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Review

Recent developments in vaccines and biological therapies against Japanese encephalitis virus

& ORCID Icon
Pages 851-864 | Received 25 Feb 2018, Accepted 10 Jul 2018, Published online: 19 Jul 2018

References

  • World Health Organization. Japanese encephalitis vaccines: WHO position paper – February 2015. Wkly Epidemiol Rec. 2015;90:69–87.
  • Campbell G, Hills S, Fischer M, et al. Estimated global incidence of Japanese encephalitis: a systematic review. Bull World Health Organ. 2011;89:766–74,774A–774E.
  • Turtle L, Driver C. Risk assessment for Japanese encephalitis vaccination. Hum Vaccin Immunother. 2018 Jan 2;14(1):213–217.
  • Heffelfinger JD, Li X, Batmunkh N, et al. Japanese Encephalitis Surveillance and Immunization - Asia and Western Pacific Regions, 2016. MMWR Morb Mortal Wkly Rep. 2017;66:579–583.
  • Hanna JN, Ritchie SA, Phillips DA, et al. An outbreak of Japanese encephalitis in the Torres Strait, Australia, 1995. Med J Aust. 1996;165:256–260.
  • Hanna JN, Ritchie SA, Phillips DA, et al. Japanese encephalitis in north Queensland, Australia, 1998. Med J Aust. 1999;170:533–536.
  • Ravanini P, Huhtamo E, Ilaria V, et al. Japanese encephalitis virus RNA detected in Culex pipiens mosquitoes in Italy. Euro Surveill. 2012;17:pii: 20221.
  • Simon-Loriere E, Faye O, Prot M, et al. Autochthonous Japanese encephalitis with yellow fever coinfection in Africa. N Engl J Med. 2017;376:1483–1485.
  • Buescher EL, Scherer WF, Rosenberg MZ, et al. Ecologic studies of Japanese encephalitis virus in Japan. II. Mosquito infection. Am J Trop Med Hyg. 1959;8:651–664.
  • Buescher EL, Scherer WF, McClure HE, et al. Ecologic studies of Japanese encephalitis virus in Japan. IV. Avian infection. Am J Trop Med Hyg. 1959;8:678–688.
  • Buescher EL, Scherer WF. Ecologic studies of Japanese encephalitis virus in Japan. IX. Epidemiologic correlations and conclusions. Am J Trop Med Hyg. 1959;8:719–722.
  • Halstead SB, Jacobson J. Japanese encephalitis. Adv Virus Res. 2003;61:103–138.
  • Xu Y, Zhaori G, Vene S, et al. Viral etiology of acute childhood encephalitis in Beijing diagnosed by analysis of single samples. Pediatr Infect Dis J. 1996;15:1018–1024.
  • Kumari R, Kumar K, Rawat A, et al. First indigenous transmission of Japanese encephalitis in urban areas of National Capital Territory of Delhi, India. Trop Med Int Health. 2013;18:743–749.
  • Grossman RA, Edelman R, Willhight M, et al. Study of Japanese encephalitis virus in Chiangmai Valley, Thailand. 3. Human seroepidemiology and inapparent infections. Am J Epidemiol. 1973;98:133–149.
  • Watt G, Jongsakul K. Acute undifferentiated fever caused by infection with Japanese encephalitis virus. Am J Trop Med Hyg. 2003;68:704–706.
  • Griffiths MJ, Turtle L, Solomon T. Japanese encephalitis virus infection. Handb Clin Neurol. 2014;123:561–576.
  • Solomon T, Dung NM, Kneen R, et al. Seizures and raised intracranial pressure in Vietnamese patients with Japanese encephalitis. Brain. 2002;125:1084–1093.
  • Hills SL, Griggs AC, Fischer M. Japanese encephalitis in travelers from non-endemic countries, 1973-2008. Am J Trop Med Hyg. 2010;82:930–936.
  • Solomon T, Dung NM, Kneen R, et al. Japanese encephalitis. J Neurol Neurosurg Psychiat. 2000;68:405–415.
  • Kumar R, Tripathi P, Singh S, et al. Clinical features in children hospitalized during the 2005 epidemic of Japanese encephalitis in Uttar Pradesh, India. Clin Infect Dis. 2006;43:123–131.
  • Ooi MH, Lewthwaite P, Lai BF, et al. The epidemiology, clinical features, and long-term prognosis of Japanese encephalitis in Central Sarawak, Malaysia, 1997-2005. Clin Infect Dis. 2008;47:458–468.
  • Tsarev SA, Sanders ML, Vaughn DW, et al. Phylogenetic analysis suggests only one serotype of Japanese encephalitis virus. Vaccine. 2000;18(Suppl 2):36–43.
  • Uchil PD, Satchidanandam V. Phylogenetic analysis of Japanese encephalitis virus: envelope gene based analysis reveals a fifth genotype, geographic clustering, and multiple introductions of the virus into the Indian subcontinent. Am J Trop Med Hyg. 2001;65:242–251.
