Association of hyperuricemia and pulmonary hypertension: A systematic review and meta-analysis

References

• Galie N, Hoeper MM, Humbert M, Torbicki A, Vachiery JL, Barbera JA. Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). Eur Heart J. 2009;30:2493–537.
   PubMed Web of Science ®Google Scholar
• Andersen CU, Mellemkjaer S, Nielsen-Kudsk JE, Bendstrup E, Simonsen U, Hilberg O. Diagnostic and prognostic role of biomarkers for pulmonary hypertension in interstitial lung disease. Respir Med. 2012;106(12):1749–55.
   PubMed Web of Science ®Google Scholar
• Bendayan D, Shitrit D, Ygla M, Huerta M, Fink G, Kramer MR. Hyperuricemia as a prognostic factor in pulmonary arterial hypertension. Respir Med. 2003;97(2):130–3.
   PubMed Web of Science ®Google Scholar
• Castillo-Martínez D, Marroquín-Fabián E, Lozada-Navarro AC, Mora-Ramírez M, Juárez M, Sánchez-Muñoz F, et al. Levels of uric acid may predict the future development of pulmonary hypertension in systemic lupus erythematosus: a seven-year follow-up study. Lupus 2016;25(1):61–6.
   PubMed Web of Science ®Google Scholar
• Dimitroulas T, Giannakoulas G, Dimitroula H, Sfetsios T, Parcharidou D, Karvounis H. Significance of serum uric acid in pulmonary hypertension due to systemic sclerosis: a pilot study. Rheumatol Int. 2011;31(2):263–7.
   PubMed Web of Science ®Google Scholar
• Huang C, Li M, Liu Y, Wang Q, Guo X, Zhao J, et al. Baseline characteristics and risk factors of pulmonary arterial hypertension in systemic lupus erythematosus patients. Medicine 2016;95(10):e2761.
   PubMed Web of Science ®Google Scholar
• Joshi K, Anjum F, Gowda S, Damania D, Graham-Hill S, Gillette P, et al. Uric Acid as a potential biomarker of pulmonary arterial hypertension in patients with sickle cell disease. Indian J Hematol Blood Transfus. 2011;27(2):96–100.
   PubMed Web of Science ®Google Scholar
• Rich JD, Rich S. Clinical diagnosis of pulmonary hypertension. Circulation 2014;130(20):1820–30.
   PubMed Web of Science ®Google Scholar
• Sung YK, Chung L. Connective tissue disease-associated pulmonary arterial hypertension. Rheum Dis Clin North Am. 2015;41(2):295–313.
   PubMed Web of Science ®Google Scholar
• Coghlan JG, Denton CP, Grunig E, Bonderman D, Distler O, Khanna D, et al. Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study. Ann Rheum Dis. 2014;73(7):1340–9.
   PubMed Web of Science ®Google Scholar
• Hoeper MM, Hohlfeld JM, Fabel H. Hyperuricaemia in patients with right or left heart failure. Eur Respir J. 1999;13(3):682–5.
   PubMed Web of Science ®Google Scholar
• Van Albada ME, Loot FG, Fokkema R, Roofthooft MTR, Berger RMF. Biological serum markers in the management of pediatric pulmonary arterial hypertension. Pediatr Res. 2008;63(3):321–7.
   PubMed Web of Science ®Google Scholar
• Nagaya N, Uematsu M, Satoh T, Kyotani S, Sakamaki F, Nakanishi N, et al. Serum uric acid levels correlate with the severity and the mortality of primary pulmonary hypertension. Am J Respir Crit Care Med. 1999;160(2):487–92.
   PubMed Web of Science ®Google Scholar
• Voelkel MA, Wynne KM, Badesch DB, Groves BM, Voelkel NF. Hyperuricemia in severe pulmonary hypertension. Chest 2000;117(1):19–24.
   PubMed Web of Science ®Google Scholar
• Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009;62(10):1006–12.
   PubMed Web of Science ®Google Scholar
• Deeks JJ, Dinnes J, D'Amico R, Sowden AJ, Sakarovitch C, Song F, et al. Evaluating non-randomised intervention studies. Health Technol Assess 2003;7:1–173.
   Google Scholar
• Marvisi M, Vento MG, Balzarini L, Mancini C, Marvisi C. Continuous positive airways pressure and uvulopalatopharyngoplasty improves pulmonary hypertension in patients with obstructive sleep apnoea. Lung 2015;193(2):269–74.
