699
Views
32
CrossRef citations to date
0
Altmetric
Review

Novel biological therapies for the treatment of diabetic foot ulcers

, , , , &
Pages 979-987 | Received 15 Mar 2017, Accepted 18 May 2017, Published online: 01 Jun 2017

References

  • Diabetes Atlas. International Diabetes Federation. 7th ed. Brussels, 2015.
  • Ozcan L, Ghorpade DS, Zheng Z, et al. Hepatocyte DACH1 is increased in obesity via nuclear exclusion of HDAC4 and promotes hepatic insulin resistance. Cell Rep. 2016;15:2214–2225.
  • Adeghate E, Schattner P, Dunn E. An update on the etiology and epidemiology of diabetes mellitus. Ann N Y Acad Sci. 2006;1084:1–29. .
  • Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes. 2005;54:1615–1625.
  • Goldin A, Beckman JA, Schmidt AM, et al. Advanced glycation-end products: sparking the development of diabetic vascular injury. Circulation. 2006;114:597–605.
  • Kaneto H, Xu G, Song KH, et al. Activation of the hexosamine pathway leads to deterioration of pancreatic β-cell function through the induction of oxidative stress. J Biol Chem. 2001;276:31099–31104.
  • Das Evcimen N, King GL. The role of protein kinase C activation and the vascular complications of diabetes. Pharmacol Res. 2007;55:498–510.
  • Abbott CA, Carrington AL, Ashe H, et al. The North-West diabetes foot care study: incidence of, and risk factors for new diabetic foot ulceration in a community-based patient cohort. Diabet Med. 2002;19:377–384.
  • Amin N, Doupis J. Diabetic foot disease: from the evaluation of the “foot at risk” to the novel diabetic ulcer treatment modalities. World J Diabetes. 2016;7(7):153–164.
  • Park SY, Rhee SY, Chon S, et al. Effects of foot complications in patients with Type 2 diabetes mellitus on public healthcare: an analysis based on the Korea National Diabetes Program Cohort. J Diabetes Complications. 2016 Jun 29;pii:S1056-8727(16)30253-7.
  • Boulton AJM. The diabetic foot. In: De Groot LJ, Chrousos G, Dungan K, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; p. 2000–2016.
  • Tahergorabi Z, Khazaei M. Imbalance of angiogenesis in diabetic complications: the mechanisms. Int J Prev Med. 2012;3:827–838.
  • Margolis DJ, Allen-Taylor L, Hoffstad O, et al. Diabetic neuropathic foot ulcers and amputation. Wound Repair Regen. 2005;13:230–236.
  • Edmonds M. Diabetic foot ulcers. Drugs. 2006;66:913–929. 25: 109-120.
  • Izumi Y, Satterfield K, Lee S, et al. Risk of re-amputation in diabetic patients stratified by limb and level of amputation: a 10-year observation. Diabetes Care. 2006;29:566–570. .
  • Calles-Escandon J, Cipolla M. Diabetes and endothelial dysfunction: a clinical perspective. Endocr Rev. 2001;22:36–52.
  • Stirban A, Rösen P, Tschoepe D. Complications of type 1 diabetes: new molecular findings. Mount Sinai J Med. 2008;75:328–351.
  • Di Marzio D, Mohn A, Mokini ZH, et al. Macroangiopathy in adults and children with diabetes: from molecular mechanisms to vascular damage (part 1). Horm Metab Res. 2006;38:691–705.
  • Yu R, Yekta B, Vakili L, et al. Proatherogenic high-density lipoprotein, vascular inflammation, and mimetic peptides. Curr Atheroscler Rep. 2008;10:171–176.
  • Lotfy M, Adeghate J, Kalasz H, et al. Chronic complications of diabetes mellitus: a mini review. Curr Diabetes Rev. 2017;13:3–10.
  • Le NN, Rose MB, Levinson H, et al. Implant healing in experimental animal models of diabetes. J Diabetes Sci Technol. 2011;5:605–618.
  • Moura LI, Dias AM, Carvalho E, et al. Recent advances on the development of wound dressings for diabetic foot ulcer treatment–a review. Acta Biomater. 2013;9:7093–7114.
