Nrf2 participates in mechanisms for reducing the toxicity and enhancing the antitumour effect of Radix Tripterygium wilfordii to S180-bearing mice by herbal-processing technology

References

• Alonso-Castro AJ, Domínguez F, García-Carrancá A. 2013. Rutin exerts antitumor effects on nude mice bearing SW480 tumor. Arch Med Res. 44:346–351.
   PubMed Web of Science ®Google Scholar
• Bai XD, Zhang LX, Chen T, Li GZ, Wang XH, Zhang WG. 2003. Study on recovery of ethyl acetate after extracting Tripterygium wifordii extractum with ethyl acetate. Zhongguo Zhong Yao Za Zhi. 28:226–228.
   PubMedGoogle Scholar
• Bao J, Dai SM. 2011. A Chinese herb Tripterygium wilfordii Hook F in the treatment of rheumatoid arthritis: mechanism, efficacy, and safety. Rheumatol Int. 31:1123–1129.
   PubMed Web of Science ®Google Scholar
• Cai H, Li J, Wang JM, Zhang ZL, Wang QX, Tang JF, Cui Y, Li JY. 2017. Historical evolution, theoretical foundation and modern research strategies of processed-herb technology. Shizhen Guoyi Guoyao. 28:2703–2705.
   Google Scholar
• Cao LJ, Yan M, Li HD, Zhang BK, Fang PF. 2015a. Progress on mechanism of Tripterygium wilfordii-induced liver injury and detoxification mechanism of licorice. Zhongguo Zhong Yao Za Zhi. 40:2537–2541.
   PubMedGoogle Scholar
• Cao LL, Wang WX, Zhang L, Ding AW, Dou ZH, Wang YH. 2015b. Study on toxicity of vinegar-processed Kansui Radix on basis of symptom-based prescription theory. Zhongguo Zhong Yao Za Zhi. 40:3249–3255.
   PubMedGoogle Scholar
• Chen WC, Liou SS, Tzeng TF, Lee SL, Liu IM. 2012. Wound repair and anti-inflammatory potential of Lonicera japonica in excision wound-induced rats. BMC Complem Altern Med. 12:9.
   PubMed Web of Science ®Google Scholar
• Chen HY, Cao YD, Yan XJ, Zhang L, Geng XX, Ding AW. 2013. Study on detoxication and mechanism of vinegar-processed Euphorbia pekinensis on normal liver cells LO2. Zhongguo Zhong Yao Za Zhi. 38:866–870.
   PubMedGoogle Scholar
• Chen P, Zhang JY, Sha BB, Ma YE, Hu T, Ma YC, Sun H, Shi JX, Dong ZM, Li P. 2017. Luteolin inhibits cell proliferation and induces cell apoptosis via down-regulation of mitochondrial membrane potential in esophageal carcinoma cells EC1 and KYSE450. Oncotarget. 8:27471–27480.
   PubMedGoogle Scholar
• Fei HL, Sun H, Chen XT. 2017. Advances in research on Yinhuagancao decoction. Yaoxue Fuwu Yu Yanjiu. 7:226–228.
   Google Scholar
• Ge Y, Xie H, Li S, Jin B, Hou J, Zhang H, Shi M, Liu Z. 2013. Treatment of diabetic nephropathy with Tripterygium wilfordii Hook F extract: a prospective, randomized, controlled clinical trial. J Trans Med. 11:134.
   PubMed Web of Science ®Google Scholar
• Gong L, Wu H, Yu HL, Zhao TF, Xu QX. 2013. [Comparative study on toxicity of extracts from Phytolaccae Radix before and after being processed with vinegar]. Zhongguo Zhong Yao Za Zhi. 38:1610–1613.
   PubMedGoogle Scholar
• Gu LZ, Zhang BS, Nan JH. 1988. Anti-inflammatory effects of two species of Lysimachia christinae Hance and Desmodium styracifolium (Osbeck) Merr. Zhong Yao Tong Bao. 13:40–42, 63.
   PubMedGoogle Scholar
• Guo AL, Chen LM, Wang YM, Liu XQ, Zhang QW, Gao HM, Wang ZM, Xiao W, Wang ZZ. 2014. Influence of sulfur fumigation on the chemical constituents and antioxidant activity of buds of Lonicera japonica. Molecules. 19:16640–16655.
   PubMed Web of Science ®Google Scholar
• Guo R, Wang T, Zhou G, Xu M, Yu X, Zhang X, Sui F, Li C, Tang L, Wang Z. 2018. Botany, phytochemistry, pharmacology and toxicity of Strychnos nux-vomica L.: a review. Am J Chin Med. 46:1–23.
