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Research Article

Salidroside orchestrates metabolic reprogramming by regulating the Hif-1α signalling pathway in acute mountain sickness

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Pages 1538-1548 | Received 13 May 2021, Accepted 07 Oct 2021, Published online: 05 Nov 2021

References

  • Baik SH, Kang S, Lee W, Choi H, Chung S, Kim JI, Mook-Jung I. 2019. A breakdown in metabolic reprogramming causes microglia dysfunction in Alzheimer's disease. Cell Metab. 30(3):493–507.e6.
  • Chang PK, Yen IC, Tsai WC, Chang TC, Lee SY. 2018. Protective effects of Rhodiola crenulata extract on hypoxia-induced endothelial damage via regulation of AMPK and ERK pathways. Int J Mol Sci. 19(8):2286.
  • Chang X, Zhang K, Zhou R, Luo F, Zhu L, Gao J, He H, Wei T, Yan T, Ma C. 2016. Cardioprotective effects of salidroside on myocardial ischemia–reperfusion injury in coronary artery occlusion-induced rats and Langendorff-perfused rat hearts. Int J Cardiol. 215:532–544.
  • Chang YW, Yao HT, Hsieh SH, Lu TJ, Yeh TK. 2007. Quantitative determination of salidroside in rat plasma by on-line solid-phase extraction integrated with high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 857(1):164–169.
  • Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, et al. 2014. mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity. Science. 345(6204):1250684.
  • Erecińska M, Silver IA. 2001. Tissue oxygen tension and brain sensitivity to hypoxia. Respir Physiol. 128:9.
  • Gupta V, Lahiri SS, Sultana S, Kumar R. 2009. Mechanism of action of Rhodiola imbricata Edgew during exposure to cold, hypoxia and restraint (C–H–R) stress induced hypothermia and post stress recovery in rats. Food Chem Toxicol. 47(6):1239–1245.
  • Gupta V, Saggu S, Tulsawani RK, Sawhney RC, Kumar R. 2008. A dose dependent adaptogenic and safety evaluation of Rhodiola imbricata Edgew, a high altitude rhizome. Food Chem Toxicol. 46(5):1645–1652.
  • Hinckelmann MV, Virlogeux A, Niehage C, Poujol C, Choquet D, Hoflack B, Zala D, Saudou F. 2016. Self-propelling vesicles define glycolysis as the minimal energy machinery for neuronal transport. Nat Commun. 7:13233.
  • Ikemoto A, Bole DG, Ueda T. 2003. Glycolysis and glutamate accumulation into synaptic vesicles. Role of glyceraldehyde phosphate dehydrogenase and 3-phosphoglycerate kinase. J Biol Chem. 278(8):5929–5940.
  • Iyer NV, Kotch LE, Agani F, Leung SW, Laughner E, Wenger RH, Gassmann M, Gearhart JD, Lawler AM, Yu AY, et al. 1998. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev. 12(2):149–162.
  • Liang ZL, Zhang XY, Wang F, Zhang K, Liu HF, Liu HL. 2018. Understanding molecular mechanisms of Rhodiola rosea for the treatment of acute mountain sickness through computational approaches (a STROBE-compliant article). Medicine. 97(39):e11886.
  • Liu B, Wei H, Lan M, Jia N, Liu J, Zhang M. 2020. MicroRNA-21 mediates the protective effects of salidroside against hypoxia/reoxygenation-induced myocardial oxidative stress and inflammatory response. Exp Ther Med. 19(3):1655–1664.
  • Liu X, Wen S, Yan F, Liu K, Liu L, Wang L, Zhao S, Ji X. 2018. Salidroside provides neuroprotection by modulating microglial polarization after cerebral ischemia. J Neuroinflamm. 15:39.
