316
Views
0
CrossRef citations to date
0
Altmetric
Special Report

Treatment of obesity with medications binding the glucagon-like peptide 1 receptor: what is the current state of play?

&
Pages 131-138 | Received 17 Nov 2023, Accepted 25 Jan 2024, Published online: 02 Feb 2024

References

  • Obesity Atlas 2023 | World obesity federation global obesity observatory [Internet]. [cited 2023 Sep 25]. Available from: https://data.worldobesity.org/publications/?cat=19
  • Horton ES, Silberman C, Davis KL, et al. Weight loss, glycemic control, and changes in cardiovascular biomarkers in patients with type 2 diabetes receiving incretin therapies or insulin in a large cohort database. Diabetes Care. 2010 Aug;33(8):1759–1765.
  • Padwal R, Li SK, Lau DCW. Long-term pharmacotherapy for obesity and overweight. Cochrane Database Syst Rev [Internet]. 2004 Oct 20 [cited 2023 Sep 25];2003(3):CD004094. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15266516
  • Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet. 2006 Nov 11;368(9548):1696–1705. doi: 10.1016/S0140-6736(06)69705-5
  • Garvey WT, Birkenfeld AL, Dicker D, et al. Efficacy and safety of liraglutide 3.0 mg in individuals with overweight or obesity and type 2 diabetes treated with basal insulin: the SCALE insulin randomized controlled trial. Diabetes Care [Internet]. 2020 May 1 [cited 2023 Sep 30];43(5):1085–1093. Available from: /pmc/articles/PMC7171937/
  • Drucker DJ. The biology of incretin hormones. Cell Metab. 2006 Mar;3(3):153–165. doi: 10.1016/j.cmet.2006.01.004
  • Curtis L, Holt H, Richardson T, et al. GLP-1 analogue use in patients with sub-optimally controlled type 1 diabetes or obesity improves weight and HbA1c. Pract Diabetes. 2016 Jan 1;33(1):13–17. doi: 10.1002/pdi.1991
  • Pi-Sunyer X, Astrup A, Fujioka K, et al. A randomized, controlled trial of 3.0 mg of Liraglutide in weight management. N Engl J Med [Internet] 2015 Jul 2 [cited 2023 Sep 30];373(1):11–22. Available from: https://pubmed.ncbi.nlm.nih.gov/26132939/
  • Nordisk N, Buse JB, Bain SC, et al. Cardiovascular risk reduction with liraglutide: an exploratory mediation analysis of the LEADER trial. Diabetes Care. 2020;43(7):1546–1552. doi: 10.2337/dc19-2251
  • Wilding JPH, Batterham RL, Calanna S, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021 Mar 18;384(11):989–1002. doi: 10.1056/NEJMoa2032183
  • Astrup A, Rössner S, Van Gaal L, et al. Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study. Lancet. 2009;374(9701):1606–1616. doi: 10.1016/S0140-6736(09)61375-1
  • Davies M, Færch L, Jeppesen OK, et al. Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial. Lancet. 2021 Mar 13;397(10278):971–984. doi: 10.1016/S0140-6736(21)00213-0
  • Amaro A, Sugimoto D, Wharton S. Efficacy and safety of semaglutide for weight management: evidence from the STEP program. Postgrad Med [Internet]. 2022 [cited 2023 Nov 4];134(sup1):5–17. Available from: 10.1080/00325481.2022.2147326
  • Rubino D, Abrahamsson N, Davies M, et al. Effect of continued weekly subcutaneous semaglutide vs placebo on weight loss maintenance in adults with overweight or obesity: the STEP 4 randomized clinical trial. JAMA [Internet]. 2021 Apr 13 [cited 2023 Oct 26];325(14):1414–1425. Available from: https://jamanetwork.com/journals/jama/fullarticle/2777886
  • Marso SP, Bain SC, Consoli A, et al. For the S 6 I. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med. 2016;375(19):1834–1844. doi: 10.1056/NEJMoa1607141
  • Irfan IH. Obesity, cardiovascular disease, and the promising role of semaglutide: insights from the SELECT trial. Curr Probl Cardiol. 2024 Jan 1;49(1):102060. doi: 10.1016/j.cpcardiol.2023.102060
  • Medicines Agency E. Human Medicines Division Pharmacovigilance Risk Assessment Committee {PRAC}. 2023 [cited 2023 Oct 31]. Available from: www.ema.europa.eu/contact
  • Garvey WT, Frias JP, Jastreboff AM, et al. Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes [SURMOUNT-2]: a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet. 2023 Aug 19 [cited 2023 Oct 26];402(10402):613–626. Available from: http://www.thelancet.com/article/S014067362301200X/fulltext
  • le Roux CW, Zhang S, Aronne LJ, et al. Tirzepatide for the treatment of obesity: rationale and design of the SURMOUNT clinical development program. Obesity (Silver Spring) [Internet]. 2023 Jan 1 [cited 2023 Oct 26];31(1):96. Available from: /pmc/articles/PMC10107501/
  • Jastreboff AM, Kaplan LM, Frías JP, et al. Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. N Engl J Med [Internet]. 2023 Aug 10 [cited 2023 Oct 26];389(6): 514–526. doi: 10.1056/NEJMoa2301972
  • Frias JP, Deenadayalan S, Erichsen L, et al. Efficacy and safety of co-administered once-weekly cagrilintide 2·4 mg with once-weekly semaglutide 2·4 mg in type 2 diabetes: a multicentre, randomised, double-blind, active-controlled, phase 2 trial. Lancet [Internet]. 2023 Aug 26 [cited 2023 Oct 26];402(10403):720–730. Available from: http://www.thelancet.com/article/S0140673623011637/fulltext
  • Medscape Registration [Internet]. [cited 2023 Oct 31]. Available from: https://www.medscape.com/viewarticle/993928?form=fpf
  • Wharton S, Blevins T, Connery L, et al. Daily oral GLP-1 receptor agonist orforglipron for adults with obesity. N Engl J Med [Internet]. 2023 Sep 7 [cited 2023 Oct 26];389(10):877–888. doi: 10.1056/NEJMoa2302392
  • Frias JP, Hsia S, Eyde S, et al. Efficacy and safety of oral orforglipron in patients with type 2 diabetes: a multicentre, randomised, dose-response, phase 2 study. Lancet [Internet]. 2023 Aug 5 [cited 2023 Oct 26];402(10400):472–483. Available from: http://www.thelancet.com/article/S0140673623013028/fulltext
  • Bezin J, Gouverneur A, Enichon MP, et al. GLP-1 receptor agonists and the risk of thyroid cancer. Diabetes Care. 2023 [cited 2023 Oct 31];46(2):384–390. doi: 10.2337/dc22-1148
  • Sharma A, Parachuri N, Kumar N, et al. Semaglutide and the risk of diabetic retinopathy—current perspective. [cited 2023 Oct 31]. doi: 10.1038/s41433-021-01741-5
  • Zhang P, Liu Y, Ren Y, et al. The efficacy and safety of liraglutide in the obese, non-diabetic individuals: a systematic review and meta-analysis. Afr Health Sci. 2019 [cited 2023 Sep 30];19(3):2591–2599. doi: 10.4314/ahs.v19i3.35
  • Garvey WT, Mechanick JI, Brett EM, et al. American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity. Executive summary complete guidelines available at: https://www.aace.com/publications/guidelines. Endocr Pract [Internet]. 2016 Jul 1 [cited 2023 Sep 25];22(7):842–884. Available from: https://pubmed.ncbi.nlm.nih.gov/27472012/

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.