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Original

Combined protocol of cell therapy for chronic spinal cord injury. Report on the electrical and functional recovery of two patients

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Pages 202-209 | Published online: 07 Jul 2009

References

  • Moalem G, Leibowitz-Amit R, Yoles E, et al. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nature Med 1999; 5: 49–55
  • Yoles E, Hauben E, Palgio O, et al. Protective autoimmunity is a physiological response to CNS trauma. J Neurosci 2001; 21: 3740–8
  • Kerschensteiner M, Gallmeier E, Behrens L, et al. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation?. J Exp Med 1999; 189: 865–70
  • Leone AM, Rutella S, Bonanno G, et al. Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function. Eur Heart J 2005; 26: 1196–204
  • Moviglia GA, Varela G, Gaeta CA , et al Autoreactive T cells induce in vitro BM mesenchymal stem cell transdifferentiation to neural stem cells. Cytotherapy 2006;8:116–201.
  • Jerne NK. Towards a network theory of the immune system. Ann Immunol (Inst Pasteur) 1974; 125C: 373–89
  • Ehrhard PB, Erb P, Graumann U, Otten U. Expression of nerve growth factor and nerve growth factor receptor tyrosine kinase Trk in activated CD4-positive T-cell clones. Proc Natl Acad Sci USA 1993; 90: 10984–8
  • US Department of Health and Human Services, FDA, CDER, CBER, ORA. Guidance for Industry Sterile Drug Products produced by Aseptic Processing. Current Good Manufacturer Practices. FDAWashington DC, USA. September, 2004 c GMP.
  • Moviglia GA, Iraola N, Varela G , et al. T cell vaccination (TCV) for secondary chronic progressive multiple sclerosis (CPMS), associated to β interferon (β IFN) and total plasma exchange (TPX) pre-treatment. Proceedings of Benzon Symposium No. 49, Multiple Sclerosis: Genetics, Pathogenesis and Therapy. Copenhagen: 19–22 August 2002.
  • Prockop DJ, Gregory CA, Spees JL. One strategy for cell and gene therapy: harnessing the power of adult stem cells to repair tissues. Proc Natl Acad Sci USA 2003; 100(Suppl 1)11917–23
  • Tondreau T, Meuleman N, Delforge A, et al. Mesenchymal stem cells derived from CD133-positive cells in mobilized peripheral blood and cord blood: proliferation,Oct4 expression, and plasticity. Stem Cells 2005; 23: 1105–12
  • Gallacher L, Murdoch B, Wu DM, et al. Isolation and characterization of human CD34− Lin− CD34+ Lin− hematopoietic stem cells using cell surface markers AC133 and CD7. Blood 2000; 95: 2813–20
  • Moalem G, Gdalyahu A, Shani Y, et al. Production of neurotrophins by activated T cells: implications for neuroprotective autoimmunity. J Autoimmun 2000; 15: 331–45
  • Muhallab S, Lundberg C, Gielen AW, et al. Differential expression of neurotrophic factors and inflammatory cytokines by myelin basic protein-specific and other recruited T cells infiltrating the central nervous system during experimental autoimmune encephalomyelitis. Scand J Immunol 2002; 55: 264–73
  • Chu K, Kim M, Jeong SW, et al. Human neural stem cells can migrate, differentiate, and integrate after intravenous transplantation in adult rats with transient forebrain ischemia. Neurosci Lett 2003; 343: 129–33
  • Kang K-S, Kim SW, Oh YH, et al. A 37-year-old spinal cord-injured female patient, transplanted of multipotent stem cells from human UC blood, with improved sensory perception and mobility, both functionally and morphologically: a case study. Cytotherapy 2005; 7: 368–73
  • Satake K, Lou J, Lenke LG. Migration of mesenchymal stem cells through cerebrospinal fluid into injures spinal cord tissue. Spine 2004; 29: 1971–9
  • Sipski M, Jackson AB, Gomez- Marín O, et al. Effects of gender on neurogenic and functional recovery alter spinal cord injury. Arch Phys Med Rehabil 2004; 85: 1826–36
  • Myckatyn TM, Mackinnon SE, McDonald JW. Stem cell transplantation and other novel techniques for promoting recovery from spinal cord injury. Transplant Immunol 2004; 12: 343–58
  • Ankeny DP, McTigue DM, Jakeman LB. Bone marrow transplants provide tissue protection and directional guidance for axon after contusive spinal cord injury in rats. Exp Neurol 2004; 190: 17–31
  • Gluckman E, Rocha V, Boyer-Chammard A, et al. Outcome of cord blood transplantation from related and unrelated donors. N Engl J Med 1997; 337: 373–81

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