1,820
Views
9
CrossRef citations to date
0
Altmetric
Research Article

ShenQi FuZheng injection as an adjunctive treatment to chemotherapy in breast cancer patients: a meta-analysis

, &
Pages 612-624 | Received 18 Apr 2019, Accepted 21 Aug 2019, Published online: 15 Sep 2019

References

  • Aticam K, Akomatine M. 2011. Clinical observation of Shenqi Fuzheng injection combined with chemotherapy in treatment of advanced breast cancer. Guide China Med. 9:311–312.
  • Carioli G, Malvezzi M, Rodriguez T, Bertuccio P, Negri E, La Vecchia C. 2017. Trends and predictions to 2020 in breast cancer mortality in Europe. Breast. 36:89–95.
  • Cha XY, Jia CF. 2010. Clinical observation of Shenqi Fuzheng injection combined with lifein in improving the immune function of breast cancer patients. Modern J Integr Tradit Chin Western Med. 19:3288–3289.
  • Chen F, Li NH. 2007. Clinical observation of Shenqi Fuzheng injection in assist chemotherapy of breast cancer. J Strait Pharm. 12:75–76.
  • Chen JM, Xie XH, Liu H, Chen YJ. 2010. Clinical observation of Shenqi Fuzheng injection in patients with advanced breast cancer undergoing chemotherapy. Modern J Integr Tradit Chin Western Med. 19:2651–2652.
  • Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ, He J. 2016. Cancer statistics in China, 2015. CA Cancer J Clin. 66(2):115–132.
  • Chen XC. 2016. Clinical effect of Shenqi Fuzheng injection combined with chemotherapy for breast cancer. World Latest Med Inform. 16:144–146.
  • Chen Y, Gan L, Zheng W, Wang J, Wang C, Dehua C. 2016. Effect of Shenqi Fuzheng injection combined with chemotherapy in treating breast cancer. J Clin Trant Chin Med. 28:1120–1122.
  • Dai ZJ, Wang XJ, Kang HF, Guan HT, Liu XX, Song LQ, Cheng C, Ji ZZ. 2007. Clinical observation of efficacy and adverse reactions on Shenqi Fuzheng injection used in patients with breast cancer receiving neoadjuvant chemotherapy. J Adverse Drug React. 9:10–14.
  • Dai Z, Wan X, Kang H, Ji Z, Liu L, Liu X, Song L, Min W, Ma X. 2008. Clinical effects of Shenqi Fuzheng injection in the neoadjuvant chemotherapy for local advanced breast cancer and the effects on T-lymphocyte subsets. J Tradit Chin Med. 28(1):34–38.
  • Deeks JJ, Higgins JP, Altman DG. 2011. Analysing data and undertaking meta-analyses. In: Higgins JP, Green S, editors. Cochrane handbook for systematic reviews of interventions. Hoboken (NJ): John Wiley & Sons, Ltd.; p. 243–296.
  • Feng Q. 2014. Clinical study on the reduction of cardiotoxicity in breast cancer patients treated with FAC chemotherapy regimen by dexrazoxane combined with Shenqi Fuzheng injection. Jilin J Tradit Chin Med. 34:256–259.
  • Fu YJ. 2014. Clinical observation of traditional Chinese medicine and Western medicine in the treatment of breast cancer. China Pract Med. 9:138–139.
  • Gao SR, Xia HP. 2009. Effect of Shenqi Fuzheng injection combined with chemotherapy in treatment of advanced breast cancer on T-lymphocyte Ag-NORs. Chin Clin Oncol. 14:1003–1006.
  • Gopalakrishnan S, Ganeshkumar P. 2013. Systematic reviews and meta-analysis: understanding the best evidence in primary healthcare. J Fam Med Primary Care. 2:9–14.
  • He Y. 2015. Effect of adjuvant therapy with Shenqi Fuzheng injection on breast cancer patients undergoing chemotherapy. Contemp Med Forum. 13:267–268.
