Adipokines are possible risk markers for aortic stenosis requiring surgery

References

• Thaden JJ, Nkomo VT, Enriquez-Sarano M. The global burden of aortic stenosis. Prog Cardiovasc Dis. 2014; 56(6):565–571. doi: 10.1016/j.pcad.2014.02.006.
   PubMed Web of Science ®Google Scholar
• Lindman BR, Clavel MA, Mathieu P, et al. Calcific aortic stenosis. Nat Rev Dis Primers. 2016;2:16006. doi: 10.1038/nrdp.2016.6.
   PubMed Web of Science ®Google Scholar
• Joseph J, Naqvi SY, Giri J, et al. Aortic stenosis: pathophysiology, diagnosis, and therapy. Am J Med. 2017;130(3):253–263. Mardoi: 10.1016/j.amjmed.2016.10.005.
   PubMed Web of Science ®Google Scholar
• Otto CM, Kuusisto J, Reichenbach DD, et al. Characterization of the early lesion of ‘degenerative’ valvular aortic stenosis. Histological and immunohistochemical studies. Circulation. 1994;90(2):844–853. doi: 10.1161/01.cir.90.2.844.
   PubMed Web of Science ®Google Scholar
• Yan AT, Koh M, Chan KK, et al. Association Between cardiovascular risk factors and aortic stenosis: the CANHEART aortic stenosis study. J Am Coll Cardiol. 2017;69(12):1523–1532. doi: 10.1016/j.jacc.2017.01.025.
   PubMed Web of Science ®Google Scholar
• Stewart BF, Siscovick D, Lind BK, et al. Clinical factors associated with calcific aortic valve disease. Cardiovascular health study. J Am Coll Cardiol. 1997;29(3):630–634. doi: 10.1016/s0735-1097(96)00563-3.
   PubMed Web of Science ®Google Scholar
• Meidell Blylod V, Rinnström D, Pennlert J, et al. Traditional cardiovascular risk factors and their relation to future surgery for valvular heart disease or ascending aortic disease: a case-referent study. J Am Heart Assoc. 2022;11(14)[:e023954. Mismatch]
   PubMedGoogle Scholar
• Redfors B, Furer A, Lindman BR, et al. Biomarkers in aortic stenosis: a systematic review. Structural Heart. 2017;1(1-2):18–30. doi: 10.1080/24748706.2017.1329959.
   Web of Science ®Google Scholar
• Ljungberg J, Holmgren A, Bergdahl IA, et al. Lipoprotein(a) and the apolipoprotein B/A1 ratio independently associate With surgery for aortic stenosis only in patients with concomitant coronary artery disease. J Am Heart Assoc. 2017;6(12):1–11. doi: 10.1161/JAHA.117.007160.
   Web of Science ®Google Scholar
• Holmgren A, Ljungberg J, Hultdin J, et al. Troponin T but not C reactive protein is associated with future surgery for aortic stenosis: a population-based nested case-referent study. Open Heart. 2020;7(2):1–10. doi: 10.1136/openhrt-2020-001325.
   Web of Science ®Google Scholar
• Soderberg S, Ahren B, Jansson JH, et al. Leptin is associated with increased risk of myocardial infarction. J Intern Med. 1999;246(4):409–418. doi: 10.1046/j.1365-2796.1999.00571.x.
   PubMed Web of Science ®Google Scholar
• Soderberg S, Stegmayr B, Stenlund H, et al. Leptin, but not adiponectin, predicts stroke in males. J Intern Med. 2004;256(2):128–136. doi: 10.1111/j.1365-2796.2004.01351.x.
   PubMed Web of Science ®Google Scholar
• Martin SS, Qasim A, Reilly MP. Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease. J Am Coll Cardiol. 2008;52(15):1201–1210. doi: 10.1016/j.jacc.2008.05.060.
   PubMed Web of Science ®Google Scholar
• Bełtowski J. Role of leptin in blood pressure regulation and arterial hypertension. J Hypertens. 2006; 24(5):789–801. doi: 10.1097/01.hjh.0000222743.06584.66.
   PubMed Web of Science ®Google Scholar
• Lilja M, Rolandsson O, Norberg M, et al. The impact of leptin and adiponectin on incident type 2 diabetes is modified by sex and insulin resistance [research support, Non-U.S. Metab Syndr Relat Disord. 2012;10(2):143–151. doi: 10.1089/met.2011.0123.
