Publication Cover
Human Fertility
an international, multidisciplinary journal dedicated to furthering research and promoting good practice
Volume 3, 2000 - Issue 2
26
Views
8
CrossRef citations to date
0
Altmetric
Original Article

Function of the polycystic ovary

Pages 80-85 | Published online: 03 Jul 2009

References

  • Adams J, Polson DW, Abdulwahid N, Morris DV, Franks S, Mason HD, Tucker M, Price J, Jacobs HS. Multifollicular ovaries: clinical and endocrine features and response to pulsatile gonadotrophin releasing hormone. Lancet 1985; 2: 1375–1378
  • Almahbobi G, Anderiesz C, Hutchinson P, McFarlane JR, Wood C, Trounson AO. Functional integrity of granulosa cells from polycystic ovaries. Clinical Endocrinology 1996; 44: 571–580
  • Axelrod LR, Goldzeiher JW. The polycystic ovary III. Steroid biosynthesis in normal and polycystic ovarian tissue. Clinical Endocrinology 1962; 22: 431–440
  • Chang RJ, Laufer LR, Meldrum DR, Defazio J, Lu JKH, Vale WW, Rivier JE, Judd H. Steroid secretion in polycystic ovarian disease after ovarian suppression by a long-acting gonadotrophin-releasing agonist. Journal of Clinical Endocrinology and Metabolism 1983; 56: 897–903
  • Conway GS, Honour JW, Jacobs HS. Heterogeneity of the polycystic ovary syndrome; clinical, endocrine and ultrasound features in 556 patients. Clinical Endocrinology 1989; 30: 459–470
  • Erickson GF, Hsueh AJW, Quigley ME, Rebar RW, Yen SS. Functional studies of aromatase activity in human granulosa cells from normal and polycystic ovaries. Journal of Clinical Endocrinology and Metabolism 1979; 49: 514–518
  • Erickson GF, Magoffin DA, Dyer CA, Hofeditz C. The ovarian androgen producing cells; a review of structure/function relationships. Endocrine Reviews 1985; 6: 371–399
  • Franks S. Polycystic ovary syndrome: a changing perspective. Clinical Endocrinology 1989; 31: 87–120
  • Franks S. Polycystic ovary syndrome. New England Journal of Medicine 1996; 333: 853–861
  • Franks S, Mason HD. Polycystic ovary syndrome: interaction of follicle stimulating hormone and polypeptide growth factors in oestradiol production by human granulosa cells. Journal of Steroid Biochemistry and Molecular Biology 1991; 40: 405–409
  • Franks S, Mason H, White D, Willis DS. Etiology of anovulation in polycystic ovary syndrome. Steroids 1998; 63: 306–307
  • Garzo VG, Dorrington JH. Aromatase activity in human granulosa cells during follicular development and the modulation by follicle stimulating hormone and by insulin. American Journal of Obstetrics and Gynecology 1984; 148: 657–662
  • Gharani N, Waterworth DM, Williamson R, Franks S. 5′ polymorphism of the CYP17 gene is not associated with serum testosterone levels in women with polycystic ovaries (Letter). Journal of Clinical Endocrinology and Metabolism 1996; 81: 4174–4174
  • Gharani N, Waterworth DM, Batty S, White DM, Gilling-Smith C, Conway GS, McCarthy M, Franks S, Williamson R. Association of the steroid synthesis gene CYP11a with polycystic ovary syndrome and hyperandrogenism. Human Molecular Genetics 1997; 6: 397–402
  • Gilling-Smith C, Willis DS, Beard RW, Franks S. Hypersecretion of androstenedione by isolated theca cells from polycystic ovaries. Journal of Clinical Endocrinology and Metabolism 1994; 79: 1158–1165
  • Giudice LC, Morales AJ, Yen SSSC. Growth factors and polycystic ovarian syndrome. Seminars in Reproductive Endocrinology 1996; 14: 203–208
  • Goldzeiher JW, Axelrod LR. Clinical and biochemical features of polycystic ovarian disease. Fertility and Sterility 1963; 14: 631–653
  • Hughesden PE. Morphology and morphogenesis of the Stein-Leventhal ovary and of so-called ‘hyperthecosis’. Review in Obstetrical and Gynaecological Survey 1982; 37: 59–77
  • Joseph-Horne R, Mason HD, Batty SC, White DM, Hillier SG, Urquhart M, Franks S. Luteal phase progesterone excretion in ovulatory women with polycystic ovaries. Journal of Endocrinology 1998; 156: 263–263, Supplement
  • Kyei-Mensah A, Zaidi J, Campbell S. Ultrasound diagnosis of polycystic ovary syndrome. Bailliere's Clinical Endocrinology and Metabolism 1996; 10: 49–49
