2,443
Views
7
CrossRef citations to date
0
Altmetric
Research Article

Erzhi pills ameliorate cognitive dysfunction and alter proteomic hippocampus profiles induced by d-galactose and Aβ1–40 injection in ovariectomized Alzheimer’s disease model rats

, , , , , , , , & show all
Pages 1400-1412 | Received 09 Apr 2021, Accepted 24 Sep 2021, Published online: 21 Oct 2021

References

  • Bean LA, Ianov L, Foster TC. 2014. Estrogen receptors, the hippocampus, and memory. Neuroscientist. 20(5):534–545.
  • Bove R, Secor E, Chibnik LB, Barnes LL, Schneider JA, Bennett DA, De Jager PL. 2014. Age at surgical menopause influences cognitive decline and Alzheimer pathology in older women. Neurology. 82(3):222–229.
  • Cai XJ, Huang MY, Zhang L. 2011. Research progress on the source and pharmacological effects of Erzhi pills. Chin J Exp Tradi Med Form. 17:272–275.
  • Chen YH, Yan B, Guan Y, Liu YQ, Zhou YM, Huang Y, Zhou MF, Huang LP. 2019. Effect of Erjing pills on learning and memory abilities of AD rats with kidney Yin deficiency induced by ovariectomy+d-galactose combined with Aβ1-40. Tradi Chin Drug Res Clin Pharmacol. 30:1421–1427.
  • Fu LL, Ding H, Han LF, Jia L, Yang WZ, Zhang CX, Hu L, Zuo TT, Gao XM, Guo DA. 2019. Simultaneously targeted and untargeted multicomponent characterization of Erzhi pill by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry. J Chromatogr A. 1584:87–96.
  • Gao HL, Wang DQ, Wang XY, Wang ZG, Wang XM, Wu ZE, Liu H, Ma YY, Niu XH, Li LD. 2010. Effect of Erzhi pill (二至丸) on improving cerebral nerve cell apoptosis in aging rats. Chin J Integr Med. 16(6):504–509.
  • Goedert M. 2015. Alzheimer’s and Parkinson’s diseases: the prion concept in relation to assembled Aβ, tau, and α-synuclein. Science. 349(6248):1255555.
  • Gong Y, Hua N, Zang X, Huang T, He L. 2018. Melatonin ameliorates Aβ1-42-induced Alzheimer’s cognitive deficits in mouse model. J Pharm Pharmacol. 70(1):70–80.
  • Hao DC, Xiao PG. 2014. Network pharmacology: a rosetta stone for traditional Chinese medicine. Drug Dev Res. 75(5):299–312.
  • Hou M, Fu YJ, Liu C, Wei YF, Chen YF, Xie YH, Huang LP. 2016. Effects of extraction from raspberry on hippocampus proteomics of mice suffered from ovariectomized induced AD. Chi J Chin Mater Med. 41:2895–2900.
  • Hua X, Lei M, Zhang Y, Ding J, Han Q, Hu G, Xiao M. 2007. Long-term d-galactose injection combined with ovariectomy serves as a new rodent model for Alzheimer’s disease. Life Sci. 80(20):1897–1905.
  • Huang LP, Yan B, Hou M, Sun MS, He K, Guan Y, Yao LH, Zhou MF. 2017. Study on material basis and mechanism of Erzhi Wan prevent Alzheimer’s disease by network pharmacology. Chin J Chin Mater Med. 42:4211–4217.
  • Huang LP, Yan B, Hou M, Sun MS, He K, Guan Y, Yao LH, Zhou MF. 2018. Effect of Erzhi Wan on hippocampus proteomics of mice of ovariectomized-induced AD. Chin J Exp Tradi Med Form. 24:150–156.
  • Ibrahim WW, Safar MM, Khattab MM, Agha AM. 2016. 17β-Estradiol augments antidepressant efficacy of escitalopram in ovariectomized rats: neuroprotective and serotonin reuptake transporter modulatory effects. Psychoneuroendocrinology. 74:240–250.
  • Irvine K, Laws KR, Gale TM, Kondel TK. 2012. Greater cognitive deterioration in women than men with Alzheimer's disease: a meta analysis. J Clin Exp Neuropsychol. 34(9):989–998.
  • Li H, Kang T, Qi B, Kong L, Jiao Y, Cao Y, Zhang J, Yang J. 2016. Neuroprotective effects of ginseng protein on PI3K/Akt signaling pathway in the hippocampus of d-galactose/AlCl3 inducing rats model of Alzheimer’s disease. J Ethnopharmacol. 179:162–169.
  • Li L, Zhang L, Yang CC. 2016. Multi-target strategy and experimental studies of traditional Chinese medicine for Alzheimer’s disease therapy. Curr Top Med Chem. 16(5):537–548.