   PubMed Web of Science ®Google Scholar
• Bal Z, Sezer S, Uyar ME, Bal U, Kulah E, Guliyev O, et al. Pulmonary hypertension is closely related to arterial stiffness in renal transplant patients. Transplant Proc 2015;47(4):1186–9.
   PubMed Web of Science ®Google Scholar
• Jiang X, Han ZY, Wang Y, Xu XQ, Ma CR, Wu Y, et al. Hemodynamic variables and clinical features correlated with serum uric acid in patients with pulmonary arterial hypertension. Chin Med J. 2008;121(24):2497–503.
   PubMed Web of Science ®Google Scholar
• Njaman W, Iesaki T, Iwama Y, Takasaki Y, Daida H. Serum uric acid as a prognostic predictor in pulmonary arterial hypertension with connective tissue disease. Int Heart J. 2007;48(4):523–32.
   PubMed Web of Science ®Google Scholar
• Oya H, Nagaya N, Satoh T, Sakamaki F, Kyotani S, Fujita M, et al. Haemodynamic correlates and prognostic significance of serum uric acid in adult patients with Eisenmenger syndrome. Heart. 2000;84(1):53–8.
   PubMed Web of Science ®Google Scholar
• Zhang CY, Ma LL, Wang LX. Relationship between serum uric acid levels and ventricular function in patients with idiopathic pulmonary hypertension. Exp Clin Cardiol 2013;18:e37–9.
   PubMedGoogle Scholar
• Amariei DE, Juraschek SP, Kolb TM, Damico RL, Hassoun PM, Mathai SC. The utility of serum uric acid in predicting pulmonary arterial hypertension in patients with scleroderma. Am Thoracic Soc 2015;191:A4829.
   Google Scholar
• Dhaun N, Vachiery JL, Benza RL, Naeije R, Hwang LJ, Liu X, et al. Endothelin antagonism and uric acid levels in pulmonary arterial hypertension: clinical associations. J Heart Lung Transplant. 2014;33(5):521–7.
   PubMed Web of Science ®Google Scholar
• Hu EC, He JG, Liu ZH, Ni XH, Zheng YG, Gu Q, et al. High levels of serum lactate dehydrogenase correlate with the severity and mortality of idiopathic pulmonary arterial hypertension. Exp Ther Med. 2015;9(6):2109–13.
   PubMed Web of Science ®Google Scholar
• Huang YY, Su W, Zhu ZW, Tang L, Hu XQ, Zhou SH, et al. Elevated serum HMGB1 in pulmonary arterial hypertension secondary to congenital heart disease. Vascul Pharmacol. 2016;85:66–72.
   PubMed Web of Science ®Google Scholar
• Jasiewicz M, Knapp M, Waszkiewicz E, Ptaszyńska-Kopczyńska K, Szpakowicz A, Sobkowicz B, et al. Enhanced IL-6 trans-signaling in pulmonary arterial hypertension and its potential role in disease-related systemic damage. Cytokine 2015;73:286–7.
   Google Scholar
• Kim KJ, Baek IW, Park YJ, Yoon CH, Kim WU, Cho CS. High levels of uric acid in systemic lupus erythematosus is associated with pulmonary hypertension. Int J Rheum Dis. 2015;18(5):524–32.
   PubMed Web of Science ®Google Scholar
• Li ZN, He JG, Liu ZH, Gu Q, Ni XH, Cheng XS, et al. Relationship between serum uric acid levels and patient conditions and prognosis in idiopathic pulmonary arterial hypertension. Zhonghua Yi Xue Za Zhi 2012;92:3261–4.
   PubMedGoogle Scholar
• Ozpelit E, Akdeniz B, Sezgin D, Sevinc C, Tertemiz KC, Ozpelit ME, et al. Clinical and hemodynamic profiles of elderly patients with pulmonary arterial hypertension: a single center, prospective study. J Geriatr Cardiol 2017;14:20–7.
   PubMedGoogle Scholar
• Sun PY, Jiang X, Gomberg-Maitland M, Zhao QH, He J, Yuan P, et al. Prolonged QRS duration: A new predictor of adverse outcome in idiopathic pulmonary arterial hypertension. Chest 2012;141(2):374–80.
   PubMed Web of Science ®Google Scholar
• Taguchi H, Kataoka M, Yanagisawa R, Kawakami T, Tamura Y, Fukuda K, et al. Platelet level as a new prognostic factor for idiopathic pulmonary arterial hypertension in the era of combination therapy. Circ J. 2012;76(6):1494–500.
