Gender differences in cardiovascular risk, treatment, and outcomes: a post hoc analysis from the REWIND trial

References

• Nichols M, Townsend N, Scarborough P, et al. Cardiovascular disease in Europe 2014: epidemiological update. Eur Heart J. 2014;35(42):2950–2959.
   PubMedGoogle Scholar
• Wright AK, Kontopantelis E, Emsley R, et al. Cardiovascular risk and risk factor management in type 2 diabetes mellitus. Circulation. 2019;139(24):2742–2753.
   PubMed Web of Science ®Google Scholar
• Peters SA, Huxley RR, Woodward M. Diabetes as risk factor for incident coronary heart disease in women compared with men: a systematic review and meta-analysis of 64 cohorts including 858,507 individuals and 28,203 coronary events. Diabetologia. 2014;57(8):1542–1551.
   PubMed Web of Science ®Google Scholar
• Huxley R, Barzi F, Woodward M. Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies. BMJ. 2006;332(7533):73–78.
   PubMed Web of Science ®Google Scholar
• Prospective Studies Collaboration and Asia Pacific Cohort Studies Collaboration. Sex-specific relevance of diabetes to occlusive vascular and other mortality: a collaborative meta-analysis of individual data from 980 793 adults from 68 prospective studies. Lancet Diabetes Endocrinol. 2018;6:538–546.
   PubMed Web of Science ®Google Scholar
• Cangemi R, Romiti GF, Campolongo G, et al. Gender related differences in treatment and response to statins in primary and secondary cardiovascular prevention: the never-ending debate. Pharmacol Res. 2017;117:148–155.
   PubMed Web of Science ®Google Scholar
• Kulenovic I, Mortensen MB, Bertelsen J, et al. Statin use prior to first myocardial infarction in contemporary patients: inefficient and not gender equitable. Prev Med. 2016;83:63–69.
   PubMed Web of Science ®Google Scholar
• Ji H, Kim A, Ebinger JE, et al. S. Sex differences in blood pressure trajectories over the life course. JAMA Cardiol. 2020;5(3):19–26.
   PubMed Web of Science ®Google Scholar
• Regitz-Zagrosek V, Kararigas G. Mechanistic pathways of sex differences in cardiovascular disease. Physiol Rev. 2017;97(1):1–37.
   PubMed Web of Science ®Google Scholar
• Gerstein HC, Colhoun HM, Dagenais GR, et al. Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial. Lancet. 2019;394(10193):121–130.
   PubMed Web of Science ®Google Scholar
• Gerstein HC, Colhoun HM, Dagenais GR, et al. Design and baseline characteristics of participants in the researching cardiovascular events with a weekly INcretin in diabetes (REWIND) trial on the cardiovascular effects of dulaglutide. Diabetes Obes Metab. 2018;20(1):42–49.
   PubMed Web of Science ®Google Scholar
• SAS®/STAT user’s guide: high performance procedures; 2018 [accessed 2021 Feb 15]. Available from: https://documentation.sas.com/?cdcId=pgmsascdc&cdcVersion=9.4_3.4&docsetId=stathpug&docsetTarget=stathpug_introcom_stat_sect032.htm&locale=en
   Google Scholar
• Hambraeus K, Tydén P, Lindahl B. Time trends and gender differences in prevention guideline adherence and outcome after myocardial infarction: data from the SWEDEHEART registry. Eur J Prev Cardiol. 2016;23(4):340–348.
   PubMed Web of Science ®Google Scholar
• Gouni-Berthold I, Berthold HK, Mantzoros CS, et al. Sex disparities in the treatment and control of cardiovascular risk factors in type 2 diabetes. Diabetes Care. 2008;31(7):1389–1391.
   PubMed Web of Science ®Google Scholar
• Sekerija M, Poljicanin T, Erjavec K, et al. Gender differences in the control of cardiovascular risk factors in patients with type 2 diabetes -a cross-sectional study. Intern Med. 2012;51(2):161–166.
   PubMed Web of Science ®Google Scholar
• 9. Cardiovascular disease and risk management: standards of medical care in diabetes-2018. Diabetes Care. 2018;41:s86–s104.
   PubMed Web of Science ®Google Scholar
• Davies MJ, D’Alessio DA, Fradkin J, et al. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2018;41(12):2669–2701.
   PubMed Web of Science ®Google Scholar
• Grundy SM, Stone NJ, Bailey AL Jr, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol: executive summary. J Am Coll Cardiol. 2019;73(24):3168–3209.
   PubMed Web of Science ®Google Scholar
• Whelton PK, Carey RM, Aronow WS, et al. ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2018;71(19):2273–2275.
   PubMed Web of Science ®Google Scholar
• Bethel MA, Green JB, Milton J, et al. Age and sex differences in baseline characteristics of patients enrolled in the trial evaluating cardiovascular outcomes with sitagliptin (TECOS). Diabetes Obes Metab. 2015;17(4):395–402.
   PubMed Web of Science ®Google Scholar
• Clemens KK, Woodward M, Neal B, et al. Sex disparities in cardiovascular outcome trials of populations with diabetes: a systematic review and meta-analysis. Diabetes Care. 2020;43(5):1157–1163.
   PubMed Web of Science ®Google Scholar
• Peters SAE, Woodward M. Sex differences in the burden and complications of diabetes. Curr Diab Rep. 2018;18(6):33.
   PubMed Web of Science ®Google Scholar
• Peters SA, Huxley RR, Woodward M. Diabetes as a risk factor for stroke in women compared with men: a systematic review and meta-analysis of 64 cohorts, including 775,385 individuals and 12,539 strokes. Lancet. 2014;383(9933):1973–1980.
   PubMed Web of Science ®Google Scholar
• Bushnell C, McCullough LD, Awad IA, et al. Guidelines for the prevention of stroke in women: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45(5):1545–1588.
   PubMed Web of Science ®Google Scholar
• Peters SAE, Colantonio LD, Chen L, et al. Sex differences in incident and recurrent coronary events and all-cause mortality. J Am Coll Cardiol. 2020;76(15):1751–1760.
   PubMed Web of Science ®Google Scholar