  • Andros G, Armstrong DG, Attinger CE, et al. Consensus statement on negative pressure wound therapy (V.A.C.Therapy) for the management of diabetic foot wounds. Ostomywound Manage. 2006;Suppl:1–32.
  • Kessler L, Bilbault P, Ortéga F, et al. Hyperbaric oxygenation accelerates the healing rate of nonischemic chronic diabetic foot ulcers: a prospective randomized study. Diabetes Care. 2003;26:2378–2382.
  • Vijaykumar H, Pai SA, Pandey V, et al. Comparative study of collagenase and papain-urea based preparations in the management of chronic non-healing limb ulcers. Indian J Sci Technol. 2011;4:1096–1100.
  • Karapanagioti EG, Assimopoulou AN. Naturally occurring wound healing agents: an evidence-based review. Curr Med Chem. 2016;23:3285–3321.
  • Hoch RV, Soriano P. Roles of PDGF in animal development. Development. 2003;130:4769–4784.
  • Ma C, Hernandez MA, Kirkpatrick VE, et al. Topical platelet-derived growth factor vs placebo therapy of diabetic foot ulcers offloaded with windowed casts: a randomized, controlled trial. Wounds. 2015;27:83–91.
  • Scimeca CL, Bharara M, Fisher TK, et al. Novel use of platelet-rich plasma to augment curative diabetic foot surgery. J Diabetes Sci Technol. 2010;4(5):1121–1126.
  • Barrientos S, Stojadinovic O, Golinko M, et al. Growth factors and cytokines in wound healing. Wound Repair Regen. 2008;16:585–601.
  • Zhou K, Ma Y, Brogan MS. Chronic and non-healing wounds: the story of vascular endothelial growth factor. Med Hypotheses. 2015;85(4):399–404.
  • Kusumanto YH, van Weel V, Mulder NH, et al. Treatment with intramuscular vascular endothelial growth factor gene compared with placebo for patients with diabetes mellitus and critical limb ischemia: a double blind randomized trial. Hum Gene Ther. 2006;17(6):683–691 .
  • Hanft J, Pollak R, Barbul A, et al. Phase I trial on the safety of topical rhVEGF on chronic neuropathic diabetic foot ulcers. J Wound Care. 2008;17(1):30–32, 34–37.
  • Fernández-Montequín JI, Valenzuela-Silva CM, Díaz OG, et al. Intra-lesional injections of recombinant human epidermal growth factor promote granulation and healing in advanced diabetic foot ulcers: multicenter, randomised, placebo-controlled, double-blind study. Int Wound J. 2009;6:432–443.
  • Ertugrul BM, Lipsky BA, Guvenc U, et al. An assessment of intralesional epidermal growth factor for treating diabetic foot woundsthe first experiences in Turkey. J Am Podiatr Med Assoc. 2017;107:17–29.
  • Dumantepe M, Fazliogullari O, Seren M, et al. Efficacy of intralesional recombinant human epidermal growth factor in chronic diabetic foot ulcers. Growth Factors. 2015 Apr;33(2):128–132.
  • Hong JP, Jung HD, Kim YW. Recombinant human epidermal growth factor (EGF) to enhance healing for diabetic foot ulcers. Ann Plast Surg. 2006;564:394–398; discussion 399-400.
  • Uchi H, Igarashi A, Urabe K, et al. Clinical efficacy of basic fibroblast growth factor (bFGF) for diabetic ulcer. Eur J Dermatol. 2009 Sep-Oct;19(5):461–468.
  • Richard JL, Parer-Richard C, Daures JP, et al. Effect of topical basic fibroblast growth factor on the healing of chronic diabetic neuropathic ulcer of the foot. A pilot, randomized, double-blind, placebo-controlled study. Diabetes Care. 1995;18:64–69.
  • Han SK, Choi KJ, Kim WK. Clinical application of fresh fibroblast allografts for the treatment of diabetic foot ulcers: a pilot study. Plast Reconstr Surg. 2004;114(7):1783–1789.
