Potential mechanism of Achyranthis bidentatae radix plus semen vaccariae granules in the treatment of diabetes mellitus-induced erectile dysfunction in rats utilizing combined experimental model and network pharmacology

References

• Banks E, Joshy G, Abhayaratna WP, Kritharides L, Macdonald PS, Korda RJ, Chalmers JP. 2013. Erectile dysfunction severity as a risk marker for cardiovascular disease hospitalisation and all-cause mortality: a prospective cohort study. PLOS Med. 10(1):e1001372.
   PubMed Web of Science ®Google Scholar
• Chen GH, Sun DL, Jin BF, Zhang XD, Chen B. 2016. Analysis of Jin Baofang's experience in treating erectile dysfunction. Liaoning J Tradit Chin Med. 43(01):141–143.
   Google Scholar
• Chen W, Gong L, Guo Z, Wang W, Zhang H, Liu X, Yu S, Xiong L, Luo J. 2013. A novel integrated method for large-scale detection, identification, and quantification of widely targeted metabolites: application in the study of rice metabolomics. Mole Plant. 6:1769–1780.
   PubMed Web of Science ®Google Scholar
• Cui K, Tang Z, Li CC, Wang T, Rao K, Wang SG, Liu JH, Chen Z. 2018. Lipoxin A4 improves erectile dysfunction in rats with type I diabetes by inhibiting oxidative stress and corporal fibrosis. Asian J Androl. 20(2):166–172.
   PubMed Web of Science ®Google Scholar
• De Young L, Yu D, Bateman RM, Brock GB. 2004. Oxidative stress and antioxidant therapy: their bimpact in diabetes-associated erectile dysfunction. J Androl. 25(5):830–836.
   PubMedGoogle Scholar
• Garcia A, Barbas C. 2011. Gas chromatography-mass spectrometry (GC-MS)-based metabolomics. Methods Mol Biol. 708:191–204.
   Google Scholar
• Garrido C, Galluzzi L, Brunet M, Puig PE, Didelot C, Kroemer G. 2006. Mechanisms of cytochrome C release from mitochondria. Cell Death Differ. 13:1423–1433.
   PubMed Web of Science ®Google Scholar
• Hao da C, Xiao PG. 2014. Network pharmacology: a Rosetta stone for traditional Chinese medicine. Drug Dev Res. 75:299–312.
   PubMed Web of Science ®Google Scholar
• Hong KM, Najjar H, Hawley M, Press RD. 2004. Quantitative real-time PCR with automated sample preparation for diagnosis and monitoring of cytomegalovirus infection in bone marrow transplant patients. Clin Chem. 50:846–856.
   PubMed Web of Science ®Google Scholar
• Hu R, Zhang W, Ou NJ, Liang Z, Yang YJ, Liu L, Liu XQ. 2020. The effect of insulin therapy on the expression of miR-126, VEGF and eNOS in the penile tissue of diabetic rats. J Tianjin Med Univ. 26:422–428.
   Google Scholar
• Hu ZC. 2000. 56 Cases of impotence treated by integrated traditional Chinese and western medicine. Shaanxi J Trad Chin Med. (11):503.
   Google Scholar
• Itoga A, Zha X, Nagase K, Aoki Y, Ito H, Yokoyama O. 2020. Correcting imbalance of sex hormones by a phosphodiesterase 5 inhibitor improves copulatory dysfunction in male rats with type 2 diabetes. BMJ Open Diab Res Care. 8(1):e001111.
   PubMed Web of Science ®Google Scholar
• Lau LC, Adaikan PG. 2014. Possibility of inhibition of calcium-activated chloride channel rescuing erectile failures in diabetes. Int J Impot Res. 26(4):151–155.
   PubMed Web of Science ®Google Scholar
• Li X. 2019. Clinical and experimental study of huoxue tongluo qiwei decoction on diabetic erectile dysfunction [dissertation]. China (CN): Beijing Univ Chin Med.
   Google Scholar
• Li XR, Zhang YS, Wang JS, Ding J, Sheng W, Shang JW. 2020. Research on the mechanism and treatment of diabetic erectile dysfunction in Chinese and Western medicine. Chin J Sex. 29(01):111–115.