  • Morita K. Molecular epidemiology of Japanese encephalitis in East Asia. Vaccine. 2009;27:7131–7132.
  • Markoff L. Points to consider in the development of a surrogate for efficacy of novel Japanese encephalitis virus vaccines. Vaccine. 2000;18(Suppl 2):26–32.
  • Erra EO, Askling HH, Yoksan S, et al. Cross-protective capacity of Japanese encephalitis (JE) vaccines against circulating heterologous JE virus genotypes. Clin Infect Dis. 2013;56:267–270.
  • Bonaparte M, Dweik B, Feroldi E, et al. Immune response to live-attenuated Japanese encephalitis vaccine (JE-CV) neutralizes Japanese encephalitis virus isolates from south-east Asia and India. BMC Infect Dis. 2014;14:156.
  • Singh A, Mitra M, Sampath G, et al. A Japanese encephalitis vaccine from India induces durable and cross-reactive immunity against temporally and spatially wide-ranging global field strains. J Infect Dis. 2015;212:715–725.
  • Pan XL, Liu H, Wang HY, et al. Emergence of genotype I of Japanese encephalitis virus as the dominant genotype in Asia. J Virol. 2011;85:9847–9853.
  • Lannes N, Summerfield A, Filgueira L. Regulation of inflammation in Japanese encephalitis. J Neuroinflammation. 2017;14:158.
  • Myint KS, Kipar A, Jarman RG, et al. Neuropathogenesis of Japanese encephalitis in a primate model. PLoS Negl Trop Dis. 2014;8:e2980.
  • Burke DS, Lorsomrudee W, Leake CJ, et al. Fatal outcome in Japanese encephalitis. Am J Trop Med Hyg. 1985;34:1203–1210.
  • Solomon T. Flavivirus encephalitis. N Engl J Med. 2004;351:370–378.
  • Van Gessel Y, Klade CS, Putnak R, et al. Correlation of protection against Japanese encephalitis virus and JE vaccine (IXIARO) induced neutralizing antibody titres. Vaccine. 2011;29:5925–5931.
  • Turtle L, Bali T, Buxton G, et al. Human T cell responses to Japanese encephalitis virus in health and disease. J Exp Med. 2016;213:1331–1352.
  • Jain N, Oswal N, Chawla AS, et al. CD8 T cells protect adult naive mice from JEV-induced morbidity via lytic function. PLoS Negl Trop Dis. 2017;11:e0005329.
  • Larena M, Regner M, Lee E, et al. Pivotal role of antibody and subsidiary contribution of CD8+ T cells to recovery from infection in a murine model of Japanese encephalitis. J Virol. 2011;85:5446–5455.
  • Yang Y, Liang N, Tan Y, et al. Epidemiological trends and characteristics of Japanese encephalitis changed based on the vaccination program between 1960 and 2013 in Guangxi Zhuang Autonomous Region, southern China. Int J Infect Dis. 2016;45:135–138.
  • Sunwoo JS, Jung KH, Lee ST, et al. Reemergence of Japanese Encephalitis in South Korea, 2010-2015. Emerg Infect Dis. 2016;22:1841–1843.
  • Amicizia D, Zangrillo F, Lai PL, et al. Overview of Japanese encephalitis disease and its prevention. Focus on IC51 vaccine (IXIARO®). J Prev Med Hyg. 2018;59:E99–E107.
  • Gao X, Li X, Li M, et al. Vaccine strategies for the control and prevention of Japanese encephalitis in Mainland China, 1951-2011. PLoS Negl Trop Dis. 2014;8:e3015.
  • Halstead SB, Thomas SJ. Japanese encephalitis: new options for active immunization. Clin Infect Dis. 2010;50:1155–1164.
  • Hegde NR, Gore MM. Japanese encephalitis vaccines: immunogenicity, protective efficacy, effectiveness, and impact on the burden of disease. Hum Vaccin Immunother. 2017;13:1–18.
  • Centers for Disease Control and Prevention (CDC). Japanese encephalitis surveillance and immunization–Asia and the Western Pacific, 2012. MMWR Morb Mortal Wkly Rep. 2013;62:658–662.
  • Hoke CH, Nisalak A, Sangawhipa N, et al. Protection against Japanese encephalitis by inactivated vaccines. N Engl J Med. 1988;319:608–614.
  • Poland JD, Cropp CB, Craven RB, et al. Evaluation of the potency and safety of inactivated Japanese encephalitis vaccine in US inhabitants. J Infect Dis. 1990;161:878–882.
  • Ishikawa T, Yamanaka A, Konishi E. A review of successful flavivirus vaccines and the problems with those flaviviruses for which vaccines are not yet available. Vaccine. 2014;32:1326–1337.
  • Plesner AM. Allergic reactions to Japanese encephalitis vaccine. Immunol Allergy Clin North Am. 2003;23:665–697.
