In vitro characterization of two lineage-negative CD34⁺ cell-enriched hematopoietic cell populations from human UC blood

References

• Broxmeyer HE, Douglas GW, Hangoc G, et al. Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Proc Natl Acad Sci USA 1989; 86: 3828–32
   PubMed Web of Science ®Google Scholar
• Cairo MS, Wagner JE. Placental and/or umbilical cord blood: an alternative source of hematopoietic stem cells for transplantation. Blood 1997; 90: 4665–78
   PubMed Web of Science ®Google Scholar
• Mayani H, Lansdorp PM. Biology of human umbilical cord blood-derived hematopoietic stem/progenitor cells. Stem Cells 1998; 16: 153–65
   PubMed Web of Science ®Google Scholar
• Lansdorp PM, Dragowska W, Mayani H. Ontogeny-related changes in proliferative potential of human hematopoietic cells. J Exp Med 1993; 178: 787–91
   PubMed Web of Science ®Google Scholar
• Szilvassy SJ. The biology of hematopoietic stem cells. Arch Med Res 2003; 34: 446–60
   PubMed Web of Science ®Google Scholar
• Gluckman E. Current status of umbilical cord blood hematopoietic stem cell transplantation. Exp Hematol 2000; 28: 1197–205
   PubMed Web of Science ®Google Scholar
• Laughlin MJ, Barker J, Bambach B, et al. Hematopoietic engraftment and survival in adult recipients of umbilical cord blood from unrelated donors. N Engl J Med 2001; 344: 1815–22
   PubMed Web of Science ®Google Scholar
• Chao NJ, Koh LP, Long GD, et al. Adult recipients of umbilical cord blood transplants after nonmyeloablative preparative regimens. Biol Blood Marrow Transplant 2004; 10: 569–75
   PubMedGoogle Scholar
• Rocha V, Wagner JE, Sobocinski K, et al. Comparison of graft-vs-host disease in children transplanted with HLA identical sibling umbilical cord blood vs HLA identical sibling bone marrow transplant. N Engl J Med 2000; 342: 1846–54
   PubMed Web of Science ®Google Scholar
• Migliaccio A, Adamson JW, Stevens CE, et al. Cell dose and speed of engraftment in placental/umbilical cord blood transplantation: graft progenitor content is a better predictor than nucleated cell quantity. Blood 2000; 96: 2717–22
   PubMed Web of Science ®Google Scholar
• Piacibello W, Sanavio F, Garetto L, et al. Extensive amplification and self-renewal of human primitive hematopoietic stem cells from cord blood. Blood 1997; 89: 2644–53
   PubMed Web of Science ®Google Scholar
• Summers YJ, Heyworth CM, De Winter EA, et al. Cord blood G0 CD34+ cells have a thousand-fold higher capacity for generating progenitors in vitro than G1 CD34+ cells. Stem Cells 2001; 19: 505–13
   PubMed Web of Science ®Google Scholar
• Mayani H, Alvarado-Moreno JA, Flores-Guzman P. Biology of human hematopoietic stem and progenitor cells present in circulation. Arch Med Res 2003; 34: 476–88
   PubMedGoogle Scholar
• Shpall EJ, Quinones R, Giller R, et al. Transplantation of ex vivo expanded cord blood cells. Biol Blood Marrow Transplant 2002; 8: 368–76
   PubMed Web of Science ®Google Scholar
• Jaroscak J, Goltry K, Smith A, et al. Augmentation of umbilical cord blood (UCB) transplantation with ex vivo-expanded UCB cells: results of a phase I trial using the Aastrom-Replicell System. Blood 2003; 101: 5061–7
   PubMed Web of Science ®Google Scholar
• Douay L. Experimental culture conditions are critical for the ex vivo expansion of hematopoietic cells. J Hematother Stem Cell Res 2001; 10: 341–6
   PubMedGoogle Scholar
• Butler AC, Fitzsimons EJ, Graham GJ. Ex vivo expansion of cord blood cells: the clinical potential. Cord Blood Characteristics, SBA Cohen, E Gluckman, P Rubinstein, JA Madrigal. Martin Dunitz, UK 2000; 169–203
   Google Scholar
• Wognum AW, Eaves AC, Thomas TE. Identification and isolation of hematopoietic stem cells. Arch Med Res 2003; 34: 461–75
   PubMed Web of Science ®Google Scholar
• Flores-Guzman P, Gutierrez-Rodriguez M, Mayani H. In vitro proliferation, expansion and differentiation of a CD34+ cell-enriched hematopoietic cell population from human umbilical cord blood in response to recombinant cytokines. Arch Med Res 2002; 33: 107–14
   PubMed Web of Science ®Google Scholar
