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Research Article

Huoxue Qianyang Qutan recipe attenuates cardiac fibrosis by inhibiting the NLRP3 inflammasome signalling pathway in obese hypertensive rats

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Pages 1043-1055 | Received 26 Apr 2021, Accepted 05 Jul 2021, Published online: 06 Aug 2021

References

  • Afshin A, Forouzanfar MH, Reitsma MB, Sur P, Estep K, Lee A, Marczak L, Mokdad AH, Moradi-Lakeh M, Naghavi M, et al. 2017. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med. 377(1):13–27.
  • Al-Mazroua HA, Al-Rasheed NM, Korashy HM. 2013. Downregulation of the cardiotrophin-1 gene expression by valsartan and spironolactone in hypertrophied heart rats in vivo and rat cardiomyocyte H9c2 cell line in vitro: a novel mechanism of cardioprotection. J Cardiovasc Pharmacol. 61(4):337–344.
  • Aurigemma GP, de Simone G, Fitzgibbons TP. 2013. Cardiac remodeling in obesity. Circ Cardiovasc Imaging. 6(1):142–152.
  • Bekhbat M, Rowson SA, Neigh GN. 2017. Checks and balances: the glucocorticoid receptor and NFĸB in good times and bad. Front Neuroendocrinol. 46:15–31.
  • Bluher M. 2019. Obesity: global epidemiology and pathogenesis. Nat Rev Endocrinol. 15:288–298.
  • Chooi Y, Ding C, Magkos F. 2019. The epidemiology of obesity. Metabolism. 92:6–10.
  • Dhume A, Lu S, Horowits R. 2006. Targeted disruption of N-RAP gene function by RNA interference: a role for N-RAP in myofibril organization. Cell Motil Cytoskeleton. 63(8):493–511.
  • Disma N, O'Leary JD, Loepke AW, Brambrink AM, Becke K, Clausen NG, De Graaff JC, Liu F, Hansen TG, McCann ME, et al. 2018. Anesthesia and the developing brain: a way forward for laboratory and clinical research. Paediatr Anaesth. 28(9):758–763.
  • Erken HA, Erken G, Genç O. 2013. Blood pressure measurement in freely moving rats by the tail cuff method. Clin Exp Hypertens. 35(1):11–15.
  • Frangogiannis N. 2019. Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities. Mol Aspects Med. 65:70–99.
  • Gan W, Ren J, Li T, Lv S, Li C, Liu Z, Yang M. 2018. The SGK1 inhibitor EMD638683, prevents Angiotensin II-induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activation. Biochim Biophys Acta Mol Basis Dis. 1864(1):1–10.
  • Gao R, Shi H, Chang S, Gao Y, Li X, Lv C, Yang H, Xiang H, Yang J, Xu L, et al. 2019. The selective NLRP3-inflammasome inhibitor MCC950 reduces myocardial fibrosis and improves cardiac remodeling in a mouse model of myocardial infarction. Int Immunopharmacol. 74:105575.
  • Global Burden of Diseases, Injuries, and Risk Factors Study (GRF). 2020. Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 396:1223–1249.
  • González A, López B, Ravassa S, San José G, Díez J. 2020. Reprint of “The complex dynamics of myocardial interstitial fibrosis in heart failure. Focus on collagen cross-linking”. Biochim Biophys Acta Mol Cell Res. 1867(3):118521.
  • Hariri N, Thibault L. 2010. High-fat diet-induced obesity in animal models. Nutr Res Rev. 23(2):270–299.
  • Hinderer S, Schenke-Layland K. 2019. Cardiac fibrosis – a short review of causes and therapeutic strategies. Adv Drug Deliv Rev. 146:77–82.
  • Ji T, Han Y, Yang W, Xu B, Sun M, Jiang S, Yu Y, Jin Z, Ma Z, Yang Y, et al. 2019. Endoplasmic reticulum stress and NLRP3 inflammasome: crosstalk in cardiovascular and metabolic disorders. J Cell Physiol. 234(9):14773–14782.
  • Jia G, DeMarco VG, Sowers JR. 2016. Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy. Nat Rev Endocrinol. 12(3):144–153.
  • Kim S, Joe Y, Jeong SO, Zheng M, Back SH, Park SW, Ryter SW, Chung HT. 2014. Endoplasmic reticulum stress is sufficient for the induction of IL-1β production via activation of the NF-κB and inflammasome pathways. Innate Immun. 20(8):799–815.
  • Krenning G, Zeisberg EM, Kalluri R. 2010. The origin of fibroblasts and mechanism of cardiac fibrosis. J Cell Physiol. 225(3):631–637.
  • Levin BE. 1999. Arcuate NPY neurons and energy homeostasis in diet-induced obese and resistant rats. Am J Physiol. 276(2):R382–R387.
  • Li R, Lu K, Wang Y, Chen M, Zhang F, Shen H, Yao D, Gong K, Zhang Z. 2017. Triptolide attenuates pressure overload-induced myocardial remodeling in mice via the inhibition of NLRP3 inflammasome expression. Biochem Biophys Res Commun. 485(1):69–75.