  • Takahashi H, Pool V, Tsai TF, et al. Adverse events after Japanese encephalitis vaccination: review of post-marketing surveillance data from Japan and the United States. The VAERS Working Group. Vaccine. 2000;18:2963–2969.
  • Ferguson M, Kurane I, Wimalaratne O, et al. WHO informal consultation group. WHO informal consultation on the scientific basis of specifications for production and control of inactivated Japanese encephalitis vaccines for human use, Geneva, Switzerland, 1–2 June 2006. Vaccine. 2007;25:5233–5243.
  • World Health Organization. Global Advisory Committee on Vaccine Safety, 9–10 June 2005. Weekly Epidemiol Rec. 2005;80:242–247.
  • Yu Y. Phenotypic and genotypic characteristics of Japanese encephalitis attenuated live vaccine virus SA14-14-2 and their stabilities. Vaccine. 2010;28:3635–3641.
  • Gromowski GD, Firestone CY, Bustos-Arriaga J, et al. Genetic and phenotypic properties of Vero cell-adapted Japanese encephalitis virus SA14-14-2 vaccine strain variants and a recombinant clone, which demonstrates attenuation and immunogenicity in mice. Am J Trop Med Hyg. 2015;92:98–107.
  • Yun SI, Song BH, Kim JK, et al. A molecularly cloned, live-attenuated Japanese encephalitis vaccine SA14-14-2 virus: a conserved single amino acid in the IJ hairpin on the viral E glycoprotein determines neurovirulence in mice. PLoS Pathog. 2014;10:e1004290.
  • Fan JM, Luo J, Chen L, et al. Genetic analysis of strains of Japanese encephalitis virus isolated from swine in central China. Virus Genes. 2010;40:357–361.
  • Yang D, Li XF, Ye Q, et al. Characterization of live-attenuated Japanese encephalitis vaccine virus SA14-14-2. Vaccine. 2014;32:2675–2681.
  • Liu ZL, Hennessy S, Strom BL, et al. Short-term safety of live attenuated Japanese encephalitis vaccine (SA14-14-2): results of a randomized trial with 26,239 subjects. J Infect Dis. 1997;176:1366–1369.
  • Ginsburg AS, Meghani A, Halstead SB, et al. Use of the live attenuated Japanese Encephalitis vaccine SA 14-14-2 in children: A review of safety and tolerability studies. Hum Vaccin Immunother. 2017;13:2222–2231.
  • Tsai TF. New initiatives for the control of Japanese encephalitis by vaccination: minutes of a WHO/CVI meeting, Bangkok, Thailand, 13–15 October 1998. Vaccine. 2000;18(Suppl. 2):1–25.
  • Sohn YM, Park MS, Rho HO, et al. Primary and booster immune responses to SA14-14-2 Japanese encephalitis vaccine in Korean infants. Vaccine. 1999;17:2259–2264.
  • Bista MB, Banerjee MK, Shin SH, et al. Efficacy of single-dose SA14-14-2 vaccine against Japanese encephalitis: a case control study. Lancet. 2001;358:791–795.
  • Ohrr H, Tandan JB, Sohn YM, et al. Effect of single dose of SA14-14-2 vaccine 1 year after immunisation in Nepalese children with Japanese encephalitis: a case-control study. Lancet. 2005;366:1375–1378.
  • Wijesinghe PR, Abeysinghe MRN, Yoksan S, et al. Immunogenicity of live attenuated Japanese encephalitis SA 14-14-2 vaccine among Sri Lankan children with previous receipt of inactivated JE vaccine. Vaccine. 2016;34:5923–5928.
  • Vashishtha VM, Kalra A, Bose A, et al. Indian Academy of Pediatrics (IAP) recommended immunization schedule for children aged 0 through 18 years, India, 2013 and updates on immunization. Indian Pediatr. 2013;50:1095–1108.
  • Erra EO, Kantele A. The Vero cell-derived, inactivated, SA14-14-2 strain-based vaccine (Ixiaro) for prevention of Japanese encephalitis. Expert Rev Vaccines. 2015;14:1167–1179.
  • Tauber E, Kollaritsch H, Von Sonnenburg F, et al. Randomized, double-blind, placebo-controlled phase 3 trial of the safety and tolerability of IC51, an inactivated Japanese encephalitis vaccine. J Infect Dis. 2008;198:493–499.
  • Schuller E, Klingler A, Dubischar-Kastner K, et al. Safety profile of the Vero cell-derived Japanese encephalitis virus (JEV) vaccine IXIARO®. Vaccine. 2011;29:8669–8676.
  • Rabe IB, Miller ER, Fischer M, et al. Adverse events following vaccination with an inactivated, Vero cell culture-derived Japanese encephalitis vaccine in the United States, 2009-2012. Vaccine. 2015;33:708–712.