• Dufour C, Corcione A, Svahn J, et al. TNF-alpha and IFN-gamma are overexpressed in the bone marrow of Fanconi anemia patients and TNF-alpha suppresses erythropoiesis in vitro. Blood 2003; 102: 2053–9
   PubMed Web of Science ®Google Scholar
• Aggarwal BB. Signalling pathways of the TNF superfamily: a double-edge sword. Nat Rev Immunol 2003; 3: 745–56
   PubMed Web of Science ®Google Scholar
• Collins RH. CD34+ selected cells in clinical transplantation. Stem Cells 1994; 21: 577–85
   Google Scholar
• Ueda T, Tsuji K, Yoshino H, et al. Expansion of human NOD/SCID repopulating cells by stem cell factor, Flk2/Flt3 ligand, thrombopoietin, IL-6, and IL-6 receptor. J Clin Invest 2000; 105: 1013–21
   PubMed Web of Science ®Google Scholar
• Mayani H, Little M-T, Dragowska W, et al. Differential effects of the hematopoietic inhibitors MIP-1α, TGF-β, and TNF-α on cytokine-induced proliferation of subpopulations of CD34+ cells purified from cord blood and fetal liver. Exp Hematol 1995; 23: 422–7
   PubMed Web of Science ®Google Scholar
• Forraz N, Pettengell R, McGuckin CP. Characterization of a lineage-negative stem-progenitor cell population optimized for ex vivo expansion and enriched for LTC-IC. Stem Cells 2004; 22: 100–8
   PubMed Web of Science ®Google Scholar
• Briddell RA, Kern BP, Zilm KL, et al. Purification of CD34+ cells is essential for optimal ex vivo expansion of umbilical cord blood cells. J Hematother 1997; 6: 145–50
   PubMedGoogle Scholar
• McNiece I, Harrington J, Turney J, et al. Ex vivo expansion of cord blood mononuclear cells on mesenchymal stem cells. Cytotherapy 2004; 6: 311–17
   PubMed Web of Science ®Google Scholar
• Ryu K-H, Shin H-Y, Ahn H-S, et al. Comparison of efficiency of ex vivo expansion of whole blood, mononuclear cells and purified CD34+ cells from human umbilical cord blood. Haematologica 2004; 89: 606–7
   PubMedGoogle Scholar
• Denning-Kendall PA, Nicol A, Horsley H, et al. Is in vitro expansion of human cord blood cells clinically relevant?. Bone Marrow Transplant 1998; 21: 225–32
   PubMedGoogle Scholar
• Ohmizono Y, Sakabe H, Kimura T, et al. Thrombopoietin augments ex vivo expansion of human cord blood-derived hematopoietic progenitors in combination with stem cell factor and flt3 ligand. Leukemia 1997; 11: 524–30
   PubMed Web of Science ®Google Scholar
• Migliaccio G, Migliaccio AR, Druzin ML, et al. Long-term generation of colony-forming cells in liquid culture of CD34+ cord blood cells in the presence of recombinant human stem cell factor. Blood 1992; 79: 2620–7
   PubMed Web of Science ®Google Scholar
• Stiff P, Pecora AL, Parthasarathy M. Umbilical cord blood transplants in adults using a combination of unexpanded and ex vivo expanded cells: preliminary clinical observations (abstract). Blood 1998; 92(Suppl)646a
   Google Scholar
• Pecora AL, Stiff P, Jennis A, et al. Prompt and durable engraftment in two older adult patients with high risk chronic myelogenous leukemia (CML) using ex vivo expanded and unmanipulated unrelated umbilical cord blood. Bone Marrow Transplant 2000; 25: 797–9
   PubMed Web of Science ®Google Scholar
• Kogler G, Nurnberger W, Fischer J, et al. Simultaneous cord blood transplantation of ex vivo expanded together with non-expanded cells for high risk leukemia. Bone Marrow Transplant 1999; 24: 397–403
   PubMed Web of Science ®Google Scholar
• McNiece I. Ex vivo expansion of hematopoietic cells (editorial). Exp Hematol 2004; 32: 409–10
   PubMedGoogle Scholar
• Gluckman E. Ex vivo expansion of cord blood cells (editorial). Exp Hematol 2004; 32: 410–12
   PubMed Web of Science ®Google Scholar
• Wagner JE, Verfaillie CM. Ex vivo expansion of umbilical cord blood hemopoietic stem and progenitor cells (editorial). Exp Hematol 2004; 32: 412–13
   PubMedGoogle Scholar
• Peled T, Mandel J, Goudsmid R, et al. Pre-clinical development of cord blood-derived progenitor cell graft expanded ex vivo with cytokines and the polyamine copper chelator tetraethylenepentamine. Cytotherapy 2004; 6: 344–55
   PubMed Web of Science ®Google Scholar