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Research Article

Icariin inhibits the expression of IL-1β, IL-6 and TNF-α induced by OGD/R through the IRE1/XBP1s pathway in microglia

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Pages 1471-1477 | Received 11 May 2021, Accepted 06 Oct 2021, Published online: 28 Oct 2021

References

  • Anuncibay-Soto B, Pérez-Rodriguez D, Santos-Galdiano M, Font-Belmonte E, Ugidos IF, Gonzalez-Rodriguez P, Regueiro-Purriños M, Fernández-López A. 2018. Salubrinal and robenacoxib treatment after global cerebral ischemia. Exploring the interactions between ER stress and inflammation. Biochem Pharmacol. 151:26–37.
  • Bravo R, Gutierrez T, Paredes F, Gatica D, Rodriguez AE, Pedrozo Z, Chiong M, Parra V, Quest AF, Rothermel BA, et al. 2012. Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics. Int J Biochem Cell Biol. 44(1):16–20.
  • Concha NO, Smallwood A, Bonnette W, Totoritis R, Zhang G, Federowicz K, Yang J, Qi H, Chen S, Campobasso N, et al. 2015. Long-range inhibitor-induced conformational regulation of human IRE1α endoribonuclease activity. Mol Pharmacol. 88(6):1011–1023.
  • Cui J, Liu Y, Chang X, Gou W, Zhou X, Liu Z, Li Z, Wu Y, Zuo D. 2019. Acetaldehyde induces neurotoxicity in vitro via oxidative stress- and Ca2+ imbalance-mediated endoplasmic reticulum stress. Oxid Med Cell Longev. 2019:2593742.
  • Deng QY. 2008. Treatment of 80 cases of ischemic apoplexy in convalescent stage by tonifying kidney and activating blood circulation. J Pract Chin Med. 24:16–17.
  • He M, Huang XF, Gao G, Zhou T, Li W, Hu J, Chen J, Li J, Sun T. 2019. Olanzapine-induced endoplasmic reticulum stress and inflammation in the hypothalamus were inhibited by an ER stress inhibitor 4-phenylbutyrate. Psychoneuroendocrinology. 104:286–299.
  • Kato H, Nakajima S, Saito Y, Takahashi S, Katoh R, Kitamura M. 2012. mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathway. Cell Death Differ. 19(2):310–320.
  • Krebs J, Agellon LB, Michalak M. 2015. Ca2+ homeostasis and endoplasmic reticulum (ER) stress: an integrated view of calcium signaling. Biochem Biophys Res Commun. 460(1):114–121.
  • Li X, Han F, Shi Y. 2015. IRE1α-XBP1 pathway is activated upon induction of single-prolonged stress in rat neurons of the medial prefrontal cortex. J Mol Neurosci. 57(1):63–72.
  • Li Y, Guo Y, Tang J, Jiang J, Chen Z. 2015. New insights into the roles of CHOP-induced apoptosis in ER stress. Acta Biochim Biophys Sin. 47(2):146–147.
  • Liu D, Ye Y, Xu L, Yuan W, Zhang Q. 2018. Icariin and mesenchymal stem cells synergistically promote angiogenesis and neurogenesis after cerebral ischemia via PI3K and ERK1/2 pathways. Biomed Pharmacother. 108:663–669.
  • Lubamba BA, Jones LC, O'Neal WK, Boucher RC, Ribeiro CM. 2015. X-Box-binding protein 1 and innate immune responses of human cystic fibrosis alveolar macrophages. Am J Respir Crit Care Med. 192(12):1449–1461.
  • Mahura IS. 2003. Cerebral ischemia–hypoxia and biophysical mechanisms of neurodegeneration and neuroprotection effects. Fiziol Zh. 49(2):7–12.
  • Mallard C, Tremblay ME, Vexler ZS. 2019. Microglia and neonatal brain injury. Neuroscience. 405:68–76.
