Myrtenol improves brain damage and promotes angiogenesis in rats with cerebral infarction by activating the ERK1/2 signalling pathway

References

• Abu Zeid E H, Hussein M M Ali H. 2018. Ascorbic acid protects male rat brain from oral potassium dichromate-induced oxdative DNA damage and apoptotic changes: the expression patterns of caspase-3, P 53, Bax, and Bcl-2 genes. Environ Sci Pollut Res. 25(13):13056–13066.
   PubMed Web of Science ®Google Scholar
• Ahnstedt H, Mostajeran M, Blixt F W, Warfvinge K, Ansar S, Krause DN, Edvinsson L. 2015. U0126 attenuates cerebral vasoconstriction and improves long-term neurologic outcome after stroke in female rats. J Cereb Blood Flow Metab. 35(3):454–460.
   PubMed Web of Science ®Google Scholar
• Baldrati L, Schmitt C, Gomonay O, Lebrun R, Ramos R, Saitoh E, Sinova J, Kläui M. 2020. Efficient spin torques in antiferromagnetic CoO/Pt quantified by comparing field- and current-induced switching. Phys Rev Lett. 125:e077201.
   Web of Science ®Google Scholar
• Britto RM, Silva-Neto JAD, Mesquita TRR, Vasconcelos CML, de Almeida GKM, Jesus ICG, Santos PHD, Souza DS, Miguel-Dos-Santos R, de Sá LA, et al. 2018. Myrtenol protects against myocardial ischemia-reperfusion injury through antioxidant and anti-apoptotic dependent mechanisms. Food Chem Toxicol. 111:557–566.
   PubMed Web of Science ®Google Scholar
• Chan SJ, Esposito E, Hayakawa K, Mandaville E, Smith RAA, Guo S, Niu W, Wong PT, Cool SM, Lo EH, et al. 2020. Vascular endothelial growth factor 165-binding heparan sulfate promotes functional recovery from cerebral ischemia. Stroke. 51(9):2844–2853.
   PubMed Web of Science ®Google Scholar
• Dai J, Peng L, Fan K, Wang H, Wei R, Ji G, Cai J, Lu B, Li B, Zhang D, et al. 2009. Osteopontin induces angiogenesis through activation of PI3K/AKT and ERK1/2 in endothelial cells. Oncogene. 28(38):3412–3422.
   PubMed Web of Science ®Google Scholar
• Dojo Soeandy C, Elia AJ, Cao Y, Rodgers C, Huang S, Elia AC, Henderson JT. 2020. Necroptotic-apoptotic regulation in an endothelin-1 model of cerebral ischemia. Cell Mol Neurobiol. DOI:10.1007/s10571-020-00942-y.
   PubMed Web of Science ®Google Scholar
• García, D, Lapuerta, M, Villa, AL, Alarcón, E, Bustamante, F, 2020. Influence of molecular structure of oleoresin-derived compounds on flame properties and emissions from laminar flames. Environ Sci Pollut Res. 27(27):33890–33902.
   PubMed Web of Science ®Google Scholar
• Garcia JH, Wagner S, Liu KF, Hu XJ. 1995. Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation. Stroke. 26(4):627–634; discussion 635.
   PubMed Web of Science ®Google Scholar
• Gomes BS, Neto BPS, Lopes EM, Cunha FVM, Araújo AR, Wanderley CWS, Wong DVT, Júnior RCPL, Ribeiro RA., Sousa DP, Venes R. Medeiros, J. 2017. Anti-inflammatory effect of the monoterpene myrtenol is dependent on the direct modulation of neutrophil migration and oxidative stress. Chem Biol Interact. 273:73–81.
   PubMed Web of Science ®Google Scholar
• Heimfarth L, Dos Anjos KS, de Carvalho Y, Dos Santos BL, Serafini MR, de Carvalho Neto AG, Nunes PS, Beserra Filho JIA, da Silva SP, Ribeiro AM, et al. 2020. Characterization of β-cyclodextrin/myrtenol complex and its protective effect against nociceptive behavior and cognitive impairment in a chronic musculoskeletal pain model. Carbohydr Polym. 244:e116448.
