α-Amylase and dipeptidyl peptidase-4 (DPP-4) inhibitory effects of Melicope latifolia bark extracts and identification of bioactive constituents using in vitro and in silico approaches

References

• Abdullah N, Kasim K. 2017. In-vitro antidiabetic activity of Clinacanthus nutans extracts. Int J Pharmacogn Phytochem. 9:846–852.
   Google Scholar
• Abdullahi M, Adeniji SE. 2020. In-silico molecular docking and adme/pharmacokinetic prediction studies of some novel carboxamide derivatives as anti-tubercular agents. Chem Afr. 3(4):989–1000.
   Google Scholar
• Akhtar N, Jafri L, Green BD, Kalsoom S, Mirza B. 2018. A multi-mode bioactive agent isolated from Ficus microcarpa L. Fill. with therapeutic potential for Type 2 diabetes mellitus. Front Pharmacol. 9:1376–1390.
   PubMed Web of Science ®Google Scholar
• Alqahtani AS, Hidayathulla S, Rehman MT, ElGamal AA, Al-Massarani S, Razmovski-Naumovski V, Alqahtani MS, El Dib RA, Alajmi MF. 2019. Alpha-amylase and alpha-glucosidase enzyme inhibition and antioxidant potential of 3-oxolupenal and katononic acid isolated from Nuxia oppositifolia. Biomolecules. 10(1):61–80.
   PubMed Web of Science ®Google Scholar
• Asadi S, Khodagholi F, Esmaeili MA, Tusi SK, Ansari N, Shaerzadeh F, Sonboli A, Ghahremanzamaneh M. 2011. Chemical composition analysis, antioxidant, antiglycating activities and neuroprotective effects of S. choloroleuca, S. mirzayanii and S. santolinifolia from Iran. Am J Chin Med. 39(3):615–638.
   PubMed Web of Science ®Google Scholar
• Baek NI, Ahn EM, Kim HY, Park YD. 2000. Furanocoumarins from the root of Angelica dahurica. Arch Pharm Res. 23(5):467–470.
   PubMed Web of Science ®Google Scholar
• Bruni R, Barreca D, Protti M, Brighenti V, Righetti L, Anceschi L, Mercolini L, Benvenuti S, Gattuso G, Pellati F. 2019. Botanical sources, chemistry, analysis, and biological activity of furanocoumarins of pharmaceutical interest. Molecules. 24(11):2163–2188.
   PubMed Web of Science ®Google Scholar
• Budipramana K, Junaidin J, Ruslan Wirasutisna K, Budipramana Y, Sukrasno S. 2019. An integrated in silico and in vitro assays of dipeptidyl peptidase-4 and α-glucosidase inhibition by stellasterol from Ganoderma australe. Sci Pharm. 87(3):21–29.
   Web of Science ®Google Scholar
• Chelladurai GRM, Chinnachamy C. 2018. Alpha amylase and alpha glucosidase inhibitory effects of aqueous stem extract of Salacia oblonga and its GC-MS analysis. Braz J Pharm Sci. 54(1):10.
   Web of Science ®Google Scholar
• Divya K, Vivek HK, Nagendra Prasad MN, Priya BS, Najunda Swamy S. 2014. Management of type 2 diabetes mellitus by DPP-IV inhibition-A review. Int J Pharm Phytopharmacol Res. 4:138–143.
   Google Scholar
• El Omari N, Sayah K, Fettach S, El Blidi O, Bouyahya A, El Abbes Faouzi M, Kamal R, Barkiyou M. 2019. 2019. Evaluation of in vitro antioxidant and antidiabetic activities of Aristolochia longa extracts. Evid Based Complement Alternat Med. 2019:7384735–7384739.
   PubMed Web of Science ®Google Scholar
• Eliaser EM, Ho JH, Hashim NM, Rukayadi Y, Ee GCL, Razis AFA. 2018. Phytochemical constituents and biological activities of Melicope lunu-ankenda. Molecules. 23(10):2708–2730.