   PubMed Web of Science ®Google Scholar
• He DY, Dai SM. 2011. Anti-inflammatory and immunomodulatory effects of Paeonia lactiflora Pall., a traditional Chinese herbal medicine. Front Pharmacol. 2:1–5.
   PubMed Web of Science ®Google Scholar
• Jung JC, Lee YH, Kim SH, Kim KJ, Kim KM, Oh S, Jung YS. 2016. Hepatoprotective effect of licorice, the root of Glycyrrhiza uralensis Fischer, in alcohol-induced fatty liver disease. BMC Complemen Alt Med. 16:19.
   PubMed Web of Science ®Google Scholar
• Lee SC, Kwon YS, Son KH, Kim HP, Heo MY. 2005. Antioxidative constituents from Paeonia lactiflora. Arch Pharmacal Res. 28:775–783.
   PubMed Web of Science ®Google Scholar
• Li ZB, Wang ZQ, Gong CX, Geng LF, Hui NL, Zhu JJ. 2009. Toxicity-reducing and action-enhancing effects of total glucosides of paeony on Tripterygium glycosides in treating lupus nephritis. Zhongyao Xinyao Yu Linchuang Yaoli. 20:513–516.
   Google Scholar
• Li XX, Du FY, Liu HX, Ji JB, Xing J. 2015. Investigation of the active components in Tripterygium wilfordii leading to its acute hepatotoxicty and nephrotoxicity. J Ethnopharmacol. 162:238–243.
   PubMed Web of Science ®Google Scholar
• Li X, Zhou N, Wang J, Liu Z, Wang X, Zhang Q, Liu Q, Gao L, Wang R. 2018a. Quercetin suppresses breast cancer stem cells (CD44+/CD24-) by inhibiting the PI3K/Akt/mTOR-signaling pathway. Life Sci. 196:56–62.
   PubMed Web of Science ®Google Scholar
• Li MQ, Wang K, Xia SW, Zhou X. 2018b. Antitumor effect of mung bean peptides on H22 tumor bearing mice. Xibei Nongli Keji Daxue Xuebao. 46:1–5.
   Google Scholar
• Liu J, Jiang Z, Xiao J, Zhang Y, Lin S, Duan W, Yao J, Liu C, Huang X, Wang T, et al. 2009. Effects of triptolide from Tripterygium wilfordii on ERalpha and p53 expression in two human breast cancer cell lines. Phytomed. 16:1006–1013.
   PubMed Web of Science ®Google Scholar
• Liu XN, Zhao YL, Gao EZ, Liu T, Yu XH, Yu ZG. 2015. Interventional effect of mung bean flavonoids on alcohol-induced liver injury mouse model. Shenyang Yaoke Daxue Xuebao. 32:55–58.
   Google Scholar
• Liu Y, Zhong QX, Qiu HH, Wang G, Wang CC, Feng L, Jia XB. 2017. Study on attenuating hepatotoxicity of Tripterygium wilfordii through compatibility of traditional Chinese medicine compound. Zhongguo Zhong Yao Za Zhi. 42:3044–3048.
   PubMedGoogle Scholar
• Luo J, Cai W, Wu T, Xu B. 2016. Phytochemical distribution in hull and cotyledon of adzuki bean (Vigna angularis L.) and mung bean (Vigna radiate L.), and their contribution to antioxidant, anti-inflammatory and anti-diabetic activities. Food Chem. 201:350–360.
   PubMed Web of Science ®Google Scholar
• Ma ZJ, Dong JM, Wang JB, Pang JY, Pu SB. 2017. Compatibility attenuated research of Glycyrrhiza concocted Tripterygium wilfordii based on high content analysis. Zhongguo Xiandai Zhongyao. 19:1562–1565.
   Google Scholar
• Meler J, Wendt L. 1990. Pharmaceutical interaction of lidocaine hydrochloride and sodium carboxymethylcellulose in “hydrocortisonum” suspension. Die Pharmazie. 45:692–693.
   PubMed Web of Science ®Google Scholar
• Ouyang J, Xu H, Li M, Dai X, Fu F, Zhang X, Lan Q. 2018. Paeoniflorin exerts antitumor effects by inactivating S phase kinase-associated protein 2 in glioma cells. Oncol Rep. 39:1052–1062.
   PubMed Web of Science ®Google Scholar
• Seon MR, Park SY, Kwon SJ, Lim SS, Choi HJ, Park H, Lim DY, Kim JS, Lee CH, Kim J, et al. 2012. Hexane/ethanol extract of Glycyrrhiza uralensis and its active compound isoangustone A induce G1 cycle arrest In DU145 human prostate and 4T1 murine mammary cancer cells. J Nutr Biochem. 23:85–92.