   Google Scholar
• Li Y, Liu F. 2014. The expression of Cyt C and Caspase 3 in the lens epithelial cells of STZ-induced diabetic rats. Recent Advan Ophthalmol. 34:228–231.
   Google Scholar
• Long P, Yan W, Liu J, Li M, Chen T, Zhang Z, An J. 2019. Therapeutic effect of traditional Chinese medicine on a rat model of branch retinal vein occlusion. J Ophthalmology. 2019:1–13.
   Web of Science ®Google Scholar
• Lu CC, Jiann BP, Sun CC, Lam HC, Chu CH, Lee JK. 2009. Association of glycemic control with risk of erectile dysfunction in men with type 2 diabetes. J Sex Med. 6(6):1719–1728.
   PubMed Web of Science ®Google Scholar
• Luo ES, Yang QF, Xu WL. 2019. The efficacy of low-dose tadalafil combined with Xuefu Zhuyu tablets in the treatment of diabetic erectile dysfunction. China Prac Med. 14(24):111–112.
   Google Scholar
• Ma HF, Liu Y, Wang B, Dang J, Ma JX, Zhu YT, Li HS. 2017. Clinical randomized controlled study of tongluo xifeng qiwei decoction in the treatment of erectile dysfunction. Chin J Sex Sci. 26 (02):78–81.
   Google Scholar
• Ma TT, Zhang GL, Dai CF, Zhang BR, Cao KX, Wang CG, Yang GW, Wang XM. 2020. Scutellaria barbata and Hedyotis diffusa herb pair for breast cancer treatment: potential mechanism based on network pharmacology. J Ethnopharmacol. 259:112929.
   PubMed Web of Science ®Google Scholar
• Melincovici CS, Boşca AB, Şuşman S, Mărginean M, Mihu C, Istrate M, Moldovan IM, Roman AL, Mihu CM. 2018. Vascular endothelial growth factor (VEGF) – key factor in normal and pathological angiogenesis. Rom J Morphol Embryol. 59:455–467.
   PubMed Web of Science ®Google Scholar
• Mo J, Cui QL, Yao J, Zhang FT, Tan XH. 2012. The effect of recombinant human interleukin-10 on the apoptosis of human microvascular endothelial cells under hypoxia. J Prac Pediatr. 27:1107–1110.
   Google Scholar
• Mo Q, Hao EW, Qin WH, Hou XT, Deng JG, Wu Y. 2020. Research progress on the qualitative basis and pharmacological effects of drugs in smoothing blood circulation and removing blood stasis. Chin J Exp Formulas. 26(01):205.
   Google Scholar
• Neves D. 2013. Advanced glycation end-products: a common pathway in diabetes and age-related erectile dysfunction. Free Radic Res. 47 (sup1):49–69.
   PubMed Web of Science ®Google Scholar
• Park J, Chai JS, Kim SW, Paick JS, Cho MC. 2018. Inhibition of Jun N-terminal kinase improves erectile function by alleviation of cavernosal apoptosis in a rat model of cavernous nerve injury. Urology. 113:253.e9–253.e16.
   PubMed Web of Science ®Google Scholar
• Penson DF, Wessells H. 2004. Erectile dysfunction in diabetic patients. Diabetes Spectr. 17(4):225–230.
   Google Scholar
• Qiu WC, Guo XM, Zhu MLM, Chen KC, Zhu Y. 2021. Research progress in treatment of diabetic nephropathy with traditional Chinese medicine. J Liaoning Univ Trad Chin Med. 23(04):157–162.
   Google Scholar
• Richards D, Vinik A. 2002. Etiology and treatment of erectile failure in diabetes mellitus. Curr Diab Rep. 2:501–509.
   PubMedGoogle Scholar
• Scaldaferri F, Vetrano S, Sans M, Arena V, Straface G, Stigliano E, Repici A, Sturm A, Malesci A, Panes J, et al. 2009. VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis. Gastroenterology. 136:585–595.
