Publication Cover
Human Fertility
an international, multidisciplinary journal dedicated to furthering research and promoting good practice
Volume 24, 2021 - Issue 2
160
Views
3
CrossRef citations to date
0
Altmetric
Original Articles

Relation between sperm protamine transcripts with global sperm DNA methylation and sperm DNA methyltransferases mRNA in men with severe sperm abnormalities

, , &
Pages 105-111 | Received 27 Oct 2017, Accepted 17 Sep 2018, Published online: 26 Apr 2019

References

  • Adiga, S.K., Ehmcke, J., Schlatt, S., Kliesch, S., Westernstroer, B., Luetjens, C.M., … Gromoll, J. (2011). Reduced expression of DNMT3B in the germ cells of patients with bilateral spermatogenic arrest does not lead to changes in the global methylation status. Molecular Human Reproduction, 17, 545–549. doi: 10.1093/molehr/gar023.
  • Aoki, V.W., Emery, B.R., & Carrell, D.T. (2006). Global sperm deoxyribonucleic acid methylation is unaffected in protamine-deficient infertile males. Fertility and Sterility, 86, 1541–1543. doi: 10.1016/j.fertnstert.200.
  • Aoki, V.W., Liu, L., & Carrell, D.T. (2005). Identification and evaluation of a novel sperm protamine abnormality in a population of infertile males. Human Reproduction, 20, 1298–1306. doi: 10.1093/humrep/deh798.
  • Aoki, V.W., Liu, L., & Carrell, D.T. (2006). A novel mechanism of protamine expression deregulation highlighted by abnormal protamine transcript retention in infertile human males with sperm protamine deficiency. MHR: Basic Science of Reproductive Medicine, 12, 41–50. doi: 10.1093/molehr/gah258.
  • Bahreinian, M., Tavalaee, M., Abbasi, H., Kiani-Esfahani, A., Shiravi, A.H., & Nasr-Esfahani, M.H. (2015). DNA hypomethylation predisposes sperm to DNA damage in individuals with varicocele. Systems Biology in Reproductive Medicine, 61, 179–186. doi: 10.3109/19396368.2015.1020116.
  • Barzideh, J., Scott, R., & Aitken, R. (2013). Analysis of the global methylation status of human spermatozoa and its association with the tendency of these cells to enter apoptosis. Andrologia, 45, 424–429. doi: 10.1111/and.12033.
  • Carrell, D.T., Emery, B.R., & Hammoud, S. (2008). The aetiology of sperm protamine abnormalities and their potential impact on the sperm epigenome. International Journal of Andrology, 31, 537–545. doi: 10.1111/j.1365-2605.2008.00872.x.
  • Consales, C., Leter, G., Bonde, J.P.E., Toft, G., Eleuteri, P., Moccia, T., … Spano, M. (2014). Indices of methylation in sperm DNA from fertile men differ between distinct geographical regions. Human Reproduction, 29, 2065–2072. doi: 10.1093/humrep/deu176.
  • Depa-Martynow, M., Kempisty, B., Jagodziński, P.P., Pawelczyk, L., & Jedrzejczak, P. (2012). Impact of protamine transcripts and their proteins on the quality and fertilization ability of sperm and the development of preimplantation embryos. Reproductive Biology, 12, 57–72. doi: 10.1016/S1642-431X(12)60077-1.
  • Dhillon, V.S., Shahid, M., & Husain, S.A. (2007). Associations of MTHFR DNMT3b 4977 bp deletion in mtDNA and GSTM1 deletion, and aberrant CpG island hypermethylation of GSTM1 in non-obstructive infertility in Indian men. MHR: Basic Science of Reproductive Medicine, 13, 213–222. doi: 10.1093/molehr/gal118.
  • Fatemi, M., Hermann, A., Gowher, H., & Jeltsch, A. (2002). Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA. European Journal of Biochemistry, 269, 4981–4984. doi: 10.1046/j.1432-1033.2002.03198.x.
  • Hammadeh, M., Hamad, M., Montenarh, M., & Fischer-Hammadeh, C. (2010). Protamine contents and P1/P2 ratio in human spermatozoa from smokers and non-smokers. Human Reproduction, 25, 2708–2720. doi: 10.1093/humrep/deq226.
  • Hammoud, S.S., Purwar, J., Pflueger, C., Cairns, B.R., & Carrell, D.T. (2010). Alterations in sperm DNA methylation patterns at imprinted loci in two classes of infertility. Fertility and Sterility, 94, 1728–1733. doi: 10.1016/j.fertnstert.2009.09.010.
  • Hirasawa, R., Chiba, H., Kaneda, M., Tajima, S., Li, E., Jaenisch, R., & Sasaki, H. (2008). Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes & Development, 22, 1607–1616. doi: 10.1101/gad.1667008.
  • Houshdaran, S., Cortessis, V.K., Siegmund, K., Yang, A., Laird, P.W., & Sokol, R.Z. (2007). Widespread epigenetic abnormalities suggest a broad DNA methylation erasure defect in abnormal human sperm. PLoS One, 2, e1289. doi: 10.1371/journal.pone.0001289.