  • Lyons A, Kanesa-Thasan N, Kuschner RA, et al. A phase 2 study of a purified, inactivated virus vaccine to prevent Japanese encephalitis. Vaccine. 2007;25:3445–3453.
  • Tauber E, Kollaritsch H, Korinek M, et al. Safety and immunogenicity of a Vero-cell-derived, inactivated Japanese encephalitis vaccine: a non-inferiority, phase III, randomised controlled trial. Lancet. 2007;370:1847–1853.
  • Kaltenbock A, Dubischar-Kastner K, Schuller E, et al. Immunogenicity and safety of IXIARO® (IC51) in a Phase II study inhealthy Indian children between 1 and 3 years of age. Vaccine. 2010;28:834–839.
  • Dubischar-Kastner K, Eder S, Buerger V, et al. Long-term immunity and immune response to a booster dose following vaccination with the inactivated Japanese encephalitis vaccine IXIARO, IC51. Vaccine. 2010;28:5197–5202.
  • Paulke-Korinek M, Kollaritsch H, Kundi M, et al. Persistence of antibodies six years after booster vaccination with inactivated vaccine against Japanese encephalitis. Vaccine. 2015;33:3600–3604.
  • Cramer JP, Dubischar K, Eder S, et al. Immunogenicity and safety of the inactivated Japanese encephalitis vaccine IXIARO® in elderly subjects: open-label, uncontrolled, multi-center, phase 4 study. Vaccine. 2016;34:4579–4585.
  • Takeshita N, Lim CK, Mizuno Y, et al. Immunogenicity of single-dose Vero cell-derived Japanese encephalitis vaccine in Japanese adults. J Infect Chemother. 2014;20:238–242.
  • Okada K, Iwasa T, Namazue J, et al. Safety and immunogenicity of a freeze-dried, cell culture-derived Japanese encephalitis vaccine (inactivated) (JEBIK®V) in children. Vaccine. 2012;30:5967–5972.
  • Kikukawa A, Gomi Y, Akechi M, et al. Superior immunogenicity of a freeze-dried, cell culture-derived Japanese encephalitis vaccine (inactivated). Vaccine. 2012;30:2329–2335.
  • Yun KW, Lee HJ, Kang JH, et al. Safety and immunogenicity of a freeze-dried, Vero cell culture-derived, inactivated Japanese encephalitis vaccine (KD-287, ENCEVAC®) versus a mouse brain-derived inactivated Japanese encephalitis vaccine in children: a phase III, multicenter, double-blinded, randomized trial. BMC Infect Dis. 2015;15:7.
  • Chanthavanich P, Limkittikul K, Sirivichayakul C, et al. Immunogenicity and safety of inactivated chromatographically purified Vero cell-derived Japanese encephalitis vaccine in Thai children. Hum Vaccin Immunother. 2018;1–6. DOI:10.1080/21645515.2017.1414763
  • Chambers TJ, Nestorowicz A, Mason PW, et al. Yellow fever/Japanese encephalitis chimeric viruses: construction and biological properties. J Virol. 1999;73:3095–3101.
  • Guy B, Guirakhoo F, Barban V, et al. Preclinical and clinical development of YFV 17D-based chimeric vaccines against dengue. West Nile and Japanese encephalitis viruses. Vaccine. 2010;28:632–649.
  • Guirakhoo F, Zhang ZX, Chambers TJ, et al. Immunogenicity, genetic stability, and protective efficacy of a recombinant, chimeric yellow fever-Japanese encephalitis virus (ChimeriVax-JE) as a live, attenuated vaccine candidate against Japanese encephalitis. Virology. 1999;257:363–372.
  • Monath TP, Soike K, Levenbook I, et al. Recombinant, chimaeric live, attenuated vaccine (ChimeriVax) incorporating the envelope genes of Japanese encephalitis (SA14-14-2) virus and the capsid and nonstructural genes of yellow fever (17D) virus is safe, immunogenic and protective in non-human primates. Vaccine. 1999;17:1869–1882.
  • Monath TP, Levenbook I, Soike K, et al. Chimeric yellow fever virus 17D-Japanese encephalitis virus vaccine: dose-response effectiveness and extended safety testing in rhesus monkeys. J Virol. 2000;74:1742–1751.
  • Arroyo J, Guirakhoo F, Fenner S, et al. Molecular basis for attenuation of neurovirulence of a yellow fever virus/Japanese encephalitis virus chimera vaccine (ChimeriVax-JE). J Virol. 2001;75:934–942.
  • Monath TP, Arroyo J, Levenbook I, et al. Single mutation in the flavivirus envelope protein hinge region increases neurovirulence for mice and monkeys but decreases viscerotropism for monkeys: relevance to development and safety testing of live, attenuated vaccines. J Virol. 2002;76:1932–1943.
  • Monath TP, Guirakhoo F, Nichols R, et al. Chimeric live, attenuated vaccine against Japanese encephalitis (ChimeriVax-JE): phase 2 clinical trials for safety and immunogenicity, effect of vaccine dose and schedule, and memory response to challenge with inactivated Japanese encephalitis antigen. J Infect Dis. 2003;188:1213–1230.