   PubMed Web of Science ®Google Scholar
• Shamloul R, Ghanem H. 2013. Erectile dysfunction. Lancet. 381(9861):153–165.
   PubMed Web of Science ®Google Scholar
• Tao W, Xu X, Wang X, Li B, Wang Y, Li Y, Yang L. 2013. Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal radix curcumae formula for application to cardiovascular disease. J Ethnopharmacol. 145(1):1–10.
   PubMed Web of Science ®Google Scholar
• Thorve VS, Kshirsagar AD, Vyawahare NS, Joshi VS, Ingale KG, Mohite RJ. 2011. Diabetes-induced erectile dysfunction: epidemiology, pathophysiology and management. J Diabetes Complications. 25:129–136.
   PubMed Web of Science ®Google Scholar
• Vita R, Benvenga S, Giammusso B, La Vignera S. 2019. Determinants of early response to low-intensity extracorporeal shockwaves for the treatment of vasculogenic erectile dysfunction: an open-label, prospective study. JCM. 8(7):1017.
   Google Scholar
• Wang JG, Tan Y, Wang WR, Xie ZP, Li T. 2018. Compound xuanju capsule combined with tadalafil in the treatment of erectile dysfunction with abdominal obesity. J Hubei Univ Med. 37:338–340.
   Google Scholar
• Wang XF, Zhu JC, Deng CH. 2013. Guidelines for the diagnosis and treatment of andrological diseases in China. 2013 ed. China, CN: People Health Publishing House; p. 71–78.
   Google Scholar
• Wang JS, Li X, Chen ZL, Feng JL, Bao BH, Deng S, Dai HH, Meng FC, Wang B, Li HS. 2021. Effect of leech-centipede medicine on improving erectile function in DIED rats via PKC signalling pathway-related molecules. J Ethnopharmacol. 267:113463.
   PubMed Web of Science ®Google Scholar
• Xie J, Niu MZ, Zhang R. 2020. The changes of NAGL, sfrp5, ACE levels in T2DM patients with hypertension and the relationship with left ventricular remodeling. J Integrated Tradi Chin West Med Cardio-Cerebrovascular Dis. 18(08):1270.
   Google Scholar
• Yafi FA, Jenkins L, Albersen M, Corona G, Isidori AM, Goldfarb S, Maggi M, Nelson CJ, Parish S, Salonia A, et al. 2016. Erectile dysfunction. Nat Rev Dis Primers. 2:16003.
   PubMed Web of Science ®Google Scholar
• Yang KB, Huang XJ, Zhang XG, Chen G, Bo J. 2014. Efficacy of low-dose tadalafil combined with shuganyishen capsule in the treatment of mild to moderate erectile dysfunction. Nat J Androl China. 20:267–272.
   Google Scholar
• Yang ZH, Song Y, Chu GP, Qiu P, Peng WP, Meng XF. 2015. Salidroside inhibits high glucose-damaged neuronal activity caspase 3 and promotes BDNF expression. Chin J Hist Cyto. 24:439–442.
   Google Scholar
• Yu XD, Wang JS, Zuo G. 2019. Traditional Chinese medicine on treating diabetic mellitus erectile dysfunction: protocol for a systematic review and meta-analysis. Medicine. 98(13):e14928.
   PubMed Web of Science ®Google Scholar
• Zeng J. 2018. Clinical observation on the treatment of diabetic erectile dysfunction with the method of invigorating the kidney and promoting blood circulation combined with sildenafil. Beijing: Beijing University of Chinese Medicine.
   Google Scholar
• Zhao RL, He YM. 2018. Network pharmacology analysis of the anti-cancer pharmacological mechanisms of Ganoderma lucidum extract with experimental support using Hepa1-6-bearing C57 BL/6 mice. J Ethnopharmacol. 210:287–295.
   PubMed Web of Science ®Google Scholar
• Zhu XX. 2018. Study on the protective effect and mechanism of flavonoid glycosides from wang buliu xing on vascular endothelial cell injury induced by high glucose [dissertation]. China, CN: Jiangnan University.
   Google Scholar