Transgene-enforced co-stimulation of CD4⁺ T cells leads to enhanced and sustained anti-tumor effector functioning

References

• Castellino F, Germain RN. Cooperation between CD4+ and CD8+ T cells: when, where, and how. Annu Rev Immunol 2006; 24: 519–40
   PubMed Web of Science ®Google Scholar
• Knutson KL, Disis ML. Tumor antigen-specific T helper cells in cancer immunity and immunotherapy. Cancer Immunol Immunother 2005; 54: 721–8
   PubMed Web of Science ®Google Scholar
• Janssen EM, Lemmens EE, Wolfe T, et al. CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes. Nature 2003; 421: 852–6
   PubMed Web of Science ®Google Scholar
• Shedlock DJ, Shen H. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 2003; 300: 337–9
   PubMed Web of Science ®Google Scholar
• Baskar S, Ostrand-Rosenberg S, Nabavi N, et al. Constitutive expression of B7 restores immunogenicity of tumor cells expressing truncated major histocompatibility complex class II molecules. Proc Natl Acad Sci USA 1993; 90: 5687–90
   PubMed Web of Science ®Google Scholar
• Chen L, Ashe S, Brady WA, et al. Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Cell 1992; 71: 1093–102
   PubMed Web of Science ®Google Scholar
• Townsend SE, Allison JP. Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells. Science 1993; 259: 368–70
   PubMed Web of Science ®Google Scholar
• Kahlon KS, Brown C, Cooper LJ, et al. Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells. Cancer Res 2004; 64: 9160–6
   PubMed Web of Science ®Google Scholar
• Cooper LJ, Al-Kadhimi Z, Serrano LM, et al. Enhanced antilymphoma efficacy of CD19-redirected influenza MP1-specific CTLs by cotransfer of T cells modified to present influenza MP1. Blood 2005; 105: 1622–31
   PubMed Web of Science ®Google Scholar
• Serrano LM, Pfeiffer T, Olivares S, et al. Differentiation of naive cord-blood T cells into CD19-specific cytolytic effectors for posttransplantation adoptive immunotherapy. Blood 2006; 107: 2643–52
   PubMed Web of Science ®Google Scholar
• Cooper LJ, Kalos M, DiGiusto D, et al. T-cell genetic modification for re-directed tumor recognition. Cancer Chemother Biol Response Modif 2005; 22: 293–324
   PubMedGoogle Scholar
• Whitmire JK, Ahmed R. Costimulation in antiviral immunity: differential requirements for CD4(+) and CD8(+) T cell responses. Curr Opin Immunol 2000; 12: 448–55
   PubMed Web of Science ®Google Scholar
• Cheuk AT, Mufti GJ, Guinn BA. Role of 4-1BB:4-1BB ligand in cancer immunotherapy. Cancer Gene Ther 2004; 11: 215–26
   PubMed Web of Science ®Google Scholar
• Debinski W, Gibo DM, Obiri NI, et al. Novel anti-brain tumor cytotoxins specific for cancer cells. Nat Biotechnol 1998; 16: 449–53
   PubMed Web of Science ®Google Scholar
• Nash KT, Thompson JP, Debinski W. Molecular targeting of malignant gliomas with novel multiply-mutated interleukin 13-based cytotoxins. Crit Rev Oncol Hematol 2001; 39: 87–98
   Google Scholar
• Donnelly ML, Hughes LE, Luke G, et al. The ‘cleavage’ activities of foot-and-mouth disease virus 2A site-directed mutants and naturally occurring ‘2A-like’ sequences. J Gen Virol 2001; 82: 1027–41
   PubMed Web of Science ®Google Scholar
• Meisel R, Bardenheuer W, Strehblow C, et al. Efficient protection from methotrexate toxicity and selection of transduced human hematopoietic cells following gene transfer of dihydrofolate reductase mutants. Exp Hematol 2003; 31: 1215–22
   Google Scholar
• Hibi M, Lin A, Smeal T, et al. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 1993; 7: 2135–48
   PubMed Web of Science ®Google Scholar
• Chang L, Kamata H, Solinas G, et al. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell 2006; 124: 601–13
   PubMed Web of Science ®Google Scholar