  • Bhatt TR, Crabtree MB, Guirakhoo F, et al. Growth characteristics of the chimeric Japanese encephalitis virus vaccine candidate, ChimeriVax-JE (YF/JE SA14-14-2), in Culex tritaeniorhynchus, Aedes albopictus, and Aedes aegypti mosquitoes. Am J Trop Med Hyg. 2000;62:480–484.
  • Feroldi E, Pancharoen C, Kosalaraksa P, et al. Single-dose, live-attenuated Japanese encephalitis vaccine in children aged 12-18 months: randomized, controlled phase 3 immunogenicity and safety trial. Hum Vaccin Immunother. 2012;8:929–937.
  • Feroldi E, Capeding MR, Boaz M, et al. Memory immune response and safety of a booster dose of Japanese encephalitis chimeric virus vaccine (JE-CV) in JE-CV-primed children. Hum Vaccin Immunother. 2013;9:889–897.
  • Capeding MR, Alberto ER, Bouckenooghe A, et al. Five-year antibody persistence following a Japanese encephalitis chimeric virus vaccine (JE-CV) booster in JE-CV–primed children in the Philippines. J Infect Dis. 2018;217:567–571.
  • Kosalaraksa P, Watanaveeradej V, Pancharoen C, et al. Long-term immunogenicity of a single dose of Japanese encephalitis chimeric virus vaccine in toddlers and booster response 5 years after primary immunization. Pediatr Infect Dis J. 2017;36:e108–13.
  • Nasveld PE, Ebringer A, Elmes N, et al. Long term immunity to live attenuated Japanese encephalitis chimeric virus vaccine: randomized, double-blind, 5-year phase II study in healthy adults. Hum Vaccin. 2010;6:1038–1046.
  • Chokephaibulkit K, Houillon G, Feroldi E, et al. Safety and immunogenicity of a live attenuated Japanese encephalitis chimeric virus vaccine (IMOJEV®) in children. Expert Rev Vaccines. 2016;15:153–166.
  • Chokephaibulkit K, Sirivichayakul C, Thisyakorn U, et al. Safety and immunogenicity of a single administration of live-attenuated Japanese encephalitis vaccine in previously primed 2- to 5-year-olds and naive 12- to 24-month-olds: multicenter randomized controlled trial. Pediatr Infect Dis J. 2010;29:1111–1117.
  • Feroldi E, Pancharoen C, Kosalaraksa P, et al. Primary immunization of infants and toddlers in Thailand with Japanese encephalitis chimeric virus vaccine in comparison with SA14-14-2: a randomized study of immunogenicity and safety. Pediatr Infect Dis J. 2014;33:643–649.
  • Huang LM, Lin TY, Chiu CH, et al. Concomitant administration of live attenuated Japanese encephalitis chimeric virus vaccine (JE-CV) and measles, mumps, rubella (MMR) vaccine: randomized study in toddlers in Taiwan. Vaccine. 2014;32:5363–5369.
  • Torresi J, McCarthy K, Feroldi E, et al. Immunogenicity, safety and tolerability in adults of a new single-dose, live-attenuated vaccine against Japanese encephalitis: randomised controlled phase 3 trials. Vaccine. 2010;28:7993–8000.
  • Kim DS, Houillon G, Jang GC, et al. A randomized study of the immunogenicity and safety of Japanese encephalitis chimeric vaccine (JECV) in comparison with SA14-14-2 vaccine in children in the Republic of Korea. Hum Vaccin Immunother. 2014;10:2656–2663.
  • Ferguson M, Johnes S, Li L, et al. Effect of genomic variation in the challenge virus on the neutralization titres of recipients of inactivated JE vaccines – report of a collaborative study on PRNT50 assays for Japanese encephalitis virus (JE) antibodies. Biologicals. 2008;36:111–116.
  • Chokephaibulkit K, Sirivichayakul C, Thisyakorn U, et al. Long-term follow-up of Japanese encephalitis chimeric virus vaccine: immune responses in children. Vaccine. 2016;34:5664–5669.
  • Feroldi E, Boaz M, Yoksan S, et al. Persistence of wild-type Japanese encephalitis virus strains cross-neutralization 5 years after JE-CV immunization. J Infect Dis. 2017;215:221–227.
  • Chotpitayasunondh T, Pruekprasert P, Puthanakit T, et al. Post-licensure, phase IV, safety study of a live attenuated Japanese encephalitis recombinant vaccine in children in Thailand. Vaccine. 2017;35:299–304.
  • Rey FA, Stiasny K, Vaney MC, et al. The bright and the dark side of human antibody responses to flaviviruses: lessons for vaccine design. EMBO Rep. 2017;pii: e45302.
