Compound Danshen Dripping Pill inhibits high altitude-induced hypoxic damage by suppressing oxidative stress and inflammatory responses

References

• A X, Li Z, Luo W, Chai J. 2020. Long-term compound danshen dripping pills therapy reduces the no-reflow phenomenon in nondiabetes mellitus patients after primary percutaneous coronary intervention for acute myocardial infarction. Ann Palliat Med. 9(3):1144–1151.
   PubMed Web of Science ®Google Scholar
• Bailey DM, Davies B. 2001. Acute mountain sickness; prophylactic benefits of antioxidant vitamin supplementation at high altitude. High Alt Med Biol. 2(1):21–29.
   PubMed Web of Science ®Google Scholar
• Balaban DY, Duffin J, Preiss D, Mardimae A, Vesely A, Slessarev M, Zubieta-Calleja GR, Greene ER, MacLeod DB, Fisher JA. 2013. The in-vivo oxyhaemoglobin dissociation curve at sea level and high altitude. Respir Physiol Neurobiol. 186(1):45–52.
   PubMed Web of Science ®Google Scholar
• Barshtein G, Ben-Ami R, Yedgar S. 2007. Role of red blood cell flow behavior in hemodynamics and hemostasis. Expert Rev Cardiovasc Ther. 5(4):743–752.
   PubMedGoogle Scholar
• Ciaccio C, Di Pierro D, Sbardella D, Tundo GR, Curatolo P, Galasso C, Santarone ME, Casasco M, Cozza P, Cortelazzo A, et al. 2017. Oxygen exchange and energy metabolism in erythrocytes of Rett syndrome and their relationships with respiratory alterations. Mol Cell Biochem. 426(1–2):205–213.
   PubMed Web of Science ®Google Scholar
• Clarke C. 2006. Acute mountain sickness: medical problems associated with acute and subacute exposure to hypobaric hypoxia. Postgrad Med J. 82(973):748–753.
   PubMed Web of Science ®Google Scholar
• Collier DJ, Wolff CB, Hedges A-M, Nathan J, Flower RJ, Milledge JS, Swenson ER. 2016. Benzolamide improves oxygenation and reduces acute mountain sickness during a high-altitude trek and has fewer side effects than acetazolamide at sea level. Pharmacol Res Perspect. 4(3):e00203.
   PubMed Web of Science ®Google Scholar
• Ding F, Yan Y, Huang J, Mei J, Zhu J, Liu H. 2013. The involvement of AQP1 in heart oedema induced by global myocardial ischemia. Cell Biochem Funct. 31(1):60–64.
   PubMed Web of Science ®Google Scholar
• Dong C, Wang G, Li B, Xiao K, Ma Z, Huang H, Wang X, Bai C. 2012. Anti-asthmatic agents alleviate pulmonary edema by upregulating AQP1 and AQP5 expression in the lungs of mice with OVA-induced asthma. Respir Physiol Neurobiol. 181(1):21–28.
   PubMed Web of Science ®Google Scholar
• Dosek A, Ohno H, Acs Z, Taylor AW, Radak Z. 2007. High altitude and oxidative stress. Respir Physiol Neurobiol. 158(2–3):128–131.
   PubMed Web of Science ®Google Scholar
• Fagenholz PJ, Gutman JA, Murray AF, Harris NS. 2007. Treatment of high altitude pulmonary edema at 4240 m in Nepal. High Alt Med Biol. 8(2):139–146.
   PubMed Web of Science ®Google Scholar
• Fan P, Ma H, Jing L, Li L, Jia Z. 2013. The antioxidative effect of a novel free radical scavenger 4'-hydroxyl-2-substituted phenylnitronyl nitroxide in acute high-altitude hypoxia mice. Biol Pharm Bull. 36(6):917–924.
   PubMed Web of Science ®Google Scholar
• Feng P. 2019. Effect of compound Danshen dripping pills on blood oxygen saturation and heart rate of passengers on high altitude trains. Qinghai J Med. 49(04):23–24. Chinese
   Google Scholar
• Gong G, Yin L, Yuan L, Sui D, Sun Y, Fu H, Chen L, Wang X. 2018. Ganglioside GM1 protects against high altitude cerebral edema in rats by suppressing the oxidative stress and inflammatory response via the PI3K/AKT-Nrf2 pathway. Mol Immunol. 95:91–98.
   PubMed Web of Science ®Google Scholar
• Guilbert C, Chayer B, Allard L, Yu FTH, Cloutier G. 2017. Influence of erythrocyte aggregation on radial migration of platelet-sized spherical particles in shear flow. J Biomechan. 61:26–33.
