199
Views
10
CrossRef citations to date
0
Altmetric
Original Research

Thymosin β4 inhibits PDGF-BB induced activation, proliferation, and migration of human hepatic stellate cells via its actin-binding domain

ORCID Icon, &
Pages 177-184 | Received 19 Dec 2017, Accepted 16 May 2018, Published online: 31 Jul 2018

References

  • Bataller R. Brenner DA: liver fibrosis. J Clin Invest. 2005;115:209–218.
  • Nieto N and Rojkind M. Pathophysiology of alcoholic liver disease. In: Edited by, Arias IM. The liver: biology and pathobiology. 5th ed. ed. Oxford, UK: Wiley-Blackwell; 2009.
  • Rojkind M and Reyes-Gordillo K. Hepatic stellate cells. In: Edited by, Arias IM. The liver: biology and pathobiology. 5th Ed. ed. Oxford, UK: Wiley-Blackwell; 2009.
  • Shah R, Reyes-Gordillo K, Arellanes-Robledo J, et al. TGF-beta1 up-regulates the expression of PDGF-beta receptor mRNA and induces a delayed PI3K-, AKT-, and p70(S6K) -dependent proliferative response in activated hepatic stellate cells. Alcohol Clin Exp Res. 2013;37:1838–1848.
  • Goldstein AL, Hannappel E, Kleinman HK . Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues. Trends Mol Med. 2005;11:421–429.
  • Crockford D, Turjman N, Allan C, et al. Thymosin beta4: structure, function, and biological properties supporting current and future clinical applications. Ann N Y Acad Sci. 2010;1194:179–189.
  • Sosne G, Kleinman HK. Primary mechanisms of thymosin beta4 repair activity in dry eye disorders and other tissue injuries. Invest Ophthalmol Vis Sci. 2015;56:5110–5117.
  • Sosne G, Qiu P, Goldstein AL, et al. Biological activities of thymosin beta4 defined by active sites in short peptide sequences. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology. 2010;24:2144–2151.
  • Reyes-Gordillo K, Shah R, Arellanes-Robledo J, et al. Protective effects of thymosin beta4 on carbon tetrachloride-induced acute hepatotoxicity in rats. Ann N Y Acad Sci. 2012;1269:61–68.
  • Reyes-Gordillo K, Shah R, Popratiloff A, et al. Thymosin-beta4 (Tbeta4) blunts PDGF-dependent phosphorylation and binding of AKT to actin in hepatic stellate cells. Am J Pathol. 2011;178:2100–2108.
  • Scaglione S, Kliethermes S, Cao G, et al. The epidemiology of cirrhosis in the United States: a population-based study. J Clin Gastroenterol. 2015;49:690–696.
  • Rudnick DA. Antifibrotic therapies in liver disease: ready for primetime? Clin Liver Dis. 2017;9:138–140.
  • Huang Y, Deng X, Liang J. Modulation of hepatic stellate cells and reversibility of hepatic fibrosis. Exp Cell Res. 2017;352:420–426.
  • Nemolato S, Van Eyken P, Cabras T, et al. Expression pattern of thymosin beta 4 in the adult human liver. European Journal of Histochemistry: EJH. 2011;55:e25.
  • Paulussen M, Landuyt B, Schoofs L, et al. Thymosin beta 4 mRNA and peptide expression in phagocytic cells of different mouse tissues. Peptides. 2009;30:1822–1832.
  • Kim J, Wang S, Hyun J, et al. Hepatic stellate cells express thymosin Beta 4 in chronically damaged liver. PloS One. 2015;10:e0122758.
  • Xiao Y, Qu C, Ge W, et al. Depletion of thymosin beta4 promotes the proliferation, migration, and activation of human hepatic stellate cells. Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2014;34:356–367.
  • Barnaeva E, Nadezhda A, Hannappel E, et al. Thymosin beta4 upregulates the expression of hepatocyte growth factor and downregulates the expression of PDGF-beta receptor in human hepatic stellate cells. Ann N Y Acad Sci. 2007;1112:154–160.
  • Kastanis GJ, Hernandez-Nazara Z, Nieto N, et al. The role of dystroglycan in PDGF-BB-dependent migration of activated hepatic stellate cells/myofibroblasts. American Journal of Physiology Gastrointestinal and Liver Physiology. 2011;301:G464–74.
  • Lechuga CG, Hernandez-Nazara ZH, Hernandez E, et al. PI3K is involved in PDGF-beta receptor upregulation post-PDGF-BB treatment in mouse HSC. American Journal of Physiology Gastrointestinal and Liver Physiology. 2006;291:G1051–61.
  • Borkham-Kamphorst E, Herrmann J, Stoll D, et al. Dominant-negative soluble PDGF-β receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis. Lab Invest. 2004;84:766–777.
  • Lechuga CG, Hernandez-Nazara ZH, Dominguez Rosales JA, et al. TGF-beta1 modulates matrix metalloproteinase-13 expression in hepatic stellate cells by complex mechanisms involving p38MAPK, PI3-kinase, AKT, and p70S6k. American Journal of Physiology Gastrointestinal and Liver Physiology. 2004;287:G974–87.
  • Fan H, Ma L, Fan B, et al. Role of PDGFR-beta/PI3K/AKT signaling pathway in PDGF-BB induced myocardial fibrosis in rats. Am J Transl Res. 2014;6:714–723.
  • Son G, Hines IN, Lindquist J, et al. Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis. Hepatology. 2009;50:1512–1523.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.