The rise of the biocyborg: synthetic biology, artificial chimerism and human enhancement

References

• Addison, C.. 2020. “Crispr Cowboys? Genetic Self-Experimentation and the Limits of the Person.” In Personhood in the Age of Biolegality. Biolegalities, edited by M. de Leeuw and S. van Wichelen. Cham: Palgrave Macmillan. doi:https://doi.org/10.1007/978-3-030-27848-9_9.
   Google Scholar
• Agar, N. 2008. Liberal eugenics: In defence of human enhancement. New Jersey: John Wiley & Sons.
   Google Scholar
• Andrianantoandro, E., S. Basu, D. K. Karig, and R. Weiss. 2006. “Synthetic Biology: New Engineering Rules for An Emerging Discipline.” Molecular Systems Biology 2 (1): 2006.0028. doi:https://doi.org/10.1038/msb4100073.
   PubMedGoogle Scholar
• Arthur, W. B. 2009. The Nature of Technology: What it is and How it Evolves. Simon and Schuster.
   Google Scholar
• Blackiston, D., E. Lederer, S. Kriegman, S. Garnier, J. Bongard, and M. Levin. 2021. “A Cellular Platform for the Development of Synthetic Living Machines.” Science Robotics 6 (52): eabf1571.
   PubMed Web of Science ®Google Scholar
• Clynes, M. E., and N. S. Kline. 1995. “Cyborgs and Space.” In The Cyborg Handbook, edited by C. H. Gray, 29–34. London: Routledge.
   Google Scholar
• Cooper, M., and C. Waldby. 2014. Clinical Labor: Tissue Donors and Research Subjects in the Global Bioeconomy, 279. Durham, NC: Duke University Press.
   Google Scholar
• Cyranoski, D. 2019. “The Crispr-Baby Scandal: What's Next for Human Gene-Editing.”
   Google Scholar
• Dalibert, L. 2014. “Posthumanism and Somatechnologies: Exploring the Intimate Relations Between Humans and Technologies.”
   Google Scholar
• Dekkers, W., and M. O. Rikkert. 2007. “Memory Enhancing Drugs and Alzheimer's Disease: Enhancing the Self Or Preventing the Loss of it?” Medicine, Health Care and Philosophy 10 (2): 141.
   PubMedGoogle Scholar
• Doudna, J. A., and E. Charpentier. 2014. “The New Frontier of Genome Engineering with Crispr-cas9.” Science 346 (6213): 1258096. doi:https://doi.org/10.1126/science.1258096.
   PubMed Web of Science ®Google Scholar
• Dunbar, C. E., K. A. High, J. K. Joung, D. B. Kohn, K. Ozawa, and M. Sadelain. 2018. “Gene Therapy Comes of Age.” Science 359 (6372): eaan4672. doi:https://doi.org/10.1126/science.aan4672.
   PubMed Web of Science ®Google Scholar
• Funk, M. 2018. “Liz Parrish Wants to Live Forever”. Accessed April 23 2020. https://www.outsideonline.com/2325556/liz-parrish-live-forever.
   Google Scholar
• Garcia, V. 2016. “Une scientifique assure avoir “rajeuni” de 20 ans grâce à une thérapie génique.” Accessed April 23 2018. https://www.lexpress.fr/actualite/sciences/une-scientifique-assure-avoir-rajeuni-de-20-ans-grace-a-une-therapie-genique_1786793.html.
   Google Scholar
• Giubilini, A., S. Sanyal, S. Clarke, J. Savulescu, and C. A. J. Coady. 2016. “The Ethics of Human Enhancement: Understanding the Debate.”
   Google Scholar
• Goldberg, J. 1995. “Recalling Totalities: The Mirrored Stages of Arnold Schwarzenegger.” In The Cyborg Handbook, edited by C. H. Gray, 233–254. New York: Routledge.
   Google Scholar
• Gosmann, C., M. N. Anahtar, S. A. Handley, M. Farcasanu, G. Abu-Ali, B. A. Bowman, and N. Padavattan, et al. 2017. “Lactobacillus-deficient Cervicovaginal Bacterial Communities are Associated with Increased Hiv Acquisition in Young South African Women.” Immunity 46 (1): 29–37.
   PubMed Web of Science ®Google Scholar
• Gray, C. H. 2012. “Cyborging the Posthuman: Participatory Evolution.” In The Posthuman Condition: Ethics, Aesthetics and Politics of Biotechnical Challenges, edited by K. Lippert-Rasmussen, M. Rosendahl Thomsen, and J. Wamberg, 27–39. Aarrhus: Aarhus University Press.
