2,845
Views
21
CrossRef citations to date
0
Altmetric
Research Article

Cardioprotective effect of rosmarinic acid against myocardial ischaemia/reperfusion injury via suppression of the NF-κB inflammatory signalling pathway and ROS production in mice

, , , , , , , , & show all
Pages 220-229 | Received 23 Aug 2020, Accepted 15 Jan 2021, Published online: 18 Feb 2021

References

  • Anusuya C, Manoharan S. 2011. Antitumor initiating potential of rosmarinic acid in 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch carcinogenesis. J Environ Pathol Toxicol Oncol. 30(3):199–211.
  • Benedec D, Hanganu D, Oniga I, Tiperciuc B, Olah NK, Raita O, Bischin C, Silaghi-Dumitrescu R, Vlase L. 2015. Assessment of rosmarinic acid content in six Lamiaceae species extracts and their antioxidant and antimicrobial potential. Pak J Pharm Sci. 28(6 Suppl):2297–2303.
  • Berhow MA, Affum AO, Gyan BA. 2012. Rosmarinic acid content in antidiabetic aqueous extract of Ocimum canum Sims grown in Ghana. J Med Food. 15(7):611–620.
  • Cai X, Yang F, Zhu L, Xia Y, Wu Q, Xue H, Lu Y. 2019. Rosmarinic acid, the main effective constituent of Orthosiphon stamineus, inhibits intestinal epithelial apoptosis via regulation of the Nrf2 pathway in mice. Molecules. 24(17):3027.
  • Cao W, Mo K, Wei S, Lan X, Zhang W, Jiang W. 2019. Effects of rosmarinic acid on immunoregulatory activity and hepatocellular carcinoma cell apoptosis in H22 tumor-bearing mice. Korean J Physiol Pharmacol. 23(6):501–508.
  • Diao J, Wei J, Yan R, Liu X, Li Q, Lin L, Zhu Y, Li H. 2016. Rosmarinic acid suppressed high glucose-induced apoptosis in H9c2 cells by ameliorating the mitochondrial function and activating STAT3. Biochem Biophys Res Commun. 477(4):1024–1030.
  • Fan YT, Yin GJ, Xiao WQ, Qiu L, Yu G, Hu YL, Xing M, Wu DQ, Cang XF, Wan R, et al. 2015. Rosmarinic acid attenuates sodium taurocholate-induced acute pancreatitis in rats by inhibiting nuclear factor-κB activation. Am J Chin Med. 43(6):1117–1135.
  • Frank A, Bonney M, Bonney S, Weitzel L, Koeppen M, Eckle T. 2012. Myocardial ischemia reperfusion injury: from basic science to clinical bedside. Semin Cardiothorac Vasc Anesth. 16(3):123–132.
  • Fujimoto A, Shingai Y, Nakamura M, Maekawa T, Sone Y, Masuda T. 2010. A novel ring-expanded product with enhanced tyrosinase inhibitory activity from classical Fe-catalyzed oxidation of rosmarinic acid, a potent antioxidative Lamiaceae polyphenol. Bioorg Med Chem Lett. 20(24):7393–7396.
  • Gardin JM, Adams DB, Douglas PS, Feigenbaum H, Forst DH, Fraser AG, Grayburn PA, Katz AS, Keller AM, Kerber RE, American Society of Echocardiography, et al. 2002. Recommendations for a standardized report for adult transthoracic echocardiography: a report from the American society of echocardiography's nomenclature and standards committee and task force for a standardized echocardiography report. J Am Soc Echocardiogr. 15(3):275–290.
  • Gonzalez-Montero J, Brito R, Gajardo AI, Rodrigo R. 2018. Myocardial reperfusion injury and oxidative stress: therapeutic opportunities. World J Cardiol. 10(9):74–86.
  • Han J, Wang D, Ye L, Li P, Hao W, Chen X, Ma J, Wang B, Shang J, Li D, et al. 2017. Rosmarinic acid protects against inflammation and cardiomyocyte apoptosis during myocardial ischemia/reperfusion injury by activating peroxisome proliferator-activated receptor gamma. Front Pharmacol. 8:1–11.
  • Hardy N, Viola HM, Johnstone VP, Clemons TD, Cserne SH, Singh R, Smith NM, Iyer KS, Hool LC. 2015. Nanoparticle-mediated dual delivery of an antioxidant and a peptide against the L-type Ca2+ channel enables simultaneous reduction of cardiac ischemia-reperfusion injury. ACS Nano. 9(1):279–289.
  • Hausenloy DJ, Yellon DM. 2013. Myocardial ischemia-reperfusion injury: a neglected therapeutic target. J Clin Invest. 123(1):92–100.