  • Higgins JPT, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, Savovic J, Schulz KF, Weeks L, Sterne JAC. 2011. The Cochrane collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 343(2):d5928.
  • Hong RD. 2015. Effect of Shenqi Fuzheng injection combined with chemotherapy on advanced triple-negative breast cancer. J N Pharm. 12:25–26.
  • Hong Wei X. 2005. Shenqi Fuzheng injection combined with FEC in the treatment of breast carcinoma. J Med Theory Pract. 18:885–887.
  • Huang ZF, Wei JS, Li HZ. 2008. Effect of Shenqi Fuzheng injection combined with chemotherapy on thirty patients with advanced breast cancer. Chin J Integr Tradit Western Med. 28:152–154.
  • Hutchins LF, Green SJ, Ravdin PM, Lew D, Martino S, Abeloff M, Lyss AP, Allred C, Rivkin SE, Osborne CK. 2005. Randomized, controlled trial of cyclophosphamide, methotrexate, and fluorouracil versus cyclophosphamide, doxorubicin, and fluorouracil with and without tamoxifen for high-risk, node-negative breast cancer: treatment results of intergroup protocol INT-0102. J Clin Oncol. 23(33):8313–8321.
  • Iooss B, Saltelli A. 2017. Introduction to sensitivity analysis. In: Ghanem R, Higdon D, Owhadi H, editors. Handbook of uncertainty quantification. Cham, Switzerland: Springer International Publishing; p. 1103–1122.
  • Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJM, Gavaghan DJ, McQuay HJ. 1996. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 17(1):1–12.
  • Jia CF, Duan M, Duan X. 2016. Clinical effects of Shenqi Fuzheng injection and chemotherapy on hematopoietic and immune function in patients with breast cancer. J Hainan Med Univ. 22:1866–1869.
  • Jiang HJ, Zhang HZ, Hu XG, Ma J. 2015. A meta-analysis of Shenqi Fuzheng combined with radiation in the treatment of nonsmall cell lung cancer. J Can Res Ther. 11:101–103.
  • Jin L, Yixi B, Waikei L, Wenwen L, Fang L, Xuan Z, Jing L, Hongping W. 2008. Immunoregulatory and anti-tumor effects of polysaccharopeptide and Astragalus polysaccharides on tumor-bearing mice. Immunopharmacol Immunotoxicol. 30(4):771–782.
  • Karnofsky DA, Burchenal JH. 1949. The clinical evaluation of chemotherapeutic agents in cancer. In: McLeod CM, editor. Evaluation of chemotherapeutic agents. New York (NY): Columbia University Press.
  • Lee YW, Chen TL, Shih YRV, Tsai CL, Chang CC, Liang HH, Tseng SH, Chien SC, Wang CC. 2014. Adjunctive traditional Chinese medicine therapy improves survival in patients with advanced breast cancer: a population-based study. Cancer. 120(9):1338–1344.
  • Leggett S, Koczwara B, Miller M. 2015. The impact of complementary and alternative medicines on cancer symptoms, treatment side effects, quality of life, and survival in women with breast cancer-a systematic review. Nutr Cancer. 67(3):373–391.
  • Li J, Wang JC, Ma B, Gao W, Chen P, Sun R, Yang KH. 2015a. Shenqi Fuzheng injection for advanced gastric cancer: a systematic review of randomized controlled trials. Chin J Integr Med. 21(1):71–79.
  • Li X, Yang G, Li X, Zhang Y, Yang J, Chang J, Sun X, Zhou X, Guo Y, Xu Y. 2013. Traditional Chinese medicine in cancer care: a review of controlled clinical studies published in Chinese. PLoS One. 8:e60338-e60338.
  • Li XL, Tian QY, Ma WJ. 2004. Clinical observation of Shenqi Fuzheng injection combined with chemotherapy in treatment of advanced breast cancer. J Modern Oncol. 12:574–575.
