A simple and efficient method for generating Nurr1-positive neuronal stem cells from human wisdom teeth (tNSC) and the potential of tNSC for stroke therapy

References

• Bossolasco P, Cova L, Calzarossa C, Rimoldi SG, Borsotti C, Lambertenghi D, et al. Neuro-glial differentiation of human bone marrow stem cells in vitro. Exp Neurol. 2004; 193:312–25.
   Google Scholar
• Sanchez-Ramos JR. Neural cells derived from adult bone marrow and umbilical cord blood. J Neurosci Res. 2002; 69:880–93.
   PubMed Web of Science ®Google Scholar
• Mitchell KE, Weiss ML, Mitchell BM, Martin P, Davis D, Morales L, et al. Matrix cells from Wharton's jelly from neurons and glia. Stem Cells. 2003; 21:50–60.
   PubMed Web of Science ®Google Scholar
• Berger MJ, Adams SD, Tigges BM, Sprague SL, Wang X-J, Collins DP, et al. Differentiation of umbilical cord blood-derived multilineage progenitor cells into respiratory epithelial cells. Cytotherapy. 2006; 8:480–7.
   PubMed Web of Science ®Google Scholar
• Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat M-L, et al. Generation of a functional mammary gland from a single stem cell. Nature. 2006; 439:84–8.
   PubMed Web of Science ®Google Scholar
• Yusta-Boyo MJ, González M, Pavón N, Martin AB, de la Fuente R, García-Castro J, et al. Absence of hematopoiesis from transplanted olfactory bulb neural stem cells. Eur J Neurosci. 2004; 19:505–12.
   Google Scholar
• Aust L, Devlin B, Foster SJ, Halvorsen YDC, Hicok K, du Laney T, et al. Yield of human adipose-derived adult stem cells from liposuction aspirates. Cytotherapy. 2004; 6:7–14.
   PubMed Web of Science ®Google Scholar
• Urbanek K, Quaini F, Tasca G, Torella D, Castaldo C, Nadal-Ginard B, et al. Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy. PNAS. 2003; 100:10440–5.
   PubMed Web of Science ®Google Scholar
• Svendsen CN, Caldwell MA, Ostenfeld T. Human neural stem cells: isolation, expansion and transplantation. Brain Pathol. 1999; 9:499–513.
   PubMed Web of Science ®Google Scholar
• Dotto GP, Cotsarelis G. Rac 1 up for epidermal stem cells. Science. 2005; 309:890–1.
   Google Scholar
• Benitah SA, Frye M, Glogauer M, Watt FM. Stem cell depletion through epidermal deletion of Rac 1. Science. 2005; 309:933–5.
   PubMed Web of Science ®Google Scholar
• Koizumi N, Inatomi T, Suzuki T, Sotozono C, Kinoshita S. Cultivated corneal epithelial stem cell transplantation in ocular surface disorders. Ophthalmology. 2001; 108:1569–74.
   PubMed Web of Science ®Google Scholar
• Tropepe V, Coles BLK, Chiasson BJ, Horsford DJ, Elia AJ, McInnes RR, et al. Retinal stem cells in the adult mammalian eye. Science. 2000; 287:2032–6.
   PubMed Web of Science ®Google Scholar
• Chen Y, Dong X-J, Zhang G-R, Shao J-Z, Xiang L-X. Transdifferentiation of mouse BM cells into hepatocyte-like cells. Cytotherapy. 2006; 8:381–9.
   PubMed Web of Science ®Google Scholar
• Tomita M, Adachi Y, Yamada H, Takahashi K, Kiuchi K, Oyaizu H, et al. Bone marrow-derived stem cells can differentiate into retinal cells in injured rat retina. Stem Cells. 2002; 20:279–83.
   PubMed Web of Science ®Google Scholar
• Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. PNAS. 2000; 97:13625–30.
   PubMed Web of Science ®Google Scholar
• Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, et al. SHED: stem cells from human exfoliated deciduous teeth. PNAS. 2003; 100:5807–12.
   PubMed Web of Science ®Google Scholar
• Petersen BE, Bowen WC, Patrene KD, Mars WM, Sullivan AK, Murase N, Boggs SS, et al. Bone marrow as a potential source of hepatic oval cells. Science. 1999; 284:1168–70.
   PubMed Web of Science ®Google Scholar
• Orlic D. BM stem cells and cardiac repair: where do we stand in 2004?. Cytotherapy. 2004; 7:3–15.
   Google Scholar
• Lamoury FMJ, Croitoru-Lamoury J, Brew BJ. Undifferentiated mouse mesenchymal stem cells spontaneously express neural and stem cell markers Oct-4 and Rex-1. Cytotherapy. 2006; 8:228–42.
   PubMed Web of Science ®Google Scholar
• Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini FC, Krause DS, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006; 8:315–17.
   PubMed Web of Science ®Google Scholar
• Nosrat IV, Smith CA, Mullally P, Olson L, Nosrat CA. Dental pulp cells provide neurotrophic support for dopaminergic neurons and differentiate into neurons in vitro; implications for tissue engineering and repair in the nervous system. Eur J Neurosci. 2004; 19:2388–98.