  • Imai K, Nakanishi I, Ohkubo K, Ohno A, Mizuno M, Fukuzumi S, Matsumoto KI, Fukuhara K. 2019. Synthesis and radical-scavenging activity of C-methylated fisetin analogues. Bioorg Med Chem. 27(8):1720–1727.
  • Ito N, Yabe T, Gamo Y, Nagai T, Oikawa T, Yamada H, Hanawa T. 2008. Rosmarinic acid from Perillae Herba produces an antidepressant-like effect in mice through cell proliferation in the hippocampus. Biol Pharm Bull. 31(7):1376–1380.
  • Jie Z, Xiujian W, Jin L. 2019. Pharmacological mechanism and apoptosis effect of baicalein in protecting myocardial ischemia reperfusion injury in rats. Pak J Pharm Sci. 32(1):407–412.
  • Lai XL, Liu HX, Hu X, Tian JF, Shang JJ, Li X, Zhou Q, Xing WL. 2020. Acute myocardial infarction in Chinese medicine hospitals in China from 2006 to 2013: an analysis of 2311 patients from hospital data. Chin J Integr Med. 26(1):1–7.
  • Li R, Liu Y, Xie J, Huang X, Zhang L, Liu H, Li L. 2019. Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence. Free Radic Biol Med. 135:116–124.
  • Liu JY, Shang J, Mu XD, Gao ZY. 2019. Protective effect of down-regulated microRNA-27a mediating high thoracic epidural block on myocardial ischemia-reperfusion injury in mice through regulating ABCA1 and NF-κB signaling pathway. Biomed Pharmacother. 112:108606.
  • Liu Z, Huang Y, Jiao Y, Chen Q, Wu D, Yu P, Li Y, Cai M, Zhao Y. 2020. Polystyrene nanoplastic induces ROS production and affects the MAPK-HIF-1/NFκB-mediated antioxidant system in Daphnia pulex. Aquat Toxicol. 220:105420.
  • Lou PH, Lucchinetti E, Zhang L, Affolter A, Schaub MC, Gandhi M, Hersberger M, Warren BE, Lemieux H, Sobhi HF, et al. 2014. The mechanism of Intralipid®-mediated cardioprotection complex IV inhibition by the active metabolite, palmitoylcarnitine, generates reactive oxygen species and activates reperfusion injury salvage kinases. PLoS One. 9(1):e87205.
  • Luft JG, Steffens L, Moras AM, Da RM, Leipnitz G, Regner GG, Pfluger PF, Goncalves D, Moura DJ, Pereira P. 2019. Rosmarinic acid improves oxidative stress parameters and mitochondrial respiratory chain activity following 4-aminopyridine and picrotoxin-induced seizure in mice. Naunyn Schmiedebergs Arch Pharmacol. 392(11):1347–1358.
  • Mailloux RJ, Craig AD, Christian SL. 2016a. Induction of mitochondrial reactive oxygen species production by GSH mediated S-glutathionylation of 2-oxoglutarate dehydrogenase. Redox Biol. 8:285–297.
  • Mailloux RJ, Gardiner D, O'Brien M. 2016b. 2-Oxoglutarate dehydrogenase is a more significant source of O2·–/H2O2 than pyruvate dehydrogenase in cardiac and liver tissue. Free Radic Biol Med. 97:501–512.
  • Nagasundaram N, George Priya Doss C, Chakraborty C, Karthick V, Thirumal Kumar D, Balaji V, Siva R, Aiping L, Zhang G, Hailong Z. 2016. Mechanism of artemisinin resistance for malaria PfATP6 L263 mutations and discovering potential antimalarials: An integrated computational approach. Sci Rep. 6:30106.
  • Noguchi-Shinohara M, Ono K, Hamaguchi T, Iwasa K, Nagai T, Kobayashi S, Nakamura H, Yamada M. 2015. Pharmacokinetics, safety and tolerability of Melissa officinalis extract which contained rosmarinic acid in healthy individuals: a randomized controlled trial. PLoS One. 10(5):e126422.
  • Osakabe N, Takano H, Sanbongi C, Yasuda A, Yanagisawa R, Inoue K, Yoshikawa T. 2004. Anti-inflammatory and anti-allergic effect of rosmarinic acid (RA); inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanism. Biofactors. 21(1–4):127–131.
  • Qiu Z, He Y, Ming H, Lei S, Leng Y, Xia ZY. 2019. Lipopolysaccharide (LPS) aggravates high glucose- and hypoxia/reoxygenation-induced injury through activating ROS-dependent NLRP3 inflammasome-mediated pyroptosis in H9C2 cardiomyocytes. J Diabetes Res. 2019:8151836.