  • Li XL, Wang XQ, Qu HO. 2015b. Effect of Shenqi Fuzheng injection combined with chemotherapy on breast cancer. Chin J Clin Pharm. 31:267–269.
  • Li Y, Li X. 2014. Observation on the effect of Shenqi Fuzheng injection combined with chemotherapy in the treatment of breast cancer. Chin J Modern Drug Appl. 18:152–153.
  • Li YQ, Peng SP. 2002. Shenqi Fuzheng injection combined with chemotherapy in 35 cases of breast cancer after operation. Modern J Integr Tradit Chin Western Med. 22:827–827.
  • Liang F, Zhang Q, Zhang L, Yan G, Li J. 2014. Shenqi Fuzheng injection combined with chemotherapy in treatment of breast cancer. Chin Pract Med. 38:175–176.
  • Liu XY, Song XL. 2017. Effect of Shenqi Fuzheng injection on immune function and quality of life in patients with breast cancer. Shanghai Med Pharm J. 38(19):29–31.
  • Liu Y, Pan T, Zou W, Sun Y, Cai Y, Wang R, Han P, Zhang Z, He Q, Ye F. 2016. Relationship between traditional Chinese medicine constitutional types with chemotherapy-induced nausea and vomiting in patients with breast cancer: an observational study. BMC Complement Altern Med. 16(1):451–451.
  • Liu Y. 2017. Clinical efficacy of different drugs in treatment of breast cancer. Clin Res Pract. 2:16–17.
  • Lu MY, Li HS, Yang B. 2010. The effects of Shenqi Fuzheng injection on the immune function of patients with breast cancer treated with CAF regimen chemotherapy. J Basic Clin Oncol. 23:236–238.
  • Lv Y, Zhang G, Ma Y, Ma M, Liao R, Xiang J, Chen R, Yan X, Bie F, Huang M, et al. 2015. Shenqi Fuzheng injection combined with chemotherapy for breast cancer: a meta-analysis of randomized controlled trials. Evid Based Comp Alt Med eCAM. 2015:635858.
  • Maughan K, Lutterbie M, Ham P. 2010. Treatment of breast cancer. Am Fam Physician. 1:1339–1346.
  • Montero AJ, Eapen S, Gorin B, Adler P. 2012. The economic burden of metastatic breast cancer: a U.S. managed care perspective. Breast Cancer Res Treat. 134(2):815–822.
  • Nie JY, Zhou TN, Zhang Y, Chen WL. 2005. Effect of Shenqi Fuzheng injection combined with chemotherapy on serum CA153 level and immunocyte activity in patients with stage IV breast cancer. J Pract Oncol. 20:452–453.
  • Ou ZF, Xu Y, Wang P. 2017. Effect of Shenqi Fuzheng injection and three-dimensional conformal radiotherapy on T lymphocyte subsets and tumor biomarkers in patients with breast cancer. J Henan Univ Sci Tech. 34:104–106.
  • Peart O. 2015. Breast intervention and breast cancer treatment options. Radiol Technol. 86(5):535M–558M.
  • Qi FH, Zhao L, Zhou AY, Zhang B, Li AY, Wang ZX, Han JQ. 2015. The advantages of using traditional Chinese medicine as an adjunctive therapy in the whole course of cancer treatment instead of only terminal stage of cancer. Biosci Trends. 9(1):16–34.
  • Qi LW, Cao J, Li P, Yu QT, Wen XD, Wang YX, Li CY, Bao KD, Ge XX, Cheng XL. 2008. Qualitative and quantitative analysis of Radix Astragali products by fast high-performance liquid chromatography-diode array detection coupled with time-of-flight mass spectrometry through dynamic adjustment of fragmentor voltage. J Chromatogr A. 1203(1):27–35.