  • Mo ZT, Li WN, Zhai YR, Gao SY. 2017. The effects of icariin on the expression of HIF-1α, HSP-60 and HSP-70 in PC12 cells suffered from oxygen-glucose deprivation-induced injury. Pharm Biol. 55(1):848–852.
  • Mo ZT, Li WN, Zhai YR, Gong QH. 2015. Protective effect of icariin against PC12 cells inflammatory injury induced by oxygen glucose deprivation. Trad Chin Drug Res Clin Pharmacol. 26:21–24.
  • Mo ZT, Liao YL, Zheng J, Li WN. 2020. Icariin protects neurons from endoplasmic reticulum stress-induced apoptosis after OGD/R injury via suppressing IRE1α-XBP1 signaling pathway. Life Sci. 255:117847.
  • Pinkaew D, Chattopadhyay A, King MD, Chunhacha P, Liu Z, Stevenson HL, Chen Y, Sinthujaroen P, McDougal OM, Fujise K. 2017. Fortilin binds IRE1α and prevents ER stress from signaling apoptotic cell death. Nat Commun. 8(1):18.
  • Shi L, Wang Z, Liu X, Li M, Zhang S, Song X. 2018. Bax inhibitor-1 is required for resisting the early brain injury induced by subarachnoid hemorrhage through regulating IRE1-JNK pathway. Neurol Res. 40(3):189–196.
  • Su L, Zhang R, Chen Y, Zhu Z, Ma C. 2017. Raf Kinase inhibitor protein attenuates ischemic-induced microglia cell apoptosis and activation through NF-κB pathway. Cell Physiol Biochem. 41(3):1125–1134.
  • Tam AB, Mercado EL, Hoffmann A, Niwa M. 2012. ER stress activates NF-κB by integrating functions of basal IKK activity, IRE1 and PERK. PLoS One. 7(10):e45078.
  • Wen GD, Zeng CL. 2017. Therapeutic effect of kidney tonifying and blood activating therapy on ischemic stroke in recovery period. Inner Mongolia Trad Chin Med. 4:19–20.
  • Wu R, Li X, Xu P, Huang L, Cheng J, Huang X, Jiang J, Wu LJ, Tang Y. 2017. TREM2 protects against cerebral ischemia/reperfusion injury. Mol Brain. 10(1):20.
  • Xie Y, Ye S, Zhang J, He M, Dong C, Tu W, Liu P, Shao C. 2016. Protective effect of mild endoplasmic reticulum stress on radiation-induced bystander effects in hepatocyte cells. Sci Rep. 6:38832.
  • Xiong D, Deng Y, Huang B, Yin C, Liu B, Shi J, Gong Q. 2016. Icariin attenuates cerebral ischemia–reperfusion injury through inhibition of inflammatory response mediated by NF-κB, PPARα and PPARγ in rats. Int Immunopharmacol. 30:157–162.
  • Yang Z, Zhong L, Xian R, Yuan B. 2015. MicroRNA-223 regulates inflammation and brain injury via feedback to NLRP3 inflammasome after intracerebral hemorrhage. Mol Immunol. 65(2):267–276.
  • Yao ST, Cao F, Chen JL, Chen W, Fan RM, Li G, Zeng YC, Jiao S, Xia XP, Han C, et al. 2017. NLRP3 is required for complement-mediated caspase-1 and IL-1beta activation in ICH. J Mol Neurosci. 61(3):385–395.
  • Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K. 2001. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell. 107(7):881–891.
  • Yuan L, Li X, Feng J, Yin C, Yuan F, Wang X. 2014. IRE1α is essential for Xenopus pancreas development. J Biomed Res. 28(2):123–131.
  • Yue S, Zhu J, Zhang M, Li C, Zhou X, Zhou M, Ke M, Busuttil RW, Ying QL, Kupiec-Weglinski JW, et al. 2016. The myeloid heat shock transcription factor 1/β-catenin axis regulates NLR family, pyrin domain-containing 3 inflammasome activation in mouse liver ischemia/reperfusion injury. Hepatology. 64(5):1683–1698.
  • Zhu HR, Wang ZY, Zhu XL, Wu XX, Li EG, Xu Y. 2010. Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha expression in experimental stroke. Neuropharmacology. 59(1–2):70–76.