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Original

Human embryonic stem cells: a journey beyond cell replacement therapies

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Pages 530-541 | Published online: 07 Jul 2009

References

  • Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981; 292: 154–6
  • Martin GR. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA 1981; 78: 7634–8
  • Bradley A, Hasty P, Davis A, Ramirez-Solis R. Modifying the mouse: design and desire. Biotechnology (NY) 1992; 10: 534–9
  • Keller G. Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev 2005; 19: 1129–55
  • Lerou PH, Daley GQ. Therapeutic potential of embryonic stem cells. Blood Rev 2005; 19: 321–31
  • Reubinoff BE, Pera MF, Fong CY, et al. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol 2000; 18: 399–404
  • Thomson JA, Itskovitz-Eldor J, Shapiro SS, et al. Embryonic stem cell lines derived from human blastocysts. Science 1998; 282: 1145–7
  • Hoffman LM, Carpenter MK. Characterization and culture of human embryonic stem cells. Nat Biotechnol 2005; 23: 699–708
  • Chadwick K, Wang L, Li L, et al. Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells. Blood 2003; 102: 906–15
  • Cerdan C, Rouleau A, Bhatia M. VEGF-A165 augments erythropoietic development from human embryonic stem cells. Blood 2004; 103: 2504–12
  • Kehat I, Kenyagin-Karsenti D, Snir M, et al. Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J Clin Invest 2001; 108: 407–14
  • Levenberg S, Golub JS, Amit M, et al. Endothelial cells derived from human embryonic stem cells. Proc Natl Acad Sci USA 2002; 99: 4391–6
  • Lumelsky N, Blondel O, Laeng P, et al. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 2001; 292: 1389–94
  • Nistor GI, Totoiu MO, Haque N, et al. Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation. Glia 2005; 19: 335–96
  • Xu C, Police S, Rao N, Carpenter MK. Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells. Circ Res 2002; 91: 501–8
  • Sottile V, Seuwen K, Kneissel M. Enhanced marrow adipogenesis and bone resorption in estrogen-deprived rats treated with the PPARgamma agonist BRL49653 (rosiglitazone). Calcif Tissue Int 2004; 75: 329–37
  • Wang L, Li L, Shojaei F, et al. Endothelial and hematopoietic cell fate of human embryonic stem cells originates from primitive endothelium with hemangioblastic properties. Immunity 2004; 21: 31–41
  • Wang, L, Menendez, P, Shojaei, F, , et al. Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HoxB4 expression. J Exp Med 2005:1603–15.
  • Kaufman DS, Hanson ET, Lewis RL, et al. Hematopoietic colony-forming cells derived from human embryonic stem cells. Proc Natl Acad Sci USA 2001; 98: 10716–21
  • Andrews PW. Human teratocarcinomas. Biochim Biophys Acta 1988; 948: 17–36
  • Iuchi S, Dabelsteen S, Easley K, et al. Immortalized keratinocyte lines derived from human embryonic stem cells. Proc Natl Acad Sci USA 2006; 103: 1792–7
  • He JQ, Ma Y, Lee Y, et al. Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization. Circ Res 2003; 93: 32–9
  • Menendez P, Bueno C, Wang L, Bhatia M. Human embryonic stem cells: potential tool for achieving immunotolerance?. Stem Cell Reviews 2005; 1: 151–8
  • Rathjen PD, Lake J, Whyatt LM, et al. Properties and uses of embryonic stem cells: prospects for application to human biology and gene therapy. Reprod Fertil Dev 1998; 10: 31–47
  • Lebkowski JS, Gold J, Xu C, et al. Human embryonic stem cells: culture, differentiation, and genetic modification for regenerative medicine applications. Cancer J 2001; 7(Suppl 2)S83–93
  • Brivanlou AH, Gage FH, Jaenisch R, et al. Stem cells. Setting standards for human embryonic stem cells. Science 2003; 300: 913–6
  • Menendez P, Wang L, Bhatia M. Genetic manipulation of human embryonic stem cells: a system to study early human development and potential therapeutic applications. Curr Gene Ther 2005; 5: 375–85
  • Lensch MW, Daley GQ. Scientific and clinical opportunities for modeling blood disorders with embryonic stem cells. Blood 2006; 107: 2605–12
  • Pera M, Trounson A. Human embryonic stem cells: prospects for development. Development 2004; 131: 5515–25
  • Weissman IL. Medicine: politic stem cells. Nature 2006; 439: 145–7