   PubMed Web of Science ®Google Scholar
• Iizuka T, Oki K, Hayashida K, Minami K, Izawa Y, Takahashi S, Shimizu H, Fukuda K, Nakahara J. 2019. Cerebral infarction after transcatheter aortic valve implantation in Japan: Retrospective analysis at a single high-volume center. J Stroke Cerebrovasc Dis. 28(12):e104455.
   PubMed Web of Science ®Google Scholar
• Krylatov AV, Tsibulnikov SY, Mukhomedzyanov AV, Boshchenko AA, Goldberg VE, Jaggi AS, Erben RG, Maslov LN. 2021. The role of natriuretic peptides in the regulation of cardiac tolerance to ischemia/reperfusion and postinfarction heart remodeling. J Cardiovasc Pharmacol Ther. 26(2):e1074248420952243, 148.
   Web of Science ®Google Scholar
• Lapi D, Colantuoni A. 2015. Remodeling of cerebral microcirculation after ischemia-reperfusion. J Vasc Res. 52(1):22–31.
   PubMed Web of Science ®Google Scholar
• Li J, Zhang K, Zhang Q, Zhou X, Wen L, Ma J, Niu L, Li C. 2020. PPAR-γ mediates Ta-VNS-induced angiogenesis and subsequent functional recovery after experimental stroke in rats. Biomed Res Int. 2020:e8163789.
   PubMed Web of Science ®Google Scholar
• Li HB, Liang WB, Zhou L.2020. The experimental research on neuroplasticity in rats' hippocampus subjected to chronic cerebral hypoperfusion and interfered by modified Dioscorea pills. Heliyon. 628(1):e02897.
   Google Scholar
• Liu A, Zhu W, Sun L, Han G, Liu H, Chen Z, Zhuang L, Jiang W, Xue X. 2018a. Ginsenoside Rb1 administration attenuates focal cerebral ischemic reperfusion injury through inhibition of HMGB1 and inflammation signals. Exp Ther Med. 16:3020–3026.
   PubMed Web of Science ®Google Scholar
• Liu H, Ren X, Ma C. 2018b. Effect of berberine on angiogenesis and HIF-1α/VEGF signal transduction pathway in rats with cerebral ischemia - reperfusion Injury. J Coll Physicians Surg Pak. 28:753–757.
   PubMed Web of Science ®Google Scholar
• Liu HM, Chen HH. 1994. Correlation between fibroblast growth factor expression and cell proliferation in experimental brain infarct: studied with proliferating cell nuclear antigen immunohistochemistry. J Neuropathol Exp Neurol. 53:118–126.
   PubMed Web of Science ®Google Scholar
• Liu J, Wang Y, Akamatsu Y, Lee CC, Stetler RA, Lawton MT, Yang GY. 2014. Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials. Prog Neurobiol. 115:138–156.
   PubMed Web of Science ®Google Scholar
• Liu X, Jiao K, Jia CC, Li GX, Yuan Q, Xu JK, Hou Y, Wang B. 2019. BAP31 regulates IRAK1-dependent neuroinflammation in microglia. J Neuroinflammation. 16(1):e281.
   PubMed Web of Science ®Google Scholar
• Moreira MR, Salvadori MG, de Almeida AA, de Sousa DP, Jordán J, Satyal P, de Freitas RM, de Almeida RN. 2014. Anxiolytic-like effects and mechanism of (-)-myrtenol: a monoterpene alcohol. Neurosci Lett. 579: 119–124.
   PubMed Web of Science ®Google Scholar
• Morris-Blanco KC, Chokkalla AK, Bertogliat MJ, Vemuganti R.2021. TET3 regulates DNA hydroxymethylation of neuroprotective genes following focal ischemia. J Cereb Blood Flow Metab. 41(3):e271678X20912965, 603.