  • Chen HW, Pan CH, Liau MY, et al. Screening of protective antigens of Japanese encephalitis virus by DNA immunization: a comparative study with conventional viral vaccines. J Virol. 1999;73:10137–10145.
  • Konishi E, Fujii A, Mason PW. Generation and characterization of a mammalian cell line continuously expressing Japanese encephalitis virus subviral particles. J Virol. 2001;75:2204—12.
  • Konishi E, Pincus S, Paoletti E, et al. Mice immunized with a subviral particle containing the Japanese encephalitis virus prM/M and E proteins are protected from lethal JEV infection. Virology. 1992;188:714—20.
  • Qiao M, Ashok M, Bernard KA, et al. Induction of sterilizing immunity against West Nile Virus (WNV), by immunization with WNV-like particles produced in insect cells. J Infect Dis. 2004;190:2104—8.
  • Cj W, Tl L, Hw H, et al. Development of an effective Japanese encephalitis virus-specific DNA vaccine. Microbes Infect. 2006;8:2578–2586.
  • Xu XG, Wang ZS, Zhang Q, et al. Baculovirus surface display of E envelope glycoprotein of Japanese encephalitis virus and its immunogenicity of the displayed proteins in mouse and swine models. Vaccine. 2011;29:636–643.
  • Higuchi A, Toriniwa H, Komiya T, et al. Recombinant measles AIK-C vaccine strain expressing the prM-E antigen of Japanese encephalitis virus. PLoS One. 2016;11:e0150213.
  • Liu H, Wu R, Liu K, et al. Enhanced immune responses against Japanese encephalitis virus using recombinant adenoviruses coexpressing Japanese encephalitis virus envelope and porcine interleukin-6 proteins in mice. Virus Res. 2016;222:34–40.
  • Kofler RM, Aberle JH, Aberle SW, et al. Mimicking live flavivirus immunization with a noninfectious RNA vaccine. Proc Natl Acad Sci USA. 2004;101:1951—6.
  • Mason PW, Shustov AV, Frolov I. Production and characterization of vaccines based on flaviviruses defective in replication. Virology. 2006;351:432—43.
  • Ishikawa T, Widman DG, Bourne N, et al. Construction and evaluation of a chimeric pseudoinfectious virus vaccine to prevent Japanese encephalitis. Vaccine. 2008;26:2772–2781.
  • Ishikawa T, Wang G, Widman DG, et al. Enhancing the utility of a prM/E-expressing chimeric vaccine for Japanese encephalitis by addition of the JEV NS1 gene. Vaccine. 2011;29:7444–7455.
  • Nickols B, Tretyakova I, Tibbens A, et al. Plasmid DNA launches live-attenuated Japanese encephalitis virus and elicits virus-neutralizing antibodies in BALB/c mice. Virology. 2017;512:66–73.
  • Gromowski GD, Firestone CY, Hanson CT, et al. Japanese encephalitis virus vaccine candidates generated by chimerization with dengue virus type 4. Vaccine. 2014;32:3010–3018.
  • Lobigs M, Pavy M, Hall RA, et al. An inactivated Vero cell-grown Japanese encephalitis vaccine formulated with Advax, a novel inulin-based adjuvant, induces protective neutralizing antibody against homologous and heterologous flaviviruses. J Gen Virol. 2010;91:1407–1417.
  • Larena M, Prow NA, Hall RA, et al. JE-ADVAX vaccine protection against Japanese encephalitis virus mediated by memory B cells in the absence of CD8(+) T cells and pre-exposure neutralizing antibody. J Virol. 2013;87:4395–4402.
  • Petrovsky N, Larena M, Siddharthan V, et al. An inactivated cell culture Japanese encephalitis vaccine (JE-ADVAX) formulated with delta inulin adjuvant provides robust heterologous protection against West Nile encephalitis via cross-protective memory B cells and neutralizing antibody. J Virol. 2013;87:10324–10333.
  • Li Y, Xu M, Chen L, et al. Evaluation of murine bone marrow-derived dendritic cells loaded with inactivated virus as a vaccine against Japanese encephalitis virus. Vaccine. 2009;27:6004–6010.
  • Barnes D, Kunitomi M, Vignuzzi M, et al. Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines. Cell Host Microbe. 2008 Sep 11;4(3):239–248.
  • Yen LC, Lin YL, Sung HH, et al. Neurovirulent flavivirus can be attenuated in mice by incorporation of neuron-specific microRNA recognition elements into viral genome. Vaccine. 2013;31:5915–5922.
  • Teterina NL, Liu G, Maximova OA, et al. Silencing of neurotropic flavivirus replication in the central nervous system by combining multiple microRNA target insertions in two distinct viral genome regions. Virology. 2014;456-457:247–258.
  • Li SH, Dong H, Li XF, et al. Rational design of a flavivirus vaccine by abolishing viral RNA 2ʹ-O methylation. J Virol. 2013;87:5812–5819.