   PubMed Web of Science ®Google Scholar
• Geng Y, Lu Z-M, Huang W, Xu H-Y, Shi J-S, Xu Z-H. 2013. Bioassay-guided isolation of dpp-4 inhibitory fractions from extracts of submerged cultured of Inonotus obliquus. Molecules. 18(1):1150–1161.
   PubMed Web of Science ®Google Scholar
• Hamid HA, Yusoff MM, Liu M, Karim MR. 2015. α-Glucosidase and α-amylase inhibitory constituents of Tinospora crispa: Isolation and chemical profile confirmation by ultra-high performance liquid chromatography-quadrupole time-of-flight/mass spectrometry. J Funct Foods. 16:74–80.
   Web of Science ®Google Scholar
• Iheagwam FN, Israel EN, Kayode KO, De Campos OC, Ogunlana OO, Chinedu SN. 2019a. GC-MS analysis and inhibitory evaluation of Terminalia catappa leaf extracts on major enzymes linked to diabetes. Evid Based Complement Alternat Med. 2019:6316231.
   PubMed Web of Science ®Google Scholar
• Iheagwam FN, Israel EN, Kayode KO, DeCampos OC, Ogunlana OO, Chinedu SN. 2020. Nauclea latifolia Sm. leaf extracts extenuate free radicals, inflammation, and diabetes-linked enzymes. Oxi Med Cell. 2020:5612486.
   Google Scholar
• Iheagwam FN, Ogunlana OO, Chinedu SN. 2019b. Model optimization and in silico analysis of potential dipeptidyl peptidase-iv antagonists from GC-MS identified compounds in Nauclea latifolia leaf extracts. IJMS. 20(23):5913–5940.
   Google Scholar
• Jafari AA, Miroliaei M, Angelova VT, Emamzadeh R, Djukic MM, Djuric A, Saso L. 2016. Antioxidant activity and protective role on protein glycation of synthetic aminocoumarins. Electron J Biotechnol. 24:43–48.
   Web of Science ®Google Scholar
• Jha V, Bhadoriya KS. 2018. Synthesis, pharmacological evaluation and molecular docking studies of pyrimidinedione based DPP-4 inhibitors as antidiabetic agents. J M Struct. 1158:96–105.
   Web of Science ®Google Scholar
• Jo S-H, Ka E-H, Lee H-S, Apostolidis E, Jang H-D, Kwon Y-I. 2009. Comparison of antioxidant potential and rat intestinal α-glucosidase inhibitory activities of quercetin, rutin and isoquercetin. Int J Appl Res Nat Prod. 2:52–60.
   Google Scholar
• Kalhotra P, Chittepu V, Osorio-Revilla G, Gallardo-Velázquez T. 2019. Discovery of galangin as a potential DPP-4 inhibitor that improves insulin-stimulated skeletal muscle glucose uptake: a combinational therapy for diabetes. IJMS. 20(5):1228–1239.
   Google Scholar
• Kassim NK, Lim PC, Ismail A, Awang K. 2019. Isolation of antioxidative compounds from Micromelum minutum guided by preparative thin layer chromatography-2,2-diphenyl-1-picrylhydrazyl (PTLC-DPPH) bioautography method. Food Chem. 272:185–191.
   PubMed Web of Science ®Google Scholar
• Kim BR, Kim H, Choi I, Kim J-B, Jin C, Han A-R. 2018. DPP-IV inhibitory potentials of flavonol glycosides isolated from the seeds of Lens culinaris: in vitro and molecular docking analyses. Molecules. 23(8):1998–2008.
   PubMed Web of Science ®Google Scholar
• Lin D, Xiao M, Zhao J, Li Z, Xing B, Li X, Kong M, Li L, Zhang Q, Liu Y, et al. 2016. An overview of plant phenolic compounds and their importance in human nutrition and management of type 2 diabetes. Molecules. 21(10):1374–1393.
   PubMed Web of Science ®Google Scholar
• Lin SR, Chang CH, Tsai MJ, Cheng H, Chen JC, Leong MK, Weng CF. 2019. The perceptions of natural compounds against dipeptidyl peptidase 4 in diabetes: from in silico to in vivo. Ther Adv Chronic Dis. 10:1–16.