   PubMed Web of Science ®Google Scholar
• Volkov AV, Kurmukov IA, Yudkina NN, Glukhova SI, Nikolaeva EV. Impact of bosentan therapy on stress-induced pulmonary hypertension in patients with systemic sclerosis. Ter Arkh. 2015;87(1):49–56.
   PubMed Web of Science ®Google Scholar
• Yamada Y, Okuda S, Kataoka M, Tanimoto A, Tamura Y, Abe T, et al. Prognostic value of cardiac magnetic resonance imaging for idiopathic pulmonary arterial hypertension before initiating intravenous prostacyclin therapy. Circ J. 2012;76(7):1737–43.
   PubMed Web of Science ®Google Scholar
• Essex MN, Hopps M, Bienen EJ, Udall M, Mardekian J, Makinson GT. Evaluation of the relationship between serum uric acid levels and cardiovascular events in patients with gout: a retrospective analysis using electronic medical record data. J Clin Rheumatol. 2017;23(3):160–6.
   PubMed Web of Science ®Google Scholar
• Gertler MM, Garn SM, Levine SA. Serum uric acid in relation to age and physique in health and in coronary heart disease. Ann Intern Med. 1951;34(6):1421–31.
   PubMed Web of Science ®Google Scholar
• Cannon PJ, Stason WB, Demartini FE, Sommers SC, Laragh JH. Hyperuricemia in primary and renal hypertension. N Engl J Med. 1966;275(9):457–64.
   PubMed Web of Science ®Google Scholar
• Feig DI, Kang DH, Johnson RJ. Uric acid and cardiovascular risk. N Engl J Med. 2008;359(17):1811–21.
   PubMed Web of Science ®Google Scholar
• Elsayed NM, Nakashima JM, Postlethwait EM. Measurement of uric acid as a marker of oxygen tension in the lung. Arch Biochem Biophys. 1993;302(1):228–32.
   PubMed Web of Science ®Google Scholar
• Huizer T, de Jong JW, Nelson JA, Czarnecki W, Serruys PW, Bonnier JJ, et al. Urate production by human heart. J Mol Cell Cardiol. 1989;21(7):691–5.
   PubMed Web of Science ®Google Scholar
• McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med. 1985;312(3):159–63.
   PubMed Web of Science ®Google Scholar
• Braghiroli A, Sacco C, Erbetta M, Ruga V, Donner CF. Overnight urinary uric acid: creatinine ratio for detection of sleep hypoxemia. Validation study in chronic obstructive pulmonary disease and obstructive sleep apnea before and after treatment with nasal continuous positive airway pressure. Am Rev Respir Dis. 1993;148(1):173–8.
   PubMed Web of Science ®Google Scholar
• Hasday JD, Grum CM. Nocturnal increase of urinary uric acid:creatinine ratio. A biochemical correlate of sleep-associated hypoxemia. Am Rev Respir Dis. 1987;135(3):534–8.
   PubMed Web of Science ®Google Scholar
• Sorg O. Oxidative stress: a theoretical model or a biological reality?. C R Biol. 2004;327(7):649–62.
   PubMed Web of Science ®Google Scholar
• Zharikov SI, Swenson ER, Lanaspa M, Block ER, Patel JM, Johnson RJ. Could uric acid be a modifiable risk factor in subjects with pulmonary hypertension?. Med Hypotheses. 2010;74(6):1069–74.
   PubMed Web of Science ®Google Scholar
• Sautin YY, Johnson RJ. Uric acid: the oxidant-antioxidant paradox. Nucleosides Nucleotides Nucleic Acids. 2008;27(6-7):608–19.
   PubMed Web of Science ®Google Scholar
• Waring WS, Webb DJ, Maxwell SR. Systemic uric acid administration increases serum antioxidant capacity in healthy volunteers. J Cardiovasc Pharmacol. 2001;38(3):365–71.
   PubMed Web of Science ®Google Scholar
• Ames BN, Cathcart R, Schwiers E, Hochstein P. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci U S A,1981;78(11):6858–62.
   PubMed Web of Science ®Google Scholar
• Okafor ON, Farrington K, Gorog DA. Allopurinol as a therapeutic option in cardiovascular disease. Pharmacol Ther. 2017;172:139–50.
   PubMed Web of Science ®Google Scholar
• Feig DI, Soletsky B, Johnson RJ. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA 2008;300(8):924–32.
   PubMed Web of Science ®Google Scholar
• Park KY, Kim HJ, Ahn HS, Kim SH, Park EJ, Yim S-Y, et al. Effects of coffee consumption on serum uric acid. Semin Arthritis Rheum 2016;45:580–6.
   PubMed Web of Science ®Google Scholar