   PubMed Web of Science ®Google Scholar
• Li S, Shin HJ, Ding EL, et al. Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis. Jama. 2009;302(2):179–188. doi: 10.1001/jama.2009.976.
   PubMed Web of Science ®Google Scholar
• Glader CA, Birgander LS, Soderberg S, et al. Lipoprotein(a), Chlamydia pneumoniae, leptin and tissue plasminogen activator as risk markers for valvular aortic stenosis. Eur Heart J. 2003;24(2):198–208. doi: 10.1016/s0195-668x(02)00385-8.
   PubMed Web of Science ®Google Scholar
• Rosa M, Paris C, Sottejeau Y, et al. Leptin induces osteoblast differentiation of human valvular interstitial cells via the akt and ERK pathways. Acta Diabetol. 2017;54(6):551–560. doi: 10.1007/s00592-017-0980-3.
   PubMed Web of Science ®Google Scholar
• Mohty D, Pibarot P, Cote N, et al. Hypoadiponectinemia is associated with valvular inflammation and faster disease progression in patients with aortic stenosis. Cardiology. 2011;118(2):140–146. doi: 10.1159/000327588.
   PubMed Web of Science ®Google Scholar
• Norberg M, Wall S, Boman K, et al. The västerbotten intervention programme: background, design and implications. Glob Health Action. 2010;3:1–15.
   Web of Science ®Google Scholar
• Eriksson M, Holmgren L, Janlert U, et al. Large improvements in major cardiovascular risk factors in the population of northern Sweden: the MONICA study 1986–2009. J Intern Med. 2011;269(2):219–231. doi: 10.1111/j.1365-2796.2010.02312.x.
   Google Scholar
• Hallmans G, Agren A, Johansson G, et al. Cardiovascular disease and diabetes in the Northern Sweden health and disease study cohort – evaluation of risk factors and their interactions [evaluation studies]. Scand J Public Health Suppl. 2003;61:18–24. doi: 10.1080/14034950310001432.
   PubMedGoogle Scholar
• Ljungberg J, Janiec M, Bergdahl IA, et al. Proteomic biomarkers for incident aortic stenosis requiring valvular replacement. Circulation. 2018;138(6):590–599. doi: 10.1161/CIRCULATIONAHA.117.030414.
   PubMed Web of Science ®Google Scholar
• Ljungberg J, Johansson B, Engstrom KG, et al. Traditional cardiovascular risk factors and their relation to future surgery for valvular heart disease or ascending aortic disease: a Case-Referent study. J Am Heart Assoc. 2017;6(5):1–12.
   Web of Science ®Google Scholar
• Ljungberg J, Johansson B, Bergdahl IA, et al. Mild impairment of renal function (shrunken pore syndrome) is associated with increased risk for future surgery for aortic stenosis. Scand J Clin Lab Invest. 2019;79(7):524–530. doi: 10.1080/00365513.2019.1664761.
   PubMed Web of Science ®Google Scholar
• Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia. Report of a WHO/IDF Consultation World Health Organization, 2006.
   Google Scholar
• Flower L, Ahuja RH, Humphries SE, et al. Effects of sample handling on the stability of interleukin 6, tumour necrosis factor-alpha and leptin. Cytokine. 2000;12(11):1712–1716. doi: 10.1006/cyto.2000.0764.
   PubMed Web of Science ®Google Scholar
• Lee SA, Kallianpur A, Xiang YB, et al. Intra-individual variation of plasma adipokine levels and utility of single measurement of these biomarkers in population-based studies. Cancer Epidemiol Biomarkers Prev. 2007;16(11):2464–2470. doi: 10.1158/1055-9965.EPI-07-0374.
   PubMed Web of Science ®Google Scholar
• Lilja M, Rolandsson O, Shaw JE, et al. Higher leptin levels in Asian Indians than Creoles and Europids: a potential explanation for increased metabolic risk [research support, Non-U.S. Int J Obes. 2010;34(5):878–885. doi: 10.1038/ijo.2010.19.
   Web of Science ®Google Scholar
• Ciccone M, Vettor R, Pannacciulli N, et al. Plasma leptin is independently associated with the intima-media thickness of the common carotid artery. Int J Obes Relat Metab Disord. 2001;25(6):805–810. doi: 10.1038/sj.ijo.0801623.