  • Lockwood G. The role of inhibin in polycystic ovary syndrome. Human Fertility 2000; 3: 86–92
  • McNatty KP. Hormonal correlates of follicular development in the human ovary. Australian Journal of Biological Sciences 1981; 34: 249–268
  • McNatty KP, More-Smith D, Makris A, Osathanondh R, Ryan KJ. The microenvironment of the human follicle: interrelationships among the steroid levels in antral fluid, the population of granulosa cells and the status of the oocyte in vivo and in vitro. Journal of Clinical Endocrinology and Metabolism 1979; 49: 851–860
  • McNatty KP, Moore-Smith D, Makris A, DeGrazia C, Tulchinsky D, Osathanondh R, Schiff I, Ryan KJ. The intraovarian sites of androgen and estrogen formation in women with normal and hyperandrogenic ovaries as judged by in vitro experiments. Journal of Clinical Endocrinology and Metabolism 1980; 50: 755–763
  • Mason HD, Willis DS, Beard RW, Winston RML, Margara R, Franks S. Estradiol production by granulosa cells of normal and polycystic ovaries (PCO): relationship to menstrual cycle history and to concentrations of gonadotrophins and sex steroids in follicular fluid. Journal of Clinical Endocrinology and Metabolism 1994; 791: 1355–1360
  • Nelson VL, Legro RS, Strauss JF, McAllister JM. Augmented androgen production is a stable steroidogeneic phenotype of propagated theca cells from polycystic ovaries. Molecular Endocrinology 1999; 13: 946–957
  • Pache T, Hop WCJ, de Jong FH, Leerentveld RA, van Geldorp H, Van de Kamp TMM, Gooren LJG, Fauser BCJM. 17β-Oestradiol, androstenedione and inhibin levels in fluid from individual follicles of normal and polycystic ovaries, and in ovaries from androgen treated female to male transsexuals. Clinical Endocrinology 1992; 36: 565–571
  • Polson DW, Adams J, Wadsworth J, Franks S. Polycystic ovaries — a common finding in normal women. Lancet 1988a; i: 870–872
  • Polson DW, Reed MJ, Franks S, Scanlon MJ, James VHT. Serum 11-hydroxyandrostenedione as an indicator of the source of excess androgen production in women with polycystic ovaries. Journal of Clinical Endocrinology and Metabolism 1988b; 66: 946–950
  • Poretsky L, Kalin MF. The gonadotropic function of insulin. Endocrine Reviews 1987; 8: 132–145
  • Rosenfield RL, Barnes RB, Cara JF, Lucky AW. Dysregulation of cytochrome P450c 17α as the cause of polycystic ovarian syndrome. Fertility and Sterility 1990; 53: 785–791
  • Short RV, London DR. Defective biosynthesis of ovarian steroids in the Stein-Leventhal syndrome. British Medical Journal 1961; i: 1724–1727
  • Stein IF, Leventhal ML. Amenorrhoea associated with bilateral polycystic ovaries. American Journal of Obstetrics and Gynaecology 1935; 29: 181–191
  • Tilly JL. Apoptosis and ovarian function. Reviews of Reproduction 1996; 1: 162–172
  • Takayama K, Fukaya T, Sasano H, Funayama Y, Suzuki T, Takaya R, Wada Y, Yajima A. Immunohistochemical study of steroidogenesis and cell proliferation in polycystic ovarian syndrome. Human Reproduction 1996; 11: 1387–1392
  • Urbanek M, Legro RS, Driscoll DA, Azziz R, Ehrmann DA, Norman RJ, Strauss JF, Spielman RS, Dunaif A. Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin. Proceedings National Academy of Sciences of the USA 1999; 96: 8573–8578
  • Willis DS, Mason HD, Gilling-Smith C, Franks S. Modulation by insulin of follicle stimulating hormone and luteinising hormone actions in human granulosa cells of normal and polycystic ovaries. Journal of Clinical Endocrinology and Metabolism 1996; 81: 302–309
  • Willis DS, Mason HD, Watson H, Brincat M, Galca R, Franks S. Premature response to LH of granulosa cells from anovulatory women with PCOS: relevance to mechanism of anovulation. Journal of Clinical Endocrinology and Metabolism 1998; 83: 3984–3991
  • White DM, Leigh A, Wilson C, Franks S. Gonadotrophin and gonadal steroid response to a single dose of a long-acting agonist of gonadotrophin-releasing hormone in ovaulatory and anovulatory women with polycystic ovary syndrome. Clinical Endocrinology 1995; 42: 475–481
  • Yen S. The polycystic ovary syndrome. Clinical Endocrinology 1980; 12: 177–207

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.