2,968
Views
14
CrossRef citations to date
0
Altmetric
Research Article

Andrographolide emeliorates maltol aluminium-induced neurotoxicity via regulating p62-mediated Keap1-Nrf2 pathways in PC12 cells

, , , , & ORCID Icon
Pages 230-239 | Received 22 Sep 2020, Accepted 25 Jan 2021, Published online: 26 Feb 2021

References

  • Banerjee M, Parai D, Chattopadhyay S, Mukherjee SK. 2017. Andrographolide: antibacterial activity against common bacteria of human health concern and possible mechanism of action. Folia Microbiol. 62(3):237–244.
  • Bera S, Camblor-Perujo S, Calleja Barca E, Negrete-Hurtado A, Racho J, De Bruyckere E, Wittich C, Ellrich N, Martins S, Adjaye J, et al. 2020. AP-2 reduces amyloidogenesis by promoting BACE1 trafficking and degradation in neurons. EMBO Rep. 21(6):e47954.
  • Caccamo A, Ferreira E, Branca C, Oddo S. 2017. p62 improves AD-like pathology by increasing autophagy. Mol Psychiatry. 22(6):865–873.
  • Cisternas P, Oliva CA, Torres VI, Barrera DP, Inestrosa NC. 2019. Presymptomatic treatment with andrographolide improves brain metabolic markers and cognitive behavior in a model of early-onset Alzheimer’s disease. Front Cell Neurosci. 13:295–313.
  • Das S, Mishra KP, Ganju L, Singh SB. 2017. Andrographolide – a promising therapeutic agent, negatively regulates glial cell derived neurodegeneration of prefrontal cortex, hippocampus and working memory impairment. J Neuroimmunol. 313:161–175.
  • Dhivya Bharathi M, Justin-Thenmozhi A, Manivasagam T, Ahmad Rather M, Saravana Babu C, Mohamed Essa M, Guillemin GJ. 2019. Amelioration of aluminum maltolate-induced inflammation and endoplasmic reticulum stress-mediated apoptosis by tannoid principles of Emblica officinalis in neuronal cellular model. Neurotox Res. 35(2):318–330.
  • Farzi MA, Sadigh-Eteghad S, Ebrahimi K, Talebi M. 2018. Exercise improves recognition memory and acetylcholinesterase activity in the beta amyloid-induced rat model of Alzheimer's disease. Ann Neurosci. 25(3):121–125.
  • Gu L, Lu J, Li Q, Wu N, Zhang L, Li H, Xing W, Zhang X. 2020. A network-based analysis of key pharmacological pathways of Andrographis paniculata acting on Alzheimer’s disease and experimental validation. J Ethnopharmacol. 251:1–42.
  • Gu L, Yu Q, Li Q, Zhang L, Lu H, Zhang X. 2018. Andrographolide protects PC12 cells against beta-amyloid-induced autophagy-associated cell death through activation of the Nrf2-mediated p62 signaling pathway. Int J Mol Sci. 19:1–15.
  • Gupta S, Mishra KP, Kumar B, Singh SB, Ganju L. 2020. Andrographolide attenuates complete Freund’s adjuvant induced arthritis via suppression of inflammatory mediators and pro-inflammatory cytokines. J Ethnopharmacol. 261:1–27.
  • Huang Z, Ji H, Shi J, Zhu X, Zhi Z. 2020. Engeletin attenuates Aβ1-42-induced oxidative stress and neuroinflammation by Keap1/Nrf2 pathway. Inflammation. 43(5):1759–1771.
  • Johnson VJ, Kim SH, Sharma RP. 2005. Aluminum-maltolate induces apoptosis and necrosis in neuro-2a cells: potential role for p53 signaling. Toxicol Sci. 83(2):329–339.
  • Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, et al. 2010. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol. 12(3):213–223.
  • Lindsay CB, Zolezzi JM, Rivera DS, Cisternas P, Bozinovic F, Inestrosa NC. 2020. Andrographolide reduces neuroinflammation and oxidative stress in aged Octodon degus. Mol Neurobiol. 57(2):1131–1145.
