Publication Cover
Human Fertility
an international, multidisciplinary journal dedicated to furthering research and promoting good practice
Volume 3, 2000 - Issue 2
52
Views
8
CrossRef citations to date
0
Altmetric
Original Article

Hyperinsulinaemia and polycystic ovary syndrome

Pages 93-95 | Published online: 03 Jul 2009

References

  • Balen AH, Conway GS, Kaltsas G, Techatraisak L, Manning P, West C, Jacobs HS. Polycystic ovary syndrome: the spectrum of the disorder in 1741 patients. Human Reproduction 1995; 10: 2107–2111
  • Conway GS, Jacobs HS. Clinical implications of hyperinsulinaemia in women. Clinical Endocrinology 1993; 39: 623–632
  • Conway GS, Jacobs HS, Holly JMP, Wass JAS. Effects of luteinising hormone, insulin, insulin-like growth factor I and insulin-like growth factor small binding protein in the polycystic ovary syndrome. Clinical Endocrinology 1990; 33: 593–603
  • Conway GS, Agrawal R, Betteridge DJ, Jacobs HS. Risk factors for coronary artery disease in lean and obese women with the polycystic ovary syndrome. Clinical Endocrinology 1992; 37: 119–126
  • Dahlgren E, Johansson S, Lindstedt G, Knutsson F, Oden A, Janson PO, Mattson LA, Crona N, Kundberg PA. Women with polycystic ovary syndrome wedge resected in 1956 to 1965: a long-term follow-up focusing on natural history and hormones. Fertility and Sterility 1992; 57: 505–513
  • Dunaif A, Graf M, Mandeli J, Laumas V, Dobrjansky A. Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia. Journal of Clinical Endocrinology and Metabolism 1987; 65: 499–507
  • Dunaif A, Xia J, Book CB, Schenker E, Tang Z. Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome. Journal of Clinical Investigation 1995; 96: 801–810
  • Dunaif A, Scott D, Finegood D, Quintana B, Whitcomb R. The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 1996; 81: 3299–3306
  • Ehrmann DA, Schneider DJ, Sobel BE, Cavaghan MK, Imperial J, Roscnfield RL, Polonsky KS. Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 1997; 82: 2108–2116
  • Franks S. Polycystic ovary syndrome. New England Journal of Medicine 1995; 333: 853–861
  • Franks S, Gilling-Smith C, Watson H, Willis D. Insulin action in the normal and polycystic ovary. Endocrinology and Metabolism Clinics of North America 1999; 28: 361–378
  • Holte J, Gennarelli G, Wide L, Lithell H, Berne C. High prevalence of polycystic ovaries and associated clinical, endocrine, and metabolic features in women with previous gestational diabetes mellitus. Journal of Clinical Endocrinology and Metabolism 1998; 83: 1143–1150
  • Kiddy DS, Hamilton-Fairley D, Seppela M, Koistinen R, James VHT, Reed MJ, Franks S. Diet-induced changes in sex hormone-binding globulin and free testosterone in women with normal and polycystic ovaries: correlation with serum insulin and insulin-like growth factor-1. Clinical Endocrinology 1989; 31: 757–763
  • Legro RS, Kunselman AR, Dodson WC, Dunaif A. Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. Journal of Clinical Endocrinology and Metabolism 1999; 84: 165–169
  • Murray RD, Davison RM, Russell RC, Conway GS. Clinical presentation of PCOS following development of an insulinoma: a case report. Human Reproduction 2000; 15: 86–88
  • Nestler JE, Jakubowicz DJ, Evans WS, Pasquali R. Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome. New England Journal of Medicine 1998; 338: 1876–1880
  • Pasquali R, Casimirri F. The impact of obesity on hyperandrogenism and polycystic ovary syndrome in premenopausal women. Clinical Endocrinology 1993; 39: 1–16
  • Pierpoint T, McKeigue PM, Isaacs AJ, Wild SH, Jacobs HS. Mortality of women with polycystic ovary syndrome at long-term follow-up. Journal of Clinical Epidemiology 1998; 51: 581–586
  • Reaven GM. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595–1607
  • Rodin DA, Bano G, Bland JM, Taylor K, Nussey SS. Polycystic ovaries and associated metabolic abnormalities in Indian subcontinent Asian women. Clinical Endocrinology 1998; 49: 91–99
  • Sattar N, Hopkinson ZE, Greer IA. Insulin-sensitising agents in polycystic ovary syndrome. Lancet 1998; 351: 305–307
  • Stein IF, Leventhal ML. Amenorrhea associated with bilateral polycystic ovaries. American Journal of Obstetrics and Gynecology 1935; 13: 181–191
  • Urbanek M, Legro RS, Driscoll DA, Azziz R, Ehrmann DA, Norman RJ, Strauss JF, Spielman R, Dunaif A. Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin. Proceedings National Academy of Sciences USA 1999; 96: 8315–8317
  • Waterworth DM, Bennett SI, Gharani N, McCarthy MI, Hague S, Batty S, Conway GS, White D, Todd JA, Franks S, Williamson R. Linkage and association of insulin gene VNTR regulatory polymorphism and polycystic ovary syndrome. Lancet 1997; 349: 986–990
  • Wilson JD, Dunham RJ, Balen AH. HIV protease inhibitors, the lipodystrophy syndrome and polycystic ovary syndrome — is there a link?. Sexually Transmitted Infections 1999; 75: 268–269

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.