  • Ishikawa T, Konishi E. Potential chemotherapeutic targets for Japanese encephalitis: current status of antiviral drug development and future challenges. Expert Opin Ther Targets. 2015;19:1379–1395.
  • Zu X, Liu Y, Wang S, et al. Peptide inhibitor of Japanese encephalitis virus infection targeting envelope protein domain III. Antiviral Res. 2014;104:7–14.
  • Chen L, Liu Y, Wang S, et al. Antiviral activity of peptide inhibitors derived from the protein E stem against Japanese encephalitis and Zika viruses. Antiviral Res. 2017;141:140–149.
  • Li C, Ge LL, Yu YL, et al. A tripeptide (NSK) inhibits Japanese encephalitis virus infection in vitro and in vivo. Arch Virol. 2014;159:1045–1055.
  • Li C, Zhang LY, Sun MX, et al. Inhibition of Japanese encephalitis virus entry into the cells by the envelope glycoprotein domain III (EDIII) and the loop3 peptide derived from EDIII. Antiviral Res. 2012;94:179–183.
  • Qiu X, Lei Y, Yang P, et al. Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies. Nat Microbiol. 2018;3:287–294.
  • Rayamajhi A, Nightingale S, Bhatta NK, et al. A preliminary randomized double blind placebo-controlled trial of intravenous immunoglobulin for Japanese encephalitis in Nepal. PLoS One. 2015;10:e0122608.
  • Caramello P, Canta F, Balbiano R, et al. Role of intravenous immunoglobulin administration in Japanese encephalitis. Clin Infect Dis. 2006;43:1620–1621.
  • Boldescu V, Behnam MAM, Vasilakis N, et al. Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond. Nat Rev Drug Discov. 2017;16:565–586.
  • Bollati M, Alvarez K, Assenberg R, et al. Structure and functionality in flavivirus NS-proteins: perspectives for drug design. Antiviral Res. 2010;87:125–148.
  • Luo D, Vasudevan SG, Lescar J. The flavivirus NS2B-NS3 protease-helicase as a target for antiviral drug development. Antiviral Res. 2015;118:148–158.
  • Mastrangelo E, Pezzullo M, De Burghgraeve T, et al. Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug. J Antimicrob Chemother. 2012;67:1884–1894.
  • Fang J, Li H, Kong D, et al. Structure-based discovery of two antiviral inhibitors targeting the NS3 helicase of Japanese encephalitis virus. Sci Rep. 2016;6:34550.
  • Li Z, Brecher M, Deng YQ, et al. Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction. Cell Res. 2017;27:1046–1064.
  • Li Z, Sakamuru S, Huang R, et al. Erythrosin B is a potent and broad-spectrum orthosteric inhibitor of the flavivirus NS2B-NS3 protease. Antiviral Res. 2018;150:217–225.
  • Brecher M, Chen H, Li Z, et al. Identification and characterization of novel broad-spectrum inhibitors of the flavivirus methyltransferase. ACS Infect Dis. 2015;1:340–349.
  • Han SR, Lee SW. Inhibition of Japanese encephalitis virus (JEV) replication by specific RNA aptamer against JEV methyltransferase. Biochem Biophys Res Commun. 2017;483:687–693.
  • Shen T, Liu K, Miao D, et al. Effective inhibition of Japanese encephalitis virus replication by shRNAs targeting various viral genes in vitro and in vivo. Virology. 2014;454-455:48–59.
  • Anantpadma M, Vrati S. siRNA-mediated suppression of Japanese encephalitis virus replication in cultured cells and mice. J Antimicrob Chemother. 2012;67:444–451.
  • Shen T, Liu K, Miao D, et al. Lentivirus-mediated RNA interference against Japanese encephalitis virus infection in vitro and in vivo. Antiviral Res. 2014;108:56–64.
  • Wu Z, Xue Y, Wang B, et al. Broad-spectrum antiviral activity of RNA interference against four genotypes of Japanese encephalitis virus based on single microRNA polycistrons. PLoS One. 2011;6:e26304.
  • Anantpadma M, Stein DA, Vrati S. Inhibition of Japanese encephalitis virus replication in cultured cells and mice by a peptide-conjugated morpholino oligomer. J Antimicrob Chemother. 2010;65:953–961.
  • Nazmi A, Dutta K, Basu A. Antiviral and neuroprotective role of octaguanidinium dendrimer-conjugated morpholino oligomers in Japanese encephalitis. PLoS Negl Trop Dis. 2010;4:e892.
  • Yoo JS, Kim CM, Kim JH, et al. Inhibition of Japanese encephalitis virus replication by peptide nucleic acids targeting cis-acting elements on the plus- and minus-strands of viral RNA. Antiviral Res. 2009;82:122–133.
  • Solomon T, Dung NM, Wills B, et al. Interferon alfa-2a in Japanese encephalitis: a randomized double-blind placebo-controlled trial. Lancet. 2003;361:821–826.