  • Lu J, Huang Q, Zhang D, Lan T, Zhang Y, Tang X, Xu P, Zhao D, Cong D, Zhao D, et al. 2020. The protective effect of DiDang tang against AlCl3-induced oxidative stress and apoptosis in PC12 cells through the activation of SIRT1-mediated Akt/Nrf2/HO-1 pathway. Front Pharmacol. 11:1–13.
  • Peng H, Yang J, Li G, You Q, Han W, Li T, Gao D, Xie X, Lee BH, Du J, et al. 2017. Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress. Cell Res. 27(5):657–674.
  • Peters F, Salihoglu H, Pratsch K, Herzog E, Pigoni M, Sgobio C, Lichtenthaler SF, Neumann U, Herms J. 2019. Tau deletion reduces plaque-associated BACE1 accumulation and decelerates plaque formation in a mouse model of Alzheimer’s disease. Embo J. 38(23):1–16.
  • Santarino IB, Viegas MS, Domingues NS, Ribeiro AM, Soares MP, Vieira OV. 2017. Involvement of the p62/NRF2 signal transduction pathway on erythrophagocytosis. Sci Rep. 7(1):16.
  • Seo JY, Pyo E, An JP, Kim J, Sung SH, Oh WK. 2017. Andrographolide activates Keap1/Nrf2/ARE/HO-1 pathway in HT22 cells and suppresses microglial activation by Abeta42 through Nrf2-related inflammatory response. Mediators Inflamm. 2017:5906189– 5906113.
  • Song J. 2018. Animal model of aluminum-induced Alzheimer’s disease. Adv Exp Med Biol. 1091:113–127.
  • Tian Y, Chang JC, Fan EY, Flajolet M, Greengard P. 2013. Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer’s APP-CTF for terminal degradation via autophagy. Proc Natl Acad Sci USA. 110(42):17071–17076.
  • Varela-Nallar L, Arredondo SB, Tapia-Rojas C, Hancke J, Inestrosa NC. 2015. Andrographolide stimulates neurogenesis in the adult hippocampus. Neural Plast. 2015:935403–935414.
  • Wan Y, Liang Y, Liang F, Shen N, Shinozuka K, Yu JT, Ran C, Quan Q, Tanzi RE, Zhang C. 2019. A curcumin analog reduces levels of the Alzheimer’s disease-associated amyloid-β protein by modulating AβPP processing and autophagy. J Alzheimers Dis. 72(3):761–771.
  • Wang N, Wang H, Li L, Li Y, Zhang R. 2019. beta-Asarone inhibits amyloid-beta by promoting autophagy in a cell model of Alzheimer’s disease. Front Pharmacol. 10:1–11.
  • Wang S, Wu YY, Wang X, Shen P, Jia Q, Yu S, Wang Y, Li X, Chen W, Wang A, et al. 2020. Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation. Aging. 12(9):8167–8190.
  • Wang W, Yang X, Chen Q, Guo M, Liu S, Liu J, Wang J, Huang F. 2020. Sinomenine attenuates septic-associated lung injury through the Nrf2-Keap1 and autophagy. J Pharm Pharmacol. 72(2):259–270.
  • Xu Y, Tang D, Wang J, Wei H, Gao J. 2019. Neuroprotection of andrographolide against microglia-mediated inflammatory injury and oxidative damage in PC12 neurons. Neurochem Res. 44(11):2619–2630.
  • Yang R, Liu S, Zhou J, Bu S, Zhang J. 2017. Andrographolide attenuates microglia-mediated Aβ neurotoxicity partially through inhibiting NF-κB and JNK MAPK signaling pathway. Immunopharmacol Immunotoxicol. 39(5):276–284.
  • Yang Y, Willis TL, Button RW, Strang CJ, Fu Y, Wen X, Grayson PRC, Evans T, Sipthorpe RJ, Roberts SL, et al. 2019. Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response. Nat Commun. 10(1):1–18.
  • Zhang Y, Wang G, Wang T, Cao W, Zhang L, Chen X. 2019. Nrf2-Keap1 pathway-mediated effects of resveratrol on oxidative stress and apoptosis in hydrogen peroxide-treated rheumatoid arthritis fibroblast-like synoviocytes. Ann NY Acad Sci. 1457(1):166–178.