   PubMed Web of Science ®Google Scholar
• Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch-Eur J Physiol. 1981; 391:85–100.
   PubMed Web of Science ®Google Scholar
• Vendrame M, Cassady J, Newcomb J, Butler T, Pennypacker KR, Zigova T, et al. Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume. Stroke. 2004; 35:2390–5.
   PubMed Web of Science ®Google Scholar
• Benedek A, Móricz K, Jurányi Z, Gigler G, Lévay G, Hársing LG, et al. Use of TTC staining for the evaluation of tissue injury in the early phases of reperfusion after focal cerebral ischemia in rats. Brain Res. 2006; 1116:159–65.
   PubMed Web of Science ®Google Scholar
• Temple S. The development of neural stem cells. Nature. 2001; 414:112–17.
   PubMed Web of Science ®Google Scholar
• Kawasaki H, Mizuseki K, Nishikawa S, Kaneko S, Kuwana Y, Nakanishi S, et al. Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. Neuron. 2000; 28:31–40.
   PubMed Web of Science ®Google Scholar
• Sanchez-Ramos JR. Neural cells derived from adult bone marrow and umbilical cord blood. J Neurosci Res. 2002; 69:880–93.
   PubMed Web of Science ®Google Scholar
• Kopen GC, Prockop DJ, Phinney DG. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. PNAS. 1999; 96:10711–16.
   PubMed Web of Science ®Google Scholar
• Woodbury D, Schwarz EJ, Prockop DJ, Black IB. Adult rat and human bone marrow stromal cells differentiate into neurons. J Neuro Res. 2000; 61:364–70.
   PubMed Web of Science ®Google Scholar
• Torii T, Kawarai T, Nakamura S, Kawakami H. Organization of the human orphan nuclear receptor Nurr1 gene. Gene. 1999; 230:225–32.
   Google Scholar
• Dezawa M, Kanno H, Hoshino M, Cho H, Matsumoto N, Itokazu Y, et al. Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation. J Clin Invest. 2004; 113:1701–10.
   PubMed Web of Science ®Google Scholar
• Gronthos S, Brahim J, Li W, Fisher LW, Cherman N, Boyde A, et al. Stem cells properties of human dental pulp stem cells. J Dent Res. 2002; 81:531–5.
   PubMed Web of Science ®Google Scholar
• Arthur A, Rychkov G, Shi S, Koblar SA, Gronthos S. Adult human dental pulp stem cells differentiate toward functionally active neurons under appropriate environmental cues. Stem Cells. 2008; 26:1787–95.
   PubMed Web of Science ®Google Scholar
• Gandia C, Armiñan A, García-Verdugo JM, Lledó E, Ruiz A, Miñana MD, et al. Human dental pulp stem cells improve left ventricular function, induce angiogenesis, and reduce infarct size in rats with acute myocardial infarction. Stem Cells. 2008; 26:638–45.
   PubMed Web of Science ®Google Scholar
• Bai X, Ma J, Pan Z, Song Y-H, Freyberg S, Yan Y, et al. Electrophysiological properties of human adipose tissue-derived stem cells. Am J Physiol. 2007; 293:C1539–50.
   Google Scholar
• Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999; 284:143–7.
   PubMed Web of Science ®Google Scholar
• Uchida N, Buck DW, He D, Reitsman MJ, Masek M, Phan TV, et al. Direct isolation of human central nervous system stem cells. PNAS. 2000; 97:14720–5.
   PubMed Web of Science ®Google Scholar
• Nosrat IV, Widenfalk J, Olson L, Nosrat CA. Dental pulp cells produce neurotrophic factors, interact with trigeminal neurons in vitro, and rescue motoneurons after spinal cord injury. Dev Biol. 2001; 238:120–32.
   PubMed Web of Science ®Google Scholar
• Chen J, Li Y, Wang L, Zhang Z, Lu D, Lu M, et al. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke. 2001; 32:1005–11.
   PubMed Web of Science ®Google Scholar
• Ding DC, Shyu WC, Chiang MF, Lin SZ, Chang YC, Wang HJ, et al. Enhancement of neuroplasticity through upregulation of β1-integrin in human umbilical cord-derived stromal cell implanted stroke model. Neurobiol Dis. 2007; 27:339–53.
   PubMed Web of Science ®Google Scholar
• Pachter JS, de Vries HE, Fabry Z. The blood–brain barrier and its role in immune privilege in the central nervous system. Neuropathol Exp Neurol. 2003; 62:593–604.
   PubMed Web of Science ®Google Scholar
• Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell response. Blood. 2005; 105:1815–22.
   PubMed Web of Science ®Google Scholar
• Bifari F, Lisi V, Mimiola E, Pasini A, Krampera M. Immune modulation by mesenchymal stem cells. Transfus Med Hemother. 2008; 35:194–204.
   PubMed Web of Science ®Google Scholar