  • Blakytny R, Jude EB, Martin Gibson J, et al. Lack of insulin-like growth factor 1 (IGF1) in the basal keratinocyte layer of diabetic skin and diabetic foot ulcers. J Pathol. 2000 Apr;190(5):589–594.
  • Aydin F, Kaya A, Karapinar L, et al. IGF-1 increases with hyperbaric oxygen therapy and promotes wound healing in diabetic foot ulcers. J Diabetes Res. 2013;2013:567834.
  • Jude EB, Blakytny R, Bulmer J, et al. Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers. Diabet Med. 2002 Jun;19(6):440–447.
  • Bennett SP, Griffiths GD, Schor AM, et al. Growth factors in the treatment of diabetic foot ulcers. Br J Surg. 2003;90:133–146.
  • Wu L, Xia YP, Roth SI, et al. Transforming growth factor-b1 fails to stimulate wound healing and impairs its signal transduction in an aged ischemic ulcer model: importance of oxygen and age. Am J Pathol. 1999;154:301–309.
  • Vatankhah N, Jahangiri Y, Landry GJ, et al. Effect of systemic insulin treatment on diabetic wound healing. Wound Repair Regen. 2017 Jan 24. DOI:10.1111/wrr.12514
  • Fan HJ, Yu JH, Cui GM, et al. Insulin pump for the treatment of diabetes in combination with ulcerative foot infections. J Biol Regul Homeost Agents. 2016;30:465–470.
  • Sun Y, Fan W, Yang W, et al. Effects of intermittent irrigation of insulin solution combined with continuous drainage of vacuum sealing drainage in chronic diabetic lower limb ulcers. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2015;29(7):812–817.
  • Lotfy M, Singh J, Kalász H, et al. Medicinal chemistry and applications of incretins and DPP-4 inhibitors in the treatment of Type 2 diabetes mellitus. Open Med Chem J. 2011;5:82–92.
  • Seo E, Lim JS, Jun JB, et al. Exendin-4 in combination with adipose-derived stem cells promotes angiogenesis and improves diabetic wound healing. J Transl Med. 2017;15(1):35.
  • Saboo A, Rathnayake A, Vangaveti VN, et al. Wound healing effects of dipeptidyl peptidase-4 inhibitors: an emerging concept in management of diabetic foot ulcer-A review. Diabetes Metab Syndr. 2016 Apr-Jun;10(2):113–119.
  • Karaaltin MV, Baghaki S. Adipose derived regenerative cell therapy for treating a diabetic wound: a case report. Wounds. 2012;24(1):e1–5.
  • Shi R, Jin Y, Cao C, et al. Localization of human adipose-derived stem cells and their effect in repair of diabetic foot ulcers in rats. Stem Cell Res Ther. 2016;7(1):155.
  • Kato Y, Iwata T, Morikawa S, et al. Allogeneic transplantation of an adipose-derived stem cell sheet combined with artificial skin accelerates wound healing in a rat wound model of Type 2 diabetes and obesity. Diabetes. 2015;64(8):2723–2734.
  • Asai J, Takenaka H, Ii M, et al. Topical application of ex vivo expanded endothelial progenitor cells promotes vascularisation and wound healing in diabetic mice. Int Wound J. 2013;10(5):527–533.
  • Huang G, Sun T, Zhang L, et al. Combined application of alginate dressing and human granulocyte-macrophage colony stimulating factor promotes healing in refractory chronic skin ulcers. Exp Ther Med. 2014;7(6):1772–1776.
  • Qin HL, Zhu XH, Zhang B, et al. Clinical evaluation of human umbilical cord mesenchymal stem cell transplantation after angioplasty for diabetic foot. Exp Clin Endocrinol Diabetes. 2016;124:497–503.
  • Benítez-Arvízu G, Í P-L, Vazquez-Campos R, et al. Autologous mesenchymal stem cells and cutaneus autograft as a treatment for chronic ulcer secondary to diabetes mellitus 2. Cir. 2015;83(6):532–536.
  • Vannini P, Ciavarella A, Mustacchio A, et al. Intra-arterial urokinase infusion in diabetic patients with rapidly progressive ischemic foot lesions. Diabetes Care. 1991;14(10):925–927.