  • Kumar R, Tripathi P, Baranwal M, et al. Randomized, controlled trial of oral ribavirin for Japanese encephalitis in children in Uttar Pradesh, India. Clin Infect Dis. 2009;48:400–406.
  • Lee E, Pavy M, Young N, et al. Antiviral effect of the heparan sulfate mimetic, PI-88, against dengue and encephalitic flaviviruses. Antiviral Res. 2006;69:31–38.
  • Ishag HZ, Li C, Huang L, et al. Griffithsin inhibits Japanese encephalitis virus infection in vitro and in vivo. Arch Virol. 2013;158:349–358.
  • Ishag HZA, Li C, Wang F, et al. Griffithsin binds to the glycosylated proteins (E and prM) of Japanese encephalitis virus and inhibit its infection. Virus Res. 2016;215:50–54.
  • Haridas V, Rajgokul KS, Sadanandan S, et al. Bispidine-amino acid conjugates act as a novel scaffold for the design of antivirals that block Japanese encephalitis virus replication. PLoS Negl Trop Dis. 2013;7(1):e2005.
  • Ishag HZ, Li C, Huang L, et al. Inhibition of Japanese encephalitis virus infection in vitro and in vivo by pokeweed antiviral protein. Virus Res. 2013;171:89–96.
  • Shi Z, Wei J, Deng X, et al. Nitazoxanide inhibits the replication of Japanese encephalitis virus in cultured cells and in a mouse model. Virol J. 2014;11:10.
  • Fang J, Sun L, Peng G, et al. Identification of three antiviral inhibitors against Japanese encephalitis virus from library of pharmacologically active compounds 1280. PLoS One. 2013;8:e78425.
  • Wang S, Liu Y, Guo J, et al. Screening of FDA-approved drugs for inhibitors of Japanese encephalitis virus infection. J Virol. 2017;91:pii: e01055-17.
  • Marceau CD, Puschnik AS, Majzoub K, et al. Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens. Nature. 2016;535:159–163.
  • Zhang R, Miner JJ, Gorman MJ, et al. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Nature. 2016;535:164–168.
  • Lopez-Sambrooks C, Shrimal S, Khodier C, et al. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat Chem Biol. 2016;12:1023–1030.
  • Puschnik AS, Marceau CD, Ooi YS, et al. A small-molecule oligosaccharyltransferase inhibitor with pan-flaviviral activity. Cell Rep. 2017;21:3032–3039.
  • Touch S, Suraratdecha C, Samnang C, et al. A cost-effectiveness analysis of Japanese encephalitis vaccine in Cambodia. Vaccine. 2010;28:4593–4599.
  • Liu W, Clemens JD, Kari K, et al. Cost-effectiveness of Japanese encephalitis (JE) immunization in Bali, Indonesia. Vaccine. 2008;26:4456–4460.
  • Ding D, Kilgore PE, Clemens JD, et al. Cost-effectiveness of routine immunization to control Japanese encephalitis in Shanghai, China. Bull World Health Organ. 2003;81:334–342.
  • Yin Z, Beeler Asay GR, et al. An economic evaluation of the use of Japanese encephalitis vaccine in the expanded program of immunization of Guizhou province, China. Vaccine. 2012;30:5569–5577.
  • Barzon L, Palù G. Current views on Zika virus vaccine development. Expert Opin Biol Ther. 2017;17:1185–1192.
  • Gaudinski MR, Houser KV, Morabito KM, et al. Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials. Lancet. 2017;pii: S0140-6736(17)33105–7.
  • Modjarrad K, Lin L, George S, et al. Preliminary aggregate safety and immunogenicity results from three trials of a purified inactivated Zika virus vaccine candidate: phase 1, randomised, double-blind, placebo-controlled clinical trials. Lancet. 2017;pii: S0140-6736(17)33106–9.
  • Lobigs M, Larena M, Alsharifi M, et al. Live chimeric and inactivated Japanese encephalitis virus vaccines differ in their cross-protective values against Murray Valley encephalitis virus. J Virol. 2009;83:2436–2445.
  • Lobigs M, Diamond MS. Feasibility of cross-protective vaccination against flaviviruses of the Japanese encephalitis serocomplex. Expert Rev Vaccines. 2012;11:177–187.
  • Cao L, Fu SGao X, et al. Low protective efficacy of the current japanese encephalitis vaccine against the emerging genotype 5 japanese encephalitis virus. Plos Negl Trop Dis. 2016;10(5):e0004686.
  • Yamshchikov G, Borisevich V, Kwok CW, et al. The suitability of yellow fever and Japanese encephalitis vaccines for immunization against West Nile virus. Vaccine. 2005;23:4785–4792.
  • Halstead SB. Neutralization and antibody-dependent enhancement of dengue viruses. Adv Virus Res. 2003;60:421–467.
  • The Lancet Infectious Diseases. The dengue vaccine dilemma. Lancet Infect Dis. 2018;18:123

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