   PubMed Web of Science ®Google Scholar
• Maahs DM, Ogden LG, Kinney GL, et al. Low plasma adiponectin levels predict progression of coronary artery calcification. Circulation. 2005;111(6):747–753. 5doi: 10.1161/01.CIR.0000155251.03724.A5.
   PubMed Web of Science ®Google Scholar
• Soderberg S, Olsson T, Eliasson M, et al. Plasma leptin levels are associated with abnormal fibrinolysis in men and postmenopausal women. J Intern Med. 1999;245(5):533–543. doi: 10.1046/j.1365-2796.1999.00472.x.
   PubMed Web of Science ®Google Scholar
• Nakata M, Yada T, Soejima N, et al. Leptin promotes aggregation of human platelets via the long form of its receptor. Diabetes. 1999;48(2):426–429. doi: 10.2337/diabetes.48.2.426.
   PubMed Web of Science ®Google Scholar
• Shin MK, Eraso CC, Mu YP, et al. Leptin induces hypertension acting on transient receptor potential melastatin 7 channel in the carotid body. Circ Res. 2019;125(11):989–1002. doi: 10.1161/CIRCRESAHA.119.315338.
   PubMed Web of Science ®Google Scholar
• Schneiderman J, Schaefer K, Kolodgie FD, et al. Leptin locally synthesized in carotid atherosclerotic plaques could be associated with lesion instability and cerebral emboli. J Am Heart Assoc. 2012;1(5):e001727.
   PubMed Web of Science ®Google Scholar
• Sasako T, Kadowaki H, Fujiwara T, et al. Severe aortic stenosis during leptin replacement therapy in a patient with generalized lipodystrophy-associated progeroid syndrome due to an LMNA variant: a case report. J Diabetes Investig. 2022;13(9):1636–1638. doi: 10.1111/jdi.13827.
   PubMed Web of Science ®Google Scholar
• Arita Y, Kihara S, Ouchi N, et al. Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation. 2002;105(24):2893–2898. doi: 10.1161/01.cir.0000018622.84402.ff.
   PubMed Web of Science ®Google Scholar
• Marsche G, Zelzer S, Meinitzer A, et al. Adiponectin predicts high-density lipoprotein cholesterol efflux capacity in adults irrespective of body mass index and fat distribution. J Clin Endocrinol Metab. 2017;102(11):4117–4123. doi: 10.1210/jc.2017-00933.
   PubMed Web of Science ®Google Scholar
• Gucuk Ipek E, Guray U, Guray Y, et al. Relationship between serum adiponectin levels and calcific aortic valve disease. Kardiol Pol. 2013;71(3):241–246. doi: 10.5603/KP.2013.0035.
   PubMed Web of Science ®Google Scholar
• Roberts WC, Ko JM. Frequency by decades of unicuspid, bicuspid, and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis, with or without associated aortic regurgitation. Circulation. 2005;111(7):920–925. doi: 10.1161/01.CIR.0000155623.48408.C5.
   PubMed Web of Science ®Google Scholar
• Iacobellis G. Epicardial adipose tissue in contemporary cardiology. Nat Rev Cardiol. 2022;19(9):593–606. doi: 10.1038/s41569-022-00679-9.
   PubMed Web of Science ®Google Scholar
• Christou GA, Andriopoulou CE, Liakopoulou A, et al. Unraveling the role of resistin, retinol-binding protein 4 and adiponectin produced by epicardial adipose tissue in cardiac structure and function: evidence of a paracrine effect. Hormones. 2023;22(2):321–330. doi: 10.1007/s42000-023-00447-5.
   PubMedGoogle Scholar
• Katsiki N, Mantzoros C, Mikhailidis DP. Adiponectin, lipids and atherosclerosis. Curr Opin Lipidol. 2017; 28(4):347–354. doi: 10.1097/MOL.0000000000000431.
   PubMed Web of Science ®Google Scholar
• Zhang T, Yang P, Li T, et al. Leptin expression in human epicardial adipose tissue is associated with local coronary atherosclerosis. Med Sci Monit. 2019;25:9913–9922. doi: 10.12659/MSM.918390.
   PubMed Web of Science ®Google Scholar
• Mahabadi AA, Kahlert HA, Dykun I, et al. Epicardial adipose tissue thickness independently predicts severe aortic valve stenosis. J Heart Valve Dis. 2017;26(3):262–267.
   PubMedGoogle Scholar