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Research Article

Effect of leech-centipede medicine on improving erectile function in diabetes-induced erectile dysfunction rats via PDE5 signalling pathway-related molecules

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Pages 165-172 | Received 02 Oct 2020, Accepted 15 Jan 2021, Published online: 11 Feb 2021

References

  • Akingba AG, Burnett AL. 2001. Endothelial nitric oxide synthase protein expression, localization, and activity in the penis of the alloxan-induced diabetic rat. Mol Urol. 5(4):189–197.
  • Assaly-Kaddoum R, Giuliano F, Laurin M, Gorny D, Kergoat M, Bernabé J, Vardi Y, Alexandre L, Behr-Roussel D. 2016. Low intensity extracorporeal shock wave therapy improves erectile function in a model of type II diabetes independently of NO/cGMP pathway. J Urol. 196(3):950–956.
  • Castela Â, Costa C. 2016. Molecular mechanisms associated with diabetic endothelial-erectile dysfunction. Nat Rev Urol. 13(5):266–274.
  • Chamness SL, Ricker DD, Crone JK, Dembeck CL, Maguire MP, Burnett AL, Chang TSK. 1995. The effect of androgen onnitric oxide synthase in the male reproductive tract of the rat. Fertil Steril. 63(5):1101–1107.
  • Cho NH, Shaw JE, Karuranga S, Huang Y, da Rocha Fernandes JD, Ohlrogge AW, Malanda B. 2018. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 138:271–281.
  • Heaton JP, Varrin SJ, Morales A. 1991. The characterization of a bio-assay of erectile function in a rat model. J Urol. 145(5):1099–1102.
  • Irwin GM. 2019. Erectile dysfunction. Prim Care. 46(2):249–255.
  • Li JB, Liu WQ, Tang XH, Li ZF, Di PT, Liu WC, Peng JY. 2013. Analysis on clinical application of insect drugs. Shanghai J Trad Chinese Med. 47:66–68.
  • Li X, Zhao Q, Wang J, Wang J, Dai H, Li H, Wang B. 2018. Efficacy and safety of PDE5 inhibitors in the treatment of diabetes mellitus erectile dysfunction: protocol for a systematic review. Medicine. 97(40):e12559.
  • Ma HF, Liu Y, Wang B, Dang J, Ma JX, Zhu YT, Li HS. 2017. Clinical randomized controlled study for the treatment of erectile dysfunction by Tong Luo Xi Feng Qi Wei soup. China J Human Sex. 26:78–81.
  • Othman MS, Hafez MM, Abdel Moneim AE. 2020. The potential role of zinc oxide nanoparticles in microRNAs dysregulation in STZ-induced type 2 diabetes in rats. Biol Trace Elem Res. 197(2):606–618.
  • Podlasek CA, Zelner DJ, Bervig TR, Gonzalez CM, McKenna KE, McVary KT. 2001. Characterization and localization of nitric oxide synthase isoforms in the BB/WOR diabetic rat. J Urol. 166(2):746–755.
  • Pu XY, Wang XH, Gao WC, Yang ZH, Li SL, Wang HP, Wu YL. 2008. Insulin-like growth factor-1 restores erectile function in aged rats: modulation the integrity of smooth muscle and nitric oxide-cyclic guanosine monophosphate signaling activity. J Sex Med. 5(6):1345–1354.
  • Reilly CM, Stopper VS, Mills TM. 1997. Androgens modulate the alpha-adrenergic responsiveness of vascular smooth muscle in the corpus cavernosum. J Androl. 18(1):26–31.
  • Roth A, Kalter-Lftbovhx O, Kerbis Y, Tekenbaum-Koren E, Chen J, Sobol T, Raz I. 2003. Prevalence and risk factors for erectile dysfunction in men with diabetes, hypertension, or both diseases: a community survey among 1,412 Israeli men. Clin Cardiol. 26(1):25–30.
  • Ryan JG, Gajraj J. 2012. Erectile dysfunction and its association with metabolic syndrome and endothelial function among patients with type 2 diabetes mellitus. J Diabetes Complications. 26(2):141–147.
  • Saad F. 2009. The role of testosterone in type 2 diabetes and metabolic syndrome in men. Arq Bras Endocrinol Metabol. 53(8):901–907.
  • Shamloul R, Ghanem H. 2013. Erectile dysfunction. Lancet. 381(9861):153–165.
  • Sullivan ME, Mumtaz FH, Dashwood MR, Thompson CS, Naseem KM, Bruckdorfer KR, Mikhailidis DP, Morgan RJ. 2002. Enhanced relaxation of diabetic rabbit cavernosal smooth muscle in response to nitric oxide: potential relevance to erectile dysfunction. Int J Impot Res. 14(6):523–532.
  • Wang C, Cunningham G, Dobs A, Iranmanesh A, Matsumoto AM, Snyder PJ, Weber T, Berman N, Hull L, Swerdloff RS. 2004. Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men. J Clin Endocrinol Metab. 89(5):2085–2098.
  • Xin ZC, Lin GT, Zhang ZW, Guo YL. 2001. Advances in the research of penile erection and erection dysfunction. Pro Phys Sci. 32:129–134.
  • Xu M, Sheng Z. 2018. Research progress on the mechanism of traditional Chinese insects' medicine treatment of diabetic neurological complications. China J Clin Pharm Ther. 23:597–600.
  • Zhang JJ, Liu QF, Wu CY. 2014. Study on activities of hyperglycemia and hyperlipemia of polysaccharides from Grateloupia filicina. J Fisheries Res. 36:21–28.
  • Zhang XH, Morelli A, Luconi M, Vignozzi L, Filippi S, Marini M, Vannelli GB, Mancina R, Forti G, Maggi M. 2005. Testosterone regulates PDE5 expression and in vivo responsiveness to tadalafil in rat corpus cavernosum. Eur Urol. 47(3):409–416.