   Web of Science ®Google Scholar
• Peng L, Yin J, Ge M, Wang S, Xie L, Li Y, Si JQ, Ma K. 2019. Isoflurane post-conditioning ameliorates cerebral ischemia/reperfusion injury by enhancing angiogenesis through activating the Shh/Gli signaling pathway in rats. Front Neurosci. 13:321–321.
   PubMed Web of Science ®Google Scholar
• Rajizadeh MA, Najafipour H, Samareh Fekr M, Rostamzadeh F, Jafari E, Bejeshk MA, Masoumi-Ardakani Y. 2019. Anti-inflammatory and anti-oxidative effects of myrtenol in the rats with Allergic Asthma. Iran J Pharm Res. 18:1488–1498.
   PubMed Web of Science ®Google Scholar
• Reis C, Akyol O, Ho WM, Araujo C, Huang L, Applegate R, Zhang JH. 2017. Phase I and Phase II therapies for acute ischemic stroke: An update on currently studied drugs in clinical research. Biomed Res Int. 2017: e4863079, 14.
   Web of Science ®Google Scholar
• Ren F, Fang Q, Xi H, Feng T, Wang L, Hu J. 2020. Platelet-derived growth factor-BB and epidermal growth factor promote dairy goat spermatogonial stem cells proliferation via Ras/ERK1/2 signaling pathway. Theriogenology. 155:205–212.
   PubMed Web of Science ®Google Scholar
• Seo JH, Yu JH, Suh H, Kim MS, Cho SR. 2013. Fibroblast growth factor-2 induced by enriched environment enhances angiogenesis and motor function in chronic hypoxic-ischemic brain injury. PLoS One. 8(9):e74405.
   PubMed Web of Science ®Google Scholar
• Sergio L, Thomé AMC, Trajano L, Mencalha AL, da Fonseca AS, de Paoli F. 2018. Photobiomodulation prevents DNA fragmentation of alveolar epithelial cells and alters the mRNA levels of caspase 3 and Bcl-2 genes in acute lung injury. Photochem. Photobiol. Sci. 17(7):975–983.
   PubMed Web of Science ®Google Scholar
• Shi Z-f, Fang Q, Chen Y, Xu L-x, Wu M, Jia M, Lu Y, Wang X-x, Wang Yu-jiao, Yan Xu, Dong L-p. 2021. Methylene blue ameliorates brain edema in rats with experimental ischemic stroke via inhibiting aquaporin 4 expression. Acta Pharmacol Sin. 42(3):382–392.
   PubMed Web of Science ®Google Scholar
• Snyder A, Alsauskas ZC, Leventhal JS, Rosenstiel PE, Gong P, Chan JJ, Barley K, He JC, Klotman ME, Ross MJ, et al. 2010. HIV-1 viral protein r induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cells. Aids. 24(8):1107–1119.
   PubMed Web of Science ®Google Scholar
• Song Y, Dai F, Zhai D, Dong Y, Zhang J, Lu B, Luo J, Liu M, Yi Z. 2012. Usnic acid inhibits breast tumor angiogenesis and growth by suppressing VEGFR2-mediated AKT and ERK1/2 signaling pathways. Angiogenesis. 15(3):421–432.
   PubMed Web of Science ®Google Scholar
• Surinkaew P, Apaijai N, Sawaddiruk P, Jaiwongkam T, Kerdphoo S, Chattipakorn N, Chattipakorn SC. 2020. Mitochondrial fusion promoter alleviates brain damage in rats with cardiac ischemia/reperfusion injury. JAD. 77(3):993–1003.
   Google Scholar
• Taguchi A, Soma T, Tanaka H, Kanda T, Nishimura H, Yoshikawa H, Tsukamoto Y, Iso H, Fujimori Y, Stern DM, et al. 2004. Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model. J. Clin. Invest. 114(3):330–338.
