Randomized double-blinded pilot clinical study of the antidiabetic activity of Balanites aegyptiaca and UPLC-ESI-MS/MS identification of its metabolites

References

• Abdel Motaal A, El-Askary H, Crockett S, Kunert O, Sakr B, Shaker S, Grigore A, Albulescu R, Bauer R. 2015. Aldose reductase inhibition of a saponin-rich fraction and new furostanol saponin derivatives from Balanites aegyptiaca. Phytomedicine. 22:829–836.
   PubMed Web of Science ®Google Scholar
• Abdel Motaal A, Shaker S, Haddad PS. 2012. Antidiabetic activity of standardized extracts of Balanites aegyptiaca fruits using cell-based bioassays. Phcog J. 4:20–24.
   Google Scholar
• Campbell-Tofte J, Hansen HS, Mu H, Molgaard P. 2007. Increased lipids in non-lipogenic tissues are indicators of the severity of type 2 diabetes in mice. Prostaglandins Leukot Essent Fatty Acids. 76:9–18.
   PubMed Web of Science ®Google Scholar
• Chapagain BP, Wiesman Z. 2008. Metabolite profiling of saponins in Balanites aegyptiaca plant tissues using LC (RI)-ESI/MS and MALDI-TOF/MS. Metabolomics. 4:357–366.
   Web of Science ®Google Scholar
• Cui M, Song F, Zhou Y, Liu Z, Liu S. 2000. Rapid identification of saponins in plant extracts by electrospray ionization multi-stage tandem mass spectrometry and liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 14:1280–1286.
   PubMedGoogle Scholar
• Deshpande AD, Harris-Hayes M, Schootman M. 2008. Epidemiology of diabetes and diabetes-related complications. Phys Ther. 88:1254–1264.
   PubMed Web of Science ®Google Scholar
• Duvillard L, Pont F, Florentin E, Gambert P, Verges B. 2000. Inefficiency of insulin therapy to correct apolipoprotein A-I metabolic abnormalities in non-insulin-dependent diabetes mellitus. Atherosclerosis. 152:229–237.
   PubMed Web of Science ®Google Scholar
• Farag MA, Porzel A, Wessjohann LA. 2015. Unraveling the active hypoglycemic agent trigonelline in Balanites aegyptiaca date fruit using metabolite fingerprinting by NMR. J Pharm Biomed Anal. 10:383–387.
   Google Scholar
• Gad MZ, El-Sawalhi MM, Ismail MF, El-Tanbouly ND. 2006. Biochemical study of the anti-diabetic action of the Egyptian plants fenugreek and balanites. Mol Cell Biochem. 281:173–183.
   PubMed Web of Science ®Google Scholar
• Gertsch J. 2009. How scientific is the science in ethnopharmacology? Historical perspectives and epistemological problems. J Ethnopharmacol. 122:177–183.
   PubMed Web of Science ®Google Scholar
• Hall JBWD. 1991. Balanites aegyptiaca Del. - A Monograph, School of Agricultural and Forest Science.: University of Wales, Banger.
   Google Scholar
• Kamel MS. 1998. A furostanol saponin from fruits of Balanites aegyptiaca. Phytochemistry. 48:755–757.
   PubMed Web of Science ®Google Scholar
• Kamel MS, Ohtani K, Kurokawa T, Assaf MH, el-Shanawany MA, Ali AA, Kasai R, Ishibashi S, Tanaka O. 1991. Studies on Balanites aegyptiaca fruits, an antidiabetic Egyptian folk medicine. Chem Pharm Bull. 39:1229–1233.
   PubMed Web of Science ®Google Scholar
• Koski RR. 2006. Practical review of oral antihyperglycemic agents for type 2 diabetes mellitus. Diabetes Educ. 32:869–876.
   PubMed Web of Science ®Google Scholar
• Liang F, Li LJ, Abliz Z, Yang YC, Shi JG. 2002. Structural characterization of steroidal saponins by electrospray ionization and fast-atom bombardment tandem mass spectrometry. Rapid Commun Mass Spectrom. 16:1168–1173.
   PubMedGoogle Scholar
• Liu Y, Liang F, Cui L, Xia M, Zhao L, Yang Y, Shi J, Abliz Z. 2004. Multi-stage mass spectrometry of furostanol saponins combined with electrospray ionization in positive and negative ion modes. Rapid Commun Mass Spectrom. 18:235–238.
   PubMedGoogle Scholar
• Lorenzati B, Zucco C, Miglietta S, Lamberti F, Bruno G. 2010 . Oral hypoglycemic drugs: pathophysiological basis of their mechanism of action oral hypoglycemic drugs: pathophysiological basis of their mechanism of action. Pharmaceuticals (Basel). 3:3005–3020.
   PubMedGoogle Scholar
• Monnier L, Lapinski H, Colette C. 2003. Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA(1c). Diabetes Care. 26:881–885.
   PubMed Web of Science ®Google Scholar
• Proestos C, Kapsokefalou M, Komaitis M. 2008. Analysis of naturally occurring phenolic compounds in aromatic plants by RP-HPLC and GC-MS after silylation. J Food Quality. 31:402–414.
   Web of Science ®Google Scholar
• Roden M. 2005. Muscle triglycerides and mitochondrial function: possible mechanisms for the development of type 2 diabetes. Int J Obes Relat Metab Disord. 29:111–115.
   Web of Science ®Google Scholar
• Satterfield M, Brodbelt JS. 2001. Structural characterization of flavonoid glycosides by collisionally activated dissociation of metal complexes. J Am Soc Mass Spectrom. 12:537–549.
   PubMed Web of Science ®Google Scholar
• Schulz KF, Altman DG, Moher D. 2010. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. J Clin Epidemiol. 63:834–840.
   PubMed Web of Science ®Google Scholar
• Sviridov D, Nestel P. 2002. Dynamics of reverse cholesterol transport: protection against atherosclerosis. Atherosclerosis. 161:245–254.
   PubMed Web of Science ®Google Scholar
• Tzoulaki I, Molokhia M, Curcin V, Little MP, Millett CJ, Ng A, Hughes RI, Khunti K, Wilkins MR, Majeed A, et al. 2009. Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database. BMJ. 339:b4731
   PubMed Web of Science ®Google Scholar
• World Health Organization. 2000. Preventing and managing the global epidemic. Report of a WHO Consultation. In: WHO Technical Report Series 894: World Health Organization, Geneva.
   Google Scholar
• World Health Organisation. 2016. Global report on diabetes: World Health Organization, Geneva.
   Google Scholar
• Zanutto FV, Boldrin PK, Varanda EA, Fernandes de Souza S, Sano PT, Vilegas W, Campaner dos Santos L. 2012. Characterization of flavonoids and naphthopyranones in methanol extracts of Paepalanthus chiquitensis Herzog by HPLC-ESI-IT-MSn and their mutagenic activity. Molecules. 18:244–262.
   PubMed Web of Science ®Google Scholar