• Brown CE, Wright CL, Naranjo A, et al. Biophotonic cytotoxicity assay for high-throughput screening of cytolytic killing. J Immunol Methods 2005; 297: 39–52
   PubMed Web of Science ®Google Scholar
• Kane LP, Weiss A. The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3. Immunol Rev 2003; 192: 7–20
   PubMedGoogle Scholar
• Rincon M, Pedraza-Alva G. JNK and p38 MAP kinases in CD4+ and CD8+ T cells. Immunol Rev 2003; 192: 131–42
   PubMed Web of Science ®Google Scholar
• Glimcher LH, Murphy KM. Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev 2000; 14: 1693–711
   PubMed Web of Science ®Google Scholar
• Finney HM, Akbar AN, Lawson AD. Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain. J Immunol 2004; 172: 104–13
   PubMed Web of Science ®Google Scholar
• Kowolik CM, Topp MS, Gonzalez S, et al. CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells. Cancer Res 2006; 66: 10995–1004
   PubMed Web of Science ®Google Scholar
• Imai C, Mihara K, Andreansky M, et al. Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia. Leukemia 2004; 18: 676–84
   PubMed Web of Science ®Google Scholar
• Pule MA, Straathof KC, Dotti G, et al. A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells. Mol Ther 2005; 12: 933–41
   PubMed Web of Science ®Google Scholar
• Su B, Jacinto E, Hibi M, et al. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 1994; 77: 727–36
   PubMed Web of Science ®Google Scholar
• Chialda L, Zhang M, Brune K, Pahl A. Inhibitors of mitogen-activated protein kinases differentially regulate costimulated T cell cytokine production and mouse airway eosinophilia. Respir Res 2005; 6: 36
   PubMed Web of Science ®Google Scholar
• Cannons JL, Hoeflich KP, Woodgett JR, Watts TH. Role of the stress kinase pathway in signaling via the T cell costimulatory receptor 4-1BB. J Immunol 1999; 163: 2990–8
   Google Scholar
• Starck L, Scholz C, Dorken B, Daniel PT. Costimulation by CD137/4-1BB inhibits T cell apoptosis and induces Bcl-xL and c-FLIP(short) via phosphatidylinositol 3-kinase and AKT/protein kinase B. Eur J Immunol 2005; 35: 1257–66
   Google Scholar
• Kane LP, Andres PG, Howland KC, et al. Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines. Nat Immunol 2001; 2: 37–44
   PubMed Web of Science ®Google Scholar
• Minn AJ, Gupta GP, Siegel PM, et al. Genes that mediate breast cancer metastasis to lung. Nature 2005; 436: 518–24
   PubMed Web of Science ®Google Scholar
• Husain SR, Obiri NI, Gill P, et al. Receptor for interleukin 13 on AIDS-associated Kaposi's sarcoma cells serves as a new target for a potent Pseudomonas exotoxin-based chimeric toxin protein. Clin Cancer Res 1997; 3: 151–6
   PubMed Web of Science ®Google Scholar
• Kawakami K, Terabe M, Kawakami M, et al. Characterization of a novel human tumor antigen interleukin-13 receptor alpha2 chain. Cancer Res 2006; 66: 4434–42
   Google Scholar
• Kawakami M, Kawakami K, Kasperbauer JL, et al. Interleukin-13 receptor alpha2 chain in human head and neck cancer serves as a unique diagnostic marker. Clin Cancer Res 2003; 9: 6381–8
   Google Scholar
• Kawakami M, Kawakami K, Takahashi S, et al. Analysis of interleukin-13 receptor alpha2 expression in human pediatric brain tumors. Cancer 2004; 101: 1036–42
   PubMed Web of Science ®Google Scholar
• Kioi M, Kawakami M, Shimamura T, et al. Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy. Cancer 2006; 107: 1407–18
   PubMed Web of Science ®Google Scholar
• Croft M. Costimulation of T cells by OX40, 4-1BB, and CD27. Cytokine Growth Factor Rev 2003; 14: 265–73
   PubMed Web of Science ®Google Scholar
• Lee SW, Park Y, Song A, et al. Functional dichotomy between OX40 and 4-1BB in modulating effector CD8 T cell responses. J Immunol 2006; 177: 4464–72
   Google Scholar