7
Views
4
CrossRef citations to date
0
Altmetric
Original Paper

Activated platelets rapidly up-regulate CD40L expression and can effectively mature and activate autologous ex vivo differentiated DC

, , &
Pages 487-497 | Published online: 07 Jul 2009

  • Banchereau J, Briere F', Caux C et al. Immunobiology of dendritic cells. Annu Rev Immunol 2000;18:767— 811 .
  • Gunzer M, Jänich S, Varga G, Grabbe S. Dendritic cells and tumor immunity. Semin Immunol 2001;13:291–302.
  • Whiteside TL, Odoux C. Dendritic cell biology and cancer therapy. Cancer Immunol Immunother 2004;53:240— 8.
  • Schuler G, Schuler-Thurner B, Steinman RM. The use of dendritic cells in cancer immunotherapy. Curr Opin Immunol 2003;15:138–47.
  • Mellman I, Steinman RM. Dendritic cells: specialized and regulated antigen processing machines. Cell 2001;106:255— 8.
  • McIlroy D, Gregoire M. Optimizing dendritic cell-based antic-ancer immunotherapy: maturation state does have clinical impact. Cancer Immunol Immunother 2003;52:583–91.
  • Morelli AE, Hackstein H, Thomson AW. Potential of tolerogenicdendritic cells for transplantation. Semin Immunol 2001;13:323–35.
  • Aiba S, Tagami H. Dendritic cell activation induced by various stimuli, e.g. exposure to microorganisms, their products, cyto-kines, and simple chemicals as well as adhesion to extracellular matrix. y Dermatol Sci 1998;20:1–13.
  • Reddy A, Sapp M, Feldman M et al. A monocyte conditioned medium is more effective than defined cytokines in mediating the terminal maturation of human dendritic cells. Blood 1997;90:3640— 6.
  • Jonuleit H, Kuhn U, Muller G et al. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimu-latory dendritic cells under fetal calf serum-free conditions. Eur y Immunol 1997;27:3135–42.
  • Caux C, Massacrier C, Vanbervliet B et al. Activation of humandendritic cells through CD40 cross-linking. y Exp Med 1994;180:1263— 72.
  • Ridge JP, Di Rosa F', Matzinger P. A conditioned dendritic cellcan be a temporal bridge between a CD4 T-helper and a T-killer cell. Nature 1998;393: 474— 8.
  • Bouchard BA, Butenas S, Mann KG, Tracy PS. Interactions between platelets and the coagulation system. In: Michelson AD, editor. Platelets. San Diego, CA: Academic Press, 2002: 229— 54.
  • Elzey BD, Tian J, Jensen RJ et al. Platelet-mediated modulationof adaptive immunity. A communication link between innate and adaptive immune compartments. Immunio 2003;19:9— 19.
  • Matsue H, Kusuhara M, Matsue K et al. Dendritic cell-based immunoregulatory strategies. Int Arch Allergy Immunol 2002;127:251–8.
  • Hart DN. Dendritic cells and their emerging clinical applica-tions. Pathology 2001;33:479–92.
  • Lee AW, Truong T, Bickham K et al. A clinical grade cocktail ofcytokines and PGE2 results in uniform maturation of human monocyte-derived dendritic cells: implications for immunother-apy. Vaccine 2002;20(Suppl 4):A8—A22.
  • Rieser C, Bock G, Klocker H et al. Prostaglandin E2 and tumornecrosis factor alpha cooperate to activate human dendritic cells: synergistic activation of interleukin 12 production. y Exp Med 1997;186:1603— 8.
  • Rescigno M, Pig-uet V, Valzasina B et al. Fas engagement inducesthe maturation of dendritic cells (DCs), the release of inter-leukin (IL)-lbeta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction: a new role for Fas ligand in inflammatory responses. y Exp Med 2000;192:1661— 8.
  • Morel Y, Truneh A, Sweet RW et al. The TNF superfamily members LIGHT and CD154 (CD40 ligand) costimulate induction of dendritic cell maturation and elicit specific CTL activity. y Immunol 2001;167:2479–86.
  • Josien R, Li HL, Ingulli E et al. TRANCE, a tumor necrosis factor family member, enhances the longevity and adjuvant properties of dendritic cells in vivo. y Exp Med 2000;191:495–502.
  • Grewal IS, Flavell RA. A central role of CD40 ligand in the regulation of CD4T-cell responses. Immunol Today1996;17:410–4.
  • Henn V, Steinbach S, Biichner K et al. The inflammatory actionof CD40 ligand (CD154) expressed on activated human platelets is temporally limited by coexpressed CD40. Blood 2001;98:1047–54.
  • Phipps RP, Kaufman J, Blumberg N. Platelet derived CD154 (CD40 ligand) and febrile responses to transfusion. Lancet 2001;357: 2023— 4.
  • Henn V, Slupsky JR, Grate M et al. CD40 ligand on activatedplatelets triers an inflammatory reaction of endothelial cells. Nature 1998;391:591–4.
  • Yellin MJ, Brett J, Baum D et al. Functional interactions of T cells with endothelial cells: the role of CD4OL-CD40-mediated signals. yExp Med 1995;182:1857–64.
  • Hollenbaugh D, Mischel-Petty N, Edwards CP et al. Expressionof functional CD40 by vascular endothelial cells. y Exp Med 1995;182:33–40.
  • Inwald DP, McDowall A, Peters MJ et al. CD40 is constitutivelyexpressed on platelets and provides a novel mechanism for platelet activation. Circ Res 2003;92:1041— 8.
  • Phipps RP, Koumas L, Leung E et al. The CD4O-CD40 ligand system: a potential therapeutic target in atherosclerosis. Curr Opin Investig Drugs 2001;2:773–7.
  • Yan JC, Wu ZG, Kong XT et al. Relation between upregulationof CD40 system and complex stenosis morphology in patients with acute coronary syndrome. Acta Pharmacol Sin 2004;25:251–6.
  • Nagashima H, Aoka Y, Sakomura Y et al. Matrix metalloprotei-nase 2 is suppressed by trapidil, a CD40— CD40 ligand pathway inhibitor, in human abdominal aortic aneurysm wall. y Vase Surg 2004;39:447— 53.
  • Gatti E, Velleca MA, Biedermann BC et al. Large-scale cultureand selective maturation of human Langerhans cells from granulocyte colony-stimulating factor-mobilized CD34 pro-genitors. y Immunol 2000;164:3600— 7.
  • Hilf N, Singh-Jasuja H, Schwarzmaier P et al. Human plateletsexpress heat shock protein receptors and regulate dendritic cell maturation. Blood 2002;99:3676— 82.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.