Psoralea corylifolia extract induces vasodilation in rat arteries through both endothelium-dependent and -independent mechanisms involving inhibition of TRPC3 channel activity and elaboration of prostaglandin

References

• Arnal JF, Dinh-Xuan AT, Pueyo M, Darblade B, Rami J. 1999. Endothelium-derived nitric oxide and vascular physiology and pathology. Cell Mol Life Sci. 55:1078–1087.
   PubMed Web of Science ®Google Scholar
• Bapat K, Chintalwar GJ, Pandey U, Thakur VS, Sarma HD, Samuel G, Pillai MR, Chattopadhyay S, Venkatesh M. 2005. Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti-tumor agent. Appl Radiat Isot. 62:389–393.
   PubMed Web of Science ®Google Scholar
• Baranowska M, Kozlowska H, Korbut A, Malinowska B. 2007. Potassium channels in blood vessels: their role in health and disease. Postepy Hig Med Dosw. 61:596–605.
   Google Scholar
• Brayden JE, Earley S, Nelson MT, Reading S. 2008. Transient receptor potential (TRP) channels, vascular tone and autoregulation of cerebral blood flow. Clin Exp Pharmacol Physiol. 35:1116–1120.
   PubMed Web of Science ®Google Scholar
• Chaudhuri RK, Bojanowski K. 2014. Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects. Int J Cosmet Sci. 36:221–230.
   PubMed Web of Science ®Google Scholar
• Cho H, Jun JY, Song EK, Kang KH, Baek HY, Ko YS, Kim YC. 2001. Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells. Planta Med. 67:750–751.
   PubMed Web of Science ®Google Scholar
• Chopra B, Dhingra AK, Dhar KL. 2013. Psoralea corylifolia L. (Buguchi) – folklore to modern evidence: review. Fitoterapia. 90:44–56.
   PubMed Web of Science ®Google Scholar
• Filosa JA, Yao XQ, Rath G. 2013. TRPV4 and the regulation of vascular tone. J Cardiovasc Pharmacol. 61:113–119.
   PubMed Web of Science ®Google Scholar
• Freichel M, Suh SH, Pfeifer A, Schweig U, Trost C, Weissgerber P, Biel M, Philipp S, Freise D, Droogmans G, et al. 2001. Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4−/− mice. Nat Cell Biol. 3:121–127.
   PubMed Web of Science ®Google Scholar
• Gao G, Bai XY, Xuan C, Liu XC, Jing WB, Novakovic A, Yang Q, He GW. 2012. Role of TRPC3 channel in human internal mammary artery. Arch Med Res. 43:431–437.
   PubMed Web of Science ®Google Scholar
• Guo J, Wu H, Weng X, Yan J, Bi K. 2003. Studies on extraction and isolation of active constituents from Psoralen corylifolia L. and the antitumor effect of the constituents in vitro. Zhong Yao Cai. 26:185–187.
   PubMedGoogle Scholar
• Haraguchi H, Inoue J, Tamura Y, Mizutani K. 2000. Inhibition of mitochondrial lipid peroxidation by bakuchiol, a meroterpene from Psoralea corylifolia. Planta Med. 66:569–571.
   PubMed Web of Science ®Google Scholar
• Hsu PJ, Miller JS, Berger JM. 2009. Bakuchiol, an antibacterial component of Psoralidium tenuiflorum. Nat Prod Res. 23:781–788.
   PubMed Web of Science ®Google Scholar
• Inoue R, Okada T, Onoue H, Hara Y, Shimizu S, Naitoh S, Ito Y, Mori Y. 2001. The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca2+-permeable cation channel. Circ Res. 88:325–332.
   PubMed Web of Science ®Google Scholar
• Kochukov MY, Balasubramanian A, Noel RC, Marrelli SP. 2013. Role of TRPC1 and TRPC3 channels in contraction and relaxation of mouse thoracic aorta. J Vasc Res. 50:11–20.