   Web of Science ®Google Scholar
• Mahendran G, Manoj M, Murugesh E, Sathish Kumar R, Shanmughavel P, Rajendra Prasad KJ, Narmatha Bai V. 2014. In vivo anti-diabetic, antioxidant and molecular docking studies of 1, 2, 8-trihydroxy-6-methoxy xanthone and 1, 2-dihydroxy-6-methoxyxanthone-8-O-β-D-xylopyranosyl isolated from Swertia corymbosa. Phytomedicine. 21(11):1237–1248.
   PubMed Web of Science ®Google Scholar
• Makkar F, Chakraborty K. 2017. Antidiabetic and anti-inflammatory potential of sulphated polygalactans from red seaweeds Kappaphycus alvarezii and Gracilaria opuntia. Int J Food Prop. 20(6):1326–1337.
   Web of Science ®Google Scholar
• Malviya N, Jain S, Malviya S. 2010. Antidiabetic potential of medicinal plants. Acta Pol Pharm. 67(2):113–118.
   PubMed Web of Science ®Google Scholar
• Mzid M, Ben Khedir S, Ben Salem M, Regaieg W, Rebai T. 2017. Antioxidant and antimicrobial activities of ethanol and aqueous extracts from Urtica urens. Pharm Biol. 55(1):775–781.
   PubMed Web of Science ®Google Scholar
• Nazir N, Zahoor M, Nisar M, Khan I, Karim N, Abdel-Halim H, Ali A. 2018. Phytochemical analysis and antidiabetic potential of Elaeagnus umbellata (Thunb.) in streptozotocin-induced diabetic rats: pharmacological and computational approach. BMC Complement Altern Med. 18(1):332–348.
   PubMedGoogle Scholar
• Nguyen NH, Ha TKQ, Choi S, Eum S, Lee CH, Bach TT, Chinh VT, Oh WK. 2016. Chemical constituents from Melicope pteleifolia leaves. Phytochemistry. 130:291–300.
   PubMed Web of Science ®Google Scholar
• Olvera-Montaño C, Castellanos-González JA, Navarro-Partida J, Cardona-Muñoz EG, López-Contreras AK, Román-Pintos LM, Robles Rivera RR, Rodríguez-Carrizalez AD. 2019. Oxidative stress as the main target in diabetic retinopathy pathophysiology. J Diabetes Res. 2019:8562408.
   Web of Science ®Google Scholar
• Payghami N, Jamili S, Rustaiyan A, Saeidnia S, Nikan M, Gohari AR. 2014. Alpha-amylase inhibitory activity and sterol composition of the marine algae, Sargassum glaucescens. Pharmacognosy Res. 7(4):314–321.
   PubMed Web of Science ®Google Scholar
• Polonsky W, Henry R. 2016. Poor medication adherence in type 2 diabetes: recognizing the scope of the problem and its key contributors. PPA. 10:1299–1307.
   Google Scholar
• Quek A, Kassim NK, Ismail A, Latif MAM, Shaari K, Tan DC, Lim PC. 2020. Identification of dipeptidyl peptidase-4 and α-amylase inhibitors from Melicope glabra (Blume) T. G. Hartley (Rutaceae) using liquid chromatography tandem mass spectrometry, in vitro and in silico methods. Molecules. 26(1):1–16.
   PubMed Web of Science ®Google Scholar
• Ramasubbu N, Ragunath C, Mishra PJ, Thomas LM, Gyemant G, Kandra L. 2004. Human salivary alpha-amylase Trp58 situated at subsite-2 is critical for enzyme activity. Eur J Biochem. 271(12):2517–2529.
   PubMedGoogle Scholar
• Rangel ÉB, Rodrigues CO, de Sá JR. 2019. Micro- and macrovascular complications in diabetes mellitus: preclinical and clinical studies. J Diabetes Res. 2019:2161085.
   PubMed Web of Science ®Google Scholar
• Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, Colagiuri S, Guariguata L, Motala AA, Ogurtsova K. 2019. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 157:1–18.
   Web of Science ®Google Scholar
• Salehi B, Ata A, Anil Kumar NV, Sharopov F, Ramírez-Alarcón K, Ruiz-Ortega A, Ayatollahi SA, Fokou PVT, Kobarfard F, Zakaria ZA. 2019. Antidiabetic potential of medicinal plants and their active components. Biomolecules. 9:551–672.