  • Jain KK. Ethical and regulatory aspects of embryonic stem cell research. Expert Opin Biol Ther 2005; 5: 153–62
  • Lo B, Zettler P, Cedars MI, et al. A new era in the ethics of human embryonic stem cell research. Stem Cells 2005; 23: 1454–9
  • Carpenter MK, Inokuma MS, Denham J, et al. Enrichment of neurons and neural precursors from human embryonic stem cells. Exp Neurol 2001; 172: 383–97
  • Schuldiner M, Eiges R, Eden A, et al. Induced neuronal differentiation of human embryonic stem cells. Brain Res 2001; 913: 201–5
  • Zhang SC, Wernig M, Duncan ID, et al. In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nat Biotechnol 2001; 19: 1129–33
  • Reubinoff BE, Itsykson P, Turetsky T, et al. Neural progenitors from human embryonic stem cells. Nat Biotechnol 2001; 19: 1134–40
  • Schulz TC, Noggle SA, Palmarini GM, et al. Differentiation of human embryonic stem cells to dopaminergic neurons in serum-free suspension culture. Stem Cells 2004; 22: 1218–38
  • Schulz TC, Palmarini GM, Noggle SA, et al. Directed neuronal differentiation of human embryonic stem cells. BMC Neurosci 2003; 4: 27: 1–13
  • Ben-Hur T, Idelson M, Khaner H, et al. Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian rats. Stem Cells 2004; 22: 1246–55
  • Pera MF, Andrade J, Houssami S, et al. Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin. J Cell Sci 2004; 117: 1269–80
  • Perrier, AL, Tabar, V, Barberi, T, , et al. Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc Natl Acad Sci USA 2004;101:12543–8.
  • Zeng X, Cai J, Chen J, et al. Dopaminergic differentiation of human embryonic stem cells. Stem Cells 2004; 22: 925–40
  • Park SW, Kim SH, Park KH, et al. Preventive effect of antioxidants in MPTP-induced mouse model of Parkinson's disease. Neurosci Lett 2004; 363: 243–6
  • Li, XJ, Du, ZW, Zarnowska, ED, , et al. Specification of motoneurons from human embryonic stem cells. Nat Biotechnol, 2005;23:215–21.
  • Nistor GI, Totoiu MO, Haque N, et al. Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation. Glia 2005; 49: 385–96
  • Assady S, Maor G, Amit M, et al. Insulin production by human embryonic stem cells. Diabetes 2001; 50: 1691–7
  • Segev H, Fishman B, Ziskind A, et al. Differentiation of human embryonic stem cells into insulin-producing clusters. Stem Cells 2004; 22: 265–74
  • Kehat I, Amit M, Gepstein A, et al. Development of cardiomyocytes from human ES cells. Methods Enzymol 2003; 365: 461–73
  • Kehat I, Gepstein A, Spira A, et al. High-resolution electrophysiological assessment of human embryonic stem cell-derived cardiomyocytes: a novel in vitro model for the study of conduction. Circ Res 2002; 91: 659–61
  • Kehat, I, Khimovich, L, Caspi, O, , et al. Electromechanical integration of cardiomyocytes derived from human embryonic stem cells. Nat Biotechnol 2004;22:1282–9.
  • Mummery C, Ward D, van den Brink CE, et al. Cardiomyocyte differentiation of mouse and human embryonic stem cells. J Anat 2002; 200: 233–42
  • Mummery, C, Ward-van Oostwaard, D, Doevendans, P, , et al. Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells. Circulation 2003;107:2733–40.
  • Snir M, Kehat I, Gepstein A, et al. Assessment of the ultrastructural and proliferative properties of human embryonic stem cell-derived cardiomyocytes. Am J Physiol Heart Circ Physiol 2003; 285: H2355–63
  • Satin, J, Kehat, I, Caspi, O, , et al. Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes. J Physiol 2004;559:479–96.
  • Xue, T, Cho, HC, Akar, FG, , et al. Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers. Circulation 2005;111:11–20.
  • Menendez P, Wang L, Chadwick K, et al. Retroviral transduction of hematopoietic cells differentiated from human embryonic stem cell-derived CD45(neg)PFV hemogenic precursors. Mol Ther 2004; 10: 1109–20
  • Zambidis, ET, Peault, B, Park, TS, , et al. Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development. Blood 2005;106:860–70.
  • Narayan AD, Chase JL, Lewis RL, et al. Human embryonic stem cell-derived hematopoietic cells are capable of engrafting primary as well as secondary fetal sheep recipients. Blood 2005; 107: 2180–3
  • Vodyanik, MA, Bork, JA, Thomson, JA, Slukvin, II. Human embryonic stem cell-derived CD34+ cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potential. Blood 2005;105:617–26.
