Comparative pharmacokinetic analysis of raw and steamed Panax notoginseng roots in rats by UPLC-MS/MS for simultaneously quantifying seven saponins

References

• Chen B, Cai T, Jia XB. 2014. Simultaneous determination of ten active ginsenosides in steamed notoginseng by UPLC. China J Chinese Materia Med. 39:1614–1619.
   Google Scholar
• Chen B, Xu HL, Jia XB. 2013. Research progress and thought on processing of Panax notoginseng. Chinese Trad Herb Drugs. 44:482–487.
   Google Scholar
• Dai G, Jiang Z, Zhu L, Zhang Q, Zong Y, Liu S, Li C, Ju W. 2016. Simultaneous determination of notoginsenoside R1 and ginsenoside Re in rat plasma by ultra high performance liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study. J Sep Sci. 39(17):3368–3374.
   PubMed Web of Science ®Google Scholar
• Jiang RR, Dong JJ, Li X, Du FF, Jia WW, Xu F, Wang FQ, Yang JL, Niu W, Li C. 2015. Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb-drug interactions on OATP1B3. Br J Pharmacol. 172(4):1059–1073.
   PubMed Web of Science ®Google Scholar
• Lau AJ, Toh DF, Chua TK, Pang YK, Woo SO, Koh HL. 2009. Antiplatelet and anticoagulant effects of Panax notoginseng: comparison of raw and steamed Panax notoginseng with Panax ginseng and Panax quinquefolium. J Ethnopharmacol. 125(3):380–386.
   PubMed Web of Science ®Google Scholar
• Li XD, Wang JS, Chang B, Chen B, Guo C, Hou GQ, Huang DY, Du SX. 2011. Panax notoginseng saponins promotes proliferation and osteogenic differentiation of rat bone marrow stromal cells. J Ethnopharmacol. 134(2):268–274.
   PubMed Web of Science ®Google Scholar
• Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. 2001. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev. 46(1–3):3–26.
   PubMed Web of Science ®Google Scholar
• Liu H, Yang J, Du F, Gao X, Ma X, Huang Y, Xu F, Niu W, Wang F, Mao Y, et al. 2009. Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats. Drug Metab Dispos. 37(12):2290–2298.
   PubMed Web of Science ®Google Scholar
• Liu J, Wang Y, Qiu L, Yu Y, Wang C. 2014. Saponins of Panax notoginseng: chemistry, cellular targets and therapeutic opportunities in cardiovascular diseases. Expert Opin Investig Drugs. 23(4):523–539.
   PubMed Web of Science ®Google Scholar
• Ma C, Lin Q, Xue Y, Ju Z, Deng G, Liu W, Sun Y, Guan H, Cheng Z, Wang C. 2021. Pharmacokinetic studies of ginsenosides Rk1 and Rg5 in rats by UFLC-MS/MS. Biomed Chromatogr. DOI:10.1002/bmc.5108.
   Web of Science ®Google Scholar
• Sun E, Xu FJ, Zhang ZH, Jia XB. 2014. Discussion about research progress and ideas on processing mechanism of traditional Chinese medicine. Chin J Chinese Mater Med. 39:363–369.
   Google Scholar
• Sun S, Wang CZ, Tong R, Li XL, Fishbein A, Wang Q, He TC, Du W, Yuan CS. 2010. Effects of steaming the root of Panax notoginseng on chemical composition and anticancer activities. Food Chem. 118(2):307–314.
   Web of Science ®Google Scholar
• Toh DF, New LS, Koh HL, Chan EC. 2010. Ultra-high performance liquid chromatography/time-of-flight mass spectrometry (UHPLC/TOFMS) for time-dependent profiling of raw and steamed Panax notoginseng. J Pharm Biomed Anal. 52(1):43–50.
   PubMed Web of Science ®Google Scholar
• US Food and Drug Administration (US FDA). 2018. Guidance for industry, bioanalytical method validation. Centre for Drug Evaluation and Research.
   Google Scholar
• Veber DF, Johnson SR, Cheng HY, Smith BR, Ward KW, Kopple KD. 2002. Molecular properties that influence the oral bioavailability of drug candidates. J Med Chem. 45(12):2615–2623.
   PubMed Web of Science ®Google Scholar
• Wang D, Liao PY, Zhu HT, Chen KK, Xu M, Zhang YJ, Yang CR. 2012. The processing of Panax notoginseng and the transformation of its saponin components. Food Chem. 132(4):1808–1813.
