaujia A, Duggar R, Singh Y, Srinivas K, et al. 2009. Cinnamic acid, from the bark of Cinnamomum cassia, regulates glucose transport via activation of GLUT4 on L6 myotubes in a phosphatidylinositol 3-kinase independent manner. J Diabet. 1:99–106.
   PubMed Web of Science ®Google Scholar
• Lone J, Yun JW. 2016. Monoterpene limonene induces brown fat-like phenotype in 3T3-L1 white adipocytes. Life Sci. 153:198–206.
   PubMed Web of Science ®Google Scholar
• Lorenzi V, Muselli A, Bernardini AF, Berti L, Pages JM, Amaral L. 2009. Geraniol restores antibiotic activities against multidrug-resistant isolates from Gram-negative species. Antimicrob Agents Chemother. 53:2209–2211.
   PubMed Web of Science ®Google Scholar
• Malini P, Kanchana G, Rajadurai M. 2011. Antibiabetic efficacy of ellagic acid in streptozotocin-induced diabetes mellitus in albino Wistar rats. Asian J Pharm Clin Res. 4:124–128.
   Google Scholar
• Matschinsky FM. 2009. Assessing the potential of glucokinase activators in diabetes therapy. Nat Rev Drug Discov. 8:399–416.
   PubMed Web of Science ®Google Scholar
• Murali R, Saravanan R. 2012. Antidiabetic effect of d-limonene, a monoterpene in streptozotocin-induced diabetic rats. Biomed Prev Nutr. 2:269–275.
   Google Scholar
• Nain P, Saini V, Sharma S, Nain J. 2012. Antidiabetic and antioxidant potential of Emblica officinalis Gaertn. leaves extract in streptozotocin-induced type-2 diabetes mellitus (T2DM) rats. J Ethnopharmacol. 142:65–71.
   PubMed Web of Science ®Google Scholar
• Nordlie RC, Foster JD, Lange AJ. 1999. Regulation of glucose production by the liver. Annu Rev Nutr. 19:379–406.
   PubMed Web of Science ®Google Scholar
• Ozougwu JC, Obimba KC, Belonwu CD, Unakalamba CB. 2013. The pathogenesis and pathophysiology of type 1 and type 2 diabetes mellitus. J Physiol Pathophysiol. 4:46–57.
   Google Scholar
• Pattanayak SP, Sunita P, Jha S. 2009. In vivo antitussive activity of Coccinia grandis against irritant aerosol and sulfur dioxide-induced cough model in rodents. J Pharmacol. 1:157–161.
   Google Scholar
• Prasath GS, Subramanian SP. 2014. Antihyperlipidemic effect of fisetin, a bioflavonoid of strawberries, studied in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol. 28:442–449.
   PubMed Web of Science ®Google Scholar
• Prathapan A, Nampoothiri SV, Mini S, Raghu KG. 2012. Antioxidant, antiglycation and inhibitory potential of Saraca ashoka flowers against the enzymes linked to type 2 diabetes and LDL oxidation. Eur Rev Med Pharmacol Sci. 16:557–652.
   Web of Science ®Google Scholar
• Rakieten N, Rakieten ML, Nadkarni MV. 1963. Studies on the diabetogenic action of streptozotocin (NSC-37917). Cancer Chemother Rep. 29:91–98.
   PubMedGoogle Scholar
• Ramachandran V, Saravanan R. 2013. Efficacy of Asiatic acid, a pentacyclic triterpene on attenuating the key enzyme activities of carbohydrate metabolism in streptozotocin-induced diabetic rats. Phytomedicine. 20:230–236.
   PubMed Web of Science ®Google Scholar
• Rathinam A, Pari L, Chandramohan R, Sheikh BA. 2014. Histopathological findings of the pancreas, liver, and carbohydrate metabolizing enzymes in STZ-induced diabetic rats improved by administration of myrtenal. J Physiol Biochem. 70:935–946.
   PubMed Web of Science ®Google Scholar
• Selvaraja W, William Ndyeabura A. 2011. Antidiabetic activity of crude stem extracts of coscinium fenestratum on streptozotocin-induced type-2 diabetic rats. A J Pharma Clin Res. 4:47–51.
   Google Scholar
• Soumya D, Srilatha B. 2011. Late stage complications of diabetes and insulin resistance. J Diabetes Metab. 2:167.
   Google Scholar
• Srinivasan K, Ramarao P. 2007. Animal models in type 2 diabetes research: an overview. Indian J Med Res. 125:451–472.
   PubMed Web of Science ®Google Scholar
• Stanton RC. 2012. Glucose-6-phosphate dehydrogenase, NADPH, and cell survival. IUBMB Life. 64:362–369.
   PubMed Web of Science ®Google Scholar
• Sundaram R, Naresh R, Shanthi P, Sachdanandam P. 2013. Modulatory effect of green tea extract on hepatic key enzymes of glucose metabolism in streptozotocin and high fat diet induced diabetic rats. Phytomedicine. 20:577–584.
   PubMed Web of Science ®Google Scholar
• Sundaram R, Shanthi P, Sachdanandam P. 2014. Effect of tangeretin, a polymethoxylated flavone on glucose metabolism in streptozotocin-induced diabetic rats. Phytomedicine. 21:793–799.
   PubMed Web of Science ®Google Scholar
• Thiebaud D, Jacot E, DeFronzo RA, Maeder E, Jequier E, Felber JP. 1982. The effect of graded doses of insulin on total glucose uptake, glucose oxidation and glucose storage in man. Diabetes. 3:957–963.
   Google Scholar
• Tiwari M, Kakkar P. 2009. Plant derived antioxidants – geraniol and camphene protect rat alveolar macrophages against t-BHP induced oxidative stress. Toxicol in Vitro. 23:295–301.
   PubMed Web of Science ®Google Scholar
• Trinder P. 1969. Determination of glucose in blood using glucose oxidase with analternative oxygen acceptor. J Clin Pathol. 6:24–27.
   Google Scholar
• Turk Z. 2010. Glycotoxines, carbonyl stress and relevance to diabetes and its complications. Physiol Res. 59:147–156.
   PubMed Web of Science ®Google Scholar
• Vanitha P, Uma C, Suganya N, Bhakkiyalakshmi E, Suriyanarayanan S, Gunasekaran P, Sivasubramanian S, Ramkumar KM. 2014. Modulatory effects of morin on hyperglycemia by attenuating the hepatic key enzymes of carbohydrate metabolism and β-cell function in streptozotocin-induced diabetic rats. Environ Toxicol Pharmacol. 37:326–335.
   PubMed Web of Science ®Google Scholar
• Vinothkumar V, Manoharan S. 2011. Chemopreventive efficacy of geraniol against 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Redox Rep. 16:91–100.
   PubMed Web of Science ®Google Scholar
• Wilding JP. 2014. The role of the kidneys in glucose homeostasis in type 2 diabetes: clinical implications and therapeutic significance through sodium glucose co-transporter 2 inhibitors. Met Clin Exp. 63:1228–1237.
   Google Scholar
• Young PW, Cawthorne MA, Coyle PJ, Holder JC, Holman GD, Kozka IJ, Kirkham DM, Lister CA, Smith SA. 1995. Repeat treatment of obese mice with BRL 49653, a new and potent insulin sensitizer, enhances insulin action in white adipocytes. Association with increased insulin binding and cell-surface GLUT 4 as measured by photoaffinity labeling. Diabetes. 44:1087–1092.
   PubMed Web of Science ®Google Scholar