  • Woll PS, Martin CH, Miller JS, Kaufman DS. Human embryonic stem cell-derived NK cells acquire functional receptors and cytolytic activity. J Immunol 2005; 175: 5095–103
  • Zhan X, Dravid G, Ye Z, et al. Functional antigen-presenting leucocytes derived from human embryonic stem cells in vitro. Lancet 2004; 364: 163–71
  • Gerecht-Nir S, Dazard JE, Golan-Mashiach M, et al. Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem cells. Dev Dyn 2005; 232: 487–97
  • Rambhatla L, Chiu CP, Kundu P, et al. Generation of hepatocyte-like cells from human embryonic stem cells. Cell Transplant 2003; 12: 1–11
  • Lavon N, Yanuka O, Benvenisty N. Differentiation and isolation of hepatic-like cells from human embryonic stem cells. Differentiation 2004; 72: 230–8
  • Gerami-Naini B, Dovzhenko OV, Durning M, et al. Trophoblast differentiation in embryoid bodies derived from human embryonic stem cells. Endocrinology 2004; 145: 1517–24
  • Xu RH, Chen X, Li DS, et al. BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat Biotechnol 2002; 20: 1261–4
  • Clark AT, Bodnar MS, Fox M, et al. Spontaneous differentiation of germ cells from human embryonic stem cells in vitro. Hum Mol Genet 2004; 13: 727–39
  • Gerecht-Nir, S, Osenberg, S, Nevo, O, , et al. Vascular development in early human embryos and in teratomas derived from human embryonic stem cells. Biol Reprod 2004;71: 2029–36.
  • Przyborski SA. Differentiation of human embryonic stem cells after transplantation in immune-deficient mice. Stem Cells 2005; 23: 1242–50
  • Krause DS, Fackler MJ, Civin CI, May WS. CD34: structure, biology, and clinical utility. Blood 1996; 87: 1–13
  • Menendez P, Caballero MD, Prosper F, et al. The composition of leukapheresis products impacts on the hematopoietic recovery after autologous transplantation independently of the mobilization regimen. Transfusion 2002; 42: 1159–72
  • Menendez P, Perez-Simon JA, Mateos MV, et al. Influence of the different CD34+ and CD34− cell subsets infused on clinical outcome after non-myeloablative allogeneic peripheral blood transplantation from human leucocyte antigen-identical sibling donors. Br J Haematol 2002; 119: 135–43
  • Overturf K, al-Dhalimy M, Ou CM, et al. Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes. Am J Phatol 1997; 151: 1273–80
  • Carruthers, S, Stemple, DL. Genetic and genomic prospects for Xenopustropicalis research. Semin Cell Dev Biol 2006;17:46–53.
  • Berman JN, Kanki JP, Look AT. Zebrafish as a model for myelopoiesis during embryogenesis. Exp Hematol 2005; 33: 997–1006
  • Guasch G, Fuchs E. Mice in the world of stem cell biology. Nat Genet 2005; 37: 1201–6
  • Okada TS. From embryonic induction to cell lineages: revisiting old problems for modern studies. Int J Dev Biol 2004; 48: 739–42
  • Daley GQ. From embryos to embryoid bodies: generating blood from embryonic stem cells. Ann NY Acad Sci 2003; 996: 122–31
  • Davila JC, Cezar GG, Thiede M, et al. Use and application of stem cells in toxicology. Toxicol Sci 2004; 79: 214–23
  • Kaplowitz N. Idiosyncratic drug hepatoxicity. Nat Rev Drug Discovery 2005; 4: 489–99
  • Schuster D, Laggner C, Langer T. Why drugs fail? A study on side effects in new chemical entities. Curr Pharma Des 2005; 11: 3545–59
  • Sell S. Stem cell origin of cancer and differentiation therapy. Crit Rev Oncol Hematol 2004; 51: 1–28
  • Zelent A. APL and differentiation therapy: joint international congress. IDrugs 2001; 4: 1257–62
  • Allegrucci C, Denning CN, Burridge P, et al. Human embryonic stem cells as a model for nutritional programming: an evaluation. Reprod Toxicol 2005; 20: 353–67
  • Barker DJ, Osmond C. Infant mortality, childhood nutrition and ischaemic heart disease in England and Wales. Lancet 1986; 1: 1077–81
  • Lau C, Rogers JM. Embryonic and fetal programming of physiological disorders in adulthood. Birth Defects Res C Embryo Today 2004; 72: 300–12
  • McMillen IC, Robinson JS. Development origins of the metabolic syndrome: prediction, platicity and programming. Physiol Rev 2005; 85: 571–633