   Web of Science ®Google Scholar
• Wang L, Sun Y, Du F, Niu W, Lu T, Kan J, Xu F, Yuan K, Qin T, Liu C, et al. 2007. 'LC-electrolyte effects' improve the bioanalytical performance of liquid chromatography/tandem mass spectrometric assays in supporting pharmacokinetic study for drug discovery. Rapid Commun Mass Spectrom. 21(16):2573–2584.
   PubMed Web of Science ®Google Scholar
• Wang T, Guo R, Zhou G, Zhou X, Kou Z, Sui F, Li C, Tang L, Wang Z. 2016. Traditional uses, botany, phytochemistry, pharmacology and toxicology of Panax notoginseng (Burk) F.H. Chen: a review. J Ethnopharmacol. 188:234–258.
   PubMed Web of Science ®Google Scholar
• Wei B, Duan Z, Zhu C, Deng J, Fan D. 2018. Anti-anemia effects of ginsenoside Rk3 and ginsenoside Rh4 on mice with ribavirin-induced anemia. Food Funct. 9(4):2447–2455.
   PubMed Web of Science ®Google Scholar
• Wu MH, Zhang Y, Ma ZG, Cao H, Liu GP. 2018. Historical evolution of Panax notoginseng (Sanqi) processing methods. Chin J Chin Mater Med. 43:4923–4928.
   Google Scholar
• Wu R, Ru Q, Chen L, Ma B, Li C. 2014. Stereospecificity of ginsenoside Rg3 in the promotion of cellular immunity in hepatoma H22-bearing mice. J Food Sci. 79(7):H1430–1435.
   PubMed Web of Science ®Google Scholar
• Wu S, Guo CL, Cui XM, Yang XY. 2015. Simultaneous determination of ten kinds of saponins in raw and steamed Panax notoginseng root and rhizome by HPLC. J Chin Med Mater. 38:1622–1625.
   Google Scholar
• Xing R, Zhou L, Xie L, Hao K, Rao T, Wang Q, Ye W, Fu H, Wang X, Wang G, et al. 2015. Development of a systematic approach to rapid classification and identification of notoginsenosides and metabolites in rat feces based on liquid chromatography coupled triple time-of-flight mass spectrometry. Anal Chim Acta. 867:56–66.
   PubMed Web of Science ®Google Scholar
• Xiong Y, Chen L, Hu Y, Cui X. 2017. Uncovering active constituents responsible for different activities of raw and steamed Panax notoginseng roots. Front Pharmacol. 8:745.
   PubMed Web of Science ®Google Scholar
• Xiong Y, Chen L, Man J, Hu Y, Cui X. 2019. Chemical and bioactive comparison of Panax notoginseng root and rhizome in raw and steamed forms. J Ginseng Res. 43(3):385–393.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Zhang Y, Gao M, Cui X, Yang Y, van Duijn B, Wang M, Hu Y, Wang C, Xiong Y. 2019. Steamed Panax notoginseng attenuates anemia in mice with blood deficiency syndrome via regulating hematopoietic factors and JAK-STAT pathway. Front Pharmacol. 10:1578.
   PubMed Web of Science ®Google Scholar
• Zhou L, Xing R, Xie L, Rao T, Wang Q, Ye W, Fu H, Xiao J, Shao Y, Kang D, et al. 2015. Development and validation of an UFLC-MS/MS assay for the absolute quantitation of nine notoginsenosides in rat plasma: Application to the pharmacokinetic study of Panax notoginseng extract. J Chromatogr B Analyt Technol Biomed Life Sci. 995–996:46–53.
   PubMed Web of Science ®Google Scholar
• Zhou S, Jiang N, Zhang M, Xiao X, Liu Z, Xu X, Gao Q, Lv W. 2020. Analyzing active constituents and optimal steaming conditions related to the hematopoietic effect of steamed Panax notoginseng by network pharmacology coupled with response surface methodology. Biomed Res Int. 2020:9371426.
   PubMed Web of Science ®Google Scholar
• Zhu D, Zhou Q, Li H, Li S, Dong Z, Li D, Zhang W. 2018. Pharmacokinetic characteristics of steamed notoginseng by an efficient LC-MS/MS method for simultaneously quantifying twenty-three triterpenoids. J Agric Food Chem. 66(30):8187–8198.
   PubMed Web of Science ®Google Scholar