   PubMed Web of Science ®Google Scholar
• Guo J, Yong Y, Aa J, Cao B, Sun R, Yu X, Huang J, Yang N, Yan L, Li X, et al. 2016. Compound danshen dripping pills modulate the perturbed energy metabolism in a rat model of acute myocardial ischemia. Sci Rep. 6:37919.
   PubMed Web of Science ®Google Scholar
• Hackett PH, Schoene RB, Winslow RM, Peters RMJ, West JB. 1985. Acetazolamide and exercise in sojourners to 6,300 meters—a preliminary study. Med Sci Sports Exer. 17:593–597.
   PubMed Web of Science ®Google Scholar
• Hall C. 2004. Essential biochemistry and physiology of (NT-pro)BNP. Eur J Heart Fail. 6(3):257–260.
   PubMed Web of Science ®Google Scholar
• Han J, Li Q, Ma Z, Fan J. 2017. Effects and mechanisms of compound Chinese medicine and major ingredients on microcirculatory dysfunction and organ injury induced by ischemia/reperfusion. Pharmacol Ther. 177:146–173.
   PubMed Web of Science ®Google Scholar
• Harrison MF, Anderson PJ, Johnson JB, Richert M, Miller AD, Johnson BD. 2016. Acute mountain sickness symptom severity at the South Pole: the influence of self-selected prophylaxis with acetazolamide. PLoS One. 11(2):e0148206.
   PubMed Web of Science ®Google Scholar
• Higgins JPT, Green S, editors. 2011. Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated 2011 March]. Res Synth Methods. 2(2):126–130.
   Google Scholar
• Hsieh S, Tsai J, Yang S, Tang M, Hsieh Y. 2014. Metformin inhibits the invasion of human hepatocellular carcinoma cells and enhances the chemosensitivity to sorafenib through a downregulation of the ERK/JNK-mediated NF-κB-dependent pathway that reduces uPA and MMP-9 expression. Amino Acids. 46(12):2809–2822.
   PubMed Web of Science ®Google Scholar
• Hu Y, Yagüe E, Zhao J, Wang L, Bai J, Yang Q, Pan T, Zhao H, Liu J, Zhang J. 2018. Sabutoclax, pan-active BCL-2 protein family antagonist, overcomes drug resistance and eliminates cancer stem cells in breast cancer. Cancer Lett. 423:47–59.
   PubMed Web of Science ®Google Scholar
• Imray C, Wright A, Subudhi A, Roach R. 2010. Acute mountain sickness: pathophysiology, prevention, and treatment. Prog Cardiovas Dis. 52(6):467–484.
   PubMed Web of Science ®Google Scholar
• Jacqueline PH, Lorenz R, Inge HUS, M RGMT, M TABM, Daniel B, Otto S, Marco M, R HA. 2010. Changes of coagulation parameters during high altitude expedition. Swiss Med Weekly. 140 (7–8):111–117.
   PubMed Web of Science ®Google Scholar
• Jia Q, Zhu R, Tian Y, Chen B, Li R, Li L, Wang L, Che Y, Zhao D, Mo F, et al. 2019. Salvia miltiorrhiza in diabetes: a review of its pharmacology, phytochemistry, and safety. Phytomedicine. 58:152871.
   PubMed Web of Science ®Google Scholar
• Li K, Li L, Fu J, He Y, Song Z, Zhou S, Gesang L, Liu R. 2020. Efficacy of Danshen (Salvia miltiorrhiza) dripping pills for prevention of acute mountain sickness: a randomized, double-blind, placebo-controlled trial. Pakistan J Zool. 52:2215–2226.
   Web of Science ®Google Scholar
• Li L, Weng Z, Yao C, Song Y, Ma T. 2015. Aquaporin-1 deficiency protects against myocardial infarction by reducing both edema and apoptosis in mice. Sci Rep. 5:13807.
   PubMed Web of Science ®Google Scholar
• Li Y, Zhang Y, Zhang Y. 2018. Research advances in pathogenesis and prophylactic measures of acute high altitude illness. Respir Med. 145:145–152.
   PubMed Web of Science ®Google Scholar
• Li Z, Gao C, Wang Y, Liu F, Ma L, Deng C, Niu K, Lin M, Wang C. 2011. Reducing pulmonary injury by hyperbaric oxygen preconditioning during simulated high altitude exposure in rats. J Trauma. 71(3):673–679.
   PubMedGoogle Scholar
• Li Z, Guo J, Liu C, Shi Y, Li Y, Wang J, Li D, Wang J, Chen Y. 2020. Compound Danshen dripping pill promotes adaptation to acute high-altitude exposure. High Alt Med Biol. 21(3):258–264.