  • Marrif H, Juurlink BHJ. 1999. Astrocytes respond to hypoxia by increasing glycolytic capacity. J Neurosci Res. 57(2):255–260.
  • Schodel J, Ratcliffe PJ. 2019. Mechanisms of hypoxia signalling: new implications for nephrology. Nat Rev Nephrol. 15(10):641–659.
  • Semenza GL. 2004. Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology. 19:176–182.
  • Semenza GL. 2011. Oxygen sensing, homeostasis, and disease. N Engl J Med. 365(6):537–547.
  • Semenza GL. 2012. Hypoxia-inducible factors in physiology and medicine. Cell. 148(3):399–408.
  • Shevtsov VA, Zholus BI, Shervarly VI, Vol'skij VB, Korovin YP, Khristich MP, Roslyakova NA, Wikman G. 2003. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine. 10(2–3):95–105.
  • Vangeison G, Carr D, Federoff HJ, Rempe DA. 2008. The good, the bad, and the cell type-specific roles of hypoxia inducible factor-1 alpha in neurons and astrocytes. J Neurosci. 28(8):1988–1993.
  • Villa P, Bigini P, Mennini T, Agnello D, Laragione T, Cagnotto A, Viviani B, Marinovich M, Cerami A, Coleman TR, et al. 2003. Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis. J Exp Med. 198(6):971–975.
  • Wang JA, Chen TL, Jiang J, Shi H, Gui C, Luo RH, Xie XJ, Xiang MX, Zhang X. 2008. Hypoxic preconditioning attenuates hypoxia/reoxygenation-induced apoptosis in mesenchymal stem cells. Acta Pharmacol Sin. 29(1):74–82.
  • Wang JM, Qu ZQ, Wu JL, Chung P, Zeng YS. 2017. Mitochondrial protective and anti-apoptotic effects of Rhodiola crenulata extract on hippocampal neurons in a rat model of Alzheimer's disease. Neural Regen Res. 12(12):2025–2034.
  • Wang X, Hou Y, Li Q, Li X, Wang W, Ai X, Kuang T, Chen X, Zhang Y, Zhang J, et al. 2019. Rhodiola crenulata attenuates apoptosis and mitochondrial energy metabolism disorder in rats with hypobaric hypoxia-induced brain injury by regulating the HIF-1α/microRNA 210/ISCU1/2(COX10) signaling pathway. J Ethnopharmacol. 241:111801.
  • Wei Y, Hong H, Zhang X, Lai W, Wang Y, Chu K, Brown J, Hong G, Chen L. 2017. Salidroside inhibits inflammation through PI3K/Akt/HIF signaling after focal cerebral ischemia in rats. Inflammation. 40(4):1297–1309.
  • Yan R, Xu H, Fu X. 2018. Salidroside protects hypoxia-induced injury by up-regulation of miR-210 in rat neural stem cells. Biomed Pharmacother. 103:1490–1497.
  • Yellen G. 2018. Fueling thought: management of glycolysis and oxidative phosphorylation in neuronal metabolism. J Cell Biol. 217(7):2235–2246.
  • Yi L, Longfang Z, Mikray S, Yun H, Shenyi L, Ruojun Q. 2015. Protective effects of prophylactic Caplendus rhodiola capsules on acute mountain sickness. Chin J Clin. 9:2296–2299.
  • Zhang L, Ding W, Sun H, Zhou Q, Huang J, Li X, Xie Y, Chen J. 2012. Salidroside protects PC12 cells from MPP+-induced apoptosis via activation of the PI3K/Akt pathway. Food Chem Toxicol. 50(8):2591–2597.
  • Zhang L, Yu H, Sun Y, Lin X, Chen B, Tan C, Cao G, Wang Z. 2007. Protective effects of salidroside on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells. Eur J Pharmacol. 564(1–3):18–25.
  • Zheng KY, Zhang ZX, Guo AJ, Bi CW, Zhu KY, Xu SL, Zhan JY, Lau DT, Dong TT, Choi RC, et al. 2012. Salidroside stimulates the accumulation of HIF-1α protein resulted in the induction of EPO expression: a signaling via blocking the degradation pathway in kidney and liver cells. Eur J Pharmacol. 679(1–3):34–39.