  • Long HZ, Cheng Y, Zhou ZW, Luo HY, Wen DD, Gao LC. 2021. PI3K/AKT signal pathway: a target of natural products in the prevention and treatment of Alzheimer’s disease and Parkinson’s disease. Front Pharmacol. 12(648636):648636.
  • Matsuo FS, Andrade MF, Loyola AM, da Silva SJ, Silva MJB, Cardoso SV, de Faria PR. 2018. Pathologic significance of AKT, mTOR, and GSK3β proteins in oral squamous cell carcinoma-affected patients. Virchows Arch. 472(6):983–997.
  • Pair FS, Yacoubian TA. 2021. 14-3-3 proteins: novel pharmacological targets in neurodegenerative diseases. Trends Pharmacol Sci. 42(4):226–238.
  • Pandey A, Mann M. 2000. Proteomics to study genes and genomes. Nature. 405(6788):837–846.
  • Patterson C. 2018. World Alzheimer Report 2018. The state of the art of dementia research: new frontiers. An analysis of prevalence, incidence, cost and trends. London, UK: Alzheimer’s Disease International.
  • Paxinos G, Watson C. 2005. The rat brain in stereotaxic coordinates. Amsterdam: Elsevier Academic Press.
  • Peri A. 2016. Neuroprotective effects of estrogens: the role of cholesterol. J Endocrinol Invest. 39(1):11–18.
  • Pike CJ. 2017. Sex and the development of Alzheimer’s disease. J Neurosci Res. 95(1–2):671–680.
  • Pirskanen M, Hiltunen M, Mannermaa A, Helisalmi S, Lehtovirta M, Hänninen T, Soininen H. 2005. Estrogen receptor beta gene variants are associated with increased risk of Alzheimer’s disease in women. Eur J Hum Genet. 13(9):1000–1006.
  • Quiroz-Baez R, Ferrera P, Rosendo-Gutierrez R, Morán J, Bermúdez-Rattoni F, Arias C. 2011. Caspase-12 activation is involved in amyloid-β protein-induced synaptic toxicity. J Alzheimers Dis. 26(3):467–476.
  • Sadik G, Tanaka T, Kato K, Yamamori H, Nessa BN, Morihara T, Takeda M. 2009. Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein: implications for the mechanism of tau aggregation. J Neurochem. 108(1):33–43.
  • Sayas CL, Ávila J. 2021. GSK-3 and Tau: a key duet in Alzheimer’s disease. Cells. 10(4):721.
  • Sherwin BB. 2006. Estrogen and cognitive aging in women. Neuroscience. 138(3):1021–1026.
  • Sherwin BB. 2009. Estrogen therapy: is time of initiation critical for neuroprotection? Nat Rev Endocrinol. 5(11):620–627.
  • Shimada T, Fournier AE, Yamagata K. 2013. Neuroprotective function of 14-3-3 proteins in neurodegeneration. Biomed Res Int. 2013:564534–564511.
  • Song LB, Xiong HP, Li J, Liao WT, Wang L, Wu JH, Li MF. 2011. Sphingosine kinase-1 enhances resistance to apoptosis through activation of PI3K/Akt/NF-κB pathway in human non-small cell lung cancer. Clin Cancer Res. 17(7):1839–1849.
  • Souza LC, Filho CB, Goes AT, Fabbro LD, de Gomes MG, Savegnago L, Oliveira MS, Jesse CR. 2013. Neuroprotective effect of physical exercise in a mouse model of Alzheimer’s disease induced by β-amyloid1–40 peptide. Neurotox Res. 24(2):148–163.
  • Vorhees CV, Williams MT. 2006. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc. 1(2):848–858.
  • Walton JR. 2012. Cognitive deterioration and associated pathology induced by chronic low-level aluminum ingestion in a translational rat model provides an explanation of Alzheimer’s disease, tests for susceptibility and avenues for treatment. Int J Alzheimers Dis. 2012:1–947.
  • Wu JG, Wang YY, Zhang ZL, Yu B. 2015. Herbal medicine in the treatment of Alzheimer’s disease. Chin J Integr Med. 21(2):102–107.
  • Wu XF, Duan LX, Gao XL, Guo ML, Wang DM. 2019. Study on preventive and therapeutic effects of Erzhi pills on mice with Parkinson's disease induced by MPTP. Zhongguo Zhong Yao Za Zhi. 44:4219–4224.
  • Zhang B, Wang Y, Li H, Xiong R, Zhao Z, Chu X, Li Q, Sun S, Chen S. 2016. Neuroprotective effects of salidroside through PI3K/Akt pathway activation in Alzheimer’s disease models. Drug Des Devel Ther. 10:1335–1343.
  • Zhao Y, Zheng HX, Xu Y, Lin N. 2017. Research progress in phytoestrogens of traditional Chinese medicine. Chin J Chin Mater Med. 42:3474–3487.