   Google Scholar
• Greely, H. T. 2019. “Crispr'd Babies: Human Germline Genome Editing in the ‘he jiankui affair’.” Journal of Law and the Biosciences 6 (1): 111–183.
   PubMed Web of Science ®Google Scholar
• Habermas, J. 2014. The Future of Human Nature. Translated by W. Rehg, M. Pensky, and H. Beister. Cambridge: John Wiley & Sons.
   Google Scholar
• Haddow, G. 2021. “Reclaiming the Cyborg.” In Embodiment and Everyday Cyborgs, 82–114. Manchester: Manchester University Press.
   Google Scholar
• Haddow, G., E. King, I. Kunkler, and D. McLaren. 2015. “Cyborgs in the Everyday: Masculinity and Biosensing Prostate Cancer.” Science as Culture 24 (4): 484–506.
   PubMed Web of Science ®Google Scholar
• Hamzelou, J. 2017. “Time to Stop Getting Old.”
   Google Scholar
• Haraway, D.. 1991. “A Cyborg Manifesto: Science, Technology, and Socialist-Feminism in the Late Twentieth Century.” In Simians, Cyborgs, and Women: The Reinvention of Nature, 149–182. New York: Routledge.
   Google Scholar
• Haraway, D. 2004. The Haraway Reader. London: Psychology Press.
   Google Scholar
• Hirakawa, M. P., R. Krishnakumar, J. A. Timlin, J. P. Carney, and K. S. Butler. 2020. “Gene Editing and Crispr in the Clinic: Current and Future Perspectives.” Bioscience Reports 40 (4): BSR20200127. doi:https://doi.org/10.1042/BSR20200127.
   PubMed Web of Science ®Google Scholar
• Hofmann, B. 2017. “Limits to Human Enhancement: Nature, Disease, Therapy Or Betterment?” BMC Medical Ethics 18 (1): 1–11.
   PubMedGoogle Scholar
• Ignasse, J. 2017. “Un biohacker tente de devenir un surhomme en modifiant son adn.” Accessed April 23 2018. https://www.sciencesetavenir.fr/sante/un-biohacker-ancien-de-la-nasa-tente-de-devenir-un-surhomme-en-modifiantson-adn_118663.
   Google Scholar
• Ihde, D. 1990. “Technology and the Lifeworld: From Garden to Earth.”
   Google Scholar
• Ihde, D. 2008. Ironic Technics. Copenhagen: Automatic Press/VIP.
   Google Scholar
• Ireland, T. 2017. “I Want to Help Humans Genetically Modify Themselves.” Accessed April 23 2018. https://www.theguardian.com/science/2017/dec/24/josiah-zayner-diygene-editing-therapy-crispr-interview.
   Google Scholar
• Johnson, M. B., A. R. March, and L. Morsut. 2017. “Engineering Multicellular Systems: Using Synthetic Biology to Control Tissue Self-Organization.” Current Opinion in Biomedical Engineering 4: 163–173.
   PubMedGoogle Scholar
• Kastenhofer, K. 2013. “Synthetic Biology As Understanding, Control, Construction, and Creation? Techno-Epistemic and Socio-Political Implications of Different Stances in Talking and Doing Technoscience.” Futures 48: 13–22.
   Web of Science ®Google Scholar
• Kelle, A. 2009. “Ensuring the Security of Synthetic Biology–Towards a 5p Governance Strategy.” Systems and Synthetic Biology 3 (1–4): 85.
   PubMedGoogle Scholar
• Kline, R. 2009. “Where are the Cyborgs in Cybernetics?” Social Studies of Science 39 (3): 331–362.
   Web of Science ®Google Scholar
• Lafontaine, C. 2008. La société post-mortelle. Paris: Seuil. (deutsch: Die postmortale Gesellschaft, VS Verlag, 2010).
   Google Scholar
• Lafontaine, C. 2014. Le Corps-marché. la marchandisation de la vie humaine à l'ère de la bioéconomie: La marchandisation de la vie humaine à l'ère de la bioéconomie. Paris: Le Seuil.
   Google Scholar
• Latour, B. 2005. Reassembling the Social: An Introduction to Actor-Network-Theory. Oxford: Oxford University Press.