   PubMed Web of Science ®Google Scholar
• Sohn EJ, Kang DG, Lee HS. 2003. Protective effects of glycyrrhizin on gentamicin-induced acute renal failure in rats. Pharmacol Toxicol. 93:116–122.
   PubMedGoogle Scholar
• Song ZM. 1991. The use of licorice detoxification. Shanxi Zhongyi. 7:44–45.
   Google Scholar
• Song P, Hai Y, Ma W, Zhao L, Wang X, Xie Q, Li Y, Wu Z, Li Y, Li H. 2018. Arsenic trioxide combined with transarterial chemoembolization for unresectable primary hepatic carcinoma: a systematic review and meta-analysis. Medicine (Baltimore). 97:1–14.
   Web of Science ®Google Scholar
• Sun WY, Wei W, Gui SY, Wu L, Wang H. 2008. Protective effect of extract from Paeonia lactiflora and Astragalus membranaceus against liver injury induced by Bacillus Calmette-Guérin and lipopolysaccharide in mice. Basic Clin Pharmacol Toxicol. 103:143–149.
   PubMed Web of Science ®Google Scholar
• Sun C, Teng Y, Li G, Yoshioka S, Yokota J, Miyamura M, Fang H, Zhang Y. 2010. Metabonomics study of the protective effects of Lonicera japonica extract on acute liver injury in dimethylnitrosamine treated rats. J Pharmaceut Biomed Anal. 53:98–102.
   PubMed Web of Science ®Google Scholar
• Tao X, Cush JJ, Garret M, Lipsky PE. 2001. A phase I study of ethyl acetate extract of the Chinese antirheumatic herb Tripterygium wilfordii Hook F in rheumatoid arthritis. J Rheumatol. 28:2160–2167.
   PubMed Web of Science ®Google Scholar
• Tao X, Fan F, Hoffmann V, Longo NS, Lipsky PE. 2006. Therapeutic impact of the ethyl acetate extract of Tripterygium wilfordii Hook F on nephritis in NZB/W F1 mice. Arthritis Res Ther. 8:R24.
   PubMed Web of Science ®Google Scholar
• Thirugnanam S, Xu L, Ramaswamy K, Gnanasekar M. 2008. Glycyrrhizin induces apoptosis in prostate cancer cell lines DU-145 and LNCaP. Oncol Rep. 20:1387–1392.
   PubMed Web of Science ®Google Scholar
• Tóth A, Végh K, Alberti Á, Béni S, Kéry Á. 2016. A new ultra-high pressure liquid chromatography method for the determination of antioxidant flavonol aglycones in six Lysimachia species. Nat Product Res. 30:2372–2377.
   PubMed Web of Science ®Google Scholar
• Wang JM, Yan XH, Cui Y. 2012a. Application status quo and strategy of using medicine to prepare medicine in Chinese medicine processing. Zhongyi Xuebao. 27:194–195.
   Google Scholar
• Wang JM, Jia YM, Cui Y. 2012b. Research progress and strategy in toxicity of Tripterygium wilfordii Hook. f. with triptolide as the main anticancer bioactive component. Shizhen Guoyi Guoyao. 23:558–559.
   Google Scholar
• Wang X, Xue M, Gu J, Fang X, Sha X. 2012c. Transdermal microemulsion drug delivery system for impairing male reproductive toxicity and enhancing efficacy of Tripterygium wilfordii Hook f. Fitoterapia. 83:690–698.
   PubMed Web of Science ®Google Scholar
• Wang J, Zhang Y, Zhang Y, Cui Y, Liu J, Zhang B. 2012d. Protective effect of Lysimachia christinae against acute alcohol-induced liver injury in mice. Biosci Trends. 6:89–97.
   PubMed Web of Science ®Google Scholar
• Wang J, Miao M, Zhang Y, Liu R, Li X, Cui Y, Qu L. 2015. Quercetin ameliorates liver injury induced with Tripterygium glycosides by reducing oxidative stress and inflammation. Can J Physiol Pharmacol. 93:427–433.
   PubMed Web of Science ®Google Scholar
• Wang Z, Ravula R, Shi L, Song Y, Yeung S, Liu M, Lau B, Hao J, Wang J, Lam CW, et al. 2016a. Overcoming chemoresistance in prostate cancer with Chinese medicine Tripterygium wilfordii via multiple mechanisms. Oncotarget. 7:61246–61261.
   PubMedGoogle Scholar
• Wang JM, Sun YY, Zhang YY, Chen YL, Li XB, Miao MS, Cui Y, Qu LB. 2016b. Component ratio and dose-effect relationship of Tripterygium wilfordii combined with Lysimachia christina in inhibiting A549 nonsmall cell lung cancer cells in vitro. Zhongguo Laonianxue Zazhi. 36:14–16.