  • Gluckman PD, Cutfield W, Hofman P, Hanson MA. The fetal, neonatal and infant microenviroments: the long-term consequences for disease risk. Early Hum Dev 2005; 81: 51–9
  • Greaves MF, Wiemels J. Origins of chromosome translocations in childhood leukaemia. Nat Rev Cancer 2003; 3: 639–49
  • Greaves M. Pre-natal origins of childhood leukemia. Rev Clin Exp Hematol 2003; 7: 233–45
  • Valk-Lingbeek ME, Bruggeman SW, van Lohuizen M. Stem cells and cancer; the polycomb connection. Cell 2004; 118: 409–18
  • Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature 2004; 432: 324–31
  • Bell DR, Van Zant G. Stem cells, aging, and cancer: inevitabilities and outcomes. Oncogene 2004; 23: 7290–6
  • Pierce GB, Johnson LD. Differentiation and cancer. In Vitro 1971; 7: 140–5
  • Pierce GB, Johnson LD. Relationship between differentiation and carcinogenesis. J Toxicol Environ Health 1977; 2: 1335–42
  • Herszfeld, D, Wolvetang, E, Langton-Bunker, E, , et al. CD30 is a survival factor and a biomarker for transformed human embryonic stem cells. Nat Biotechnol 2006;24:325–6.
  • Xu C, Inokuma MS, Denham J, et al. Feeder-free growth of undifferentiated human embryonic stem cells. Nat Biotechnol 2001; 19: 971–4
  • Amit M, Shariki C, Margulets V, Itskovitz-Eldor J. Feeder layer- and serum-free culture of human embryonic stem cells. Biol Reprod 2004; 70: 837–45
  • Wang L, Li L, Menendez P, et al. Human embryonic stem cells maintained in the absence of mouse embryonic fibroblast or conditioned media are capable of hematopoietic development. Blood 2005; 105: 4598–603
  • Xu RH, Peck RM, Li DS, et al. Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells. Nature Methods 2005; 2: 185–90
  • Andrews PW, Damjanov I, Simon D, et al. Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vitro and in vivo. Lab Invest 1984; 50: 147–62
  • Yeom YI, Fuhrmann G, Ovitt CE, et al. Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells. Development 1996; 122: 881–94
  • Rosner MH, Vigano MA, Ozato K, et al. A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature 1990; 345: 686–92
  • Mitsui K, Tokuzawa Y, Itoh H, et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 2003; 113: 631–42
  • Chambers I, Colby D, Robertson M, et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003; 113: 643–55
  • Okamoto K, Okazawa H, Okuda A, et al. A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell 1990; 60: 461–72
  • Korbling M, Anderlini P. Peripheral blood stem cell versus bone marrow allotransplantation: does the source of hematopoietic stem cells matter?. Blood 2001; 98: 2900–8
  • Robertson, S, Kennedy, M, Keller, G. Hematopoietic commitment during embryogenesis. Ann NY Acad Sci 1999;872:9–15; discussion 15–16.
  • Choi K, Kennedy M, Kazarov A, et al. A common precursor for hematopoietic and endothelial cells. Development 1998; 125: 725–32
  • Tavian M, Peault B. Embryonic development of the human hematopoietic system. Int J Dev Biol 2005; 49: 243–50
  • Dzierzak E. The emergence of definitive hematopoietic stem cells in the mammal. Curr Opin Hematol 2005; 12: 197–202
  • Dzierzak E. Ontogenic emergence of definitive hematopoietic stem cells. Curr Opin Hematol 2003; 10: 229–34
  • Shalaby F, Ho J, Stanford WL, et al. A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis. Cell 1997; 89: 981–90
  • Wood HB, May G, Healy L, et al. CD34 expression patterns during early mouse development are related to modes of blood vessel formation and reveal additional sites of hematopoiesis. Blood 1997; 90: 2300–11
  • Wang L, Menendez P, Cerdan C, Bhatia M. Hematopoietic development from human embryonic stem cell lines. Exp Hematol 2005; 33: 987–96
  • Tian, X, Woll, PS, Morris, JK, , et al. Hematopoietic engraftment of human embryonic stem cell-derived cells is regulated by recipient innate immunity. Stem Cells, 2006;24:1370–8.

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