   PubMed Web of Science ®Google Scholar
• Sarac N, Ugur A, Karaca I. 2019. Evaluation of antioxidant and antimutagenic activities of aluminum chloride. Eur Oral Res. 53(2):51–55.
   PubMedGoogle Scholar
• Shah K, Mujwar S, Gupta JK, Shrivastava SK, Mishra P. 2019. Molecular docking and in silico cogitation validate mefenamic acid prodrugs as human cyclooxygenase-2 inhibitor. Assay Drug Dev Technol. 17(6):285–291.
   PubMed Web of Science ®Google Scholar
• Sulaiman MR, Mohd Padzil A, Shaari K, Khalid S, Mossadeq WMS, Mohamad AS, Ahmad S, Akira A, Israf D, Lajis N. 2010. 2011. Antinociceptive activity of Melicope ptelefolia ethanolic extract in experimental animals. J Biomed Biotechnol. 2010:937642–937646.
   PubMedGoogle Scholar
• Sultana N, Skelton BW, Waterman PG, White AH. 2000. 3,5-Dimethoxy-3-(1,1-dimethylprop-2-enyl)-3,4-dihydropsoralen-4-one: an unusual furanocoumarin derivative from Halfordia kendack. Phytochemistry. 55(6):675–678.
   PubMed Web of Science ®Google Scholar
• Susiloningrum D, Permanasari AA, Adianti M, Tumewu L, Wahyuni TS, Tanjung M, Widyawaruyanti A, Hafid AF. 2020. The alkaloid fraction from Melicope latifolia leaves inhibits hepatitis C virus. PJ. 12(3):535–540.
   Google Scholar
• Tan DC, Idris KI, Kassim NK, Lim PC, Safinar II, Hamid M, Ng RC. 2019. Comparative study of the antidiabetic potential of Paederia foetida twig extracts and compounds from two different locations in Malaysia. Pharm Biol. 57(1):345–354.
   PubMed Web of Science ®Google Scholar
• Tanwar RS, Sharma SB, Prabhu KM. 2017. In vivo assessment of antidiabetic and antioxidative activity of natural phytochemical isolated from fruit-pulp of Eugenia jambolana in streptozotocin-induced diabetic rats. Redox Rep. 22(6):301–307.
   PubMed Web of Science ®Google Scholar
• Tran N, Pham B, Le L. 2020. Bioactive compounds in anti-diabetic plants: From herbal medicine to modern drug discovery. Biology. 9(9):252–283.
   PubMedGoogle Scholar
• Truong DH, Nguyen DH, Ta NTA, Bui AV, Do TH, Nguyen HC. 2019. Evaluation of the use of different solvents for phytochemical constituents, antioxidants, and in vitro anti-inflammatory activities of Severinia buxifolia. J Food Qual. 2019:8178294.
   Google Scholar
• Unuofin JO, Lebelo SL. 2020. Antioxidant effects and mechanisms of medicinal plants and their bioactive compounds for the prevention and treatment of type 2 diabetes: an updated review. Oxid Med Cell Longev. 2020:1356893.
   PubMed Web of Science ®Google Scholar
• Wang J, Wang H. 2017. Oxidative stress in pancreatic beta cell regeneration. Oxid Med Cell Longev. 2017:1930261–1930269.
   PubMedGoogle Scholar
• Yeap YSY, Kassim NK, Ng RC, Ee GCL, Saiful YL, Musa KH. 2017. Antioxidant properties of ginger Kaempferia angustifolia Rosc. and its chemical markers. Int J Food Prop. 20(sup1):1158–1172.
   Web of Science ®Google Scholar
• Yusof ENM, Latif MAM, Tahir MIM, Sakoff JA, Simone MI, Page AJ, Veerakumarasivam A, Tiekink ERT, Ravoof TBSA. 2019. o-Vanillin derived schiff bases and their organotin(iv) compounds: synthesis, structural characterisation, in-silico studies and cytotoxicity. IJMS. 20(4):854–888.
   Google Scholar