   Google Scholar
• Wang P, Wang W, Shi Q, Zhao L, Mei F, Li C, Zuo T, He X. 2016. Paeoniflorin ameliorates acute necrotizing pancreatitis and pancreatitis-induced acute renal injury. Mol Med Rep. 14:1123–1131.
   PubMed Web of Science ®Google Scholar
• Wang JM, Li JY, Cai H, Li JH, Zhang YY, Chen RX, Cui Y. 2017. Processing by Lysimachia christinae Hance attenuates Tripterygium wilfordii-induced toxicity in vivo. Basic Clin Pharmacol Toxicol. 121:22.
   Web of Science ®Google Scholar
• Wang JM, Li JY, Zhang YY, Cai H, Li JH, Chen RX, Li J, Cui Y. 2018a. Preliminary evaluation on the detoxification effect of Tripterygium wilfordii Radix via processed with medicinal herbs based on PCA and GCA analysis methods. Shizhen Guoyi Guoyao. 29:1349–1352.
   Google Scholar
• Wang JM, Cai H, Li JH, Chen RX, Zhang YY, Li JY, Ding NN, Liu C, Cui Y. 2018b. Detoxication mechanisms of Radix Tripterygium wilfordii via compatibility with Herba Lysimachia christinae in S180-bearing mice by involving Nrf2. Biosci Rep. 38:1–13.
   Web of Science ®Google Scholar
• Wu TY, Khor TO, Saw CL, Loh SC, Chen AI, Lim SS, Park JH, Cai L, Kong AN. 2011. Anti-inflammatory/anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis. Aaps J. 13:1–13.
   PubMed Web of Science ®Google Scholar
• Wu X, Chen X, Huang Q, Fang D, Li G, Zhang G. 2012. Toxicity of raw and processed roots of Polygonum multiflorum. Fitoterapia. 83:469–475.
   PubMed Web of Science ®Google Scholar
• Xie HJ, Gao HW, Wang J, Li CB, Zhang CW, Liu CY. 2018. The mechanism of total flavonoids of Lysimachiae Herba on kidney injury induced by calcium oxalate crystallization. Zhongguo Zhongxiyi Jiehe Waike Zazhi. 24:58–63.
   Google Scholar
• Xin SB, Yan H, Ma J, Sun Q, Shen L. 2016. Protective effects of luteolin on lipopolysaccharide-induced acute renal injury in mice. Int Med J Exp Clin Res. 22:5173–5180.
   Google Scholar
• Yagmurca M, Yasar Z, Bas O. 2015. Effects of quercetin on kidney injury induced by doxorubicin. Bratislavske Lekarske Listy. 116:486–489.
   PubMed Web of Science ®Google Scholar
• Yan Y, Liu N, Hou N, Dong L, Li J. 2017. Chlorogenic acid inhibits hepatocellular carcinoma in vitro and in vivo. J Nutritional Biochem. 46:68–73.
   PubMed Web of Science ®Google Scholar
• Yang JW. 2016. Clinical observation of mung bean licorice decoction in treating lung injury caused by paraquat poisoning. Neimenggu Zhongyiyao. 35:41–42.
   Google Scholar
• Ye HY, Jin J, Jin LW, Chen Y, Zhou ZH, Li ZY. 2017. Chlorogenic acid attenuates lipopolysaccharide-induced acute kidney injury by inhibiting TLR4/NF-κB signal pathway. Inflammation. 40:523–529.
   PubMed Web of Science ®Google Scholar
• Yun JW, Kim SH, Kim YS, You JR, Kwon E, Jang JJ, Park IA, Kim HC, Kim HH, Che JH, et al. 2015. Evaluation of subchronic (13week) toxicity and genotoxicity potential of vinegar-processed Genkwa Flos. Reg Toxicol Pharmacol. 72:386–393.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Wang J, Sun X, Jia L, Li J, Shan L, Li R, Liu H, Wang R, Song X, et al. 2014. Microcalorimetry coupled with chemometric techniques for toxicity evaluation of Radix Aconiti Lateralis Preparata (Fuzi) and its processed products on Escherichia coli. Appl Microbiol Biotechnol. 98:437–444.
   PubMed Web of Science ®Google Scholar
• Zhao XM, Gong M, Dong JM, Wang JB, Xiao XH, Zhao KJ, Ma ZJ. 2017. [Preliminary research on effect of licorice-processed Tripterygium wilfordii on reducing liver toxicity]. Zhongguo Zhong Yao Za Zhi. 42:119–124.
   PubMedGoogle Scholar