Huaiqihuang (HQH) granule alleviates cyclophosphamide-induced nephrotoxicity via suppressing the MAPK/NF-κB pathway and NLRP3 inflammasome activation

References

• Abdel-Latif GA, Elwahab AHA, Hasan RA, ElMongy NF, Ramzy MM, Louka ML, Schaalan MF. 2020. A novel protective role of sacubitril/valsartan in cyclophosphamide induced lung injury in rats: impact of miRNA-150-3p on NF-κB/MAPK signaling trajectories. Sci Rep. 10(1):13045.
   PubMed Web of Science ®Google Scholar
• Ahlmann M, Hempel G. 2016. The effect of cyclophosphamide on the immune system: implications for clinical cancer therapy. Cancer Chemother Pharmacol. 78(4):661–671.
   PubMed Web of Science ®Google Scholar
• El-Sebaey AM, Abdelhamid FM, Abdalla OA. 2019. Protective effects of garlic extract against hematological alterations, immunosuppression, hepatic oxidative stress, and renal damage induced by cyclophosphamide in rats. Environ Sci Pollut Res Int. 26(15):15559–15572.
   PubMed Web of Science ®Google Scholar
• El-Shabrawy M, Mishriki A, Attia H, Emad Aboulhoda B, Emam M, Wanas H. 2020. Protective effect of tolvaptan against cyclophosphamide-induced nephrotoxicity in rat models. Pharmacol Res Perspect. 8(5):e00659.
   PubMed Web of Science ®Google Scholar
• Geng HY, Cao L, Wang W, Chen DK, Chen CY, Chu M, Ji LN, Wang JJ, Tu J, Li JG. 2015. A prospective, randomized, controlled clinical study of Huai Qi Huang granules in treatment of childhood primary nephrotic syndrome. Chinese J Contemp Pediatrics. 17:31–34.
   Google Scholar
• Ghareeb MA, Sobeh M, El-Maadawy WH, Mohammed HS, Khalil H, Botros S, Wink M. 2019. Chemical profiling of polyphenolics in Eucalyptus globulus and evaluation of its hepato-renal protective potential against cyclophosphamide induced toxicity in mice. Antioxidants. 8(9):415.
   Web of Science ®Google Scholar
• Gunes S, Sahinturk V, Uslu S, Ayhanci A, Kacar S, Uyar R. 2018. Protective effects of selenium on cyclophosphamide-induced oxidative stress and kidney injury. Biol Trace Elem Res. 185(1):116–123.
   PubMed Web of Science ®Google Scholar
• Guo Y, Wang M, Mou J, Zhao Z, Yang J, Zhu F, Pei G, Zhu H, Wang Y, Xu G, et al. 2018. Pretreatment of Huaiqihuang extractum protects against cisplatin-induced nephrotoxicity. Sci Rep. 8(1):7333.
   PubMedGoogle Scholar
• Has AL, Alotaibi MF, Bin-Jumah M, Elgebaly H, Mahmoud AM. 2019. Olea europaea leaf extract up-regulates Nrf2/ARE/HO-1 signaling and attenuates cyclophosphamide-induced oxidative stress, inflammation and apoptosis in rat kidney. Biomed Pharmacother. 111:676–685.
   PubMed Web of Science ®Google Scholar
• Iqubal A, Syed MA, Ali J, Najmi AK, Haque MM, Haque SE. 2020a. Nerolidol protects the liver against cyclophosphamide-induced hepatic inflammation, apoptosis, and fibrosis via modulation of Nrf2, NF-κB p65, and caspase-3 signaling molecules in Swiss albino mice. Biofactors. 46(6):963–973.
   PubMed Web of Science ®Google Scholar
• Iqubal A, Syed MA, Najmi AK, Azam F, Barreto GE, Iqubal MK, Ali J, Haque SE. 2020b. Nano-engineered nerolidol loaded lipid carrier delivery system attenuates cyclophosphamide neurotoxicity – probable role of NLRP3 inflammasome and caspase-1. Exp Neurol. 334:113464.
   PubMed Web of Science ®Google Scholar
• Jiang S, Zhang Z, Huang F, Yang Z, Yu F, Tang Y, Ding G. 2020. Protective effect of low molecular weight peptides from Solenocera crassicornis head against cyclophosphamide-induced nephrotoxicity in mice via the Keap1/Nrf2 pathway. Antioxidants. 9(8):745.
   Web of Science ®Google Scholar
• Jiang X, Ren Z, Zhao B, Zhou S, Ying X, Tang Y. 2020. Ameliorating effect of pentadecapeptide derived from Cyclina sinensis on cyclophosphamide-induced nephrotoxicity. Mar Drugs. 18(9):462.
   PubMed Web of Science ®Google Scholar
• Jiang X, Yang F, Zhao Q, Tian D, Tang Y. 2019. Protective effects of pentadecapeptide derived from Cyclaina sinensis against cyclophosphamide-induced hepatotoxicity. Biochem Biophys Res Commun. 520(2):392–398.
   PubMed Web of Science ®Google Scholar
• Kim EK, Choi EJ. 2010. Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta. 1802(4):396–405.