   PubMed Web of Science ®Google Scholar
• Li X, Lee YJ, Kim YC, Jeong GS, Cui HZ, Kim HY, Kang DG, Lee HS. 2011. Bakuchicin induces vascular relaxation via endothelium-dependent NO-cGMP signaling. Phytother Res. 25:1574–1578.
   PubMed Web of Science ®Google Scholar
• Lind L, Granstam SO, Millgard J. 2000. Endothelium-dependent vasodilation in hypertension: a review. Blood Press. 9:4–15.
   PubMed Web of Science ®Google Scholar
• Matsuda H, Kiyohara S, Sugimoto S, Ando S, Nakamura S, Yoshikawa M. 2009. Bioactive constituents from Chinese natural Medicines. XXXIII. Inhibitors from the seeds of Psoralea corylifolia on production of nitric oxide in lipopolysaccharide-activated macrophages. Biol Pharm Bull. 32:147–149.
   PubMed Web of Science ®Google Scholar
• Nelson MT, Cheng H, Rubart M, Santana LF, Bonev AD, Knot HJ, Lederer WJ. 1995. Relaxation of arterial smooth muscle by calcium sparks . Science. 270:633–637.
   PubMed Web of Science ®Google Scholar
• Oparil S, Zaman MA, Calhoun DA. 2003. Pathogenesis of hypertension. Ann Intern Med. 139:761–776.
   PubMed Web of Science ®Google Scholar
• Qian X, Francis M, Kohler R, Solodushko V, Lin M, Taylor MS. 2014. Positive feedback regulation of agonist-stimulated endothelial Ca2+ dynamics by K(Ca)3.1 channels in mouse mesenteric arteries. Arterioscler Thromb Vasc Biol. 34:127–135.
   PubMed Web of Science ®Google Scholar
• Ruan B, Kong LY, Takaya Y, Niwa M. 2007. Studies on the chemical constituents of Psoralea corylifolia L. J Asian Nat Prod Res. 9:41–44.
   PubMed Web of Science ®Google Scholar
• Tamargo J, Duarte J, Ruilope LM. 2015. New antihypertensive drugs under development. Curr Med Chem. 22:305–342.
   PubMed Web of Science ®Google Scholar
• Tan G, Yang T, Miao H, Chen H, Chai Y, Wu H. 2015. Characterization of compounds in Psoralea corylifolia using high-performance liquid chromatography diode array detection, time-of-flight mass spectrometry and quadrupole ion trap mass spectrometry. J Chromatogr Sci. 53:1455–1462.
   PubMed Web of Science ®Google Scholar
• Vanhoutte PM. 2009. COX-1 and vascular disease. Clin Pharmacol Ther. 86:212–215.
   PubMed Web of Science ®Google Scholar
• Versari D, Daghini E, Virdis A, Ghiadoni L, Taddei S. 2009. Endothelium-dependent contractions and endothelial dysfunction in human hypertension. Br J Pharmacol. 157:527–536.
   PubMed Web of Science ®Google Scholar
• Waldman SA, Leitman DC, Andresen J, Murad F. 1988. Guanylate cyclase and the adrenal natriuretic factor receptor. Science. 240:805–806.
   PubMed Web of Science ®Google Scholar
• Wang Y, Hong C, Zhou C, Xu D, Qu HB. 2011. Screening antitumor compounds psoralen and isopsoralen from Psoralea corylifolia L. seeds. Evid Based Complement Alternat Med. 2011:363052.
   PubMedGoogle Scholar
• Yeon SI, Kim JY, Yeon DS, Abramowitz J, Birnbaumer L, Muallem S, Lee YH. 2014. Transient receptor potential canonical type 3 channels control the vascular contractility of mouse mesenteric arteries. PLoS One. 9:e110413.
   PubMed Web of Science ®Google Scholar
• Zhang DX, Gutterman DD. 2011. Transient receptor potential channel activation and endothelium-dependent dilation in the systemic circulation. J Cardiovasc Pharmacol. 57:133–139.
   PubMed Web of Science ®Google Scholar