  • Qi QG, Li Y, Ying W, Li H, Yu G, Xu YY, Wang F, Zhang W. 2013. Impact of Shenqi Fuzheng combination chemotherapy on the expression levels of TNF-α, CCL18 and IL-6 in the serum of breast cancer patients. Chin J New Drugs. 22:1196–1201.
  • Qian ZZ, Yang D, Liu YZ, Yong P. 2010. Pharmacopoeia of the people’s republic of China (2010 edition): a milestone in development of China’s healthcare. Chin Herb Med. 2:157–160.
  • Qiao YC, Cui T. 2013. The observation of SFI combined with capecitabineon in the maintenance treatment of metastatic breast cancer. Chin J Geriatr Care. 11:46–47.
  • Qiu ZC. 2010. Clinical observation of Shenqi Fuzheng injection combined with chemotherapy in treatment of advanced breast cancer. J Liaoning Univ Tradit Chin Med. 12:174–175.
  • Qu ZF, Xu Y, Wang P. 2017. Effect of Shenqi Fuzheng injection and three-dimensional conformal radiotherapy on T lymphocyte subsets and tumor biomarkers in patients with breast cancer. J Henan Univ Sci Tech.
  • Ren JP, Li XM, Wu CQ, Hu QR, Chen SY, Liu YJ. 2005. Clinical observation on protective effect of Shenqi Fuzheng injection on postoperative radiotherapy for breast cancer. Acta Chin Med Pharm. 33:32–33.
  • She Q, Zhang J, Li YH, Li ZQ, Cheng YG, Yang WQ. 2017. Shenqi Fuzheng injection as a postoperative adjuvant to chemotherapy for breast cancer. J Guangxi Med Univ. 34:1734–1737.
  • Shi H, Lu N, Zhang X. 2013. Effect of Shenqi Fuzheng injection combined with chemotherapy on female breast cancer with lung metastasis. Modern Pract Med. 25:661–662.
  • Siegel RL, Miller KD, Jemal A. 2019. Cancer statistics, 2019. CA A Cancer J Clin. 69(1):7–34.
  • Song ZJ. 2004. Clinical observation of Shenqi Fuzheng injection in enhancing efficacy and reducing toxicity after chemotherapy for breast cancer. Chin Clin Doct. 32:62–63.
  • Su Y, Zhou Q. 2016. Clinical observation of Shenqi Fuzheng decoction combined with CEF regimen in the treatment of breast cancer. J Hubei Coll Tradit Chin Med. 18:71–73.
  • Tao ZQ, Shi AM, Lu CY, Song T, Zhang ZG, Zhao J. 2015. Breast cancer: epidemiology and etiology. Cell Biochem Biophys. 72(2):333–338.
  • Tin MMY, Cho CH, Chan K, James AE, Ko J. 2007. Astragalus saponins induce growth inhibition and apoptosis in human colon cancer cells and tumor xenograft. Carcinogenesis. 28(6):1347–1355.
  • Wang DJ. 2013. Clinical observation of Chinese and Western drugs for the treatment of 76 cases of breast cancer. Med Recapitulate. 19:2676–2678.
  • Wang F. 2015a. Comparative analysis of different drugs in the treatment of breast cancer. Chin Health Stand Manag. 6:238–239.
  • Wang JX, Tong X, Li PB, Cao H, Su WW. 2012. Immuno-enhancement effects of Shenqi Fuzheng injection on cyclophosphamide-induced immunosuppression in Balb/c mice. J Ethnopharmacol. 139(3):788–795.
  • Wang SM, Guo YW, Huang GS. 2006. Application of Shenqi Fuzheng injection in adjuvant chemotherapy after breast cancer operation. China Med Her. 3:124.
  • Wang W. 2015b. Clinical Study of Shenqi Fuzheng injection combined with new assistant chemotherapy on breast cancer. China J Chin Med. 30:466–467.
  • Wang XF, Guo HQ, Ning LI, Deng WY. 2016. Analysis the effect of Shenqi Fuzheng injection combine with chemotherapy in treatment of breast cancer. China Contin Med Educ. 8:197–198.