  • Guo J, Meng QH, Yin QY, et al. Study of effect of tongsaimai tablets on experimental diabetic foot model rats. Zhongguo Zhong Yao Za Zhi. 2014;39(11):2091–2096.
  • Muhammad AA, Arulselvan P, Cheah PS, et al. Evaluation of wound healing properties of bioactive aqueous fraction from Moringa oleifera Lam on experimentally induced diabetic animal model. Drug Des Devel Ther. 2016;10:1715–1730.
  • Steed DL, Ricotta JJ, Prendergast JJ, et al. Promotion and acceleration of diabetic ulcer healing by arginine-glycine-aspartic acid (RGD) peptide matrix. RGD Study Group. Diabetes Care. 1995;18(1):39–46.
  • Cullen B, Watt PW, Lundqvist C, et al. The role of oxidised regenerated cellulose/collagen in chronic wound repair and its potential mechanism of action. Int J Biochem Cell Biol. 2002;34:1544–1556.
  • Lázaro-Martínez JL, García-Morales E, Beneit-Montesinos JV, et al. Randomized comparative trial of a collagen/oxidized regenerated cellulose dressing in the treatment of neuropathic diabetic foot ulcers. Cir Esp. 2007;82:27–31.
  • Letendre S, LaPorta G, O’Donnell E, et al. Pilot trial of biovance collagen-based wound covering for diabetic ulcers. Adv Skin Wound Care. 2009;22(4):161–166.
  • Wilshaw SP, Kearney J, Fisher J, et al. Biocompatibility and potential of acellular human amniotic membrane to support the attachment and proliferation of allogeneic cells. Tissue Eng Part A. 2008;14(4):463–472.
  • Asai J, Takenaka H, Hirakawa S, et al. Topical simvastatin accelerates wound healing in diabetes by enhancing angiogenesis and lymphangiogenesis. Am J Pathol. 2012 Dec;181(6):2217–2224.
  • Toker S, Gulcan E, Cayc MK, et al. Topical atorvastatin in the treatment of diabetic wounds. Am J Med Sci. 2009 Sep;338(3):201–204.
  • Kalani M, Apelqvist J, Blombäck M, et al. Effect of dalteparin on healing of chronic foot ulcers in diabetic patients with peripheral arterial occlusive disease: a prospective, randomized, double-blind, placebo-controlled study. Diabetes Care. 2003 Sep;26(9):2575–2580.
  • Kalani M, Silveira A, Blombäck M, et al. Beneficial effects of dalteparin on haemostatic function and local tissue oxygenation in patients with diabetes, severe vascular disease and foot ulcers. Thromb Res. 2007;120(5):653–661.
  • Lyons TE, Miller MS, Serena T, et al. Talactoferrin alfa, a recombinant human lactoferrin promotes healing of diabetic neuropathic ulcers: a phase 1/2 clinical study. Am J Surg. 2007;193:49–54.
  • Shi E, Shofler D. Maggot debridement therapy: a systematic review. Br J Community Nurs. 2014;Suppl Wound Care:S6–13.
  • Pinheiro MA, Ferraz JB, Junior MA, et al. Use of maggot therapy for treating a diabetic foot ulcer colonized by multidrug resistant bacteria in Brazil. Indian J Med Res. 2015 Mar;141(3):340–342.
  • Zhang J, Sun XJ, Chen J, et al. Increasing the miR-126 expression in the peripheral blood of patients with diabetic foot ulcers treated with maggot debridement therapy. J Diabetes Complications. 2017;31:241–244.
  • Netten JJ, Price PE, Lavery LA, et al. Prevention of foot ulcers in the at‐risk patient with diabetes: a systematic review. Diabetes/Metabolism Research and Reviews. 2016 Jan 1;32(S1):84–98.
  • Pound N, Chipchase S, Treece K, et al. Ulcer-free survival following management of foot ulcers in diabetes. Diabet Med. 2005;22(10):1306–1309.
  • Bus SA, Waaijman R, Arts M, et al. Effect of custom-made footwear on foot ulcer recurrence in diabetes: a multicentre randomized controlled trial. Diabetes Care. 2013;36:4109–4116.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.