   PubMed Web of Science ®Google Scholar
• Li Z, Xu S, Liu P. 2018. Salvia miltiorrhiza Burge (Danshen): a golden herbal medicine in cardiovascular therapeutics. Acta Pharmacol Sin. 39(5):802–824.
   PubMed Web of Science ®Google Scholar
• Liang Y, Zou J, Zhang X, Wang Y, Tai J, Guo D, Cui C, Wang J, Cheng J, Shi Y. 2018. The relationship between compound Danshen dripping pills with isosorbide mononitrate in the treatment of elderly patients with unstable angina pectoris. Evid Based Complement Alternat Med. 2018:1–3429151.
   Web of Science ®Google Scholar
• Lisk C, McCord J, Bose S, Sullivan T, Loomis Z, Nozik-Grayck E, Schroeder T, Hamilton K, Irwin DC. 2013. Nrf2 activation: a potential strategy for the prevention of acute mountain sickness. Free Radic Biol Med. 63:264–273.
   PubMed Web of Science ®Google Scholar
• Liu L, Zhang X. 2017. Effect of compound danshen dropping pill and trimetazidine on blood oxygen saturation and heart rate of medical-team members after entering plateau. Med J Nat Defending Forces Northwest China. 38(04):215–219. Chinese
   Google Scholar
• Lu W, Zhang X, Cheng S, Shi B. 2016. Protective effects of compound Danshen dripping pills on early diabetic kidney disease and its underlying mechanism. J Xi’an Jiaotong Univ (Med Sci). 37(01):128–133.
   Google Scholar
• Mairbäurl H, Weber RE. 2012. Oxygen transport by hemoglobin. Comprehen Physiol. 2:1463–1489.
   PubMed Web of Science ®Google Scholar
• Mannucci PM, Gringeri A, Peyvandi F, Paolantonio TD, Mariani G. 2002. Short-term exposure to high altitude causes coagulation activation and inhibits fibrinolysis. Thromb Haemost. 87(2):342–343.
   PubMed Web of Science ®Google Scholar
• Nieto Estrada VH, Molano Franco D, Medina RD, Gonzalez Garay AG, Martí-Carvajal AJ, Arevalo-Rodriguez I. 2017. Interventions for preventing high altitude illness: part 1. Commonly-used classes of drugs. Cochrane Database Syst Rev. 6(6):CD009761.
   PubMedGoogle Scholar
• Ono Y, Morifusa M, Ikeda S, Kunishige C, Tohma Y. 2017. A case of non-cardiogenic pulmonary edema provoked by intravenous acetazolamide. Acute Med Surg. 4(3):349–352.
   PubMed Web of Science ®Google Scholar
• Pajuelo Reguera D, Čunátová K, Vrbacký M, Pecinová A, Houštěk J, Mráček T, Pecina P. 2020. Cytochrome C oxidase subunit 4 isoform exchange results in modulation of oxygen affinity. Cells. 9(2):443.
   PubMed Web of Science ®Google Scholar
• Pan Y, Zhang Y, Yuan J, Ma X, Zhao Y, Li Y, Li F, Gong X, Zhao J, Tang H, et al. 2020. Tetrahydrocurcumin mitigates acute hypobaric hypoxia-induced cerebral oedema and inflammation through the NF-κB/VEGF/MMP-9 pathway. Phytother Res. 34(11):2963–2977.
   PubMed Web of Science ®Google Scholar
• Reinhart WH, Kayser B, Singh A, Waber U, Oelz O, Bartsch P. 1991. Blood rheology in acute mountain sickness and high-altitude pulmonary edema. J Appl Physiol. 71(3):934–938.
   PubMed Web of Science ®Google Scholar
• Ren J, Fu L, Nile SH, Zhang J, Kai G. 2019. Salvia miltiorrhiza in treating cardiovascular diseases: a review on its pharmacological and clinical applications. Front Pharmacol. 10:753.
   PubMed Web of Science ®Google Scholar
• Roach RC, Hackett PH. 2001. Frontiers of hypoxia research: acute mountain sickness. J Exper Biol. 204(18):3161–3170.
   PubMed Web of Science ®Google Scholar
• Tan J, Gao C, Wang C, Ma L, Hou X, Liu X, Li Z. 2020. Expression of aquaporin-1 and aquaporin-5 in a rat model of high-altitude pulmonary edema and the effect of hyperbaric oxygen exposure. Dose Response. 18(4):1559325820970821.
