207
Views
97
CrossRef citations to date
0
Altmetric
Article

Efficacy and safety of xaliproden in amyotrophic lateral sclerosis: results of two phase III trials

, , , , , , , & show all
Pages 107-117 | Published online: 10 Jul 2009

References

  • Leigh PN. Pathogenic mechanisms in amyotrophic lateral sclerosis and other motor neuron disordersIn: Calne DB, ed. Neurodegenerative Diseases. Philadelphia, PA: WB Saunders and Co. 1994: 473–488.
  • Swash M, Schwartz MS. Motor neuron disease: the clinical syndrome. In: Leigh PN, Swash M, eds. Motor Neuron Disease: Biology and ManagementLondon: Springer Verlag 1995: 1–17.
  • Tysnes OB, Vollet SE, Larsen TP, Aarli JA. Prognostic factors and survival in amyotrophic lateral sclerosisNeuroepidemiol 1994; 13: 226–235.
  • Lacomblez L, Bensimon G, Leigh PN, Guillet P. Meininger V for the Amyotrophic lateral sclerosis/riluzole Study Group II. Dose- ranging study of riluzole in amyotrophic lateral sclerosisLancet 1996; 347: 1425–1431.
  • Bensimon G, Lacomblez L, Meininger V, and the ALS/riluzole study group. A controlled trial of riluzole in amyotrophic lateral sclerosisN Engl J Med 1994; 330: 585–591.
  • Miller RG, Mitchell JD, Lyon M, Moore DH. Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND) (Cochrane Review)In: The Cochrane Library, Issue 3. Oxford: Update Software (2002).
  • Fournier J, Keane PE, Ferrara P, Soubrie´ P. SR57746A: An orally active non-peptide compound with neuroprotective and neuro- trophic effectsCNS Drug Reviews 1997; 3: 148–167.
  • Labie C, Lafon C, Marmouget C et al. Effect of the neuropro- tective compound SR57746A on nerve growth factor synthesis in cultured astrocytes from neonatal rat cortexBr J Pharmacol 1999; 127: 139–144.
  • Duong F, Fournier J, Keane PE et al. The effect of the nonpeptide neurotrophic compound SR57746A on the progression of the disease state of the pmn mouseBr J Pharmacol 1998; 124: 811–817.
  • Lacomblez L, Bensimon G, Douillet P, Doppler V, Salachas F, Meininger V. Xaliproden in amyotrophic lateral sclerosis: over- view about the early clinical development programme and main resultsAmyotroph Lateral Scler Other Motor Neuron Disord (accepted in ALS and other MND).
  • Airlie House World Federation of Neurology. Guidelines for ALS clinical trialsJ Neurol Sci 1995; 129: 1–10.
  • Miller RG, Munsat TL, Swash M, Brooks BR. Consensus guidelines for the design and implementation of clinical trials in ALS2nd Airlie House Workshop 1998 (available from http:// wfnals.org).
  • Brooks BR. El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosisJ Neurol Sci 1994; 124 (suppl): 96–107.
  • European Coal and Steel Community, Quanjer PH. Working Party ‘‘Standardization of Lung Function Tests’’In: Chapter 7: Summary equations of reference values. Bull Eur Physiopathol Respir 1983; 19 (suppl 5): 45–51.
  • Hochberg Y. A sharper Bonferroni procedure for multiple tests of significanceBiometrika 1988; 75(4): 800–802.
  • Cox DR. Regression models and life-tablesJ R Stat Soc [B] 1972; 34: 187–220.
  • O’Brien PC. Procedures for comparing samples with multiple endpointsBiometrics 1984; 40: 1079–1084.
  • Committee for Proprietary Medicinal Products (CPMP). Points to consider on clinical investigation of medicinal products for the treatment of amyotrophic lateral sclerosis (ALS)EMEA 2000, Oct. 19, London: 1–4.
  • Miller RG, Rosenberg JA, Gelinas D et al. Practice parameter: the care of the patient with amyotrophic lateral sclerosis (an evidence-based review)Neurology 1999; 52: 1311–1323.
  • Goldblatt D, Greenlaw J. Starting and stopping the ventilator for patients with amyotrophic lateral sclerosisNeurol Clin 1989; 7(4): 789–806.
  • Sanjak M, Salachas F, Frija-Orvoen F et al. Prospective quality control of vital capacity (VC) as primary endpoint in interna- tional multi-centre therapeutic trial of SR57746A (xaliproden) in amyotrophic lateral sclerosis (ALS)Amyotr Lat Scler 2000; 1(supp 3): 59–60.
  • Meininger V, Bensimon G, Lacomblez L, Salachas F. Natural history of amyotrophic lateral sclerosisIn: Serratrice G and Munsat T, eds. Pathogenesis and Therapy of Amyotrophic Lateral Sclerosis, Advances in Neurology, vol. 28. Philadelphia: Lippincott-Raven Publishers, 1995: 199–207.
  • Stambler N, Charatan M, Cedarbaum JM. Prognostic indicators of survival in ALS. ALS CNTF Treatment Study GroupNeurology 1998; 50(1): 66–72.
  • Bourke SC, Shaw PJ, Gibson GJ. Respiratory function vs. sleep- disordered breathing as predictors of QOL in ALSNeurology 2001; 57: 2040–2044.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.