   Google Scholar
• Le Dévédec, N. 2014. La société de l'amélioration: le renversement de la perfectibilité humaine, de l'humanisme des lumières à l'humain augmenté.
   Google Scholar
• Le Dévédec, N. 2020. “The Biopolitical Embodiment of Work in the Era of Human Enhancement.” Body & Society 26 (1): 55–81.
   Web of Science ®Google Scholar
• Lettow, S. 2011. “Somatechnologies: Rethinking the Body in the Philosophy of Technology.” Techné: Research in Philosophy and Technology 15 (2): 110–117.
   Google Scholar
• Levin, M., J. Bongard, and J. E. Lunshof. 2020. “Applications and Ethics of Computer-Designed Organisms.” Nature Reviews Molecular Cell Biology 21 (11): 655–656.
   PubMed Web of Science ®Google Scholar
• Lussenhop, J. 2017. “Why I Injected Myself With an Untested Gene Therapy.” Accessed April 23 2018. http://www.bbc.com/news/world-us-canada-41990981.
   Google Scholar
• Macia, J., F. Posas, and R. V. Sole. 2012. “Distributed Computation: the New Wave of Synthetic Biology Devices.” Trends in Biotechnology 30 (6): 342–349.
   PubMed Web of Science ®Google Scholar
• Malet, D. 2015. “Captain America in International Relations: The Biotech Revolution in Military Affairs.” Defence Studies 15 (4): 320–340.
   Google Scholar
• Marin, F., and C. Beluffi. 2018. Computing the Minimal Crew for a Multi-Generational Space Travel Towards Proxima Centauri b. Preprint. arXiv:1806.03856.
   Google Scholar
• Martin, P. A., and I. Turkmendag. 2021. “Thinking the Unthinkable: How Did Human Germline Genome Editing Become Ethically Acceptable?” New Genetics and Society, 1–22. doi:https://doi.org/10.1080/14699915.2021.1932451.
   Google Scholar
• Mauldin, L. 2014. “Precarious Plasticity: Neuropolitics, Cochlear Implants, and the Redefinition of Deafness.” Science, Technology, & Human Values 39 (1): 130–153.
   Web of Science ®Google Scholar
• May, M. 2015. “Synthetic Biology's Clinical Applications.” Accessed April 23 2018. http://www.sciencemag.org/features/2015/09/synthetic-biology-s-clinical-applications.
   Google Scholar
• Miah, A. 2006. “Rethinking Enhancement in Sport.” Annals of the New York Academy of Sciences 1093 (1): 301–320.
   PubMedGoogle Scholar
• Mullin, E. 2018. “2017 was the Year of Gene-Therapy Breakthroughs.” Accessed April 23 2018. https://www.technologyreview.com/s/609643/2017-was-theyear-of-gene-therapy-breakthroughs/.
   Google Scholar
• Nesbeth, D. N., A. Zaikin, Y. Saka, M. Carmen Romano, C. V. Giuraniuc, O. Kanakov, and T. Laptyeva. 2016. “Synthetic Biology Routes to Bio-Artificial Intelligence.” Essays in Biochemistry 60 (4): 381–391.
   PubMed Web of Science ®Google Scholar
• Olson, S., Committee on Science, Engineering National Academies of Sciences, Medicine. 2016. “International Summit on Human Gene Editing: A Global Discussion.” In International Summit on Human Gene Editing: A Global Discussion. US: National Academies Press.
   Google Scholar
• Oudshoorn, N. 2020. Resilient Cyborgs: Living and Dying with Pacemakers and Defibrillators. Singapore: Springer Nature.
   Google Scholar
• Oudshoorn, N. 2021. “Graying the Cyborg Revisited. How Age Matters when Technologies Move Under the Skin.” TECNOSCIENZA: Italian Journal of Science & Technology Studies 11 (2): 13–32.
   Web of Science ®Google Scholar
• Parrish, E. 2017. “One Year Anniversary of Bioviva's Gene Therapy Against Human Aging.” https://bioviva-science.com/blog/2017/3/2/one-year-anniversary-of-biovivasgene-therapy-against-hu-man-aging.
   Google Scholar
• Pepper, J. W. 2014. “The Evolution of Bacterial Social Life: From the Ivory Tower to the Front Lines of Public Health.” Evolution, Medicine, and Public Health 2014 (1): 65–68.
   PubMedGoogle Scholar
• Pio-Lopez, L. 2018. “Biopolitique et transhumanisme: Approches politique, sociale et stratégique.” Master's thesis. Université Jean-Moulin Lyon 3.