  • Wu M. 2012. Clinical observation of Shenqi Fuzheng injection in adjuvant treatment of 36 patients with breast cancer after operation. Health Required. 11:418–419.
  • Xiao HW. 2005. Shenqi-fuzheng injection combined with FEC in the treatment of breast carcinoma. J Med Theory Pract. 18:885–886.
  • Xie F. 2014. Clinical analysis Shenqi Fuzheng injection combined with chemotherapy in the treatment of breast cancer. Guide China Med. 13:19–20.
  • Xiong Y, Zhao Q, Gu L, Liu C, Wang C. 2018. Shenqi Fuzheng injection reverses cisplatin resistance through mitofusin-2-mediated cell cycle arrest and apoptosis in A549/DDP cells. Evid Based Comp Alternative Med. 2018:8258246.
  • Xu DY, Yue Z. 2010. Clinical observation of Shenqi Fuzheng injection combined with radiotherapy for breast cancer. Chin J Modern Drug Appl. 4:171–172.
  • Xu ZH, Xia Y. 2016. Clinical observation of Shenqi Fuzheng injection combined with radiotherapy for breast cancer. Chin Health Care Nutr. 26:257.
  • Yang B, Li H, Qi Y, Lu M. 2007. Clinical study on breast cancer treated by Fuzheng Peiben method combined with chemotherapy. J Chin Med Mater. 30:1629–1631.
  • Yang CX, Gou YQ, Chen JY, An J, Chen WX, Hu FD. 2013. Structural characterization and antitumor activity of a pectic polysaccharide from Codonopsis pilosula. Carbohydr Polym. 98(1):886–895.
  • Yang F. 2016. Clinical significance of Shenqi Fuzheng injection in adjuvant treatment of breast cancer. Nei Mongol J Tradit Chin Med. 35:65.
  • Yang Y, Ting W, Xiao L, Shufei F, Wangxiao T, Xiaoying W, Xiumei G, Boli Z. 2017. Immunoregulation of Shenqi Fuzheng injection combined with chemotherapy in cancer patients: a systematic review and meta-analysis. Evid Based Comp Alt Med. 2017:5121538.
  • Yu Q, Zhang J, Li Y, Li C, Yang W. 2017. Clinical observation of Shenqi Fuzheng injection in adjuvant chemotherapy after radical mastectomy. J Guangxi Med Univ. 12:1734–1737.
  • Yuan JW, Kong CB, Kang GW, Liu XF, Yang SJ. 2008. Effect of Shenqi Fuzheng injection on cellular immune function in breast cancer patients undergoing neoadjuvant chemotherapy. Lishizhen Med Mater Med Res. 19:1099–1100.
  • Zhang Q, Cai J, Chen X, Shi W, Yang L, Zhou J. 2013. Shenqi Fuzheng injection combined with chemotherapy for 32 cases of advanced triple-negative breast cancer. Chin Pharm. 16:1866–1867.
  • Zhang RL. 2004. Effect of Shenqi Fuzheng injection on postoperative chemotherapy of breast cancer. J Med Forum. 25:48.
  • Zhou TN, Nie JY, Chen WL. 2006. Attenuated effect of Shenqi Fuzheng on neoadjuvant chemotherapy of breast cancer. J Pract Oncol. 21:75–77.
  • Zhu K, Li K, Dang C, Chang D. 2008. Effect of Shenqi Fuzheng injection combined with CEF chemotherapy on immune function of breast cancer patients after operation. Chin J Clin Oncol. 35:808–809.
  • Zhuang SR, Chiu HF, Chen SL, Tsai JH, Lee MY, Lee HS, Shen YC, Yan YY, Shane GT, Wang CK. 2012. Effects of a Chinese medical herbs complex on cellular immunity and toxicity-related conditions of breast cancer patients. Br J Nutr. 107(5):712–718.