  • Imken, L., Rouba, H., El Houate, B., Louanjli, N., Barakat, A., Chafik, A., & McElreavey, K. (2009). Mutations in the protamine locus: Association with spermatogenic failure? Molecular Human Reproduction, 15, 733–738. doi: 10.1093/molehr/gap056.
  • Jones, P.A. (2012). Functions of DNA methylation: Islands, start sites, gene bodies and beyond. Nature Reviews Genetics, 13, 484–492. doi: 10.1038/nrg3230.
  • Mengual, L., Ballescá, J.L., Ascaso, C., & Oliva, R. (2003). Marked differences in protamine content and P1/P2 ratios in sperm cells from percoll fractions between patients and controls. Journal of Andrology, 24, 438–447. doi: 10.1002/j.1939-4640.2003.tb02692.x.
  • Montjean, D., De La Grange, P., Gentien, D., Rapinat, A., Belloc, S., Cohen-Bacrie, P., … Benkhalifa, M. (2012). Sperm transcriptome profiling in oligozoospermia. Journal of Assisted Reproduction and Genetics, 29, 3–10. doi: 10.1007/s10815-011-9644-3.
  • Montjean, D., Zini, A., Ravel, C., Belloc, S., Dalleac, A., Copin, H., … Benkhalifa, M. (2015). Sperm global DNA methylation level: Association with semen parameters and genome integrity. Andrology, 3, 235–240. doi: 10.1111/andr.12001.
  • Nanassy, L., Liu, L., Griffin, J., & Carrell, D.T. (2011). The clinical utility of the protamine 1/protamine 2 ratio in sperm. Protein & Peptide Letters, 18, 772–777. doi: 10.2174/092986611795713934.
  • Ni, K., Steger, K., Yang, H., Wang, H., Hu, K., & Chen, B. (2014). Sperm protamine mRNA ratio and DNA fragmentation index represent reliable clinical biomarkers for men with varicocele after microsurgical varicocele ligation. The Journal of Urology, 192, 170–176. doi: 10.1016/j.juro.2014.02.046.
  • Olszewska, M., Barciszewska, M.Z., Fraczek, M., Huleyuk, N., Chernykh, V.B., Zastavna, D., … Kurpisz, M. (2017). Global methylation status of sperm DNA in carriers of chromosome structural aberrations. Asian Journal of Andrology, 19, 117–124. doi: 10.4103/1008-682X.168684.
  • Ouko, L.A., Shantikumar, K., Knezovich, J., Haycock, P., Schnugh, D.J., & Ramsay, M. (2009). Effect of alcohol consumption on CpG methylation in the differentially methylated regions of H19 and IG‐DMR in male gametes—Implications for fetal alcohol spectrum disorders. Alcoholism: Clinical and Experimental Research, 33, 1615–1627. doi: 10.1111/j.1530-0277.2009.00993.x.
  • Pedersen, M.T., & Helin, K. (2010). Histone demethylases in development and disease. Trends in Cell Biology, 20, 662–671. doi: 10.1016/j.tcb.2010.08.011.
  • Rogenhofer, N., Dansranjavin, T., Schorsch, M., Spiess, A., Wang, H., von Schonfeldt, V., … Steger, K. (2013). The sperm protamine mRNA ratio as a clinical parameter to estimate the fertilizing potential of men taking part in an ART programme. Human Reproduction, 28, 969–978. doi: 10.1093/humrep/des471.
  • Talbert, P.B., & Henikoff, S. (2010). Histone variants—Ancient wrap artists of the epigenome. Nature Reviews Molecular Cell Biology, 11, 264–275. doi: 10.1038/nrm2861.
  • Tunc, O., & Tremellen, K. (2009). Oxidative DNA damage impairs global sperm DNA methylation in infertile men. Journal of Assisted Reproduction and Genetics, 26, 537–544. doi: 10.1007/s10815-009-9346-2.
  • Urdinguio, R.G., Bayón, G.F., Dmitrijeva, M., Toraño, E.G., Bravo, C., Fraga, M.F., … Fernández, A.F. (2015). Aberrant DNA methylation patterns of spermatozoa in men with unexplained infertility. Human Reproduction, 30, 1014–1028. doi: 10.1093/humrep/dev053.
  • Wu, W., Shen, O., Qin, Y., Niu, X., Lu, C., Xia, Y., … Wang, X. (2010). Idiopathic male infertility is strongly associated with aberrant promoter methylation of methylenetetrahydrofolate reductase (MTHFR). PLoS One, 5, e13884. doi: 10.1371/journal.pone.0013884.
  • Yu, B., Zhou, H., Liu, M., Zheng, T., Jiang, L., Zhao, M., … Huang, Z. (2015). Epigenetic alterations in density selected human spermatozoa for assisted reproduction. PLoS One, 10, e0145585. doi: 10.1371/journal.pone.0145585.
  • Zini, A., & Agarwal, A. (2011). Sperm chromatin: Biological and clinical applications in male infertility and assisted reproduction. New York: Springer-Verlag.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.