   Google Scholar
• Potthast, T. 2009. “Paradigm Shifts Versus Fashion Shifts? Systems and Synthetic Biology As New Epistemic Entities in Understanding and Making'life'.” EMBO Reports 10 (S1): S42–S45.
   PubMedGoogle Scholar
• Purnick, P. E. M., and R. Weiss. 2009. “The Second Wave of Synthetic Biology: From Modules to Systems.” Nature Reviews Molecular Cell Biology 10 (6): 410.
   PubMed Web of Science ®Google Scholar
• Reardon, S. 2018. “Genetically Modified Bacteria Enlisted in Fight Against Disease.” Nature 558 (7710): 497–499.
   PubMedGoogle Scholar
• Regalado, A. 2015. “A Tale of Do-it-Yourself Gene Therapy.” Accessed April 23 2018. https://www.technologyreview.com/s/542371/a-tale-of-do-it-yourselfgene-therapy/.
   Google Scholar
• Roco, M. C., and W. S. Bainbridge. 2002. “Converging Technologies for Improving Human Performance: Integrating From the Nanoscale.” Journal of Nanoparticle Research 4 (4): 281–295.
   Web of Science ®Google Scholar
• Rose, N. 2009. The Politics of Life Itself: Biomedicine, Power, and Subjectivity in the Twenty-First Century. Princeton: Princeton University Press.
   Google Scholar
• Ruder, W. C., T. Lu, and J. J. Collins. 2011. “Synthetic Biology Moving Into the Clinic.” Science 333 (6047): 1248–1252.
   PubMed Web of Science ®Google Scholar
• Sandel, M. J. 2007. The Case Against Perfection: Ethics in the Age of Genetic Engineering. Cambridge: Harvard university press.
   Google Scholar
• Schyfter, P., E. Frow, and J. Calvert. 2013. “Guest Editorial: Synthetic Biology: Making Biology Into an Engineering Discipline.”
   Google Scholar
• Sender, R., S. Fuchs, and R. Milo. 2016. “Revised Estimates for the Number of Human and Bacteria Cells in the Body.” PLoS Biology 14 (8): e1002533.
   PubMed Web of Science ®Google Scholar
• Shalem, O., N. E. Sanjana, E. Hartenian, X. Shi, D. A. Scott, T. S. Mikkelsen, and D. Heckl, et al. 2014. “Genome-Scale Crispr-cas9 Knockout Screening in Human Cells.” Science 343 (6166): 84–87.
   PubMed Web of Science ®Google Scholar
• Silver, P. A. 2009. “Making Biology Easier to Engineer.” Biosocieties 4 (2–3): 283–289.
   Web of Science ®Google Scholar
• Sobchack, V. 2006. “A Leg to Stand on: Prosthetics, Metaphor, and Materiality.” In The Prosthetic Impulse: From a Posthuman Present to a Biocultural Future, 17–41. Cambridge: MIT Press.
   Google Scholar
• Stano, P., Y. Kuruma, and L. Damiano. 2018. “Synthetic Biology and (embodied) Artificial Intelligence: Opportunities and Challenges.” Adaptive Behavior 26 (1): 41–44.
   Web of Science ®Google Scholar
• van Est, R., and D. Stemerding. 2012a. Making Perfect Life: European Governance Challenges in 21st Century Bio-Engineering. Final Report. European Parliament, STOA.
   Google Scholar
• van Est, R., and D. Stemerding. 2012b. Making Perfect Life: European Governance Challenges in 21st Century Bio-Engineering. Study Summary.
   Google Scholar
• Weber, W., and M. Fussenegger. 2012. “Emerging Biomedical Applications of Synthetic Biology.” Nature Reviews Genetics 13 (1): 21–35.
   Web of Science ®Google Scholar
• Wiener, N. 2019. Cybernetics or Control and Communication in the Animal and the Machine. Cambridge, MA: MIT press.
   Google Scholar
• Zettler, P. J., C. J. Guerrini, and J. S. Sherkow. 2019a. “Finding a Regulatory Balance for Genetic Biohacking.” In Consuming Genetic Technologies: Ethical and Legal Considerations, Cambridge Univ. Press, Forthcoming.
   Google Scholar
• Zettler, P. J., C. J. Guerrini, and J. S. Sherkow. 2019b. “Regulating Genetic Biohacking.” Science 365 (6448): 34–36.
   PubMed Web of Science ®Google Scholar