  • Ramalho LN, Pasta AA, Terra VA, Augusto M, Sanches SC, Souza-Neto FP, Cecchini R, Gulin F, Ramalho FS. 2014. Rosmarinic acid attenuates hepatic ischemia and reperfusion injury in rats. Food Chem Toxicol. 74:270–278.
  • Rodriguez-Luna A, Avila-Roman J, Oliveira H, Motilva V, Talero E. 2019. Fucoxanthin and rosmarinic acid combination has anti-inflammatory effects through regulation of NLRP3 inflammasome in UVB-exposed HaCaT keratinocytes. Mar Drugs. 17(8):451.
  • Salimei PS, Marfe G, Di Renzo L, Di Stefano C, Giganti MG, Filomeni G, Ciriolo MR. 2007. The interference of rosmarinic acid in the DNA fragmentation induced by osmotic shock. Front Biosci. 12(4):1308–1317.
  • Sami A, Riaz MW, Zhou X, Zhu Z, Zhou K. 2019. Alleviating dormancy in Brassica oleracea seeds using NO and KAR1 with ethylene biosynthetic pathway, ROS and antioxidant enzymes modifications. BMC Plant Biol. 19(1):577.
  • Shen Y, Xie X, Li Z, Huang Y, Ma L, Shen X, Liu Y, Zhao Y. 2017. Interleukin-17-induced expression of monocyte chemoattractant protein-1 in cardiac myocytes requires nuclear factor κB through the phosphorylation of p65. Microbiol Immunol. 61(7):280–286.
  • Swarup V, Ghosh J, Ghosh S, Saxena A, Basu A. 2007. Antiviral and anti-inflammatory effects of rosmarinic acid in an experimental murine model of Japanese encephalitis. AAC. 51(9):3367–3370.
  • Sweitzer NK, Lopatin M, Yancy CW, Mills RM, Stevenson LW. 2008. Comparison of clinical features and outcomes of patients hospitalized with heart failure and normal ejection fraction (> or =55%) versus those with mildly reduced (40–55%) and moderately to severely reduced (<40%) fractions. Am J Cardiol. 101:1151–1156.
  • Touboul C, Angoulvant D, Mewton N, Ivanes F, Muntean D, Prunier F, Ovize M, Bejan-Angoulvant T. 2015. Ischaemic postconditioning reduces infarct size: systematic review and meta-analysis of randomized controlled trials. Arch Cardiovasc Dis. 108(1):39–49.
  • Wang Z, Chen Q, Guo H, Li Z, Zhang J, Lv L, Guo Y. 2017. Effects of dexmedetomidine on H-FABP, CK-MB, cTnI levels, neurological function and near-term prognosis in patients undergoing heart valve replacement. Exp Ther Med. 14(6):5851–5856.
  • Yildiz K, Ince AT, Sarbay KA, Sert S, Isen HC, Tozlu M, Baysal B, Akyuz U, Kocaman O, Danalioglu A. 2014. Role of serum myeloperoxidase, CPK, CK-MB, and cTnI tests in early diagnosis of myocardial ischemia during ERCP. Turk J Gastroenterol. 25(3):291–297.
  • Zhang M, Yan H, Li S, Yang J. 2017. Rosmarinic acid protects rat hippocampal neurons from cerebral ischemia/reperfusion injury via the Akt/JNK3/caspase-3 signaling pathway. Brain Res. 1657:9–15.
  • Zhang X, Ma ZG, Yuan YP, Xu SC, Wei WY, Song P, Kong CY, Deng W, Tang QZ. 2018. Rosmarinic acid attenuates cardiac fibrosis following long-term pressure overload via AMPKα/Smad3 signaling. Cell Death Dis. 9(2):102.
  • Zhang X, Zhu JX, Ma ZG, Wu HM, Xu SC, Song P, Kong CY, Yuan YP, Deng W, Tang QZ. 2019. Rosmarinic acid alleviates cardiomyocyte apoptosis via cardiac fibroblast in doxorubicin-induced cardiotoxicity. Int J Biol Sci. 15(3):556–567.
  • Zou ZW, Xu LN, Tian JY. 1993. Antithrombotic and antiplatelet effects of rosmarinic acid, a water-soluble component isolated from radix Salviae miltiorrhizae (danshen). Acta Pharmacol Sin. 28(4):241–245.
  • Zych M, Kaczmarczyk-Sedlak I, Wojnar W, Folwarczna J. 2019. Effect of rosmarinic acid on the serum parameters of glucose and lipid metabolism and oxidative stress in estrogen-deficient rats. Nutrients. 11(2):267.