  • Marczak L, Williams J, Loeffler M, For the Institute for Health Metrics and Evaluation. 2018. Global deaths attributable to high systolic blood pressure, 1990–2016. JAMA. 319(21):2163.
  • Non-Communicable Disease Risk Factor (NCDRF). 2016. Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants. Lancet. 387:1377–1396.
  • Patel M, Bernard W, Milev N, Cawthorn W, Figg N, Hart D, Prieur X, Virtue S, Hegyi K, Bonnafous S, et al. 2015. Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation. Proc Natl Acad Sci USA. 112(2):506–511.
  • Pejnovic NN, Pantic JM, Jovanovic IP, Radosavljevic GD, Djukic AL, Arsenijevic NN, Lukic ML. 2013. Galectin-3 is a regulator of metaflammation in adipose tissue and pancreatic islets. Adipocyte. 2(4):266–271.
  • Peng L, Wen L, Shi Q-F, Gao F, Huang B, Meng J, Hu C-P, Wang C-M. 2020. Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial-mesenchymal transition and inflammation. Cell Death Dis. 11(11):978.
  • Ren Z, Yang K, Zhao M, Liu W, Zhang X, Chi J, Shi Z, Zhang X, Fu Y, Liu Y, et al. 2020. Calcium-sensing receptor on neutrophil promotes myocardial apoptosis and fibrosis after acute myocardial infarction via NLRP3 inflammasome activation. Can J Cardiol. 36(6):893–905.
  • Sandanger Ø, Ranheim T, Vinge LE, Bliksøen M, Alfsnes K, Finsen AV, Dahl CP, Askevold ET, Florholmen G, Christensen G, et al. 2013. The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury. Cardiovasc Res. 99(1):164–174.
  • Susic D, Varagic J. 2017. Obesity: a perspective from hypertension. Med Clin North Am. 101(1):139–157.
  • Swanson KV, Deng M, Ting JP-Y. 2019. The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol. 19(8):477–489.
  • Talman V, Ruskoaho H. 2016. Cardiac fibrosis in myocardial infarction-from repair and remodeling to regeneration. Cell Tissue Res. 365(3):563–581.
  • Toldo S, Abbate A. 2018. The NLRP3 inflammasome in acute myocardial infarction. Nat Rev Cardiol. 15(4):203–214.
  • van Hout GPJ, Bosch L, Ellenbroek GHJM, de Haan JJ, van Solinge WW, Cooper MA, Arslan F, de Jager SCA, Robertson AAB, Pasterkamp G, et al. 2017. The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction. European Heart J. 38:828–836.
  • Wang J, Dong Z-H, Gui M-T, Yao L, Li J-H, Zhou X-J, Fu D-Y. 2019. HuoXue QianYang QuTan Recipe attenuates left ventricular hypertrophy in obese hypertensive rats by improving mitochondrial function through SIRT1/PGC-1α deacetylation pathway. Biosci Rep. 39:BSR20192909.
  • Wang J, Song M-Y, Lee JY, Kwon KS, Park B-H. 2015. The NLRP3 inflammasome is dispensable for ER stress-induced pancreatic β-cell damage in Akita mice. Biochem Biophys Res Commun. 466(3):300–305.
  • Wang Y, Liu X, Shi H, Yu Y, Yu Y, Li M, Chen R. 2020. NLRP3 inflammasome, an immune-inflammatory target in pathogenesis and treatment of cardiovascular diseases. Clin Transl Med. 10(1):91–106.
  • Willeford A, Suetomi T, Nickle A, Hoffman HM, Miyamoto S, Heller Brown J. 2018. CaMKIIδ-mediated inflammatory gene expression and inflammasome activation in cardiomyocytes initiate inflammation and induce fibrosis. JCI Insight. 3(12):e97054.
  • Xia Y, Sun X, Luo Y, Stary CM. 2019. Ferroptosis contributes to isoflurane neurotoxicity. Front Mol Neurosci. 11:486–486.
  • Yang Y, Wang H, Kouadir M, Song H, Shi F. 2019. Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors. Cell Death Dis. 10(2):128.
  • Yin Y, Yan Y, Jiang X, Mai J, Chen NC, Wang H, Yang XF. 2009. Inflammasomes are differentially expressed in cardiovascular and other tissues. Int J Immunopathol Pharmacol. 22(2):311–322.
  • Zhang Y, Hou L, Tang W, Xu F, Xu R, Liu X, Liu Y, Liu J, Yi Y, Hu T, et al. 2019. High prevalence of obesity-related hypertension among adults aged 40 to 79 years in Southwest China. Sci Rep. 9(1):15838.
  • Zhao Y, Li Q, Zhao W, Li J, Sun Y, Liu K, Liu B, Zhang N. 2015. Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium. J Ethnopharmacol. 169:210–218.
  • Zhou X, Lu B, Fu D, Gui M, Yao L, Li J. 2020. Huoxue Qianyang decoction ameliorates cardiac remodeling in obese spontaneously hypertensive rats in association with ATF6-CHOP endoplasmic reticulum stress signaling pathway regulation. Biomed Pharmacother. 121:109518.