   PubMed Web of Science ®Google Scholar
• Kim SH, Lee IC, Ko JW, Moon C, Kim SH, Shin IS, Seo YW, Kim HC, Kim JC. 2015. Diallyl disulfide prevents cyclophosphamide-induced hemorrhagic cystitis in rats through the inhibition of oxidative damage, MAPKs, and NF-κB pathways. Biomol Ther. 23(2):180–188.
   PubMed Web of Science ®Google Scholar
• Kim SM, Kim YG, Kim DJ, Park SH, Jeong KH, Lee YH, Lim SJ, Lee SH, Moon JY. 2018. Inflammasome-independent role of NLRP3 mediates mitochondrial regulation in renal injury. Front Immunol. 9:2563.
   PubMed Web of Science ®Google Scholar
• Kim YG, Kim SM, Kim KP, Lee SH, Moon JY. 2019. The role of inflammasome-dependent and inflammasome-independent NLRP3 in the kidney. Cells. 8(11):1389.
   PubMed Web of Science ®Google Scholar
• Lawrence T. 2009. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol. 1(6):a001651.
   PubMed Web of Science ®Google Scholar
• Li LT, Shi MY, Wei SY, Li T, Li B. 2013. Huai Qi Huang ameliorates proteinuria and hematuria in mild IgA nephropathy patients: a prospective randomized controlled study. J Formos Med Assoc. 112(12):766–772.
   PubMed Web of Science ®Google Scholar
• Li TX, Mao JH, Huang L, Fu HD, Chen SH, Liu AM, Liang YQ. 2017. Beneficial effects of Huaiqihuang on hyperglycemia-induced MPC5 podocyte dysfunction through the suppression of mitochondrial dysfunction and endoplasmic reticulum stress. Mol Med Rep. 16(2):1465–1471.
   PubMed Web of Science ®Google Scholar
• Lin X, Yang F, Huang J, Jiang S, Tang Y, Li J. 2020. Ameliorate effect of pyrroloquinoline quinone against cyclophosphamide-induced nephrotoxicity by activating the Nrf2 pathway and inhibiting the NLRP3 pathway. Life Sci. 256:117901.
   PubMed Web of Science ®Google Scholar
• Liu Y-H, Li K, Tian H-Q. 2020. Renoprotective effects of a new free radical scavenger, XH-003, against cisplatin-induced nephrotoxicity. Oxid Med Cell Longev. 2020:9820168.
   PubMed Web of Science ®Google Scholar
• Mohamed MT, Zaitone SA, Ahmed A, Mehanna ET, El-Sayed NM. 2020. Raspberry ketones attenuate cyclophosphamide-induced pulmonary toxicity in mice through inhibition of oxidative stress and NF-κB pathway. Antioxidants. 9(11):1168.
   Web of Science ®Google Scholar
• Mohammadi F, Nikzad H, Taghizadeh M, Taherian A, Azami-Tameh A, Hosseini SM, Moravveji A. 2014. Protective effect of Zingiber officinale extract on rat testis after cyclophosphamide treatment. Andrologia. 46(6):680–686.
   PubMed Web of Science ®Google Scholar
• Nafees S, Rashid S, Ali N, Hasan SK, Sultana S. 2015. Rutin ameliorates cyclophosphamide induced oxidative stress and inflammation in Wistar rats: role of NFκB/MAPK pathway. Chem Biol Interact. 231:98–107.
   PubMed Web of Science ®Google Scholar
• Nagi MN, Al-Shabanah OA, Hafez MM, Sayed-Ahmed MM. 2011. Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats. J Biochem Mol Toxicol. 25(3):135–142.
   PubMed Web of Science ®Google Scholar
• Pan J, Yang C, Jiang Z, Huang J. 2019. Trametes robiniophila Murr: a traditional Chinese medicine with potent anti-tumor effects. Cancer Manag Res. 11:1541–1549.
   PubMed Web of Science ®Google Scholar
• Pu J, Zhang Y, Zhou J. 2016. Effect of Huai Qi Huang on epithelial-mesenchymal transition of renal tubular epithelial cells through miR-200a. Evid Based Complement Alternat Med. 2016:8612190.
   PubMed Web of Science ®Google Scholar
• Sherif IO. 2018. Uroprotective mechanism of quercetin against cyclophosphamide-induced urotoxicity: effect on oxidative stress and inflammatory markers. J Cell Biochem. 119(9):7441–7448.
   PubMed Web of Science ®Google Scholar
• Waz S, Heeba GH, Hassanin SO, Abdel-Latif RG. 2021. Nephroprotective effect of exogenous hydrogen sulfide donor against cyclophosphamide-induced toxicity is mediated by Nrf2/HO-1/NF-κB signaling pathway. Life Sci. 264:118630.
   PubMed Web of Science ®Google Scholar
• Zhu C, Huang S, Ding G, Yuan Y, Chen Q, Pan X, Chen R, Zhang A. 2011. Protective effects of Huang Qi Huai granules on adriamycin nephrosis in rats. Pediatr Nephrol. 26(6):905–913.
   PubMed Web of Science ®Google Scholar