   Web of Science ®Google Scholar
• Viana A, Lopes MTP, Oliveira FTB, Nunes PIG, Santos VG, Braga AD, Silva ACA, Sousa DP, Viana DA, Rao VS, et al. 2019. (-)-Myrtenol accelerates healing of acetic acid-induced gastric ulcers in rats and in human gastric adenocarcinoma cells. Eur J Pharmacol. 854:139–148.
   PubMed Web of Science ®Google Scholar
• Viana AFSC, da Silva FV, Fernandes HdB, Oliveira IS, Braga MA, Nunes PIG, Viana DdA, de Sousa DP, Rao VS, Oliveira RdC, et al. 2016. Gastroprotective effect of (-)-myrtenol against ethanol-induced acute gastric lesions: possible mechanisms. J Pharm Pharmacol. 68(8):1085–1092.
   PubMed Web of Science ®Google Scholar
• Villa P, Bigini P, Mennini T, Agnello D, Laragione T, Cagnotto A, Viviani B, Marinovich M, Cerami A, Coleman TR, et al. 2003. Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis. J Exp Med. 198(6):971–975.
   PubMed Web of Science ®Google Scholar
• Wen L, Liu L, Tong L, Li J, Zhang K, Zhang Q, Li C. 2019. NDRG4 prevents cerebral ischemia/reperfusion injury by inhibiting neuronal apoptosis. Genes Dis. 6(4):448–454.
   PubMed Web of Science ®Google Scholar
• Wen X, Qi D, Sun Y, Huang X, Zhang F, Wu J, Fu Y, Ma K, Du Y, Dong H, et al. 2014. H2S attenuates cognitive deficits through Akt1/JNK3 signaling pathway in ischemic stroke. Behav Brain Res. 269:6–14.
   PubMed Web of Science ®Google Scholar
• Wild JM, Wardlaw JM, Marshall I, Warlow CP. 2000. N-acetylaspartate distribution in proton spectroscopic images of ischemic stroke: relationship to infarct appearance on T2-weighted magnetic resonance imaging. Stroke. 31(12):3008–3014.
   Web of Science ®Google Scholar
• Yi X, Xu C, Huang P, Zhang L, Qing T, Li J, Wang C, Zeng T, Lu J, Han Z. 2020. 1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea protects the blood-brain barrier against ischemic injury by upregulating tight junction protein expression, mitigating apoptosis and inflammation in vivo and in vitro model. Front Pharmacol. 11:e1197.
   PubMed Web of Science ®Google Scholar
• Yu H, Song L, Cao X, Li W, Zhao Y, Chen J, Li J, Chen Y, Yu W, Xu Y. 2020. Hederagenin attenuates cerebral ischaemia/reperfusion injury by regulating MLK3 signalling. Front Pharmacol. 11:e1173.
   PubMed Web of Science ®Google Scholar
• Yu Z, Cai M, Li X, Zhang J, Wu T, Yang F, Zhu W, Xiang Y, Zhang W, Xiang J, et al. 2018. Neuroprotective effects of Tongxinluo on focal cerebral ischemia and reperfusion injury in rats associated with the activation of the MEK1/2/ERK1/2/p90RSK signaling pathway. Brain Res. 1685: 9–18.
   PubMed Web of Science ®Google Scholar
• Zheng XW, Shan CS, Xu QQ, Wang Y, Shi YH, Wang Y, Zheng GQ 2018a. Buyang Huanwu decoction targets SIRT1/VEGF pathway to promote angiogenesis after cerebral ischemia/reperfusion injury. Front Neurosci. 12:911–911.
   PubMed Web of Science ®Google Scholar
• Zheng Y, Wu Z, Yi F, Orange M, Yao M, Yang B, Liu J, Zhu H. 2018b. By activating Akt/eNOS bilobalide B inhibits autophagy and promotes angiogenesis following focal cerebral ischemia reperfusion. Cell Physiol Biochem. 47(2):604–616.
   PubMedGoogle Scholar