   Web of Science ®Google Scholar
• Tian K, Tang W, Su Y, Zhang Y, Chen K. 2012. Observation on the effect of treating acute severe altitude sickness in portable pressurized cabin at high altitude. People’s Military Surg. 55:1155–1157. Chinese
   Google Scholar
• Toff WD, Jones CI, Ford I, Pearse RJ, Watson HG, Watt SJ, Ross JAS, Gradwell DP, Batchelor AJ, Abrams KR, et al. 2006. Effect of hypobaric hypoxia, simulating conditions during long-haul air travel, on coagulation, fibrinolysis, platelet function, and endothelial activation. JAMA. 295(19):2251–2261.
   PubMed Web of Science ®Google Scholar
• Torgovicky R, Azaria B, Grossman A, Eliyahu U, Goldstein L. 2005. Sinus vein thrombosis following exposure to simulated high altitude. Aerospace Med Human Performance. 76:144–146.
   Google Scholar
• Tripathi A, Kumar B, Sagi SSK. 2019. Prophylactic efficacy of quercetin in ameliorating the hypoxia induced vascular leakage in lungs of rats. PLOS One. 14(6):e0219075.
   PubMed Web of Science ®Google Scholar
• Wang C, Jiang H, Duan J, Chen J, Wang Q, Liu X, Wang C. 2018. Exploration of acute phase proteins and inflammatory cytokines in early stage diagnosis of acute mountain sickness. High Alt Med Biol. 19(2):170–177.
   PubMed Web of Science ®Google Scholar
• Wang C, Wang R, Xie H, Sun Y, Tao R, Liu W, Li W, Lu H, Jia Z. 2016. Effect of acetazolamide on cytokines in rats exposed to high altitude. Cytokine. 83:110–117.
   PubMed Web of Science ®Google Scholar
• Wei X, Liu Y, Li Q, Yan L, Hu B, Pan C, Li Z, Chang X, Fan J, Zhao N, et al. 2013. Treatment with Cardiotonic pills® after ischemia-reperfusion ameliorates myocardial fibrosis in rats . Microcirculation. 20(1):17–29.
   PubMed Web of Science ®Google Scholar
• Wei Y, Lu C, Wei C, Ma Y, Lee H. 2001. Oxidative stress in human aging and mitochondrial disease-consequences of defective mitochondrial respiration and impaired antioxidant enzyme system. Chinese J Physiol. 44(1):1–12.
   PubMed Web of Science ®Google Scholar
• Xiang H, Xue W, Li Y, Zheng J, Ding C, Dou M, Wu X. 2020. Knockdown of ANGPTL2 protects renal tubular epithelial cells against hypoxia/reoxygenation-induced injury via suppressing TLR4/NF-κB signaling pathway and activating Nrf2/HO-1 signaling pathway. Cell Transplant. 29:963689720946663–963689720946663.
   PubMed Web of Science ®Google Scholar
• Yanamandra U, Boddu R, Pramanik S, Mishra K, Kapoor R, Ahuja A, Chatterjee T, Das S. 2020. Prevalence and clinical characteristics of post-thrombotic syndrome in high-altitude-induced deep vein thrombosis: experience of a single tertiary care center from real-world settings. High Alt Med Biol. 21(4):319–326.
   PubMed Web of Science ®Google Scholar
• Yao D, Wang C, Han L, Zhang P, Liu J, Wang B, Zhang E. 2019. Compound danshen dripping pills combined with trimetazidine in treating unstable angina pectoris: protocol for a systematic review of randomized controlled trials. Medicine. 98(49):e18238.
   PubMed Web of Science ®Google Scholar
• Yao Y, Feng Y, Lin W. 2015. Systematic review and meta-analysis of randomized controlled trials comparing compound danshen dripping pills and isosorbide dinitrate in treating angina pectoris. Int J Cardiol. 182:46–47.
   PubMed Web of Science ®Google Scholar
• Zhang X, Pei Z, Yan X, Guo Z, Wu D. 2008. Effects of compound danshen dropping pills on cardiovascular response in plateau acclimatization. Chinese J Pathophysiological. 11:2257–2259.
   Google Scholar
• Zhang X, Zhang X, Dang Z, Su S, Li Z, Lu D. 2020. Cognitive protective mechanism of crocin pretreatment in rat submitted to acute high-altitude hypoxia exposure. Biomed Res Int. 2020:3409679.
   PubMed Web of Science ®Google Scholar
• Zheng Q, Chen W, Wang Y, Xu X. 2011. The effects of Dan-shen dripping pills on the expression of HIF-1α and VEGF in renal tissues of type 2 diabetic rats. Chinese J Health Care Med. 13:200–203.
   Google Scholar
• Zhou J, Xun Y, Huang S, Luo Z, Qin Y. 2015. Effect of compound Danshen dripping pills on the function of islet β cells of type 2 diabetic rats. Chinese Trad Patent Med. 37:1807–1810.
   Google Scholar